MP54-11 COMPARISON OF READMISSION AND SHORT-TERM MORTALITY RATES BETWEEN DIFFERENT TYPES OF URINARY DIVERSION IN PATIENTS UNDERGOING RADICAL CYSTECTOMY

Aim. To analyse the causes of death of individuals infected with the human immunodeficiency virus (HIV)/patients with acquired immunodeficiency syndrome (AIDS) in the Clinical Infectious Diseases Hospital named after S.P. Botkin in 2008-2010 taking into account the timing of disease, comorbidities, and clinical and laboratory data. Methods. The study included 439 HIV-infected individuals, who died in the Clinical Infectious Diseases Hospital named after S.P. Botkin in 2008-2010. Two groups of patients were identified: deaths from HIV/AIDS (n=306) and from other diseases (n=133, HIV infection was considered to be a concomitant disease). In both groups, analyzed were the short-term mortality rates, the presence of drugs and/or alcohol dependency, and the main causes of death (according to autopsy results). Results. In the group of patients who died of HIV-infection/AIDS and who did not receive antiretroviral therapy, generalized tuberculosis was diagnosed most often (65.7% of cases). Other rare diseases were pneumocystis pneumonia, cryptococcosis, cerebral toxoplasmosis, generalized fungal infection, cerebral lymphoma, and cytomegalovirus infection. The most frequent causes of death in the group of patients whose HIV-infection was considered to be a concomitant diseases were chronic viral hepatitis in the cirrhotic stage (42.9%) and septic thromboendocarditis, which were mainly diagnosed in social maladjusted patients: patients with alcoholism or intravenous drugs users. During evaluation of the short-term mortality rates it was established that 21 to 29% of patients in different years died on the 1st-3rd day after admission, which was related to extremely severe conditions of the patients. In Russia, including St. Petersburg, an annual increase in the number of new cases of HIV infection and increased mortality are registered, which indicates the severity of the epidemic and makes it possible to predict the increase in the number of patients requiring hospital treatment. Conclusion. The main causes of death among HIV-infected individuals in 2008-2010 were generalized tuberculosis and chronic viral hepatitis in the stage of cirrhosis; the high index of short-term mortality among HIV-infected patients suggests the need for measures for early detection of HIV-positive individuals and their medical examination, as well as an increase in the number of beds in order to provide specialized care to HIV-infected individuals in St. Petersburg.

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Short-Term Mortality and Retention Associated with Tagging Age-0 Walleye Using Passive Integrated Transponders Without Anesthesia

Journal of Fish and Wildlife Management ◽

10.3996/102017-jfwm-081 ◽

2018 ◽

Vol 9 (2) ◽

pp. 393-401

Author(s):

Daniel J. Dembkowski ◽

Daniel A. Isermann ◽

Greg G. Sass

Keyword(s):

Mortality Rates ◽

Body Cavity ◽

Pelvic Girdle ◽

The Body ◽

Fish Length ◽

Short Term ◽

Total Length ◽

Passive Integrated Transponders ◽

Short Term Mortality ◽

Pit Tagging

Abstract The ability to individually mark juvenile fishes has important implications for fisheries management. For example, marking age-0 Walleye Sander vitreus could provide important information not provided by batch-marking, including individual variation in growth and estimates of length-dependent survival and recruitment. However, the relatively small size of age-0 Walleye in northern temperate lakes has precluded use of many common tagging methods that provide information on individual fish (e.g., various anchor tags, jaw tags). Consequently, we evaluated short-term mortality and retention associated with using 12-mm passive integrated transponders (PITs) to mark age-0 Walleye (total length range = 93–216 mm; mean total length = 157 mm) by conducting 48-h within-lake net-pen trials and 7-d hatchery trials during September–October of 2015 and 2016. We did not anesthetize age-0 Walleye prior to PIT tagging. Our assessment allowed us to determine whether post-tagging mortality and PIT retention varied in relation to implant location (i.e., body cavity or pelvic girdle), fish length, and water temperature. During 2015, mean 48-h mortality rate of age-0 Walleye tagged with PITs in the body cavity was low (mean = 7%; SE = 3%) and did not differ from that of fish marked with only a fin clip (mean = 4%; SE = 2%) and reference fish (mean = 2%; SE = 1%). During 2016, mean mortality rates ranged from 2% (reference fish) to 6% (PIT inserted into pelvic girdle) and did not differ among treatments. During both years, mortality rates for nearly all treatments were highest (> 13%) when water temperatures were ≥ 20°C, but decreased below 5% when water temperatures were ≤ 17°C. During 2016, dead age-0 Walleye in both PIT treatments were smaller than fish that survived. During the 7-d hatchery trials, mean mortality rates were higher for age-0 Walleye with PITs inserted into the body cavity (mean = 13%; SE = 4%) than fish that received a PIT in the pelvic girdle (mean = 4%; SE = 1%) and reference fish (mean = 4%; SE = 2%). Retention of PITs was high (> 96%) during all net-pen and hatchery trials. Collectively, our results suggest that fisheries personnel can use PITs to tag age-0 Walleye without anesthesia with the expectations of high initial retention and low mortality. Mortality rates may be minimized by implanting PITs into the pelvic girdle when water temperatures are ≤ 17°C.

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Short-Term Mortality Associated with Definitive Chemoradiotherapy Versus Radical Cystectomy for Muscle-Invasive Bladder Cancer

International Journal of Radiation Oncology*Biology*Physics ◽

10.1016/j.ijrobp.2019.06.1946 ◽

2019 ◽

Vol 105 (1) ◽

pp. E252

Author(s):

W. Haque ◽

V. Verma ◽

E.B. Butler ◽

B.S. Teh

Keyword(s):

Bladder Cancer ◽

Radical Cystectomy ◽

Invasive Bladder Cancer ◽

Short Term ◽

Muscle Invasive Bladder Cancer ◽

Definitive Chemoradiotherapy ◽

Short Term Mortality ◽

Muscle Invasive

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P4620Circulating concentration of presepsin improves early prediction of short-term mortality in patients treated at medical cardiac intensive care units

European Heart Journal ◽

10.1093/eurheartj/ehz745.1002 ◽

2019 ◽

Vol 40 (Supplement_1) ◽

Author(s):

J Ishii ◽

H Takahashi ◽

T Nishimura ◽

H Kawai ◽

T Muramatsu ◽

...

Keyword(s):

Intensive Care ◽

Intensive Care Units ◽

High Sensitivity ◽

Mortality Rates ◽

Left Ventricular ◽

Left Ventricular Ejection ◽

Short Term ◽

Baseline Model ◽

Short Term Mortality ◽

Cardiac Intensive Care

Abstract Background Presepsin, a subtype of soluble CD14, is an inflammatory marker, which largely reflects monocytic activation. Presepsin appears to be an accurate diagnostic marker of sepsis, but its clinical significance remains unclear in cardiovascular disease. Purpose This prospective study aimed to investigate the predictive value of plasma presepsin levels on admission to medical (non-surgical) cardiac intensive care units (MCICUs) for short-term mortality. Methods We examined 1560 patients hospitalized in MCICUs and measured the baseline plasma presepsin levels at admission. Results Acute coronary syndrome was present in 46% of the patients, and acute decompensated heart failure in 36%. Before MCICUs admission, emergent coronary angiography or percutaneous coronary intervention was performed in 36%, mechanical ventilation was required for respiratory insufficiency in 2.1%, and intraaortic balloon pumps were needed for hemodynamic instability in 8.9%. During 6 months after admission, there were 113 (7.2%) deaths. Patients who died were older (median: 77 vs. 71 years, P<0.0001); had higher levels of presepsin (263 vs. 119 pg/mL, P<0.0001), B-type natriuretic peptide (BNP: 696 vs. 186 pg/mL, P<0.0001), high-sensitivity troponin T (hsTnT: 81 vs. 47 pg/mL, P=0.004), and high-sensitivity C-reactive protein (13.8 vs. 2.2 mg/L, P<0.0001); and had lower levels of estimated glomerular filtration rate (50 vs. 65 mL/min/1.73m2, P<0.0001) and left ventricular ejection fraction (43% vs. 51%, P<0.0001) than those of the survivors. In the multivariate Cox regression analysis, higher levels of presepsin (P=0.0002), BNP (P=0.04), and hsTnT (P=0.009) were all independent predictors of 6-month deaths. Quartiles of presepsin levels were associated with higher mortality rates within 6 months after admission (Table). Adding presepsin levels to a baseline model that included established risk factors, BNP, and hsTnT further enhanced reclassification (P=0.004) and discrimination (P=0.003) beyond that of the baseline model. Mortality rates according to presepsin Presepsin quartile 1st 2nd 3rd 4th P value ≤80 pg/mL 81–124 pg/mL 125–232 pg/mL >232 pg/mL 1-month mortality 0.8% 2.0% 3.3% 8.0% <0.0001 6-month mortality 0.8% 3.8% 8.2% 16.3% <0.0001 Conclusions Presepsin levels at admission could improve the prediction of short-term mortality in patients hospitalized at MCICUs.

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Introduction of an Enhanced Recovery Protocol to Reduce Short-Term Complications following Radical Cystectomy and Intestinal Urinary Diversion with Vescica Ileale Padovana Neobladder

Urologia Internationalis ◽

10.1159/000351000 ◽

2014 ◽

Vol 92 (1) ◽

pp. 35-40 ◽

Cited By ~ 5

Author(s):

Maria Angela Cerruto ◽

Vincenzo De Marco ◽

Carolina D'Elia ◽

Leonardo Bizzotto ◽

Pierpaolo Curti ◽

...

Keyword(s):

Radical Cystectomy ◽

Urinary Diversion ◽

Enhanced Recovery ◽

Short Term ◽

Enhanced Recovery Protocol

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2200. Cost-effectiveness of Ceftolozane/Tazobactam for Treating Ventilated Nosocomial Bacterial Pneumonia

Open Forum Infectious Diseases ◽

10.1093/ofid/ofz360.1880 ◽

2019 ◽

Vol 6 (Supplement_2) ◽

pp. S749-S750

Author(s):

Jaesh Naik ◽

Joe Yang ◽

David Elsea ◽

Simone Critchlow ◽

Laura Puzniak

Keyword(s):

Cost Effectiveness ◽

Initial Treatment ◽

Bacterial Pneumonia ◽

Cost Effective ◽

Mortality Rates ◽

Treatment Setting ◽

Phase Iii ◽

Short Term ◽

Life Years ◽

Short Term Mortality

Abstract Background Ventilated, hospital-acquired and ventilator-associated bacterial pneumonia (vHABP/VABP) are associated with high rates of antibiotic resistance and high morbidity and mortality in hospitalized patients. Ceftolozane/tazobactam (C/T) has shown non-inferiority to meropenem for treating HABP/VABP in a Phase III trial, ASPECT-NP. This study evaluates cost-effectiveness of C/T against meropenem in treating HABP/VABP. Methods We developed a model consisting of a short-term decision tree (reflecting the in-hospital period) followed by a long-term Markov structure (capturing lifetime costs and outcomes). Patient characteristics and clinical efficacy were informed by subjects in ASPECT-NP who received any dose of study drugs. Susceptibility was based on the Program to Assess C/T Susceptibility surveillance database. Second-line and salvage treatment were added to resemble real-world treatment patterns and used to calculate overall clinical cure and mortality rates based on results from a network meta-analysis. We analyzed two clinical scenarios: (1)”confirmed treatment’ in which C/T or meropenem is used after pathogen susceptibility is known; (2) ‘initial treatment’ of high-risk patients before susceptibility is known. Model outcomes include, percentage clinically cured, short-term mortality, direct medical costs, quality-adjusted life years (QALYs), and incremental cost-effectiveness ratios. Sensitivity analyses (SAs) were conducted to test the robustness of results. Results In the confirmed treatment setting, C/T had a higher cure rate (5.0 percentage points, the same below), lower short-term mortality (−5.1%), cost more ($2,728), and yielded higher lifetime QALYs (0.61) than meropenem ($4,472/QALY gained). In the initial treatment setting, C/T sustained a better clinical performance (9.5% more cure, −6.8% mortality, 1.16 more QALYs), yet cost less than meropenem (−$5,662) due to better susceptibility. The response and mortality rates from ASPECT-NP had the greatest impact on results. SAs showed that the result of C/T being cost-effective over meropenem was generally robust. Conclusion The results indicate that, compared with meropenem, C/T could be a cost-effective option for patients with vHABP/VABP in the US setting. Disclosures All authors: No reported disclosures.

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Contemporary incidence and mortality rates of kidney cancer in the United States

Canadian Urological Association Journal ◽

10.5489/cuaj.1760 ◽

2014 ◽

Vol 8 (7-8) ◽

pp. 247 ◽

Cited By ~ 55

Author(s):

Giorgio Gandaglia ◽

Praful Ravi ◽

Firas Abdollah ◽

Abd-El-Rahman M. Abd-El-Barr ◽

Andreas Becker ◽

...

Keyword(s):

Kidney Cancer ◽

The United States ◽

Mortality Rates ◽

Incidence Rates ◽

Short Term ◽

Annual Percent Change ◽

Cancer Specific Survival ◽

Incidence And Mortality ◽

Short Term Mortality ◽

Adjusted Incidence

Introduction: This is a timely update of incidence and mortality for renal cell carcinoma (RCC) in the United States.Methods: Relying on the Surveillance, Epidemiology, and End Results (SEER) database, we computed age-adjusted incidence, mortality rates and 5-year cancer-specific survival (CSS) for patients with histologically confirmed kidney cancer between 1975 and 2009. Long-term (1975–2009) and short-term (2000–2009) trends were examined by joinpoint analysis, and quantified using the annual percent change (APC). The reported findings were stratified according to disease stage.Results: Age-adjusted incidence rates of RCC increased by +2.76%/year between 1975 and 2009 (from 6.5 to 17.1/100 000 person years, p < 0.001), and by +2.85%/year between 2000 and 2009 (p < 0.001). For the same time points, the corresponding APC for the incidence of localized stage were +4.55%/year (from 3.0 to 12.2/100 000 person years, p < 0.001), and +4.42%/year (p < 0.001), respectively. The incidence rates of regional stage increased by +0.88%/year between 1975 and 2009 (p < 0.001), but stabilized in recent years (2000–2009: +0.56%/year, p = 0.4). Incidence rates of distant stage remained unchanged in long- and short-term trends. Overall mortality rates increased by +1.72%/year between 1975 and 2009 (from 1.2 to 5.0/100 000 person-years, P<0.001), but stabilized between 1994 and 2004 (p = 0.1). Short-term mortality rates increased in a significant fashion by +3.14%/year only for localized stage (p < 0.001).Interpretation: In contemporary years, there is a persisting upward trend in incidence and mortality of localized RCC.

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