scholarly journals The benefits for multiple management strategies of appropriate antibiotic treatment compared between defined daily dose of antibiotic and colonies of antimicrobial resistance in a community hospital

2015 ◽  
Vol 48 (2) ◽  
pp. S126
Author(s):  
Meei-Shue Kuo ◽  
Chen-Ying Tsen ◽  
Bing-Zhang Lai ◽  
Shi-Rong Duh
Keyword(s):  
Antimicrobial Resistance ◽  
Antibiotic Treatment ◽  
Community Hospital ◽  
Management Strategies ◽  
Defined Daily Dose ◽  
Daily Dose

scholarly journals Irrational Use of Antimicrobials in Poultry Farms and Antimicrobial Resistance: A Cross-Sectional Study

2021 ◽  
Vol 3 (2) ◽  
pp. 10-14
Author(s):  
Talal Alhouzani ◽  
Mohammad Saleem ◽  
Arun Sharma ◽  
Sitaram Khadka ◽  
Ravi Prasad Gupta ◽  
...  
Keyword(s):  
Public Health ◽  
Antimicrobial Resistance ◽  
Production Cycle ◽  
Defined Daily Dose ◽  
Global Public Health ◽  
Cross Sectional ◽  
Health Threat ◽  
Poultry Farms ◽  
Public Health Threat ◽  
Daily Dose

Background: The rampant use of antimicrobials in poultry farms is creating a global public health threat as antimicrobial resistance (AMR) in humans may arise from such practice. This study was conducted with the objective of quantification and hence assessment of the level of antimicrobial use in Pakistani poultry farms so that appropriate utilization of such agents can be assured. Methods: Six randomly selected poultry farms of Pakistan with ten production cycles with 20,000- 30,000 birds in every production cycle were selected for the study from 2018 to 2019. The average dosage utilized on-farm was described by the defined daily dose (DDD) and used daily dose (UDD). Results: It was found that enrofloxacin, amoxicillin, doxycycline, tylocin, and lincomycin were the antimicrobials commonly used by all poultry farms. However, only Enrofloxacin (UDD/DDD = 0.95) was being used within the rational therapeutic range. All the antimicrobials were used irrationally without proper indication and suggestion by the veterinarian. No records on antimicrobials use were found on any farm.   Conclusion: The irrational use of antimicrobials in poultry farms may lead to antimicrobial resistance which has been a global public health threat. The speedy action should be implemented to discourage such rampant use of drugs in poultry farms in Pakistan and countries with similar farming practices for the effective use of antimicrobials in the proper indication.

Comparison of the defined daily dose and days of treatment methods for evaluating the consumption of antibiotics and antifungals in the intensive care unit

2020 ◽  
Vol 44 (5) ◽  
pp. 294-300 ◽  
Author(s):  
J. Vallès ◽  
S. Fernández ◽  
E. Cortés ◽  
A. Morón ◽  
E. Fondevilla ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Defined Daily Dose ◽  
Treatment Methods ◽  
Daily Dose

scholarly journals Broad-Spectrum Antibiotic Regimen Affects Survival in Patients Receiving Nivolumab for Non-Small Cell Lung Cancer

2021 ◽  
Vol 14 (5) ◽  
pp. 445
Author(s):  
Min Jung Geum ◽  
Chungsoo Kim ◽  
Ji Eun Kang ◽  
Jae Hee Choi ◽  
Jae Song Kim ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Broad Spectrum ◽  
Small Cell ◽  
Defined Daily Dose ◽  
Small Cell Lung ◽  
Broad Spectrum Antibiotic ◽  
Negatively Associated ◽  
Daily Dose

Antibiotic-induced dysbiosis may affect the efficacy of immune checkpoint inhibitors. We investigated the impact of antibiotics on the clinical outcomes of nivolumab in patients with non-small cell lung cancer (NSCLC). Patients who received nivolumab for NSCLC between July 2015 and June 2018 and who were followed up until June 2020 were included in a retrospective cohort analysis. Of 140 eligible patients, 70 were on antibiotics. Overall survival (OS) was shorter in patients on antibiotics (ABX) compared to those not on antibiotics (NoABX) (p = 0.014). OS was negatively associated with piperacillin/tazobactam (PTZ) (HR = 3.31, 95% CI: 1.77–6.18), days of therapy (DOT) ≥ 2 weeks (HR = 2.56, 95% CI: 1.30–5.22) and DOT of PTZ. The defined daily dose (DDD) in PTZ (r = 0.27) and glycopeptides (r = 0.21) showed weak correlations with mortality. There was no difference in progression-free survival (PFS) between ABX and NoABX; however, PFS was negatively associated with the antibiotic class PTZ and DOT of PTZ. Therefore, the use of a broad-spectrum antibiotic, such as PTZ, the long-term use of antibiotics more than 2 weeks in total and the large amount of defined daily dose of specific antibiotics were associated with decreased survival in patients receiving nivolumab for NSCLC.

scholarly journals Implications of a defined daily dose fixed database for drug utilization research studies: The case of statins in Portugal

2021 ◽  
Author(s):  
Catarina Abrantes ◽  
Fernanda S. Tonin ◽  
Joana Reis‐Pardal ◽  
Margarida Castel‐Branco ◽  
Claudia Furtado ◽  
...  
Keyword(s):  
Drug Utilization ◽  
Defined Daily Dose ◽  
Utilization Research ◽  
Daily Dose ◽  
Drug Utilization Research ◽  
Research Studies

scholarly journals National Antimicrobial Consumption: Analysis of Central Warehouses Supplies to In-Patient Care Health Facilities from 2017 to 2019 in Uganda

2021 ◽  
Vol 6 (2) ◽  
pp. 83
Author(s):  
Juliet Sanyu Namugambe ◽  
Alexandre Delamou ◽  
Francis Moses ◽  
Engy Ali ◽  
Veerle Hermans ◽  
...  
Keyword(s):  
Inpatient Care ◽  
Health Facilities ◽  
World Health ◽  
Defined Daily Dose ◽  
Antimicrobial Consumption ◽  
National Medical ◽  
The World ◽  
Daily Dose ◽  
Care Health ◽  
Health Organization

Antimicrobial consumption (AMC) surveillance at global and national levels is necessary to inform relevant interventions and policies. This study analyzed central warehouse antimicrobial supplies to health facilities providing inpatient care in Uganda. We collected data on antimicrobials supplied by National Medical Stores (NMS) and Joint Medical Stores (JMS) to 442 health facilities from 2017 to 2019. Data were analyzed using the World Health Organization methodology for AMC surveillance. Total quantity of antimicrobials in defined daily dose (DDD) were determined, classified into Access, Watch, Reserve (AWaRe) and AMC density was calculated. There was an increase in total DDDs distributed by NMS in 2019 by 4,166,572 DDD. In 2019, Amoxicillin (27%), Cotrimoxazole (20%), and Metronidazole (12%) were the most supplied antimicrobials by NMS while Doxycycline (10%), Amoxicillin (19%), and Metronidazole (10%) were the most supplied by JMS. The majority of antimicrobials supplied by NMS (81%) and JMS (66%) were from the Access category. Increasing antimicrobial consumption density (DDD per 100 patient days) was observed from national referral to lower-level health facilities. Except for NMS in 2019, total antimicrobials supplied by NMS and JMS remained the same from 2017 to 2019. This serves as a baseline for future assessments and monitoring of stewardship interventions.

42 THE DEFINED DAILY DOSE CAN ASSESS POSTOPERATIVE CHANGE IN ANTIHYPERTENSIVE DRUG CONSUMPTION IN PATIENTS WITH PRIMARY ALDOSTERONISM

2013 ◽  
Vol 189 (4S) ◽  
Author(s):  
Takanobu Utsumi ◽  
Mayuko Kaga ◽  
Tomokazu Sazuka ◽  
Mitsuru Yanagisawa ◽  
Kazuyoshi Nakamura ◽  
...  
Keyword(s):  
Antihypertensive Drug ◽  
Primary Aldosteronism ◽  
Drug Consumption ◽  
Defined Daily Dose ◽  
Postoperative Change ◽  
Daily Dose

scholarly journals Study on drug utilization pattern and cost analysis among the psychiatric patients treated with various benzodiazepine derivatives

2020 ◽  
Vol 9 (6) ◽  
pp. 975
Author(s):  
Dhivya Govindasamy ◽  
Gandhibabu Ramanathan ◽  
Talari Venkata Siva Prasad ◽  
Gopalakrishnan Ganesan
Keyword(s):  
Cost Analysis ◽  
Drug Utilization ◽  
Alcohol Withdrawal ◽  
Withdrawal Syndrome ◽  
Psychiatric Patients ◽  
Age Groups ◽  
Alcohol Withdrawal Syndrome ◽  
Defined Daily Dose ◽  
Utilization Pattern ◽  
Daily Dose

Background: The objective of the study was to assess drug utilization pattern and cost analysis among the psychiatric patients treated with various benzodiazepine derivatives.Methods: This observational study was conducted in department of psychiatric, RMMCH, Annamalai University. The study period was 6 months (November 2018 to April 2019). A total of 50 psychiatric patients were included.Results: A total 50 patients among them 64% (32) males and 36% (18) female, were included in the study. Most of the patient were between the age groups of 18-29 years (30%). The most common clinical condition treated with benzodiazepines were alcohol dependence syndrome/alcohol withdrawal syndrome/ alcohol related psychotic disorder (34%). The majority of patients were prescribed with clonazepam (66.67%). The defined daily dose (DDD) per 100 bed days of benzodiazepines were found to be 0.89. In this study the comparison of cost analysis for the drug used and it was found that lorazepam (122%) are most expensive followed by chlordiazepoxide (93.3%) and clonazepam (78.57%). The cheapest drug was nitrazepam (36.84%).Conclusions: The majority of the patient admitted in the psychiatric department were suffering from Alcohol depending syndrome/alcohol withdrawal syndrome. The most commonly prescribed benzodiazepine was clonazepam followed by lorazepam and least prescribed diazepam and nitrazepam based on defined daily dose concept.

scholarly journals Assessment of drug utilization among geriatric patients based on defined daily dose concept in a rural tertiary care teaching hospital

2020 ◽  
Vol 9 (10) ◽  
pp. 1538
Author(s):  
K. Padmavathi ◽  
S. A. Arun Raaj ◽  
S. Subash ◽  
C. K. Dhanapal ◽  
S. Periasamy
Keyword(s):  
Drug Utilization ◽  
Geriatric Patients ◽  
Anatomical Therapeutic Chemical ◽  
Tertiary Care ◽  
Defined Daily Dose ◽  
College Hospital ◽  
Care Teaching ◽  
Essential Drug List ◽  
Daily Dose ◽  
Collection Form

Background: The objectives of the study were to use the anatomical therapeutic chemical classification (ATC) /defined daily dose (DDD) concept to study the drug utilization pattern in geriatric patients in a rural tertiary care teaching hospital.Methods: An observational study was conducted at Rajah Muthiah Medical College Hospital (OPD and IPD) over a period of six months from November 2018 to April 2019. The data was collected from 204 patients using specially designed data collection form. The patients were selected based on inclusion and exclusion criteria. Results: A total of 204 patients were included in this study. The study population consisting of males 130 (63.7%) and females 74 (36.2%). Diseases related to the cardiovascular system 67 (32.84%) were the most common cause for the geriatric patients to attend the hospital, followed by surgical diseases 47 (23.03%), Oncological diseases 2 (0.98%) were the least frequency encountered. The average number of drugs prescribed per prescription was 8.79. Out of 1795 drugs prescribed, 60.86% of drugs were prescribed in generic form, and 39.14% were prescribed in brand name. The study analysed that 71.25% of drugs prescribed were from essential drug list (EDL) 2016-2018. Number of prescriptions with an injection was 74.04%. Paracetamol (N02B01) was the most frequently prescribed drug, followed by Amlodipine (C08CA01), Dexamethasone (H02AB02), Clopidogrel (B01AC04), Ferrous sulfate (B03AA07), Acetylsalicylic acid (B01AC06), Hydrocortisone (H02AB09), Tamsulosin (G04CA02), Atorvastatin (C10AA05), Furosemide (C03CA01).Conclusions: Drug utilization study can help in evaluating the quality of care given to the geriatric patients and promote rational use of medicines.

Sign in / Sign up

Export Citation Format

Share Document