A familial cluster of COVID-19 infection in a northern Chinese region

Abstract Background Currently, coronavirus disease 2019 (COVID-19) has spread worldwide and become a global health concern. Here, we report a familial cluster of COVID-19 infection in a northern Chinese region and share our local experience. Methods A familial cluster of six patients infected with severe acute respiratory coronavirus 2 (SARS-CoV-2) was included for analysis. The demographic data, clinical features, laboratory examinations, and epidemiological characteristics of enrolled cases were collected and analyzed. Results Two family members (Cases 1 and 2) had Hubei exposure history and were admitted to the hospital with a confirmed diagnosis of COVID-19; eight familial members who had contact with them during the incubation period were isolated in a hospital. Finally, the condition of four members (Cases 3, 4, 5, and 6) was as follows. Case 3 had negative SARS-CoV-2 RT-PCR results but was suspected to have COVID-19 because of radiographic abnormalities. Cases 4 and 5 developed COVID-19. Due to positive SARS-CoV-2 RT-PCR results, Case 6 was considered an asymptomatic carrier. In addition, four close contacts did not have evidence of SARS-CoV-2 infection. Conclusions Our findings suggest that COVID-19 has infectivity during the incubation period and preventive quarantine is effective for controlling an outbreak of COVID-19 infection.

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Possible association between the gamma-aminobutyric acid type B receptor2 gene and depression of schizophrenia in Northern Chinese population

PsycEXTRA Dataset ◽

10.1037/e511212008-001 ◽

2008 ◽

Author(s):

Ning Sun ◽

Ke Rang Zhang ◽

Qi Xu

Keyword(s):

Chinese Population ◽

Aminobutyric Acid ◽

Gamma Aminobutyric Acid ◽

Type B ◽

Acid Type ◽

Northern Chinese ◽

Northern Chinese Population

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Transmission of Renaissance herbal images to China: the Beitang copy of Mattioli’s commentaries on Dioscorides and its annotations

Archives of Natural History ◽

10.3366/anh.2020.0651 ◽

2020 ◽

Vol 47 (2) ◽

pp. 236-253

Author(s):

Wu Huiyi ◽

Zheng Cheng

Keyword(s):

Seventeenth Century ◽

Natural History ◽

National Library ◽

Materia Medica ◽

Close Analysis ◽

Northern Chinese ◽

Jesuit Missionaries ◽

Animal Names ◽

National Library Of China ◽

Made In

The Beitang Collection, heritage of a seventeenth- and eighteenth-century Jesuit library in Beijing now housed in the National Library of China, contains an incomplete copy of Pietro Andrea Mattioli’s commentary on an Italian edition of Pedanius Dioscorides's De materia medica (1568) bearing extensive annotations in Chinese. Two hundred odd plant and animal names in a northern Chinese patois were recorded alongside illustrations, creating a rare record of seventeenth-century Chinese folk knowledge and of Sino-Western interaction in the field of natural history. Based on close analysis of the annotations and other contemporary sources, we argue that the annotations were probably made in Beijing by one or more Chinese low-level literati and Jesuit missionaries during the first two decades of the seventeenth century. We also conclude that the annotations were most likely directed at a Chinese audience, to whom the Jesuits intended to illustrate European craftsmanship using Mattioli’s images. This document probably constitutes the earliest known evidence of Jesuits' attempts at transmitting the art of European natural history drawings to China.

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Accuracy of the Demirjian, Willems and Nolla methods for dental age estimation in a northern Chinese population

Archives of Oral Biology ◽

10.1016/j.archoralbio.2020.104875 ◽

2020 ◽

Vol 118 ◽

pp. 104875

Author(s):

Meng-qi Han ◽

Si-xuan Jia ◽

Chen-Xu Wang ◽

Guang Chu ◽

Teng Chen ◽

...

Keyword(s):

Age Estimation ◽

Chinese Population ◽

Dental Age ◽

Dental Age Estimation ◽

Northern Chinese ◽

Northern Chinese Population

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A novel missense mutation of CRYBA1 in a northern Chinese family with inherited coronary cataract with blue punctate opacities

European Journal of Ophthalmology ◽

10.1177/11206721211008355 ◽

2021 ◽

pp. 112067212110083

Author(s):

Shu-Hua Ni ◽

Juan-Mei Zhang ◽

Jun Zhao

Keyword(s):

Missense Mutation ◽

High Throughput Sequencing ◽

Bioinformatics Analysis ◽

Genetic Defect ◽

Kinase Domain ◽

Chinese Family ◽

Heterozygous Mutation ◽

Scale Invariant ◽

The Family ◽

Northern Chinese

Purpose: To demonstrate the underlying genetic defect that contribute to inherited cataract in a northern Chinese pedigree. Methods: The study recruited a family pedigree with a diagnosis of bilateral coronary cataract with blue punctate opacities. Fourteen family members and 100 healthy volunteers were enrolled. DNA sample of the proband in this family were analyzed by high-throughput sequencing, which was then demonstrated by Sanger sequencing in the remained people in the family and 100 controls. The functional effect of mutant genes was investigated via bioinformatics analysis, including Polymorphism Phenotyping version2 (PolyPhen-2), Protein Variation Effect Analyzer (PROVEAN v1.1.3) Scale-Invariant Feature Transform (SIFT), and Mutation Taster. Results: In this three-generation family, a novel heterozygous mutation was found in the kinase domain of CRYBA1 gene (c.340C > T, p.R114C), which was only detected in patients in the family with inherited cataract and were not detected in the remained people in the family nor in normal people. The pathogenic effect of the mutation was verified via bioinformatics analysis. Conclusion: Our study presented the molecular experiments to confirm that a novel missense mutation of c.340 C > T located in exon 4 of CRYBA1 gene results in a bilateral coronary cataract with blue punctate opacities, which enriches the mutation spectrum of CRYBA1 gene in inherited cataract and deepens the understanding of the pathogenesis of inherited cataract.

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Newly-Discovered Manuscripts of a Northern-Chinese Horse King Temple Association

T oung Pao ◽

10.1163/15685322-10512p05 ◽

2019 ◽

Vol 105 (1-2) ◽

pp. 183-228 ◽

Cited By ~ 1

Author(s):

Meir Shahar

Keyword(s):

North China ◽

Rural Culture ◽

Late Imperial China ◽

Late Imperial ◽

Agrarian Economy ◽

The Social ◽

Religious Perspectives ◽

Northern Chinese ◽

Imperial China ◽

The Village

AbstractWritten documents from rural north China are rare. This essay examines the newly-discovered records of a Shanxi village association, which was dedicated to the cult of the Horse King. The manuscripts detail the activities, revenues, and expenditures of the Horse King temple association over a hundred-year period (from 1852 until 1956). The essay examines them from social, cultural, and religious perspectives. The manuscripts reveal the internal workings and communal values of a late imperial village association. They unravel the social and economic structure of the village and the centrality of theater in rural culture. Furthermore, the manuscripts bring to the fore a forgotten cult and its ecological background: the Horse King was among the most widely worshiped deities of late imperial China, his flourishing cult reflecting the significance of his protégés – horses, donkeys, and mules – in the agrarian economy.

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