scholarly journals Impact of satellite blood culture on early diagnosis of sepsis

2021 ◽  
Author(s):  
Ziqi Guo ◽  
Bo Guo ◽  
Shanmei Wang ◽  
Huifeng Zhang ◽  
Wenxiao Zhang ◽  
...  
Keyword(s):  
Blood Culture ◽  
Early Diagnosis

scholarly journals Role of Serial C-reactive Protein (CRP) in Relation to Total Leucocyte Count, Platelet Count & Blood Culture for early Diagnosis of Neonatal Septicemia in Developing Countries

2015 ◽  
Vol 32 (2) ◽  
pp. 61-65
Author(s):  
Chiranjib Barua ◽  
Md Nurul Anwar ◽  
Md Shahidullah ◽  
Shahadat Hossain ◽  
Sharmila Barua ◽  
...  
Keyword(s):  
Developing Countries ◽  
Blood Culture ◽  
Early Diagnosis ◽  
Neonatal Sepsis ◽  
Leucocyte Count ◽  
Control Group ◽  
Total Leucocyte Count ◽  
C Reactive Protein ◽  
Neonatal Septicemia ◽  
Reactive Protein

Neonatal septicemia is a clinical syndrome of systemic illness accompanied by bacteremia occuring in the first 28 days of life. Neonatal septicemia is one of the major causes of neonatal death in developing countries. Early diagnosis and treatment can prevent neonatal mortality and morbidity. The present study includes: 1) usefulness of CRP (C-reactive protein), Total Leucocyte Count, Platelet Count and Blood Culture in early diagnosis of Neonatal Sepsis, 2) significance of serial CRP in diagnosis of neonatal sepsis. 3) the prognostic value of CRP in neonatal sepsis. This is a prospective study done in neonatal ward, Chittagong Medical College Hospital and carried out from January 2008 to January 2011. Sample size was 300. One hundred fifty neonates with suspected sepsis as cases and 150 healthy babies as control were enrolled in this study. Seventy two percent of cases neonates were preterm and low birth weight. Common risk factors for neonatal septicemia which were identified in this study; preterm (72%), low birth weight (72%), premature rupture membrane (60%), chorioamnionitis (26%) and maternal urinary tract infection (16%) . Out of 150 cases of suspected neonatal sepsis total 80.7%% had raised CRP, in initial sample 70.39% were CRP positive and in 2nd sample additional 9.31% case were CRP positive . In control group 91% were CRP negative. CRP was positive in 100% of culture proven sepsis. Sensitivity of CRP was 80.67% and specificity of CRP was 76.44%. Leucocytosis was observed in 7% of cases and leucopenia was found in 11% of cases. In 82 % cases leucocyte count was found normal. In control group, 95% had normal leucocyte count and 5% had leucocytosis but no leucopenia. Sensitivity of leucocyte count was 18% and specificity was 20.68%. Thrombocytopenia was found in 28% of case group. Out of 150 cases only 15.33% yielded growth of organisms in blood culture. Klebsiella was the most common pathogen isolated which was followed by E.coli and Strph. aureus. Sensitivity of blood culture was 15.33% and specificity was 100% Therefore serial CRP can be taken as alternative method for diagnosis of neonatal sepsis specially in developing countries where blood culture is not readily available.J Bangladesh Coll Phys Surg 2014; 32: 61-65

scholarly journals Vertebral osteomyelitis in an adolescent girl

2020 ◽  
Vol 8 ◽  
pp. 2050313X2094978
Author(s):  
Shafee Salloum
Keyword(s):  
Differential Diagnosis ◽  
Back Pain ◽  
Blood Culture ◽  
Early Diagnosis ◽  
Lower Back Pain ◽  
Bacterial Growth ◽  
Adolescent Girl ◽  
Surgical Intervention ◽  
Vertebral Osteomyelitis ◽  
Lower Back

We present a case of a 13-year-old girl with vertebral osteomyelitis. She had been experiencing lower back pain for 5 weeks, initially thought to be due to muscular causes. The blood culture showed no bacterial growth, and she was treated empirically only with antibiotics. She responded well to treatment and required no surgical intervention. Vertebral osteomyelitis should be in the differential diagnosis in an adolescent who complains of worsening lower back pain. Early diagnosis and treatment are essential in avoiding complications.

scholarly journals Septicemia detection by blood buffy coat smear in primary health care centers

2012 ◽  
Vol 7 (1) ◽  
pp. 19-23
Author(s):  
BK Jha ◽  
YI Singh ◽  
S Mahadevmurthy ◽  
NK Chaudhary
Keyword(s):  
Health Care ◽  
Blood Culture ◽  
Early Diagnosis ◽  
Hospital Setting ◽  
Buffy Coat ◽  
C Reactive Protein ◽  
Klebsiella Species ◽  
Reactive Protein ◽  
Primary Health Care Centers ◽  
Health Care Centers

Early diagnosis of childhood septicemia can be done by simple tests like C-reactive protein (CRP) and anticoagulant added blood centrifuged buffy coat smear (BBCS) examination, where there is no well equipped hospital setting for blood culture and identification facility in remote health care centers. This study was conducted between 1st Jan. 2007 to 27th Dec. 2007 in College of Medical Sciences, Bharatpur, Nepal. In this study we have selected 150 suspected cases of childhood septicemia for screening CRP by kit method and BBCS by two slide techniques. This kit is supplied by Span Diagnostic Pvt. Ltd. (Surat, India). Out of 150 cases of childhood septicemia of age group 0-14 years, 83 had positive C- reactive protein (CRP >6ì g/ml), 70 were positive for BBCS and blood culture was positive only in 83 cases, where predominant organism being Klebsiella species followed by Staphylococcus species. CRP test showed 100.0% sensitivity and 87.30% specificity, where BBCS showed 76.5% sensitivity and 91.2% specificity. Blood culture reports are available only after 48-72 hours and this facility is available only in well equipped centers but CRP and BBCS are easy and cheap procedure to perform even in remote areas for early diagnosis of childhood septicemia. DOI: http://dx.doi.org/10.3126/jcmsn.v7i1.5968 JCMSN 2011; 7(1): 19-23

scholarly journals Laboratory findings in enteric group fevers in the Middle East forces

1946 ◽  
Vol 44 (6) ◽  
pp. 430-436 ◽  
Author(s):  
John C. Dick
Keyword(s):  
Middle East ◽  
Blood Culture ◽  
Early Diagnosis ◽  
Special Reference ◽  
Enteric Fever ◽  
Leucocyte Count ◽  
Causes Of Death ◽  
Laboratory Findings ◽  
Normal Limits ◽  
Enteric Group

1. The laboratory findings in a series of 215 cases of enteric fever are described and discussed, with special reference to early diagnosis.2. In the majority of the cases reviewed, the leucocyte count was about the lower level of normal limits, though considerable variation both upwards and downwards occurred.3. Blood culture was a very satisfactory and early method of diagnosis; the method used is described fully.4. Certain variations from normal in the behaviour of the organisms were encountered and are described.5. Bact. faecalis alkaligenes was isolated from blood culture in five cases in which enteric group organisms were also isolated from blood, faeces or urine and in three which were clinically enteric fever. The relation of these observations to the possibility of primary Bact. faecalis alkaligenes septicaemia is noted.6. Seventeen cases were fatal. The causes of death are described.

scholarly journals A Study on Haematological Profile in Clinically Suspected Cases of Neonatal Sepsis

2020 ◽  
pp. 97-101
Author(s):  
S. R. Upadhey ◽  
Avinash M. Mane ◽  
Atul B. Hulwan ◽  
Rohit S. Kadam ◽  
Dhirajkumar Mane
Keyword(s):  
Blood Culture ◽  
Early Diagnosis ◽  
Observational Study ◽  
Neonatal Sepsis ◽  
Scoring System ◽  
Cost Effective ◽  
Clinical Findings ◽  
Culture Positivity ◽  
Blood Culture Positivity ◽  
Haematological Profile

The present study was a two year observational study of haematological profile in clinically suspected cases of neonatal sepsis. Study analyzed the haematological findings according to Rodwell’s haematological scoring system in neonates clinically suspicious of having sepsis. It included 108 neonates admitted in NICU of our hospital during the study period of June 2015 to May 2017. According to clinical findings, Rodwell’s hematological score and blood culture positivity 108 neonates were divided into three groups; proven sepsis, probable sepsis and no sepsis. Study show that Rodwell’s haematological scoring system is a simple, quick, cost effective tool which can be used as screening test for early diagnosis of neonatal sepsis.

scholarly journals Role of Sepsis Screening in early diagnosis of Neonatal Sepsis

2017 ◽  
Vol 7 (1) ◽  
pp. 1103-1110 ◽  
Author(s):  
A Lakhey ◽  
H Shakya
Keyword(s):  
Blood Culture ◽  
Early Diagnosis ◽  
Neonatal Sepsis ◽  
Signs And Symptoms ◽  
Statistical Correlation ◽  
Clinical Syndrome ◽  
Total Leukocyte Count ◽  
Invaluable Tool ◽  
Sepsis Screen ◽  
Sepsis Screening

Background: Neonatal sepsis, a clinical syndrome of bacteremia with systemic signs and symptoms of infection in the first 4 weeks of life is a major cause of morbidity and mortality in newborn inborn. Early diagnosis is critical, as sepsis can progress more rapidly in neonates than in adults. An attempt was made to establish correlation between early neonatal sepsis screening & blood culture in neonates presenting with features of sepsis. The aim of this study is to assess the usefulness of sepsis screen in early diagnosis of neonatal septicemia.Materials and Methods: The study was done in Kist medical college and hospital, Nepal from October 2015 to October 2016.  Statistical correlation between early indicators of sepsis screen & blood culture (considered as gold standard) was established in clinically suspicious cases of neonatal sepsis. Results: Out of 150 cases studied, 72 were culture positive. CRP (77.8%) and immature: total neutrophils ratio (73%) showed highest sensitivity. CRP (66.7%), I/T ratio (61.5%) and micro ESR (60.2%) showed highest specificity. Positive predictive value was highest for CRP (68.2%) followed by I/T ratio (63.8%) and corrected total leukocyte count (56.2%)Conclusion: Serum CRP is the most sensitive marker of sepsis. Use of peripheral smear study and CRP can be implicated effectively as a sepsis screen for early diagnosis of neonatal sepsis. The combination of parameters yielded better results than single tests and proved to be an invaluable tool for early diagnosis of neonatal sepsis. 

Comparison Between Procalcitonin and Traditional Blood Biomarkers in Diagnosis of Sepsis in Iraqi Wounded Soldiers

2018 ◽  
pp. 51
Author(s):  
Meroj A. Jasem ◽  
Alia E. Mahmood ◽  
Ayser I. Mahmood ◽  
Mahmood M. Mustafa ◽  
Khalid M. Farhood
Keyword(s):  
Blood Culture ◽  
Early Diagnosis ◽  
Accurate Diagnosis ◽  
The Other ◽  
Inflammatory Biomarkers ◽  
C Reactive Protein ◽  
Blood Biomarkers ◽  
Elisa Kit ◽  
Reactive Protein ◽  
Early Biomarker

      Early diagnosis of sepsis is a very critical matter especially for soldiers in battle field; on the other hand, Procalcitonin is a new promising biomarker for fast and accurate diagnosis of sepsis. The aim of this study is to investigate the ability of Procalcitonin (PCT) to indicate sepsis earlier than blood culture and other traditional biomarkers and then get use of this in early diagnosis of sepsis.Procalcitonin concentration was measured in 44 sera of Iraqi wounded soldiers who were admitted to GHAZI AL-HARIRI Hospital for surgery, using ELISA kit of BioRay/USA, along with blood culture and other infection biomarker like C-reactive protein, ESR, W.B.C. count. Six patients had elevated PCT and 3 of them had positive blood culture, two of these three died. PCT has good correlation with other inflammatory biomarkers. It is our recommendation to accredit PCT as a very early biomarker of sepsis in Iraqi hospitals along with blood culture but earlier than it, and to use the quick test of PCT in battlefield to determine the priority of transmission of wounded soldiers to hospitals.

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