Cognitive Function and Mortality in a Community-based Elderly Cohort of First-ever Stroke Survivors and Control Subjects

Seventy-two college students were divided into three groups: Button Push-Speech (BP-S), Speech-Button Push (S-BP), and Control. BP-S subjects pushed one of two buttons on signal for 8 min. During the last 4 min, depression of the criterion button caused a buzzer to sound. After the button-push task, subjects spoke spontaneously for 30 min. During the last 20 min, the buzzer was presented contingent upon each disfluency. S-BP subjects were run under the same procedures, but the order of button-push and speech tasks was reversed. Control subjects followed the same procedures as S-BP subjects, but no buzzer signal was presented at any time. Both S-BP and BP-S subjects emitted significantly fewer disfluencies during the last 20 min (Conditioning) than during the first 10 min (Baserate) of the speaking task. The frequency of disfluencies for Control subjects did not change significantly from Baserate to Conditioning. In none of the three groups did the frequency of pushes on the criterion button change significantly from minute to minute throughout the 8-min button-push session.

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Tests for Platelet Changes, Acute Phase Reactants and Serum Lipids in Diabetes mellitus and Peripheral Vascular Disease

Thrombosis and Haemostasis ◽

10.1055/s-0038-1657283 ◽

1982 ◽

Vol 48 (03) ◽

pp. 289-293 ◽

Cited By ~ 17

Author(s):

B A van Oost ◽

B F E Veldhuyzen ◽

H C van Houwelingen ◽

A P M Timmermans ◽

J J Sixma

Keyword(s):

Diabetes Mellitus ◽

Vascular Disease ◽

Peripheral Vascular Disease ◽

Acute Phase ◽

Serum Lipids ◽

Diabetic Patients ◽

Peripheral Vascular ◽

Acute Phase Reactants ◽

Control Subjects ◽

And Control

SummaryPlatelets tests, acute phase reactants and serum lipids were measured in patients with diabetes mellitus and patients with peripheral vascular disease. Patients frequently had abnormal platelet tests and significantly increased acute phase reactants and serum lipids, compared to young healthy control subjects. These differences were compared with multidiscriminant analysis. Patients could be separated in part from the control subjects with variables derived from the measurement of acute phase proteins and serum lipids. Platelet test results improved the separation between diabetics and control subjects, but not between patients with peripheral vascular disease and control subjects. Diabetic patients with severe retinopathy frequently had evidence of platelet activation. They also had increased acute phase reactants and serum lipids compared to diabetics with absent or nonproliferative retinopathy. In patients with peripheral vascular disease, only the fibrinogen concentration was related to the degree of vessel damage by arteriography.

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Significance of community-based population medicine in prevention and control of malignant diseases

Academic Journal of Second Military Medical University ◽

10.3724/sp.j.1008.2014.00001 ◽

2014 ◽

Vol 35 (1) ◽

pp. 1

Author(s):

Guang-wen CAO

Keyword(s):

Prevention And Control ◽

Malignant Diseases ◽

Community Based ◽

And Control

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Effects of Cancer, Chemotherapy and Cytokines on Subjective and Objective Cognitive Functioning Among Patients with Breast Cancer

Cancers ◽

10.3390/cancers13112576 ◽

2021 ◽

Vol 13 (11) ◽

pp. 2576

Author(s):

Vincent Chin-Hung Chen ◽

Chin-Kuo Lin ◽

Han-Pin Hsiao ◽

Bor-Show Tzang ◽

Yen-Hsuan Hsu ◽

...

Keyword(s):

Breast Cancer ◽

Cognitive Function ◽

Cognitive Abilities ◽

Verbal Fluency ◽

Control Group ◽

Control Groups ◽

Semantic Verbal Fluency ◽

Cytokine Levels ◽

Chemotherapy Patients ◽

And Control

Background: We aimed to investigate the associations of breast cancer (BC) and cancer-related chemotherapies with cytokine levels, and cognitive function. Methods: We evaluated subjective and objective cognitive function in BC patients before chemotherapy and 3~9 months after the completion of chemotherapy. Healthy volunteers without cancer were also compared as control group. Interleukins (IL) 2, 4, 5, 6, 10, 12p70, 13, 17A, 1β, IFNγ, and TNFα were measured. Associations of cancer status, chemotherapy and cytokine levels with subjective and objective cognitive impairments were analyzed using a regression model, adjusting for covariates, including IQ and psychological distress. Results: After adjustment, poorer performance in semantic verbal fluency was found in the post-chemotherapy subgroup compared to controls (p = 0.011, η2 = 0.070); whereas pre-chemotherapy patients scored higher in subjective cognitive perception. Higher IL-13 was associated with lower semantic verbal fluency in the post-chemotherapy subgroup. Higher IL-10 was associated with better perceived cognitive abilities in the pre-chemotherapy and control groups; while IL-5 and IL-13 were associated with lower perceived cognitive abilities in pre-chemotherapy and control groups. Our findings from mediation analysis further suggest that verbal fluency might be affected by cancer status, although mediated by anxiety. Conclusions: Our findings suggest that verbal fluency might be affected by cancer status, although mediated by anxiety. Different cytokines and their interactions may have different roles of neuroinflammation or neuroprotection that need further research.

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The fate of orally administered sialic acid: First insights from patients with N-acetylneuraminic acid synthase deficiency and control subjects

Molecular Genetics and Metabolism Reports ◽

10.1016/j.ymgmr.2021.100777 ◽

2021 ◽

Vol 28 ◽

pp. 100777

Author(s):

Christel Tran ◽

Licia Turolla ◽

Diana Ballhausen ◽

Sandrine Cornaz Buros ◽

Tony Teav ◽

...

Keyword(s):

Sialic Acid ◽

Acetylneuraminic Acid ◽

Control Subjects ◽

And Control

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Sleep symptomatology is associated with greater subjective cognitive concerns: Findings from the community-based Healthy Brain Project

SLEEP ◽

10.1093/sleep/zsab097 ◽

2021 ◽

Author(s):

Jessica Nicolazzo ◽

Katharine Xu ◽

Alexandra Lavale ◽

Rachel Buckley ◽

Nawaf Yassi ◽

...

Keyword(s):

Cognitive Function ◽

Sleep Quality ◽

Cognitive Performance ◽

Sex Education ◽

Severity Index ◽

Analysis Of Covariance ◽

Psychomotor Function ◽

Community Based ◽

The Relationship ◽

Insomnia Severity

Abstract Study objectives To examine if sleep symptomatology was associated with subjective cognitive concerns or objective cognitive performance in a dementia-free community-based sample. Methods A total of 1421 middle-aged participants (mean±standard deviation = 57±7; 77% female) from the Healthy Brain Project completed the Pittsburgh Sleep Quality Index (PSQI), Insomnia Severity Index (ISI), and Epworth Sleepiness Scale (ESS) to measure sleep quality, insomnia symptom severity, and daytime sleepiness, respectively. Participants were classified as having no sleep symptomatology (normal scores on each sleep measure), moderate sleep symptomatology (abnormal scores on one sleep measure), or high sleep symptomatology (abnormal scores on at least two sleep measures), using established cut-off values. Analysis of covariance was used to compare objective cognitive function (Cogstate Brief Battery) and subjective cognitive concerns (Modified Cognitive Function Instrument) across groups. Results Following adjustments for age, sex, education, mood, and vascular risk factors, persons classified as having high sleep symptomatology, versus none, displayed more subjective cognitive concerns (d=0.24) but no differences in objective cognitive performance (d=0.00-0.18). Subjective cognitive concerns modified the association between sleep symptomatology and psychomotor function. The strength of the relationship between high sleep symptomatology (versus none) and psychomotor function was significantly greater in persons with high as compared with low cognitive concerns (β±SE =-0.37±0.16; p=0.02). Conclusions More severe sleep symptomatology was associated with greater subjective cognitive concerns. Persons reporting high levels of sleep symptomatology may be more likely to display poorer objective cognitive function in the presence of subjective cognitive concerns.

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Promoting Cancer Prevention and Control in Community-Based HIV/AIDS Service Organizations: Are They Ready?

AIDS Education and Prevention ◽

10.1521/aeap.2014.26.1.43 ◽

2014 ◽

Vol 26 (1) ◽

pp. 43-55 ◽

Cited By ~ 2

Author(s):

John A. Guidry ◽

Erica Lubetkin ◽

Geoffrey Corner ◽

Jennifer Lord-Bessen ◽

Mark Kornegay ◽

...

Keyword(s):

Cancer Prevention ◽

Prevention And Control ◽

Service Organizations ◽

Community Based ◽

Cancer Prevention And Control ◽

And Control ◽

Hiv Aids

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Mandibular deviations in TMD and non-TMD groups related to eye dominance and head posture

Journal of Clinical Pediatric Dentistry ◽

10.17796/jcpd.25.2.j7171238p2413611 ◽

2002 ◽

Vol 25 (2) ◽

pp. 147-155 ◽

Cited By ~ 12

Author(s):

N. Pradham ◽

G. White ◽

N. Mehta ◽

A. Forgione

Keyword(s):

Head Rotation ◽

Lateral Direction ◽

Head Posture ◽

Control Subjects ◽

Eye Dominance ◽

Pain Center ◽

And Control ◽

Female Subjects

This study was designed to determine whether eye-dominance affects head posture (rotation) and in turn, whether head posture is associated with mandibular frenum midline deviation, in both TMJ and control subjects. Eye dominance was determined using three tests:Porta, Hole, Point tests. Natural head posture was evaluated using the Arthrodial protractor. Mandibular frenum deviation was recorded as left, right or no deviation. Fifty female subjects were included in the study, 25 TMJ patients attending the Gelb Craniomandibular Pain Center and 25 non-TMJ control subjects. The findings indicate that eye dominance and direction of head rotation are strongly associated in both TMJ and control subjects. Further, in TMJ subjects mandibular deviation occurred in greater frequency than in controls and tends to occur in the contra lateral direction of head rotation.

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