Synergic efficacy of bioenergy expression for compound herbal medicine of Parkinson's disease: The methods of replacement series and concentration addition

2022 ◽  
pp. 104208
Author(s):  
Bor-Yann Chen ◽  
Yu-Ting Lai ◽  
Chung-Chuan Hsueh
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Herbal Medicine ◽  
Concentration Addition ◽  
Replacement Series

scholarly journals Pharmacoacupuncture for Idiopathic Parkinson’s Disease: A Systematic Review of Randomized Controlled Trials

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Ki-Ho Cho ◽  
Tae-Hun Kim ◽  
Woo-Sang Jung ◽  
Sang-Kwan Moon ◽  
Chang-Nam Ko ◽  
...  
Keyword(s):  
Systematic Review ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Herbal Medicine ◽  
Conventional Therapy ◽  
Acupuncture Points ◽  
Controlled Trials ◽  
Idiopathic Parkinson’S Disease ◽  
Randomized Controlled ◽  
Idiopathic Parkinson's Disease

Introduction. Pharmacoacupuncture is a new acupuncture treatment that stimulates acupuncture points by injecting herbal medicine into them. Recently, pharmacoacupuncture has been widely used in the treatment of idiopathic Parkinson’s disease in traditional East Asian medicine. The purpose of this systematic review is to evaluate the efficacy and safety of pharmacoacupuncture in the treatment of idiopathic Parkinson’s disease. Methods. The following electronic databases were searched for studies published in or before December 2016: Medline, Cochrane Central Register of Controlled Trials (CENTRAL), EMBASE, OASIS, and CNKI, without language restriction. The main outcome assessed was the total Unified Parkinson’s Disease Rating Scale (UPDRS) score. The details of the pharmacoacupuncture intervention, such as the herbal medicine and acupuncture points used, were also investigated. Results. From 138 studies, 3 randomized controlled trials were included; the number of patients analyzed was 134. Most of the studies showed considerable methodological flaws. There was heterogeneity of the intervention type and treatment duration in the included studies. Therefore, we could not conduct a meta-analysis. In one study, adjunctive bee venom pharmacoacupuncture therapy significantly improved total UPDRS scores compared with conventional therapy alone. Another study, which used adjunctive Kakkonein pharmacoacupuncture, did not reveal significant improvement compared with conventional therapy alone. A third study reported that Mailuoning pharmacoacupuncture was able to significantly improve the modified Webster Symptom Score when compared with no treatment. Adverse events related to the pharmacoacupuncture were reported in only one case, itching caused by the bee venom. Conclusions. Our findings regarding the efficacy of pharmacoacupuncture as a therapy for idiopathic Parkinson’s disease are currently inconclusive. Further large and rigorous clinical trials are needed.

scholarly journals Chinese Herbal Medicine Paratherapy for Parkinson's Disease: A Meta-Analysis of 19 Randomized Controlled Trials

2012 ◽  
Vol 2012 ◽  
pp. 1-15 ◽  
Author(s):  
Yan Wang ◽  
Cheng-Long Xie ◽  
Lin Lu ◽  
Deng-Lei Fu ◽  
Guo-Qing Zheng
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Herbal Medicine ◽  
Adjuvant Therapy ◽  
Adverse Effects ◽  
Chinese Herbal Medicine ◽  
Conventional Treatment ◽  
Rating Scale ◽  
Meta Analysis ◽  
Chinese Herbal

Parkinson's disease (PD) is a common and debilitating neurodegenerative disorder that needs long-term levodopa administration and can result in progressive deterioration of body functions, daily activities and participation. The objective of this meta-analysis evaluates the clinical efficacy and safety of Chinese herbal medicine (CHM) as an adjunct therapy for PD patients. Methodological issues include a systematic literature search between 1950 and April 2011 to identify randomized trials involving CHM adjuvant therapy versus western conventional treatment. The outcome measures assessed were the reduction in scores of Unified Parkinson's Disease Rating Scale (UPDRS) and adverse effects. 19 trials involving 1371 participants were included in the meta-analysis. As compared to western conventional treatment, CHM adjuvant therapy resulted in greater improvement in UPDRS I, II, III, IV scores, and UPDRS I–IV total scores (P<0.001). Adverse effects were reported in 9 studies. The side effects in CHM adjuvant therapy group were generally less than or lighter than the conventional treatment group. In conclusion, CHM adjuvant therapy may potentially alleviate symptoms of PD and generally appeared to be safe and well tolerated by PD patients. However, well-designed, randomized, placebo-controlled clinical trials are still needed due to the generally low methodological quality of the included studies.

scholarly journals Effects of combined treatment with acupuncture and herbal medicine in a mouse model of Parkinson's disease

IBRO Reports ◽  
2019 ◽  
Vol 6 ◽  
pp. S226
Author(s):  
Tae-Yeon Hwang ◽  
Min-A. Song ◽  
Sora Ahn ◽  
Ju-Young Oh ◽  
Hi-Joon Park
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Herbal Medicine ◽  
Mouse Model ◽  
Combined Treatment

scholarly journals Effects of Combined Treatment with Acupuncture and Chunggan Formula in a Mouse Model of Parkinson’s Disease

2019 ◽  
Vol 2019 ◽  
pp. 1-14
Author(s):  
Tae-Yeon Hwang ◽  
Min-A Song ◽  
Sora Ahn ◽  
Ju-Young Oh ◽  
Dong-hee Kim ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Herbal Medicine ◽  
Mouse Model ◽  
Synergistic Effects ◽  
Neuroprotective Effect ◽  
Combined Treatment ◽  
Erk Signaling ◽  
Suboptimal Dose ◽  
Abnormal Motor

Parkinson’s disease is the second most common neurodegenerative disease. Patients with Parkinson’s disease can be treated with a combination of acupuncture and herbal medicine, but studies on the synergistic effects of the combined treatment have not yet been conducted. Thus, we subjected an MPTP-induced Parkinson’s disease mouse model to the combined treatment. We used acupoint GB34 for acupuncture and modified Chunggantang (KD5040) as the herbal medicine, as they have been reported to be effective in Parkinson’s disease. We investigated the suboptimal dose of KD5040 and then used this dose in the combined treatment. The results showed that the combined treatment had a synergistic effect on improvements in abnormal motor function and neurodegeneration compared with the use of acupuncture or herbal medicine alone. The combined treatment also had a neuroprotective effect via the PI3K/AKT and MAPK/ERK signaling pathways. These findings suggest that the combined treatment with acupuncture and KD5040 can help improve the symptoms of Parkinson’s disease.

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