PTEN: a novel target for vitamin D in melanoma

2022 ◽  
pp. 106059
Author(s):  
Artur Shariev ◽  
Nicole Painter ◽  
Vivienne E. Reeve ◽  
Nikolas K. Haass ◽  
Mark S. Rybchyn ◽  
...  
Keyword(s):  
Vitamin D ◽  
Novel Target

scholarly journals Transcriptomic Response to 1,25-Dihydroxyvitamin D in Human Fibroblasts with or without a Functional Vitamin D Receptor (VDR): Novel Target Genes and Insights into VDR Basal Transcriptional Activity

Cells ◽  
2019 ◽  
Vol 8 (4) ◽  
pp. 318 ◽  
Author(s):  
Pedro L. F. Costa ◽  
Monica M. França ◽  
Maria L. Katayama ◽  
Eduardo T. Carneiro ◽  
Regina M. Martin ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Target Genes ◽  
Human Fibroblasts ◽  
Transcriptomic Response ◽  
Dihydroxyvitamin D ◽  
1,25 Dihydroxyvitamin D ◽  
Vitamin D Resistant Rickets ◽  
Novel Target ◽  
Proliferation Assays

The vitamin D receptor (VDR) mediates vitamin D actions beyond bone health. While VDR activation by 1,25-dihydroxyvitamin D (1,25D) leads to robust transcriptional regulation, less is known about VDR actions in the absence of 1,25D. We analyzed the transcriptomic response to 1,25D in fibroblasts bearing a severe homozygous hereditary vitamin D resistant rickets-related p.Arg30* VDR mutation (MUT) and in control fibroblasts (CO). Roughly 4.5% of the transcriptome was regulated by 1,25D in CO fibroblasts, while MUT cells without a functional VDR were insensitive to 1,25D. Novel VDR target genes identified in human fibroblasts included bone and cartilage factors CILP, EFNB2, and GALNT12. Vehicle-treated CO and MUT fibroblasts had strikingly different transcriptomes, suggesting basal VDR activity. Indeed, oppositional transcriptional effects in basal conditions versus after 1,25D activation were implied for a subset of target genes mostly involved with cell cycle. Cell proliferation assays corroborated this conjectured oppositional basal VDR activity, indicating that precise 1,25D dosage in target tissues might be essential for modulating vitamin D actions in human health.

scholarly journals Human Bladder as a Novel Target for Vitamin D Receptor Ligands

2005 ◽  
Vol 90 (2) ◽  
pp. 962-972 ◽  
Author(s):  
Clara Crescioli ◽  
Annamaria Morelli ◽  
Luciano Adorini ◽  
Pietro Ferruzzi ◽  
Michaela Luconi ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Receptor Ligands ◽  
Human Bladder ◽  
Novel Target

Prohibitin Is a Novel Target Gene of Vitamin D Involved in Its Antiproliferative Action in Breast Cancer Cells

2006 ◽  
Vol 66 (14) ◽  
pp. 7361-7369 ◽  
Author(s):  
Xinjian Peng ◽  
Rajeshwari Mehta ◽  
Sheng Wang ◽  
Srikumar Chellappan ◽  
Rajendra G. Mehta
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Target Gene ◽  
Antiproliferative Action ◽  
Novel Target

Association of vitamin D receptor genotypes with early onset rheumatoid arthritis

2001 ◽  
Vol 28 (1) ◽  
pp. 89-93 ◽  
Author(s):  
J. R. Garcia-Lozano ◽  
M. F. Gonzalez-Escribano ◽  
A. Valenzuela ◽  
A. Garcia ◽  
A. Nunez-Roldan
Keyword(s):  
Rheumatoid Arthritis ◽  
Vitamin D ◽  
Vitamin D Receptor ◽  
Early Onset

803: Interactions Between Ultraviolet Radiation and Polymorphisms in the Vitamin D Receptor Gene Mediate Prostate Cancer Susceptibility

2006 ◽  
Vol 175 (4S) ◽  
pp. 260-260
Author(s):  
Nicholas J. Rukin ◽  
Samuel J. Moon ◽  
Dhaval Bodiwala ◽  
Christopher J. Luscombe ◽  
Mark F. Saxby ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Vitamin D ◽  
Ultraviolet Radiation ◽  
Vitamin D Receptor ◽  
Cancer Susceptibility ◽  
Receptor Gene ◽  
Vitamin D Receptor Gene ◽  
Prostate Cancer Susceptibility

368: The Analysis of Vitamin D Receptor and Retinoid X Receptor in Renal Cell Carcinoma

2005 ◽  
Vol 173 (4S) ◽  
pp. 101-101
Author(s):  
Wataru Obara ◽  
Ryuichiro Konda ◽  
Tomoaki Fujioka
Keyword(s):  
Renal Cell Carcinoma ◽  
Vitamin D ◽  
Cell Carcinoma ◽  
Vitamin D Receptor ◽  
Renal Cell ◽  
Retinoid X Receptor

190: BXL-628, a Vitamin D Analog, Decreases RHOA/ROK Signalling in Rat and Human Bladder

2006 ◽  
Vol 175 (4S) ◽  
pp. 62-62
Author(s):  
Annamaria Morelli ◽  
Sandra Filippi ◽  
Rosa Mancina ◽  
Linda Vignozzi ◽  
Gabriella B. Vannelli ◽  
...  
Keyword(s):  
Vitamin D ◽  
Human Bladder ◽  
Vitamin D Analog

1615: Testicular Maturation Arrest to Testis Cancer - is there a Spectrum of Expression of Vitamin D Receptors and a Role for Vitamin D Treatment

2006 ◽  
Vol 175 (4S) ◽  
pp. 520-521
Author(s):  
Ajay K. Nangia ◽  
Vince Memoli ◽  
Alan Schned ◽  
Oya Hill ◽  
Catherine E. Schwender
Keyword(s):  
Vitamin D ◽  
Testis Cancer ◽  
Maturation Arrest ◽  
Vitamin D Receptors

487: Vitamin D Receptor Gene Haplotypes and Prostate Cancer in Hispanic and Non-Hispanic White Men: Results from a Case-Control Genetic Association Study

2006 ◽  
Vol 175 (4S) ◽  
pp. 158-158
Author(s):  
Kathleen C. Torkko ◽  
Phuong Mai ◽  
Robin J. Leach ◽  
Betsy A. Higgins ◽  
Adrie Van Bokhoven ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Vitamin D ◽  
Association Study ◽  
Vitamin D Receptor ◽  
Genetic Association Study ◽  
Receptor Gene ◽  
White Men ◽  
Case Control ◽  
Vitamin D Receptor Gene ◽  
Hispanic White
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