Erratum to ‘Spasticity and Range of Motion Over Time in Stroke Patients Who Received Multiple-Dose Botulinum Toxin Therapy’ [Journal of Stroke and Cerebrovascular Diseases, Vol. 29, No. 1 (January), 2020: 104481]

Abstract Background Treatment of choice for cervical dystonia comprises botulinum neurotoxin therapy. Whether additional physiotherapy can achieve better results is unclear. Objectives To show effects of physiotherapy as an add-on treatment to botulinum neurotoxin therapy. Methods 18 patients participated in this prospective interventional study (DRKS00006562) consisting of 2, 3-month periods. In the first period, usual botulinum toxin was applied. The second period comprised an additional multimodal physiotherapy program. Outcome measures were: range of motion, SF-36, Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS), surface electromyography. Results In the comparison first phase vs. second phase patients showed significant improvements in range of motion (flexion/extension: 16.3 ± 25.4; rotation: 19.1 ± 24.6), TWSTRS (severity: 3.8 ± 3.0; disability: 1.7 ± 2.0; pain: 4.4 ± 4,1) and in mental health (SF-36: 5.9 ± 7.5); p <0.05, respectively. No significant changes were seen in the lateral flexion ROM, physical health (SF-36) and the surface electromyography. Conclusion Multimodal physiotherapy is a feasible and save additional treatment option for patients with cervical dystonia. An add-on physiotherapy program can achieve better treatment outcomes. Patients benefited especially with improved range of motion, and reduced pain and severity of symptoms.

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Botulinum Toxin Therapy

Neurologic Clinics ◽

10.1016/s0733-8619(18)30311-6 ◽

1991 ◽

Vol 9 (1) ◽

pp. 205-224 ◽

Cited By ~ 13

Author(s):

Peter J. Savino ◽

Marlon Maus

Keyword(s):

Botulinum Toxin ◽

Botulinum Toxin Therapy

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Botulinum Toxin Therapy for Acute and Chronic Pain in Hair Transplant Surgery

International Society of Hair Restoration Surgery ◽

10.33589/30.2.50 ◽

2020 ◽

Vol 30 (2) ◽

pp. 50-51

Author(s):

Samuel M. Lam

Keyword(s):

Chronic Pain ◽

Botulinum Toxin ◽

Hair Transplant ◽

Botulinum Toxin Therapy

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Correction of functional constipation in patients with limited mobility after stroke

Medical alphabet ◽

10.33667/2078-5631-2019-1-6(381)-53-55 ◽

2019 ◽

Vol 1 (6) ◽

pp. 53-55

Author(s):

M. S. Turchina ◽

M. V. Bukreeva ◽

L. Yu. Korolyova ◽

Zh. E. Annenkova ◽

L. G. Polyakov

Keyword(s):

Quality Of Life ◽

Chronic Constipation ◽

Functional Constipation ◽

Cerebrovascular Diseases ◽

Medical Rehabilitation ◽

Stroke Patients ◽

Limited Mobility ◽

Complete Restoration ◽

The World

Currently, the problem of early rehabilitation of stroke patients is important, since in terms of the prevalence of cerebrovascular diseases and disability after suffering a stroke, Russia is one of the first places in the world. The complex of medical rehabilitation of such patients should provide for the early and most complete restoration of all body functions, patient education for lost skills, re-socialization of the patient and improvement of the quality of life. One of the factors contributing to a significant reduction in the quality of life after a stroke is the development of chronic constipation. The article reflects the modern methods of correction of chronic constipation in patients with limited mobility.

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The effectiveness of discharge planning and range of motion (ROM) training in increasing muscle strength of nonhemorrhagic stroke patients

GHMJ (Global Health Management Journal) ◽

10.35898/ghmj-23271 ◽

2018 ◽

Vol 2 (3) ◽

pp. 57

Author(s):

Mohamat Iskandar

Keyword(s):

Muscle Strength ◽

Range Of Motion ◽

Rating Scale ◽

Discharge Planning ◽

Intervention Group ◽

Sampling Technique ◽

Control Group ◽

Planning Program ◽

Stroke Patients ◽

Central Java

Background: Non-hemorrhagic stroke patients experience hemiparesis, an improper handling results in joint contractures. Discharge planning combined with a range of motion (ROM) training given to patients and their families are expected to improve muscle strength in patients after returning from the hospital. Aims: This study is to identify the effectiveness of discharge planning in increasing muscle strength. Methods: This is a quasi-experimental study with a pre-posttest design. A total of 34 respondents were selected by cluster random sampling technique, from RAA Soewondo Pati General Hospital of Pati, Central Java, Indonesia. The respondents were divided equally into two groups; an intervention group (N = 17) was given a discharge planning program together with stroke information and range of motion (ROM) training while the control group (N = 17) received a standard discharge planning available in the hospital. Further, Muscle Rating Scale (MRS) was employed to assess the muscle strength on the 2nd, 7th, and 14th day after discharge planning presented to the nonhemorrhagic stroke patients. Results: This present study clearly acknowledges the standard discharge planning program available in the hospital improve the muscle strength of the upper and lower extremity in the nonhemorrhagic stroke patients just 2nd day after the care (pretest), and the significant improvement was observed until the day 14. Moreover, combining the care with ROM training at the intervention group faster the recovery and the muscle strength improved significantly at the 7th day and continue increase at the day 14. Looking to the muscle strength since the 2nd day to the day 14, respectively the muscle strength of upper and lower limb at the control group improved at the point of 0.588 and 0.882, while at the group received the ROM training reached the value of 1.472 and 1.412. Conclusions: The ROM training combined to the current discharge planning program will faster the muscle strength recovery of the nonhemorrhagic stroke patients. This research provide insight how family plays important role to the success in monitoring the rehabilitation and recovery progress.

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ASSOCIATION OF PLATELET-DERIVED MICROVESICLES WITH HIGH ON-TREATMENT PLATELET REACTIVITY IN CONVALESCENT ISCHEMIC STROKE PATIENTS TREATED WITH ACETYLSALICYLIC ACID

Wiadomości Lekarskie ◽

10.36740/wlek201908102 ◽

2019 ◽

Vol 72 (8) ◽

pp. 1426-1436

Author(s):

Justyna Rosińska ◽

Joanna Maciejewska ◽

Robert Narożny ◽

Wojciech Kozubski ◽

Maria Łukasik

Keyword(s):

Platelet Aggregation ◽

Treatment Failure ◽

Acetylsalicylic Acid ◽

Platelet Reactivity ◽

Study Groups ◽

Surface Expression ◽

Cerebrovascular Diseases ◽

Stroke Patients ◽

Vascular Events ◽

The Impact

Introduction: Elevated concentrations of platelet-derived microvesicles are found in cerebrovascular diseases. The impact of acetylsalicylic acid on these microvesicles remains inconsistent, despite its well-established effect on platelet aggregation. High residual platelet aggregation is defined as high on-treatment platelet reactivity, while “treatment failure” is the occurrence of vascular events despite antiplatelet treatment. The aim of this study was to determine whether the antiaggregatory effect of acetylsalicylic acid correlates with platelet-derived microvesicles in convalescent ischaemic stroke patients and cardiovascular risk factor controls as well as to evaluate the association between high on-treatment platelet reactivity and recurrent vascular events with the studied platelet-derived microvesicle parameters. Materials and methods: The study groups consisted of 76 convalescent stroke patients and 74 controls. Total platelet-derived microvesicles, annexino-positive microvesicles number, and platelet-derived microvesicles with surface expression of proinflammatory (CD40L, CD62P, CD31) and procoagulant (PS, GPIIb/IIIa) markers were characterized and quantified using flow cytometry. Cyclooxygenase-1-specific platelet responsiveness, with whole blood impedance platelet aggregation under arachidonic acid stimulation and the serum concentration of thromboxane B2, were evaluated. Results: Neither acetylsalicylic acid intake nor modification of its daily dose caused statistically significant differences in the studied microvesicle parameters. Additionally, no statistically significant differences in the studied microvesicle parameters were revealed between high on-treatment platelet reactivity and non-high on-treatment platelet reactivity subjects in either study subgroup. However, elevated concentrations of PAC-1+/CD61+, CD62P+/CD61+ and CD31+/CD61+ microvesicles were found in stroke patients with treatment failure, defined in this study as a recurrent vascular events in a one-year follow-up period. Conclusions: This study revealed no relationship between circulating microvesicle number and platelet aggregation. The procoagulant and proinflammatory phenotype of circulating platelet-derived microvesicles might contribute to acetylsalicylic acid treatment failure.

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