The close link between the fetal programming imprinting and neurodegeneration in adulthood: The key role of “hemogenic endothelium” programming

2021 ◽  
Vol 195 ◽  
pp. 111461
Author(s):  
Alberto Allegra ◽  
Rosa Maria Giarratana ◽  
Letizia Scola ◽  
Carmela Rita Balistreri
Keyword(s):  
Fetal Programming ◽  
Hemogenic Endothelium ◽  
Close Link

Synaptojanin family members are implicated in endocytic membrane traffic in yeast

1998 ◽  
Vol 111 (22) ◽  
pp. 3347-3356 ◽  
Author(s):  
B. Singer-Kruger ◽  
Y. Nemoto ◽  
L. Daniell ◽  
S. Ferro-Novick ◽  
P. De Camilli
Keyword(s):  
Synaptic Vesicles ◽  
Direct Evidence ◽  
Family Members ◽  
Fluid Phase ◽  
Growth Defect ◽  
Temperature Sensitive ◽  
Close Link ◽  
Fluid Phase Endocytosis ◽  
Synaptojanin 1

The synaptojanins represent a subfamily of inositol 5′-phosphatases that contain an NH2-terminal Sac1p homology domain. A nerve terminal-enriched synaptojanin, synaptojanin 1, was previously proposed to participate in the endocytosis of synaptic vesicles and actin function. The genome of Saccharomyces cerevisiae contains three synaptojanin-like genes (SJL1, SJL2 and SJL3), none of which is essential for growth. We report here that a yeast mutant lacking SJL1 and SJL2 (Deltasjl1 Deltasjl2) exhibits a severe defect in receptor-mediated and fluid-phase endocytosis. A less severe endocytic defect is present in a Deltasjl2 Deltasjl3 mutant, while endocytosis is normal in a Deltasjl1 Deltasjl3 mutant. None of the mutants are impaired in invertase secretion. The severity of the endocytic impairment of the sjl double mutants correlates with the severity of actin and polarity defects. Furthermore, the deletion of SJL1 suppresses the temperature-sensitive growth defect of sac6, a mutant in yeast fimbrin, supporting a role for synaptojanin family members in actin function. These findings provide a first direct evidence for a role of synaptojanin family members in endocytosis and provide further evidence for a close link between endocytosis and actin function.

scholarly journals MicroRNAs in Cardiac Autophagy: Small Molecules and Big Role

Cells ◽  
2018 ◽  
Vol 7 (8) ◽  
pp. 104 ◽  
Author(s):  
Teng Sun ◽  
Meng-Yang Li ◽  
Pei-Feng Li ◽  
Ji-Min Cao
Keyword(s):  
Cardiac Fibrosis ◽  
Heart Diseases ◽  
Critical Role ◽  
Transcriptional Gene Silencing ◽  
Close Link ◽  
Post Transcriptional Gene Silencing ◽  
Evolutionarily Conserved ◽  
Cardiac Disorders ◽  
Cellular Components

Autophagy, which is an evolutionarily conserved process according to the lysosomal degradation of cellular components, plays a critical role in maintaining cell homeostasis. Autophagy and mitochondria autophagy (mitophagy) contribute to the preservation of cardiac homeostasis in physiological settings. However, impaired or excessive autophagy is related to a variety of diseases. Recently, a close link between autophagy and cardiac disorders, including myocardial infarction, cardiac hypertrophy, cardiomyopathy, cardiac fibrosis, and heart failure, has been demonstrated. MicroRNAs (miRNAs) are a class of small non-coding RNAs with a length of approximately 21–22 nucleotides (nt), which are distributed widely in viruses, plants, protists, and animals. They function in mediating the post-transcriptional gene silencing. A growing number of studies have demonstrated that miRNAs regulate cardiac autophagy by suppressing the expression of autophagy-related genes in a targeted manner, which are involved in the pathogenesis of heart diseases. This review summarizes the role of microRNAs in cardiac autophagy and related cardiac disorders. Furthermore, we mainly focused on the autophagy regulation pathways, which consisted of miRNAs and their targeted genes.

scholarly journals El papel del lenguaje en la construcción de explicaciones en la clase de ciencias en contextos bilingües a través del enfoque CLIL

2019 ◽  
Vol 1 (21) ◽  
pp. 105-122
Author(s):  
Mauricio Mancipe Triviño ◽  
Cynthia Marcela Ramírez Valenzuela
Keyword(s):  
Scientific Language ◽  
Natural Phenomena ◽  
L2 Proficiency ◽  
Close Link ◽  
Cognitive Linguistic ◽  
Science Classes ◽  
L1 And L2 ◽  
L1 English ◽  
Do So

This paper covers the issue with respect to elaborating explanations about natural phenomena in the Science class in bilingual contexts (Spanish (L1) – English (L2)), in which the role of the language is analysed from two perspectives: communicative and explanatory. To do so, this article focuses on the categorisation of cognitive-linguistic abilities exhibited by the students throughout the implementation of the designed unit, as well as analysing the expressions used by them from the communicative perspective; this analysis is born from the upcoming and growing concern of bilingualism implementation in Colombia and Latin America. The methodology used follows an interpretative-qualitative analysis with an inductive analysis approach, analysing the collected information during the didactic implementation in recordings, products developed by students and class diaries from a sample of 25 and 19 students belonging to two private secondary schools located in Cajicá and Bogotá, Colombia. The document presents the reflections arisen from the analysis categories built to assess the collected information: socio-linguistic abilities, communication of ideas in both L1 and L2, the conceptual, social, epistemological and didactic aspects of knowledge. It was found a close link between the L2 proficiency and the depth of the explanations elaborated by the students, enabling the more competent students in L2 to communicate better using the scientific language and getting to more complex explanations. Moreover, the implementation re-dimensioned the content perspective applied by some teachers when using the CLIL approach, placing bilingualism in the Science classes in a dimension distant from transmitting information, being a medium that fosters communicative and explanatory processes by nurturing different cognitive-linguistic abilities.

scholarly journals METHODOLOGICAL KNOWLEDGE IN THE CONTEXT OF NATURAL EDUCATION IN MODERN SCHOOL

2018 ◽  
Author(s):  
Yury Halatyuk ◽  
Taras Halatyuk
Keyword(s):  
Cognitive Skills ◽  
Cognitive Activity ◽  
Learning Activities ◽  
Effective Mechanism ◽  
Close Link ◽  
Scientific Methods ◽  
Modern School ◽  
Creative Learning ◽  
Education School

The article analyzes the place and role of methodological knowledge in the system of natural education of the modern school. It is shown that methodological knowledge is an important didactic category, an integral criterion for the effectiveness of natural education. School natural science has a powerful didactic potential for the formation of methodological knowledge. There is a close link between methodological knowledge and creative learning activities. Methodological knowledge is a means and product of creative bulk-cognitive activity. Creative educational and cognitive activity is an effective mechanism for the formation of methodological knowledge. Creative educational and cognitive activity of students is an activity directed by a teacher with the help of the appropriate system of educational means; is aimed at formulating problems and performing creative tasks; provides for the search and explanation of natural relationships and relations of observable facts, phenomena, processes through the application of methods of scientific methods of cognition, as a result of which students discover new knowledge and actively acquire them, get acquainted with the methodology of scientific knowledge, develop cognitive skills and skills, form cognitive motives and organizational qualities. The priority of the creative function of teaching is a necessary didactic condition for the formation of methodological knowledge in the process of studying natural subjects in a modern school.

199: The role of the renin angiotensin system in fetal programming of adult hypertension

2012 ◽  
Vol 206 (1) ◽  
pp. S100-S101
Author(s):  
Giuseppe Chiossi ◽  
Maged Costantine ◽  
Michael Makhlouf ◽  
Talar Kechichian ◽  
Julio Mateus ◽  
...  
Keyword(s):  
Fetal Programming ◽  
Renin Angiotensin System ◽  
Angiotensin System ◽  
Renin Angiotensin

Can Macromania be explained linguistically? Beneath the morphological boundary: A sketch of subconscious manipulation strategies in Emmanuel Macron’s political discourses

2017 ◽  
Vol 5 (1) ◽  
Author(s):  
Liane Stroebel
Keyword(s):  
Political Discourse ◽  
Morphological Evidence ◽  
Political Discussion ◽  
Close Link ◽  
Political Discourses

AbstractThis contribution focuses on the close link between perception and language. The analysis will extend beyond morphological evidence to include the role of submorphological relics. It will also raise the question of whether sensorimotor and submorphemic knowledge might have an impact on political discussion. In short, this paper seeks to tackle the question: How aware are we that words and sounds in general and in political discourse in particular are never ‘innocent’?

Probability and Combinatorics

2021 ◽  
pp. 127-162
Keyword(s):  
Close Link ◽  
Simple Tool ◽  
School Teaching

Combinatorial calculus is a branch of mathematics oriented to determine the number of distinct cases that can occur in an experiment or the number of elements that make up a set. One question often remains open in the debate about the role of combinatorics: Does the introduction of combinatorics in school teaching have an autonomous mathematical value or is it a simple tool for teaching probability? Problems of a combinatory nature can be found in many areas of mathematics, but in this chapter, emphasis will be placed on a limited circle of topics with a close link to probability. The objects presented will serve as an introduction to situations that technically relate to permutations and combinations.

Teatre Lliure, En Procés

2021 ◽  
pp. 241-252
Author(s):  
Veronica Orazi
Keyword(s):  
Social Role ◽  
Global Dimension ◽  
Set Design ◽  
Close Link ◽  
The Social ◽  
Minute Duration ◽  
Political Principles

En Procés is a project resulting from the collaboration between Lluís Pasqual and Joan Yago. They invited 11 Catalan playwrights to compose as many short plays on the facts relating to the referendum of October the 1st 2017, based on three principles: 10-minute duration, no set design, and involvement of up to three actors. The project reaffirms the social role of theatre and renews the model of the Teatro de urgencia, capable of recording history and immediate reality. It, however, transcends the context in which it was conceived and is projected into a global dimension, because it reflects universal social, humanitarian, and political principles. The chapter studies the techniques and strategies with which each author has interpreted and recreated the episodes that inspired him/her, emphasizing the close link between politics, society, theatre, and identity.

scholarly journals The Role of Magnesium in Pregnancy and in Fetal Programming of Adult Diseases

2020 ◽  
Author(s):  
Daniela Fanni ◽  
C. Gerosa ◽  
V. M. Nurchi ◽  
M. Manchia ◽  
L. Saba ◽  
...  
Keyword(s):  
Fetal Programming ◽  
Fetal Development ◽  
Normal Values ◽  
Perinatal Period ◽  
Enzymatic Reactions ◽  
Neuromuscular Activity ◽  
Mitochondrial Functions ◽  
Human Pathology ◽  
Magnesium Status

AbstractMagnesium is an essential trace metal and a necessary factor for multiple biochemical functions in humans. Its role in biology is fundamental in over 600 enzymatic reactions implicated in protein synthesis, mitochondrial functions, neuromuscular activity, bone formation, and immune system competence. Magnesium status is relevant in fetal development during gestation and in the newborn growth during the perinatal period. Moreover, magnesium is able to influence fetal programming and disease presentation in childhood or adulthood. The aim of this review is to focus on this metal homeostasis, analyzing its normal values, the causes of hypomagnesemia, the interaction with drugs and other conditions, and the diseases associated with magnesium value alteration during pregnancy, in order to study its role in fetal programming of adult diseases. The data here reported clearly indicated the existence of a connection between magnesium status and human pathology starting from intrauterine life and extending into childhood and adulthood.

Sign in / Sign up

Export Citation Format

Share Document