Case-control study of symptoms and neonatal outcome of human milk–Transmitted cytomegalovirus infection in premature infants

2006 ◽  
Vol 148 (3) ◽  
pp. 326-331 ◽  
Author(s):  
Patrick Neuberger ◽  
Klaus Hamprecht ◽  
Matthias Vochem ◽  
Jens Maschmann ◽  
Christian P. Speer ◽  
...  
Keyword(s):  
Human Milk ◽  
Premature Infants ◽  
Cytomegalovirus Infection ◽  
Case Control Study ◽  
Neonatal Outcome ◽  
Case Control ◽  
Control Study

Does Placental Weight Affects Perinatal Outcome? A Prospective Case-control Study

2020 ◽  
Vol 16 (1) ◽  
pp. 52-59
Author(s):  
Naina Kumar ◽  
Himani Agarwal
Keyword(s):  
Birth Weight ◽  
High Risk ◽  
Perinatal Outcome ◽  
Case Control Study ◽  
Neonatal Outcome ◽  
Case Control ◽  
Placental Weight ◽  
Tertiary Center ◽  
Control Study ◽  
Prospective Case Control Study

Background: Placenta plays a very important role in the growth and development of fetus. Objective: To know the correlation between placental weight and perinatal outcome in term antenatal women. Methods: Present prospective case-control study was conducted in the rural tertiary center of Northern India over one year (January-December 2018) on 1,118 term (≥37-≤42 weeks) antenatal women with singleton pregnancy fulfilling inclusion criteria with 559 women with high-risk pregnancy as cases and 559 low-risk pregnant women as controls. Placental weight, birth weight was measured immediately after delivery and compared between the two groups along with gestation, parity, fetal gender, and neonatal outcome. Statistical analysis was done using SPSS 22 version. Results: Mean placental weight [481.98±67.83 gm vs. 499.47±59.59 gm (p=.000)] and birth weight [2.68±0.53 Kg vs. 2.88±0.4 Kg (p=.000)] was significantly lower in high risk as compared to lowrisk participants, whereas placental birth weight ratio was higher in high-risk cases [18.35±2.37 vs. 17.41±1.38 (p=.000)] respectively. Placental weight was positively correlated with birth weight and placental weight and birth weight increased with increasing gestation in both cases and controls. Male neonates had higher placental weight [492.74±68.24 gm vs. 488±58.8 gm (p=0.224)] and birth weight [2.81±0.5 Kg vs. 2.74±0.45 Kg (p=0.033)] as compared to females. Neonatal Intensive Care Unit admission was significantly associated with low placental and birth weight (p=.000). Conclusion: There is a significant correlation between placental weight, birth weight and neonatal outcome, hence placental weight can be used as an indirect indicator of intrauterine fetal growth.

Neonatal Outcomes of Premature Infants Born to Women with the Novel Coronavirus (SARS-CoV-2) Infection: A Case Control Study

2021 ◽  
Author(s):  
Beril Yasa ◽  
Seyma Memur ◽  
Dilek Y. Ozturk ◽  
Onur Bagci ◽  
Sait I. Uslu ◽  
...  
Keyword(s):  
Vertical Transmission ◽  
Premature Infants ◽  
Gestational Age ◽  
Case Control Study ◽  
Case Control ◽  
Neonatal Outcomes ◽  
Study Group ◽  
Novel Coronavirus ◽  
Historical Controls ◽  
Control Study

Objective Novel coronavirus disease 2019 (COVID-19) is a disease associated with atypical pneumonia caused by the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). The first cases of COVID-19 were reported in Wuhan at the end of 2019. Transmission usually occurs via infected droplets and close personal contact; the possibility of vertical transmission is still under debate. This retrospective study aimed to analyze clinical characteristics of premature infants born to mothers with symptomatic COVID-19 disease. Study Design This case control study compared the clinical and laboratory data of 20 premature infants born to mothers infected with SARS-CoV-2 with sex and gestational age–matched historical controls. Results The median gestational age and birth weight in both groups were similar. Respiratory distress developed in 11 (55.5%) infants in study group and 19 (47.5%) infants in control group. Mechanical ventilation and endotracheal surfactant administration rates were similar. Median duration of hospitalization was 8.5 (2–76) days in study group and 12 days in historical controls. Real-time reverse-transcription polymerase chain reaction tests (RT-PCR) of nasopharyngeal swab samples for SARS-CoV-2 were found to be negative twice, in the first 24 hours and later at 24 to 48 hours of life. No neutropenia or thrombocytopenia was detected in the study group. Patent ductus arteriosus, bronchopulmonary dysplasia, and necrotizing enterocolitis rates were similar between groups. No mortality was observed in both groups. Conclusion To the best of our knowledge, this is one of the few studies evaluating the clinical outcomes of premature infants born to SARS-CoV-2 infected mothers. There was no evidence of vertical transmission of SARS-CoV-2 from symptomatic SARS-CoV-2-infected women to the neonate in our cohort. The neonatal outcomes also seem to be favorable with no mortality in preterm infants. Key Points

scholarly journals Reactivation of latent cytomegalovirus infection in patients with rheumatologic disease: a case–control study

2019 ◽  
Vol 39 (7) ◽  
pp. 1229-1240 ◽  
Author(s):  
Bradley J. Gardiner ◽  
Erica M. Haas ◽  
Rosemary C. Bailey ◽  
Jennifer K. Chow ◽  
David R. Snydman
Keyword(s):  
Cytomegalovirus Infection ◽  
Case Control Study ◽  
Case Control ◽  
Rheumatologic Disease ◽  
Control Study

Cytomegalovirus infection is associated with venous thromboembolism of immunocompetent adults—a case–control study

2011 ◽  
Vol 91 (4) ◽  
pp. 597-604 ◽  
Author(s):  
Sven Schimanski ◽  
Birgit Linnemann ◽  
Beate Luxembourg ◽  
Erhard Seifried ◽  
Wolfgang Jilg ◽  
...  
Keyword(s):  
Venous Thromboembolism ◽  
Cytomegalovirus Infection ◽  
Case Control Study ◽  
Case Control ◽  
Immunocompetent Adults ◽  
Control Study

scholarly journals Lack of association between cytomegalovirus infection and hypertensive disorders in pregnancy: a case-control study in Durango, Mexico

2017 ◽  
Vol 7 (3) ◽  
pp. 229-233 ◽  
Author(s):  
Cosme Alvarado-Esquivel ◽  
Ada A. Sandoval-Carrillo ◽  
Fernando Vazquez-Alaniz ◽  
José M. Salas-Pacheco ◽  
Jesús Hernández-Tinoco ◽  
...  
Keyword(s):  
Cytomegalovirus Infection ◽  
Case Control Study ◽  
Case Control ◽  
Hypertensive Disorders ◽  
Hypertensive Disorders In Pregnancy ◽  
Control Study ◽  
In Pregnancy

scholarly journals Analysis of the Clinical Features of Intrauterine Ureaplasma urealyticum Infection in Preterm Infants: A Case-Control Study

2021 ◽  
Vol 9 ◽  
Author(s):  
Tong Sun ◽  
Jianhua Fu
Keyword(s):  
Preterm Infants ◽  
Premature Infants ◽  
Clinical Characteristics ◽  
Case Control Study ◽  
Metabolic Bone Disease ◽  
Ureaplasma Urealyticum ◽  
Case Control ◽  
Infection Group ◽  
Metabolic Bone ◽  
Control Study

Objective: To analyze the clinical characteristics of intrauterine Ureaplasma urealyticum (UU) infection in premature infants.Method: In this single-center retrospective case-control study, 291 preterm infants born in our hospital and hospitalized in our department and gestational age no more than 32 weeks, birth weight no more than 2000 g were included from January 2019 to January 2021. Lower respiratory tract secretion, gastric fluid and urine were collected for UU RNA detection within 48 h after birth. Intrauterine UU infection is defined by at least one positive UU-PCR test of secreta or excreta of preterm infants after birth. The UU infection group included 86 preterm infants and the non-UU infection group included 205 preterm infants. We compared their clinical features, hemogram changes and disease outcomes using statistical analyses.Results: The clinical characteristics of premature infants such as the duration of oxygen use and ventilator use in hospital were significantly prolonged in the UU infection group (P < 0.05). The levels of leukocytes, platelet and procalcitonin in the UU infection group were significantly higher than in the non-UU infection group (P < 0.05). In terms of preterm complications, only the incidences of bronchopulmonary dysplasia, retinopathy of prematurity and metabolic bone disease in premature infants in the UU infection group were significantly higher than those in the non-UU infection group (P < 0.05). The mode of delivery, maternal premature rupture of membranes, and postnatal leukocyte level were independent risk factors for UU infection, while gestational hypertension was a protective factor for UU infection. The level of leukocytes in postnatal hemogram of premature infants could be used as a diagnostic index of UU infection, but the diagnostic accuracy was poor.Conclusion: In our study, UU infection can increase the incidence of bronchopulmonary dysplasia, retinopathy of prematurity and metabolic bone disease in preterm infants, but have no effect on the incidence of necrotizing enterocolitis, intracranial hemorrhage, white matter damage and other diseases in preterm infants. For high-risk premature infants, UU should be detected as soon as possible after birth, early intervention and drug treatment necessarily can improve the prognosis as much as possible.

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