scholarly journals The Soy Isoflavones for Reducing Bone Loss Study: 3-Yr Effects on pQCT Bone Mineral Density and Strength Measures in Postmenopausal Women

2011 ◽  
Vol 14 (1) ◽  
pp. 47-57 ◽  
Author(s):  
Kristine M. Shedd-Wise ◽  
D. Lee Alekel ◽  
Heike Hofmann ◽  
Kathy B. Hanson ◽  
Dan J. Schiferl ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Loss ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Soy Isoflavones ◽  
Mineral Density

scholarly journals Effect of BMI(Body Mass Index) on BMD (Bone Mineral Density) in Postmenopausal Women

2020 ◽  
Vol 28 (1) ◽  
pp. 60-66
Author(s):  
Tabassum Ghani ◽  
Subinoy Krishna Paul ◽  
Afrina Begum ◽  
Noorjahan ◽  
Mandira Sarkar ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Body Mass Index ◽  
Bone Loss ◽  
Postmenopausal Women ◽  
Body Mass ◽  
Bone Mineral ◽  
Significant Positive Correlation ◽  
Mineral Density ◽  
Positive Correlation ◽  
Medical College

Menopause is commonly associated with rapid bone loss and this bone loss manifests as a significant decrease in bone mineral density (BMD). Body weight or body mass index is the most important factor which influences BMD. Aim of this study was to evaluate the association between BMI and BMD in post menopausal women. Also to measure the correlation between age, duration of menopause, weight with BMD. This cross-sectional study was undertaken in the Department of Obstetrics and Gynaecology in Dhaka Medical College Hospital, Dhaka from January, 2012 to December, 2012. The study included women of 50 to 70 years who had menopause with three or more parity. Total 100 women were evaluated by history taking, physical examination and laboratory investigation (BMD).The results showed that there was significant positive correlation between BMI and BMD value of L1-4 and total femur (Pearson‘s coefficient was +0.285, P<0.01 and +.350, P<.001). There was also significant positive correlation between weight and T- score of L1-4 (r =+ .482, P<.01) and Total femur (r = +.513, P< .01). In addition, significant negative correlation was found between BMD with age and duration of menopause. It can be concluded that in postmenopausal women as the BMI decreases bone mineral density also decreases. So, adequate weight and BMI necessary for the prevention of osteoporosis. J Dhaka Medical College, Vol. 28, No.1, April, 2019, Page 60-66

scholarly journals The Combination of Soy Isoflavones and Resveratrol Preserve Bone Mineral Density in Hindlimb-Unloaded Mice

Nutrients ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 2043
Author(s):  
Yuko Tousen ◽  
Ryota Ichimaru ◽  
Takashi Kondo ◽  
Masaki Inada ◽  
Chisato Miyaura ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Loss ◽  
Bone Mineral ◽  
Bone Marrow Cells ◽  
Control Diet ◽  
Soy Isoflavones ◽  
Hindlimb Unloading ◽  
Mineral Density ◽  
Expression Ratio ◽  
Positive Balance

It is well known that physical inactivity during space flight or prolonged bed rest causes rapid bone loss. Soy isoflavones (ISOs) and resveratrol (RES) have been reported to be useful to maintain a positive balance for bone turnover. Therefore, we examined the combined effects of ISO and RES on bone loss that was induced by hindlimb-unloading in mice. Female eight-week-old ddY mice were divided into the following six groups (n = 6–8 each): normally housed mice, loading mice, hindlimb-unloading (UL) mice fed a control diet, UL mice fed a 0.16% ISO conjugates, UL mice fed a 0.15% RES diet, and UL mice fed a 0.16% ISO and 0.15% RES diet. After three weeks, femoral bone mineral density was markedly decreased in unloading mice. The combination of ISO and RES prevented bone loss and especially maintained the trabecular bone mineral density more effectively compared with cortical bones. ISO and/or RES inhibited the increase in the RANKL/OPG expression ratio in bone marrow cells in UL mice. These results suggest that the combination of ISO and RES had a preventive effect against bone loss induced by hindlimb-unloading in mice. These osteoprotective effects of ISO and RES may result from the inhibition of bone resorption.

Body weight and/or endogenous estradiol as determinants of cortical bone mass and bone loss in healthy early postmenopausal women

1992 ◽  
Vol 127 (3) ◽  
pp. 226-230 ◽  
Author(s):  
Emerentia CH van Beresteijn ◽  
Jan PRM van Laarhoven ◽  
Anthony GH Smals
Keyword(s):  
Bone Mineral Density ◽  
Body Mass Index ◽  
Bone Loss ◽  
Bone Mass ◽  
Cortical Bone ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Mineral Density ◽  
Early Postmenopausal Women ◽  
Cortical Bone Mineral Density

The objective was to study the independent relationships of body mass index and endogenous estradiol to cortical bone mineral density and the rate of cortical bone loss at the radius in healthy early postmenopausal women. Fifty-one healthy early postmenopausal women (aged 58–66 years) participated. The women were a subset of a population participating in a 10-year longitudinal study to elucidate the influence of dietary calcium on the rate of cortical bone loss. Cortical bone mineral density at the radius, body weight and body height were measured annually (1979–89). Concentrations of sex steroids were measured in serum samples collected during the last year of follow-up (1989). Endogenous estradiol levels, although significantly positively correlated with body mass index, were not independently related to bone mass indices of the radius. Body mass index, on the other hand, was found to be positively related to cortical bone mineral density and negatively to the rate of bone loss, even after adjustments had been made for confounding factors. Our results suggest that the level of total estradiol is not an important determinant of cortical bone mass indices in healthy early postmenopausal women. Other factors of overweight such as mechanical loading may be important.

scholarly journals Estimation of Bone Mineral Density and Bone Loss by Means of Bone Metabolic Markers in Postmenopausal Women.

1995 ◽  
Vol 42 (6) ◽  
pp. 797-802 ◽  
Author(s):  
HIROAKI MIURA ◽  
ITSUO YAMAMOTO ◽  
ITSUAKI YUU ◽  
YUSUKE KIGAMI ◽  
TOYOTSUGU OHTA ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Loss ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Mineral Density ◽  
Bone Metabolic Markers ◽  
Metabolic Markers

scholarly journals Artificial neural networks to predict future bone mineral density and bone loss rate in Japanese postmenopausal women

2017 ◽  
Vol 10 (1) ◽  
Author(s):  
Mitsunori Shioji ◽  
Takehisa Yamamoto ◽  
Takeshi Ibata ◽  
Takayuki Tsuda ◽  
Kazushige Adachi ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Neural Networks ◽  
Artificial Neural Networks ◽  
Bone Loss ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Loss Rate ◽  
Mineral Density ◽  
Artificial Neural ◽  
Bone Loss Rate

Effect of estrogenic compounds (estrogen or phytoestrogens) combined with exercise on bone and muscle mass in older individuals

2008 ◽  
Vol 33 (1) ◽  
pp. 200-212 ◽  
Author(s):  
Philip D. Chilibeck ◽  
Stephen M. Cornish
Keyword(s):  
Bone Mineral Density ◽  
Estrogen Receptor ◽  
Exercise Training ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Estrogen Therapy ◽  
Estrogen Receptor Α ◽  
Soy Isoflavones ◽  
Older Individuals ◽  
Mineral Density

Exercise has a beneficial effect on bone, possibly by stimulating estrogen receptor α. Because estrogen up-regulates this receptor, estrogen therapy combined with exercise training may be optimal for increasing bone mineral density. Studies combining estrogen therapy and exercise training in postmenopausal women show mixed results, but indicate that the combination of interventions may be more effective for increasing bone mass than either intervention alone. Plant-like estrogens (i.e phytoestrogens such as soy isoflavones) may act as weak estrogen agonists or antagonists, have small beneficial effects on bone, and may interact with exercise for increasing bone mineral density. Phytoestrogen derived from flaxseed (flax lignans) has not been evaluated as extensively as soy isoflavones and thus its effect on bone is difficult to determine. Estrogen or soy isoflavones given to postmenopausal women results in a small increase in lean tissue mass that may be mediated through estrogen receptor α on muscle or through decreased inflammation.

The effect of anastrozole on bone mineral density during the first 5 years of adjuvant treatment in postmenopausal women with early breast cancer.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. e11604-e11604
Author(s):  
Hiroaki Inoue ◽  
Akira Hirano ◽  
Kaoru Ogura ◽  
Akinori Hattori ◽  
Mari Kamimura ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Bone Mineral Density ◽  
Lumbar Spine ◽  
Bone Loss ◽  
Adjuvant Therapy ◽  
Femoral Neck ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Mineral Density ◽  
Alendronate Treatment

e11604 Background: Adjuvant therapy with aromatase inhibitors (AI) is associated with increased bone loss in postmenopausal women. We assessed changes in bone mineral density (BMD) from baseline to 60 months of treatment in patients receiving anastrozole (ANA) as initial adjuvant therapy with/without oral bisphosphonates (Bis). Methods: Postmenopausal women with endocrine responsive breast cancer receiving ANA as adjuvant therapy at our hospital since 2004 were enrolled in this study. BMD was assessed by dual-energy X-ray absorptiometry at baseline and after 6, 12, 24, 36, 48 and 60 months. Oral Bis (risedronate or alendronate) treatment was initiated when patients were diagnosed as having osteoporosis with a T-score of -2.5 or lower. Results: Fifty-seven patients were enrolled in the study between 2004 and 2011. Patients’ median age was 65 years (range 50~85) and the median follow-up period was 46.3 months (9.6~83.8). Thirty-five patients were administered Bis (risedronate in 27 patients, alendronate in 8 patients). Within 6 months of hormone therapy, BMD decreased by 0.3% from baseline at the lumbar spine and BMD decreased by 1.2% at the femoral neck. However, BMD increased by 2.8% at the lumbar spine and BMD decreased 0.5% at the femoral neck for 60 months of treatment. In patients treated with upfront Bis (n=24), 4.9% BMD increase from baseline was noted at the lumbar spine whereas in those without Bis (n=20) BMD decreased by 4.6% from baseline within 24 months (p=0.0002). Fractures were observed in 4 patients (7.0%), and 1 patient (1.8%) had fragility fracture. Conclusions: Oral Bis prevented ANA-induced bone loss, and upfront treatment of Bis significantly increased BMD at the lumber spine.

scholarly journals Prolactinoma: AMassiveEffect on Bone Mineral Density in a Young Patient

2016 ◽  
Vol 2016 ◽  
pp. 1-3 ◽  
Author(s):  
Scott Sperling ◽  
Harikrashna Bhatt
Keyword(s):  
Bone Mineral Density ◽  
Case Report ◽  
Bone Loss ◽  
Postmenopausal Women ◽  
Young Patient ◽  
Bone Mineral ◽  
Bone Health ◽  
Young Male ◽  
Mineral Density ◽  
Low Bone Mineral Density

This case highlights a prolactinoma in a young male, and its impact on bone health. Osteoporosis has been noted to be an issue in postmenopausal women with prolactinomas. This case shows a similar impact on bone health in a young male resulting in low bone mineral density for age based onZ-score. This case report highlights the possible mechanisms for the bone loss in the setting of prolactinoma and the need for assessing bone health in such patients. Furthermore it highlights the need for a thorough evaluation in such patients.

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