Dietary zinc restriction in rats alters antioxidant status and increases plasma F2 isoprostanes

The study investigated the effect of dietary zinc glycine chelate and potato fibre on the absorption and utilisation of Zn, Cu, Fe, and Mn; the activity of Zn-containing enzymes (superoxide dismutase, SOD; alkaline phosphatase, ALP); and zinc transporter concentrations (metalothionein1, MT1; zinc transporter1, ZnT1) in tissues, with a special emphasis on the small intestine. Twenty-four barrows (Danbred × Duroc) were randomly allotted to four diets (supplemented with 10 g/kg of crude fibre and 120 mg Zn/kg) that consisted of cellulose and either zinc sulphate (C) or zinc glycinate (ZnGly), or contained potato fibre supplemented with ZnSO4 (PF) or ZnGly (PF + ZnGly). Feeding PF can influence the Zn absorption in the small intestine due to reduced zinc transporters MT1 and ZnT1 in the jejunum. The activity of antioxidant enzyme SOD and liver ZnT1, and duodenal iron concentrations were increased in the PF treatments. Dietary ZnGly did not significantly influence the Zn distribution, but it may alter the absorption of Fe and Mn. Given the elevated content of thiol groups and the Zn/Cu ratio in plasma, as well as the altered SOD activity and MT content in the tissues, we can conclude that feeding PF and ZnGly can influence the mineral and antioxidant status of growing piglets. However, further research is needed in order to elucidate the effect of both dietary sources on the transport systems of other minerals in enterocytes.

Download Full-text

Influence of dietary zinc on muscle composition, flesh quality and muscle antioxidant status of young grass carp (Ctenopharyngodon idellaVal.)

Aquaculture Research ◽

10.1111/are.12392 ◽

2014 ◽

Vol 46 (10) ◽

pp. 2360-2373 ◽

Cited By ~ 31

Author(s):

Yun-Ping Wu ◽

Lin Feng ◽

Wei-Dan Jiang ◽

Yang Liu ◽

Jun Jiang ◽

...

Keyword(s):

Grass Carp ◽

Antioxidant Status ◽

Dietary Zinc ◽

Flesh Quality ◽

Muscle Composition

Download Full-text

Effects of dietary zinc on the growth, digestive enzyme activities, muscle biochemical compositions, and antioxidant status of the giant freshwater prawn Macrobrachium rosenbergii

Aquaculture ◽

10.1016/j.aquaculture.2015.05.045 ◽

2015 ◽

Vol 448 ◽

pp. 98-104 ◽

Cited By ~ 15

Author(s):

T. Muralisankar ◽

P. Saravana Bhavan ◽

S. Radhakrishnan ◽

C. Seenivasan ◽

V. Srinivasan ◽

...

Keyword(s):

Enzyme Activities ◽

Antioxidant Status ◽

Digestive Enzyme ◽

Macrobrachium Rosenbergii ◽

Freshwater Prawn ◽

Dietary Zinc ◽

Giant Freshwater Prawn ◽

Digestive Enzyme Activities ◽

Biochemical Compositions

Download Full-text

M.654 Antioxidant status and endothelium dysfunction markers in patients with diabetic retinopathy

Atherosclerosis ◽

10.1016/s0021-9150(04)90652-1 ◽

2004 ◽

Vol 5 (1) ◽

pp. 151

Author(s):

K SIEMIANOWICZ

Keyword(s):

Diabetic Retinopathy ◽

Antioxidant Status ◽

Endothelium Dysfunction

Download Full-text

Association between calcitriol and paricalcitol with oxidative stress in patients with hemodialysis

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831/a000641 ◽

2020 ◽

pp. 1-8

Author(s):

Hasan Haci Yeter ◽

Berfu Korucu ◽

Elif Burcu Bali ◽

Ulver Derici

Keyword(s):

Oxidative Stress ◽

Vitamin D ◽

Antioxidant Status ◽

Total Antioxidant Status ◽

Stress Index ◽

Total Oxidant Status ◽

Vitamin D Analog ◽

Total Antioxidant ◽

Oxidant Status ◽

And Oxidative Stress

Abstract. Background: The pathophysiological basis of chronic kidney disease and its complications, including cardiovascular disease, are associated with chronic inflammation and oxidative stress. We investigated the effects of active vitamin D (calcitriol) and synthetic vitamin D analog (paricalcitol) on oxidative stress in hemodialysis patients. Methods: This cross-sectional study was composed of 83 patients with a minimum hemodialysis vintage of one year. Patients with a history of any infection, malignancy, and chronic inflammatory disease were excluded. Oxidative markers (total oxidant and antioxidant status) and inflammation markers (C-reactive protein and interleukin-6) were analyzed. Results: A total of 47% (39/83) patients were using active or analog vitamin D. Total antioxidant status was significantly higher in patients with using active or analog vitamin D than those who did not use (p = 0.006). Whereas, total oxidant status and oxidative stress index were significantly higher in patients with not using vitamin D when compared with the patients who were using vitamin D preparation (p = 0.005 and p = 0.004, respectively). On the other hand, total antioxidant status, total oxidant status, and oxidative stress index were similar between patients who used active vitamin D or vitamin D analog (p = 0.6; p = 0.4 and p = 0.7, respectively). Conclusion: The use of active or selective vitamin D analog in these patients decreases total oxidant status and increases total antioxidant status. Also, paricalcitol is as effective as calcitriol in decreasing total oxidant status and increasing total antioxidant status in patients with chronic kidney disease.

Download Full-text

Pro-oxidant effects of a high α-tocopherol dose on kidney antioxidant biomarkers and histopathological aspects

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831/a000512 ◽

2017 ◽

Vol 87 (3-4) ◽

pp. 179-190

Author(s):

Amel Kanane ◽

Fayrouz Rouaki ◽

Mohamed Brahim Errahmani ◽

Abdenour Laraba ◽

Hayet Mesbah ◽

...

Keyword(s):

Sunflower Oil ◽

Antioxidant Status ◽

Basal Diet ◽

Inflammatory Cells ◽

Significant Rise ◽

Control Group ◽

Histopathological Changes ◽

Group 5 ◽

Oxidant Effect ◽

Higher Doses

Abstract. The aim of this study is to evaluate the effect of α-tocopherol supplementation at two doses (600 and 1200 mg × kg–1) on kidney antioxidant status and the histopathological changes in Wistar rats after 12 weeks of exposure at different diets. Forty rats has been divided into 4 groups of 10 rats each, the control group received basal diet with 5 % fresh sunflower oil (FSO), the second group: 5 % oxidized sunflower oil (OSO), the third group: 5 % OSO supplemented with 600 mg × kg–1 α-tocopherol and the fourth group: 5 % OSO supplemented with 1200 mg × kg–1 α-tocopherol. In OSO groups, the results showed highly significant increases of LPO (from 31.3 ± 0.9 to 53.8 ± 1.2 nmol of MDA formed/min/mg protein, p < 0.0001) with a significant decrease (p < = 0.001) of the antioxidant enzymatic activities (CAT, SOD, GPX, GR and G6PDH), body weight (339 ± 9 to 290 ± 3 g) and α-tocopherol levels (13.6 ± 0.6 to 6.5 ± 0.4 μg/mg protein). In OSO groups with 600 mg × kg–1 α-tocopherol, an antioxidant effect was found, reflected by a return of the parameters to values similar to those of the control group. However, higher doses of α-tocopherol (1200 mg × kg–1) induced a depletion of antioxidant status, α-tocopherol levels (6.0 ± 0.3 μg/mg protein, p < 0.001) and a very highly significant rise (p < 0.0001) of LPO content (54.86 ± 0.01 nmol of MDA formed/min/mg protein). The kidney tissues also showed changes in glomerular, severe inflammatory cells infiltration, and formation of novel vessels. So, we can conclude that the oxidative stress is attenuated by a moderate administration of 600 mg × kg–1 α-tocopherol, while a pro-oxidant effect occurs at 1200 mg × kg–1 α-tocopherol.

Download Full-text