Biomarkers of oxidative stress in schizophrenic and control subjects

2007 ◽  
Vol 76 (2) ◽  
pp. 73-85 ◽  
Author(s):  
J. Young ◽  
S.B. McKinney ◽  
B.M. Ross ◽  
K.W.J. Wahle ◽  
S.P. Boyle
Keyword(s):  
Oxidative Stress ◽  
Control Subjects ◽  
And Control ◽  
Biomarkers Of Oxidative Stress

scholarly journals Author Correction: Effect of induced hypoglycemia on inflammation and oxidative stress in type 2 diabetes and control subjects

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Hassan Kahal ◽  
Anna Halama ◽  
Ahmed Aburima ◽  
Aditya M. Bhagwat ◽  
Alexandra E. Butler ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Type 2 Diabetes ◽  
Control Subjects ◽  
Correction Effect ◽  
And Control ◽  
And Oxidative Stress

Plasma Activity of Antioxidants and Lipid Peroxidation Level Among Patients having Moderate and Severe Hypertension

2021 ◽  
Author(s):  
I Akinlua
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Antioxidant Enzymes ◽  
Severe Hypertension ◽  
Enzymatic Antioxidants ◽  
Hypertensive Patients ◽  
Control Subjects ◽  
Post Hoc ◽  
And Control ◽  
Plasma Activity

Hypertension or high blood pressure and its complications is a major cause of morbidity and mortality all over the world. The development of hypertension has been linked to atherosclerosis formation and progression which in turn has its root in free radicals induced oxidative stress and antioxidants present. This work was undertaken to determine plasma activity of enzymatic antioxidants and lipid peroxidation level in patients with moderate and severe hypertension to establish a possible association between these parameters and progression of hypertension. A total number of 60 hypertensive patients that are freshly diagnosed made up of 30 moderate and 30 severe hypertensive patients with 30 relatively healthy subjects as control recruited from Wesley Guide Hospital, Ilesa, Osun State Nigeria was used for this study. Plasma activity of catalase, superoxide dismutase, glutathione peroxidase and plasma level of malondialdehyde (MDA) was determined in both patients and control subjects using standard methodologies. The results obtained was subjected to statistical analysis using two-way analysis of variance (ANOVA) and post-hoc Duncan test with (p<0.05) considered to be significant. The result of this study revealed a significant decrease (P<0.05) in the activity of the antioxidant enzymes considered. The plasma MDA in all the patients was raised but not statistically significant p<0.05 from result obtained for the control subjects. Progressive decrease in the activity of antioxidant enzymes in these patients and a possible oxidative stress as hypertension progresses as shown in this study could be a pointer to the fact that these molecules might influence greatly the progression of hypertension.

scholarly journals Polymorphism of the APEX nuclease 1 gene in keratoconus and Fuchs endothelial corneal dystrophy

2015 ◽  
Vol 20 (1) ◽  
Author(s):  
Katarzyna A. Wojcik ◽  
Ewelina Synowiec ◽  
Anna Kaminska ◽  
Justyna Izdebska ◽  
Piotr Polakowski ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Excision Repair ◽  
Corneal Dystrophy ◽  
Dna Lesions ◽  
Control Subjects ◽  
Pcr Rflp ◽  
Polymerase Chain ◽  
Base Excision ◽  
And Control ◽  
The Relationship

AbstractHuman APEX nuclease 1 (APEX1) plays an important role in the repair of oxidative DNA lesions through base excision repair. It may influence the development of oxidative stress-related diseases. The aim of this study was to determine the relationship between the genotypes of the c.444 T>G (rs1130409) and c.-468 T>G (rs1760944) polymorphisms in the APEX1 gene and the occurrence of two oxidative stress-related eye diseases: keratoconus (KC) and Fuchs endothelial corneal dystrophy (FECD). The study involved 250 patients with KC, 209 patients with FECD, and 350 control subjects. All of the patients and control subjects underwent a detailed ophthalmic examination. The polymorphisms were genotyped by mismatch polymerase chain reaction restriction fragment length polymorphism (mismatch PCR-RFLP). We observed that the G/T and T/T genotypes of the c.-468 T>G polymorphism were respectively associated with a decreased occurrence of KC (OR 0.54, 95% CI 0.37-0.95; p = 0.030) and an increased occurrence of KC (OR 1.87, 95% CI 1.06-3.32; p = 0.032). None of these polymorphisms showed any association with FECD. Furthermore, no other association was observed, including haplotypes of the two polymorphisms. Our findings suggest that the c.-468 T>G polymorphism of the APEX1 gene may play a role in the pathogenesis of KC.

scholarly journals Effect of induced hypoglycemia on inflammation and oxidative stress in type 2 diabetes and control subjects

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Hassan Kahal ◽  
Anna Halama ◽  
Ahmed Aburima ◽  
Aditya M. Bhagwat ◽  
Alexandra E. Butler ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Type 2 Diabetes ◽  
Control Subjects ◽  
And Control ◽  
And Oxidative Stress

scholarly journals Determination of Malondialdehyde and Superoxide Dismutase in Pulmonary Tuberculosis Subjects

2020 ◽  
Vol 3 (1) ◽  
pp. 7-10
Author(s):  
Y Muhammad ◽  
◽  
S Iliya ◽  
AY Sa’idu ◽  
A Anka ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Superoxide Dismutase ◽  
Pulmonary Tuberculosis ◽  
Teaching Hospital ◽  
Serum Levels ◽  
Mean Values ◽  
Tuberculosis Patients ◽  
Control Subjects ◽  
Stress Markers ◽  
And Control

Pulmonary tuberculosis (PTB) is a dangerous bacterial infection that attacks the lungs. It has long been documented that there is an increase circulating levels of free radicals and oxidative stress markers in TB subjects. Malnutrition and deficient antioxidant capabilities further complicate the patient’s situation. The aim of this study is to determine the serum levels of malondialdehyde (MDA) and superoxide dismutase (SOD) in pulmonary tuberculosis patients and normal volunteers at Rasheed Shekoni Teaching Hospital Dutse, Jigawa State, Nigeria. The present study consists of one hundred and thirty-four (134) subjects, Ninety (90) among which are diagnosed TB patients and forty-four (44) apparently healthy controls attending Rasheed Shekoni Teaching Hospital Dutse. Venous samples were collected from ninety consecutive, consenting PTB on drugs and those that have not started medications. MDA levels were analysed using the method of Nadigar et al (1986). The mean values of MDA in the 24 tuberculosis infected males who are yet to commence drug was 4.0±0.32, 2.8±0.53 in those that are on drugs and 2.0±0.23 in the male control subjects. It was 4.1±0.35, 2.9±0.29 and 1.9±0.32 in female that are TB infected and yet to commence drugs, those on drugs and the control subjects respectively. The total mean MDA value for those on tuberculosis drugs was 4.0±0.33, 2.8±0.46 for those that are yet to commence the treatment and 2.0±0.28 for the control subjects, the serum levels of SOD was found significantly lower (p<0.005) in PTB subjects on treatment compared to those without treatment and control subjects. Conclusively, the findings of the current study showed that pulmonary tuberculosis patients are predisposed to oxidative stress leading to an increased MDA and consequent decreased SOD levels as compared to the control subjects.

Evaluation of adiponectin and leptin levels and oxidative stress in bipolar disorder patients with metabolic syndrome treated by valproic acid

2017 ◽  
Vol 31 (11) ◽  
pp. 1453-1459 ◽  
Author(s):  
Sema Akgün ◽  
Tülay Köken ◽  
Ahmet Kahraman
Keyword(s):  
Oxidative Stress ◽  
Metabolic Syndrome ◽  
Bipolar Disorder ◽  
Valproic Acid ◽  
Serum Leptin ◽  
Control Subjects ◽  
Group 2 ◽  
And Control ◽  
And Oxidative Stress ◽  
Group 1

Introduction: An increased risk for metabolic syndrome (MS) has been described for people with psychotic and mood disorders. The aim of this study was to determine the influence of valproic acid (VPA) treatment on adiponectin, leptin levels and oxidative stress in bipolar disorder (BD). Methods: Forty patients with BD receiving VPA monotherapy and 20 healthy control subjects were included in this study. BD patients were divided into two groups with and without MS as group 1 and group 2, respectively. Twenty BD patients diagnosed according to the Diagnostic and Statistical Manual for Mental Disorders (DSM IV) were assessed for MS according to the National Cholesterol Education Program (NCEP) Adult Treatment Panel (ATP III) criteria. Adiponectin, leptin, protein carbonyls, sulfhydryl (–SH) and malondialdehyde (MDA) levels were measured in 40 BD patients and 20 control subjects. Results: Serum adiponectin levels were significantly lower in group 1 patients than in group 2 and control subjects ( p<.001). Serum leptin levels were significantly higher in group 1 patients than in group 2 and control subjects ( p<.001). Serum –SH levels were significantly lower in group 2 patients than in group 1 ( p<.001) and control subjects ( p<.05). Serum carbonyl levels were significantly higher in group 1 and group 2 patients than in control subjects ( p<.001). Serum MDA levels were significantly higher in group 1 patients than in group 2 and control subjects ( p<.001). Conclusion: These results provide further evidence that VPA treatment for patients with BD contributed to the metabolic disturbances, such as the decreased serum adiponectin and –SH levels, as well as the increased serum leptin, MDA and carbonyl levels.

scholarly journals Effects of prenatal exposure to electromagnetic fields on biomarkers of oxidative stress and fertility of F1 generation In-vitro

2014 ◽  
Vol 15 (3) ◽  
pp. 165-169
Author(s):  
Jafar Soleimani Rad ◽  
Leila Roshangar ◽  
Hamideh Gharamaleki ◽  
Akram Valipoor ◽  
Kaveh Kazemi Kia
Keyword(s):  
Oxidative Stress ◽  
Electromagnetic Field ◽  
Treatment Group ◽  
Prenatal Period ◽  
Cleavage Pattern ◽  
Pregnant Rats ◽  
And Control ◽  
F1 Generation ◽  
Biomarkers Of Oxidative Stress

The aim of the present study was to evaluate the effects of Electromagnetic Field (EMF) in the prenatal period on biomarkers of oxidative stress and fertility of F1 generation. Material and Methods: The pregnant rats divided to 3 group’s treatment (EMF exposure), Sham (off -EMF) and control. After delivery the blood sample of mothers provided and pups were kept until maturity age, and then their fertility was investigated. Results: CAT in treatment group was significantly decreased but no differences in GPX were observed. In treatment group decrease in multicellular embryos and abnormality in cleavage pattern was found. Conclusion: Exposure in EMF cause oxidative stress and reduce fertility.

The Effects of a Neutral Stimulus (Buzzer) on Motor Responses and Disfluencies in Normal Speakers

1969 ◽  
Vol 12 (1) ◽  
pp. 179-184 ◽  
Author(s):  
Richard R. Martin ◽  
Gerald M. Siegel
Keyword(s):  
College Students ◽  
Neutral Stimulus ◽  
Motor Responses ◽  
Control Subjects ◽  
And Control ◽  
Speaking Task

Seventy-two college students were divided into three groups: Button Push-Speech (BP-S), Speech-Button Push (S-BP), and Control. BP-S subjects pushed one of two buttons on signal for 8 min. During the last 4 min, depression of the criterion button caused a buzzer to sound. After the button-push task, subjects spoke spontaneously for 30 min. During the last 20 min, the buzzer was presented contingent upon each disfluency. S-BP subjects were run under the same procedures, but the order of button-push and speech tasks was reversed. Control subjects followed the same procedures as S-BP subjects, but no buzzer signal was presented at any time. Both S-BP and BP-S subjects emitted significantly fewer disfluencies during the last 20 min (Conditioning) than during the first 10 min (Baserate) of the speaking task. The frequency of disfluencies for Control subjects did not change significantly from Baserate to Conditioning. In none of the three groups did the frequency of pushes on the criterion button change significantly from minute to minute throughout the 8-min button-push session.

Tests for Platelet Changes, Acute Phase Reactants and Serum Lipids in Diabetes mellitus and Peripheral Vascular Disease

1982 ◽  
Vol 48 (03) ◽  
pp. 289-293 ◽  
Author(s):  
B A van Oost ◽  
B F E Veldhuyzen ◽  
H C van Houwelingen ◽  
A P M Timmermans ◽  
J J Sixma
Keyword(s):  
Diabetes Mellitus ◽  
Vascular Disease ◽  
Peripheral Vascular Disease ◽  
Acute Phase ◽  
Serum Lipids ◽  
Diabetic Patients ◽  
Peripheral Vascular ◽  
Acute Phase Reactants ◽  
Control Subjects ◽  
And Control

SummaryPlatelets tests, acute phase reactants and serum lipids were measured in patients with diabetes mellitus and patients with peripheral vascular disease. Patients frequently had abnormal platelet tests and significantly increased acute phase reactants and serum lipids, compared to young healthy control subjects. These differences were compared with multidiscriminant analysis. Patients could be separated in part from the control subjects with variables derived from the measurement of acute phase proteins and serum lipids. Platelet test results improved the separation between diabetics and control subjects, but not between patients with peripheral vascular disease and control subjects. Diabetic patients with severe retinopathy frequently had evidence of platelet activation. They also had increased acute phase reactants and serum lipids compared to diabetics with absent or nonproliferative retinopathy. In patients with peripheral vascular disease, only the fibrinogen concentration was related to the degree of vessel damage by arteriography.

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