The associations among vitamin D deficiency, C-reactive protein, and depressive symptoms

Background. Vitamin D deficiency is widespread throughout the world. Several reports have incriminated vitamin D deficiency as the cause of rickets, osteomalacia, and other chronic diseases. Recent studies have suggested a possible link between deficiency of 25-hydroxyvitamin D and dyslipidemia.Aim. To investigate the association between 25-hydroxyvitamin D deficiency and dyslipidemia in Indian subjects.Methodology. We recruited 150 asymptomatic consecutive subjects from patients’ attendees at the Departments of Neurology and Medicine in Yashoda Hospital, Hyderabad, India. Study period was from October 2011 to March 2012. All subjects underwent 25-hydroxyvitamin D assay by chemiluminescent microparticle immunoassay, fasting blood sugar and lipid profile, calcium, phosphorus, alkaline phosphatase, and C-reactive protein (CRP).Results. Out of 150 subjects, men were 82 (54.6%), and mean age was 49.4 (±15.6) years. Among risk factors, hypertension was noted in 63/150 (42%), 25-hydroxyvitamin D deficiency in 59/150 (39.3%), diabetes in 45/150 (30%), dyslipidemia in 60 (40%), smoking in 35/150 (23.3%), and alcoholism in 27/150 (18%). Deficiency of 25-hydroxyvitamin D was significantly associated with dyslipidemia (P=0.0001), mean serum glucose (P=0.0002) mean CRP (P=0.04), and mean alkaline phosphatase (P=0.01). Multivariate analysis showed that 25-hydroxyvitamin D deficiency was independently associated with dyslipidemia (odds ratio: 1.9; 95% CI : 1.1–3.5).Conclusions. We found that deficiency of 25-hydroxyvitamin D was independently associated with dyslipidemia in Indian subjects.

Download Full-text

Vitamin D deficiency is associated with acute ischemic stroke, C-reactive protein, and short-term outcome

Metabolic Brain Disease ◽

10.1007/s11011-016-9939-2 ◽

2016 ◽

Vol 32 (2) ◽

pp. 493-502 ◽

Cited By ~ 28

Author(s):

Daniela Frizon Alfieri ◽

Márcio Francisco Lehmann ◽

Sayonara Rangel Oliveira ◽

Tamires Flauzino ◽

Francieli Delongui ◽

...

Keyword(s):

Vitamin D ◽

Ischemic Stroke ◽

Acute Ischemic Stroke ◽

Vitamin D Deficiency ◽

C Reactive Protein ◽

Short Term ◽

Term Outcome ◽

Reactive Protein ◽

Short Term Outcome

Download Full-text

Low Level of Vitamin D is Correlated with High C-Reactive Protein (CRP) and Disease Activity in Indonesian Juvenile Idiopathic Arthritis (JIA) Patients

The Indonesian Biomedical Journal ◽

10.18585/inabj.v12i2.1143 ◽

2020 ◽

Vol 12 (2) ◽

pp. 149-56

Author(s):

Desy Wulandari ◽

Wisnu Barlianto ◽

Tita Luthfia Sari

Keyword(s):

Vitamin D ◽

Juvenile Idiopathic Arthritis ◽

Serum Level ◽

Disease Activity ◽

Vitamin D Deficiency ◽

Control Group ◽

Healthy Children ◽

C Reactive Protein ◽

Low Level ◽

Reactive Protein

BACKGROUND: Vitamin D plays essential role in the regulation of inflammation, such as in pathogenesis of Juvenile Idiopathic Arthritis (JIA). Vitamin D deficiency has been reported among JIA patients, but there were conflicting results regarding the correlation with disease activity. This study aimed to assess vitamin D serum level and its correlation with C-Reactive Protein (CRP) and disease activity in JIA patients.METHODS: Children who were diagnosed with JIA according to International League of Associations for Rheumatology (ILAR) criterias were enrolled as JIA group subjects, while age and sex-matched healthy children were enrolled as the control group subjects. Vitamin D and CRP serum level were measured. Disease activity of JIA patients was calculated by Juvenile Arthritis Disease ActivityScore-27 (JADAS-27).RESULTS: Vitamin D serum level was lower in the JIA group compared to the healthy control group (p=0.000). Among 26 JIA patients, 61.5% were deficient, 30.8% were insufficient, and 7.7% had normal vitamin D. No significant different in CRP level between vitamin D group (p=0.441), but there was significant different in JADAS-27 (p=0.001). The mean of CRP and JADAS-27 were found highest in vitamin D deficiency group. Vitamin D serum level was negatively correlate with CRP (p=0.021, r=-0.452) and JADAS-27 (p=0.001 r=-0.595).CONCLUSION: Low level of vitamin D in JIA patients was inversely related to higher CRP and disease activity,suggesting that vitamin D supplementation could be havepotential role in JIA treatment.KEYWORDS: vitamin D, CRP, disease activity,JADAS-27, JIA

Download Full-text

Vitamin D Deficiency in a Male Veteran Population: Prevalence and Correlation with C-Reactive Protein.

10.1210/endo-meetings.2010.part1.p4.p1-162 ◽

2010 ◽

pp. P1-162-P1-162

Author(s):

C Kovesdy ◽

B Dunn ◽

A Iranmanesh

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

C Reactive Protein ◽

Reactive Protein ◽

Population Prevalence ◽

Male Veteran

Download Full-text

Vitamin D Deficiency is Associated With Higher Level of High Sensitivity C-reactive Protein (Hs-crp) in Patients Undergoing Elective Coronary Stenting

10.21203/rs.3.rs-73096/v1 ◽

2020 ◽

Author(s):

farzaneh foroughinia ◽

Shaghayegh Mottaghi ◽

Mohammad Reza Alimardani

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Inflammatory Diseases ◽

Inflammatory Marker ◽

Venous Blood ◽

High Sensitivity ◽

Vitamin D Status ◽

C Reactive Protein ◽

Reactive Protein ◽

Hs Crp

Abstract Background: Vitamin D deficiency, a prevalent worldwide concern, has been reported to have a pivotal role in many cardiovascular and inflammatory diseases. Percutaneous coronary intervention (PCI) is a therapeutic approach that may have several short-term and long-term cardiovascular complications, supposing to be mediated with high sensitive C-reactive protein (hs-CRP), an inflammatory marker. This study aimed to investigate the association between vitamin D status and hs-CRP level, as a prognostic marker, in patients undergoing elective PCI. Methods: The study population comprised of 150 patients who underwent elective coronary angioplasty. In order to measure vitamin D and hs-CRP levels, venous blood samples were obtained at baseline and 24 hours after PCI. Results: Our results showed a significant inverse relationship between post-PCI hs-CRP and also pre-post hs-CRP difference levels and vitamin D status. Conclusion: Hs-CRP content is higher in vitamin D deficient patients. Therefore, these patients, especially severely-deficient ones (25(OH)D<10ng/ml), may benefit from supplementation with vitamin D prior to PCI.

Download Full-text

Prevalence and clinical impact of vitamin D deficiency on abdominal tuberculosis

Therapeutic Advances in Infectious Disease ◽

10.1177/2049936117709722 ◽

2017 ◽

Vol 4 (3) ◽

pp. 83-86 ◽

Cited By ~ 2

Author(s):

Vishal Sharma ◽

Harshal S. Mandavdhare ◽

Amit Kumar ◽

Ravi Sharma ◽

Naresh Sachdeva ◽

...

Keyword(s):

Vitamin D ◽

Inflammatory Response ◽

Vitamin D Deficiency ◽

Immune Modulation ◽

Abdominal Tuberculosis ◽

Clinical Impact ◽

C Reactive Protein ◽

Reactive Protein ◽

The Mean ◽

Extensive Involvement

Background: Vitamin D is recognised to have multiple actions, including role in immune modulation. The prevalence and impact of vitamin D deficiency (VDD) in abdominal tuberculosis is unknown. Methods: We report the prevalence and clinical impact of VDD in patients with abdominal tuberculosis. The patients were divided into two groups: VDD (<20 ng/ml) or vitamin D sufficient (VDS) (⩾20 ng/ml). Groups were compared for extent (abdominal alone or extra-abdominal also) of disease and pattern of involvement (intestinal, peritoneal or both) and inflammatory response [serum C-reactive protein (CRP)]. Results: Of 63 patients, 53 had complete data (mean age: 36.3 ± 14.43, 31 males). Fourty-five (84.9%) patients had VDD and mean VD levels were 11.1 ± 10.1 ng/ml. Of 8 patients with VDS, 1 (12.5%) had extra-abdominal involvement while 13 (28.9%) with VDD had extra-abdominal involvement ( p = 0.066). The mean CRP in patients with VDD was 42.9 ± 34.9 mg/dl vis-a-vis 105.38 ± 64.8 in VDS ( p ⩽ 0.05). All seven patients with both intestinal and peritoneal involvement had VDD. Conclusion: VDD is common in abdominal tuberculosis and may be associated with more extensive involvement albeit a reduced inflammatory response.

Download Full-text