In silico validation of the indigenous knowledge of the herbal medicines among tribal communities in Sathyamangalam wildlife sanctuary, India

Indigenous knowledge of herbal medicines for skin diseases like boils, eczema, scabies, septic abscess, itching and skin allergy, burns, chicken pox, warts and leucoderma, fungal and bacterial infections, including healing cuts and wounds has been documented by randomly interviewing Chakma, Marma and Tanchunga tribes of the Hill Tracts districts of Bangladesh since 1995. The plant parts of 60 species belonging to 40 families were known to be used. The plant specimens were collected, identified and preserved at the Herbarium of Chittagong University. An enumeration of these plants is presented along with their tribal names, categories of skin diseases, plant parts with preparation and route of administration. Key words: Indigenous knowledge; Herbal medicines; Skin diseases; Tribes; Bangladesh DOI: 10.3329/bjb.v39i2.7303 Bangladesh J. Bot. 39(2): 169-177, 2010 (December)

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A Report on Wild Edible Fruits Used by the Tribal Communities Inhabiting Near Katepurna Wildlife Sanctuary, Maharashtra, India

Bioscience Biotechnology Research Communications ◽

10.21786/bbrc/13.2/87 ◽

2020 ◽

Vol 13 (2) ◽

pp. 975-980

Author(s):

Rupali P. Shirsat

Keyword(s):

Wildlife Sanctuary ◽

Tribal Communities ◽

Wild Edible Fruits

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In Silico Screening of Natural Products Isolated from Mexican Herbal Medicines against COVID-19

Biomolecules ◽

10.3390/biom11020216 ◽

2021 ◽

Vol 11 (2) ◽

pp. 216

Author(s):

Nadia A. Rivero-Segura ◽

Juan C. Gomez-Verjan

Keyword(s):

Natural Products ◽

In Silico ◽

Herbal Medicines ◽

In Silico Screening ◽

Docking Analysis ◽

Physiologically Based Pharmacokinetic ◽

Important Challenge ◽

Emodin Anthrone ◽

Therapeutic Tools ◽

Vaccine Distribution

The COVID-19 pandemic has already taken the lives of more than 2 million people worldwide, causing several political and socio-economic disturbances in our daily life. At the time of publication, there are non-effective pharmacological treatments, and vaccine distribution represents an important challenge for all countries. In this sense, research for novel molecules becomes essential to develop treatments against the SARS-CoV-2 virus. In this context, Mexican natural products have proven to be quite useful for drug development; therefore, in the present study, we perform an in silico screening of 100 compounds isolated from the most commonly used Mexican plants, against the SARS-CoV-2 virus. As results, we identify ten compounds that meet leadlikeness criteria (emodin anthrone, kaempferol, quercetin, aesculin, cichoriin, luteolin, matricin, riolozatrione, monocaffeoyl tartaric acid, aucubin). According to the docking analysis, only three compounds target the key proteins of SARS-CoV-2 (quercetin, riolozatrione and cichoriin), but only one appears to be safe (cichoriin). ADME (absorption, distribution, metabolism and excretion) properties and the physiologically based pharmacokinetic (PBPK) model show that cichoriin reaches higher lung levels (100 mg/Kg, IV); therefore, it may be considered in developing therapeutic tools.

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Survey and Documentation of Ethnobotanicals used in the Traditional Medicines System of Tribal Communities of Chirang District of Assam Against Helminthiasis

Biomedical & Pharmacology Journal ◽

10.13005/bpj/1824 ◽

2019 ◽

Vol 12 (04) ◽

pp. 1923-1935

Author(s):

Ananta Swargiary ◽

Mritunjoy Kumar Roy ◽

Manita Daimari

Keyword(s):

Sex Education ◽

Raw Materials ◽

Herbal Medicines ◽

Ananas Comosus ◽

Asparagus Racemosus ◽

Traditional Medicines ◽

Face To Face ◽

Plant Parts ◽

Tribal Communities ◽

Ancient Times

Ethnobotanical knowledge has been the backbone of rural healthcare since ancient times. Many diseases including helminthiasis are cured by traditional medicine in many parts of the world. The present study aims at exploring the ethnobotanicals used as anthelmintic medicines by the tribal communities of Chirang district of Assam. The present study was conducted in different villages under Chirang district of Assam, India. A face-to-face interview was carried out during survey work along with readymade questionnaire. In our survey work, 20 neighbouring villages were taken as a single cluster and one sample informant was collected. Information regarding the plant and plant parts used, methodology of use as well as informant demography such as age, sex, education was also collected. A total of 20 villages were surveyed and information was gathered from 27 informants, 23 kaviraja and 4 elderly people, 15 male and 12 female. The information collected revealed 43 medicinal plants belonging to 27 families. Lamiaceae was found to be most common family followed by Cucurbitaceae, Fabaceae, Zutaceae and Zingiberaceae. The most highly cited plants were Ananas comosus, Andrographis paniculata, Asparagus racemosus, Alstonia scholaris and Leucas aspera. Leaves, fruits and tubers were found to be the most commonly used plant parts. Except few, most of the herbal medicines were prepared as raw materials and are consumed orally. Documentation of important ethnomedicinal information from the remote areas of Assam will help scientific investigators to look into its scientific aspect leading to the development of new medicines against helminthiasis and many other diseases.

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Ethnobotanical Survey of Medicinal Flora of Harighal, Azad Jammu & Kashmir, Pakistan

10.21203/rs.3.rs-30299/v1 ◽

2020 ◽

Author(s):

Muhammad Shoaib Amjad ◽

Ujala Zahoor ◽

Rainer W. Bussmann ◽

Muhammad Altaf ◽

Syed Mubashar Hussain Gardazi ◽

...

Keyword(s):

Medicinal Plants ◽

Indigenous Knowledge ◽

Relative Frequency ◽

Herbal Medicines ◽

Use Value ◽

Relative Importance ◽

Importance Value ◽

Ethnobotanical Survey ◽

Mentha Longifolia ◽

Unexplored Area

Abstract Background: The present study is the first quantitative ethnobotanical evaluation of Harighal, an inaccessible and unexplored area of District Bagh Azad Jammu and Kashmir (AJK). The major objectives of the present study were exploration, quantification and comparison of ethnobotanical knowledge among different rural communities of the study area.Methodology:Data about traditional uses of important medicinal plants was gathered form 79 informants (49 men and 34 women) using a semi-structured questionnaire. To accesses novelty and agreement of informants about plant use,s various quantitative indices including use value, relative frequency of citation, relative importance, fidelity level and informant consent factor were employed. Furthermore, data presented in the present study was also compared with twenty-two papers published from adjoining areas.Result: A total of 150 medicinal plants belonging to 98 genera and 60 families were documented. Asteraceae, Fabaceae and Rosaceae were the dominant families having 15 species each. Herbs were the most used life form, and leaves were the most exploited plant part. Decoctions were the most preferred method used in preparation of herbal recipes. Mentha longifolia had the highest use value, Berberis lycium had the highest relative frequency of citation and Galium aparine had the highest relative importance value (1.05, 0.81 and 96, respectively). The highest informant consensus factor (ICF) was reported for digestive disorders. Mentha longifolia, Punica granatum, Zanthoxylum alatum and Olea ferruginea had 100% fidelity values. The Jaccard index revealed that uses of plants were more similar in two neighboring areas i.e. Pearl Valley and Toli Peer.Conclusion: In spite of living in the twenty first century, people of the study area still rely very much on herbal medicines as an effective way to treat various ailments. Elders and health practitioners of the study area are well aware of indigenous knowledge about medicinal plants, but young people are not much interested in herbal practices. Thus, valuable knowledge about the use of plants is on the verge of getting lost. The documentation of indigenous knowledge from such an unexplored area and the subsequent pharmacological and phytochemical validation of novel plant uses could serve as baseline for drug development.

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In Silico Exploration of Repurposing and Optimizing Traditional Chinese Medicine Rutin for Possibly Inhibiting SARS-CoV-2's Main Protease

10.26434/chemrxiv.12281078 ◽

2020 ◽

Author(s):

Tien Huynh ◽

Haoran Wang ◽

Wendy Cornell ◽

Binquan Luan

Keyword(s):

In Silico ◽

Molecular Mechanisms ◽

Herbal Medicines ◽

Viral Proteins ◽

Biological Functions ◽

Rna Dependent Rna Polymerase ◽

Global Pandemic ◽

Main Protease ◽

Dynamics Simulations ◽

Viral Target

<div>Coronavirus disease 2019 (COVID-19) is an ongoing global pandemic with very limited specific treatments. To fight COVID-19, various traditional antiviral medicines haveb been prescribed in China to infected patients with mild to moderate symptoms and received unexpected success in controlling the disease. However, the molecular mechanisms of how these herbal medicines interact with the virus have remained elusive. It is well known that the main protease (Mpro) of SARS-CoV-2 plays an important role in maturation of many viral proteins such as the RNA-dependent RNA polymerase. Here,we explore the underlying molecular mechanisms of the computationally determined top candidate–rutin, a key component in many traditional antiviral medicines such as Lianhuaqinwen and Shuanghuanlian, for inhibiting the viral target–Mpro. Using in silico methods (docking and molecular dynamics simulations), we revealed the dynamics and energetics of rutin when interacting with the Mpro of SARS-CoV-2, suggesting that the highly hydrophilic rutin molecule can be bound inside the Mpro’ pocket (active site) and possibly inhibit its biological functions. In addition, we optimized the structure of rutin and designed a more hydrophobic analog which satisfies the rule of five for western medicines and demonstrated that it possesses a much stronger binding affinity to the SARS-COV-2’s Mpro.<br></div>

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Indigenous knowledge systems

10.1093/med/9780198703327.003.0015 ◽

2015 ◽

Author(s):

Catherine A. Odora-Hoppers

Keyword(s):

Indigenous Knowledge ◽

Economic Value ◽

Herbal Medicines ◽

Knowledge Systems ◽

Development Education ◽

Interdisciplinary Field ◽

The Social ◽

Indigenous Knowledge Systems ◽

Social And Economic Development

Chapter 15 describes the tensions that exist between Western scientific approaches and Indigenous Knowledge Systems. It illustrates the way in which traditional knowledge of, for example, herbal medicines, has a potentially very high economic value and describes how this can be developed in partnership between local and global interests. It also covers the author’s role as Professor of Development Education in creating a new interdisciplinary field of study, which strengthens the role of Indigenous Knowledge Systems in the social and economic development of Africa and opens out new ways of seeing the world and acting to improve it.

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Ethnoveterinary Practices Of Some Plant Species By Ethnic People Of Parbat District, Nepal

Kathmandu University Journal of Science Engineering and Technology ◽

10.3126/kuset.v8i1.6042 ◽

1970 ◽

Vol 8 (1) ◽

pp. 44-50 ◽

Cited By ~ 4

Author(s):

Birendra Malla ◽

RB Chhetri

Keyword(s):

Plant Species ◽

Herbal Medicines ◽

Natural Vegetation ◽

Acorus Calamus ◽

Cuscuta Reflexa ◽

Animal Diseases ◽

Tribal Communities ◽

Schima Wallichii ◽

Stomach Disorder ◽

Time Animal

In Parbat district, tribal communities rear livestock mostly cattle, buffalo, goats, sheep etc. Most of the time animal diseases are treated by the uses of local herbal medicines extracted from the plants. All together 21 plant species belonging to 19 families are being identified having used to treat different veterinary diseases like; injury, poisoning, foot and mouth, wounds, stomach disorder, antiworms and bone facture of animals. These ethnoveterinary plants species are normally collected from nearby forest or natural vegetation. Some of them like, Acorus calamus, Cuscuta reflexa, Schima wallichii, Fraxinus floribunda etc are even domesticated by them in nearby cropland therefore such plants are readily available at any time. DOI: http://dx.doi.org/10.3126/kuset.v8i1.6042 KUSET 2012; 8(1): 44-50

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