Tochu (Eucommia ulmoides) leaf extract prevents ammonia and vitamin C deficiency induced gastric mucosal injury

Life Sciences ◽  
2003 ◽  
Vol 73 (25) ◽  
pp. 3245-3256 ◽  
Author(s):  
Jing Yang ◽  
Katsuaki Kato ◽  
Kenji Noguchi ◽  
Naohiro Dairaku ◽  
Tomoyuki Koike ◽  
...  
Keyword(s):  
Vitamin C ◽  
Leaf Extract ◽  
Mucosal Injury ◽  
Gastric Mucosal Injury ◽  
Eucommia Ulmoides ◽  
Vitamin C Deficiency

scholarly journals Effects of Artichoke Leaf Extract on Acute Gastric Mucosal Injury in Rats

2010 ◽  
Vol 33 (2) ◽  
pp. 223-229 ◽  
Author(s):  
Kazuo Ishida ◽  
Ryoji Kojima ◽  
Makoto Tsuboi ◽  
Yuka Tsuda ◽  
Mikio Ito
Keyword(s):  
Leaf Extract ◽  
Mucosal Injury ◽  
Gastric Mucosal Injury ◽  
Artichoke Leaf Extract

scholarly journals PROTECTIVE ROLE OF VITAMIN E AND VITAMIN C ON MORPHOLOGY OF GASTRIC MUCOSAL INJURY INDUCED BY ASPIRIN IN ALBINO RATS

2021 ◽  
Vol 31 (01) ◽  
pp. 8-13
Author(s):  
Iram Atta ◽  
Shazia Tufail ◽  
Raaffa Tafweez
Keyword(s):  
Gastric Ulcer ◽  
Vitamin E ◽  
Vitamin C ◽  
Mucosal Injury ◽  
Normal Mucosa ◽  
Protective Role ◽  
Gastric Mucosal Injury ◽  
Albino Rats ◽  
Group I ◽  
Aspirin Group

Background: Peptic ulcer has become an immense problem in our health care system. One of the major cause being the overuse of NSAIDs in Pakistan. Objective: To evaluate gastro protection by Vitamin E, Vitamin C and combination of Vitamin E and Vitamin C on morphology of aspirin induced gastric mucosal injury in albino rats. Methodology: 45 adult albino rats were taken and organized into 5 groups. Control was formed by Group I. Group II was given aspirin. Group III was given Vitamin C and aspirin. Group IV was given Vitamin E and aspirin. Group V received Vitamin C, Vitamin E and aspirin. All the doses were given for 14 days. Rats were then sacrificed after 24 hours and their stomachs were examined to compare the gross and histological findings regarding the colour of the gastric mucosa, presence of gastric ulcer, site of the ulcer, epithelial integrity and extent of the ulcer. Results: Increased frequency of ulcers extending into the submucosa were found in group given aspirin as compared to the rest of the groups. The group that was given combination of Vitamin E and Vitamin C along with aspirin showed significantly better condition than all the groups by showing normal mucosa and intact epithelium in most of the animals. Conclusion: Combination of Vitamin E and Vitamin C has greater defensive effect on aspirin induced gastric mucosal insult than Vitamin C or Vitamin E alone by showing reduction in frequency and severity of gastric ulcer.

scholarly journals Ethanolic Leaf Extract of Psidium Guajava L. [Myrtaceae] Protects the Stomach against Ischemia-Reperfusion Induced Gastric Mucosal Injury

2010 ◽  
Vol 1 (1) ◽  
pp. 1-3 ◽  
Author(s):  
Sadiq Yusuf ◽  
Abdulkareem Agunu ◽  
Nna Venessa Katung ◽  
Uduak Umana
Keyword(s):  
Gastric Mucosa ◽  
Leaf Extract ◽  
Ischemia Reperfusion ◽  
Mucosal Injury ◽  
Psidium Guajava ◽  
Gastric Mucosal Injury ◽  
Control Group ◽  
Root Bark ◽  
Medicinal Uses ◽  
Protective Properties

Objective: Decoction of the root, bark or leaves of Psidium guajava universally known guava has a long history of dietary and medicinal uses in Africa. This study was designed to investigate the gastric secretory and protective properties of leaf extract of guava on ischemia-reperfusion (I-R) induced gastric mucosal injury in rats.Methods: Male Wistar rats (n = 40) were divided in eight groups. Group 1 served as control group, group 2 animals were subjected to I-R without treatment, groups 3, 4, 5 and 7 were pretreated with 25, 50, 100 mg/kg of the extract orally 10 mg/kg indomethacin intraperitoneally [i.p.] 30 min before I-R respectively. Group 6 animals were pretreated with indomethacin [10mg/kg, i.p.] without I-R while group 8 animals were administered with 100mg/kg guava extract 30   minutes before administration of indomethacin [10mg/kg, i. p.] and subjected to I-R. Extent of mucosal damage was assessed by calculating the ulcer index while adherent mucus was determined by the Alcian Blue method.Results: The results obtained indicated that oral pretreatment of rats with extract of guava leaves significantly reduced and reversed I-R induced mucosal injury (P < 0.001), reduced gastric acid and adherent mucus on the gastric mucosa (P < 0.05) respectively. Indomethacin aggravated the mucosal injury induced by I-R which was reversed by 100 mg/kg extract of guava.Conclusion: In conclusion, the stimulation of mucus secretion by guava extract may be responsible for its gastro-protective properties against I-R induced mucosal injury.Keywords: guava extract; gastric mucosa; ischemia-reperfusion; indomethacin; Psidium guajavaDOI: 10.3126/ajms.v1i1.2452Asian Journal of Medical Sciences Vol.1(1) 2010 p.1-3

scholarly journals Vitamin C Deficiency in Inflammatory Bowel Disease: The Forgotten Micronutrient

2021 ◽  
Author(s):  
Katie A Dunleavy ◽  
Ryan C Ungaro ◽  
Laura Manning ◽  
Stephanie Gold ◽  
Joshua Novak ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Vitamin C ◽  
Bowel Disease ◽  
Fruits And Vegetables ◽  
Nutritional Assessment ◽  
Care Center ◽  
Tertiary Care ◽  
Case Series ◽  
Vitamin C Deficiency ◽  
Inflammatory Bowel

Abstract Background Micronutrient deficiencies are common in patients with inflammatory bowel disease (IBD). To date, the literature has focused on vitamin D, vitamin B12, and iron deficiencies. Methods We report a case series of 20 patients with IBD and vitamin C deficiency treated at a single tertiary care center. Results Sixteen (80%) patients had symptoms of clinical scurvy, including arthralgia, dry brittle hair, pigmented rash, gingivitis, easy bruising and/or brittle nails. Eighteen patients underwent a nutritional assessment, 10 (56%) patients reported complete avoidance of fruits and vegetables, and 3 (17%) reported reduced intake of fruits and vegetables. Conclusions Vitamin C deficiency should be considered in IBD patients, particularly those with reduced fruit/vegetable intake, as it can lead to significant signs and symptoms.

scholarly journals Vitamin C in Human Health and Disease

Nutrients ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1595
Author(s):  
Dariusz Nowak
Keyword(s):  
Eighteenth Century ◽  
Vitamin C ◽  
Human Health ◽  
Citrus Fruit ◽  
Ancient Egypt ◽  
Vitamin Supplement ◽  
Vitamin C Deficiency ◽  
Health And Disease

Although the symptoms related to vitamin C deficiency were known in ancient Egypt and eighteenth century Scottish surgeon James Lind found that scurvy (a disease resulting from insufficient dietary ingestion of vitamin C) could be effectively treated with citrus fruit, this vitamin was discovered only in the year 1912 and then after 21 years it was chemically synthetized and introduced to the market as the first vitamin supplement [...]

The multifactorial aetiology of gingival overgrowth: a case report illustrating diagnosis and management

Dental Update ◽  
2019 ◽  
Vol 46 (7) ◽  
pp. 662-671
Author(s):  
Rachael Y Jablonski ◽  
Bethany Rushworth ◽  
Kathryn A Durey
Keyword(s):  
Case Report ◽  
Renal Transplantation ◽  
Vitamin C ◽  
Oral Hygiene ◽  
Patient Engagement ◽  
Surgical Intervention ◽  
Gingival Overgrowth ◽  
Vitamin C Deficiency ◽  
Specialist Services ◽  
Detailed Assessment

Gingival overgrowth is the enlargement of gingival tissues and has various underlying aetiological factors. This case report highlights the multifactorial aetiology of gingival overgrowth for a patient who was prescribed an immunosuppressive strategy following renal transplantation, had poor levels of oral hygiene and a diet deficient in fruit and vegetables. The report highlights the importance of a detailed assessment to identify all underlying factors and demonstrates how a referral to the specialist services for gingival overgrowth led to a diagnosis of vitamin C deficiency. It also illustrates how both patient engagement and a conservative cause-related therapy can achieve a satisfactory resolution without any surgical intervention. CPD/Clinical Relevance: This case report highlights the importance of a detailed assessment to diagnose all relevant underlying aetiological factors involved in the development of gingival overgrowth. It also illustrates how both patient engagement and a conservative cause-related therapy can achieve a satisfactory resolution of gingival overgrowth without any surgical intervention.

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