Vitamin D deficiency is associated with metabolic syndrome in postmenopausal women

Objective: To assess the relationship between vitamin D deficiency (VD) and risk factors for metabolic syndrome (MS) in postmenopausal women with arterial hypertension (AH). Materials and methods of research. The study included 46 women aged 45–65 years with amenorrhea > 12 months, having grade 1 hypertension and metabolic syndrome. Anthropometric, laboratory and instrumental data were studied. Biochemical parameters included total cholesterol (OH), HDL, triglycerides, glucose, insulin, and 25-hydroxyvitamin-D [25 (OH)D]. Daily blood pressure monitoring was performed according to the standard protocol. Levels of 25(OH)D in blood serum was classified as-adequate (≥ 30 ng/ml) and insufficient (20–29 ng/ml). Results: Level 25 (OH)D in blood serum was sufficient in 21 women (45.6 %), insufficient – in 25 (54.4 %). Women with insufficient levels of 25 (OH)D had higher levels of cholesterol, triglycerides, insulin, and HOMA-IR. Metabolic syndrome was detected in 64 % (16/25) of women with hypovitaminosis D and in 43 % (9/21) of women with sufficient VD (p < 0.01). The correlation analysis established the relationship of the low level of 25 (OH)D (< 30 ng / ml) with MS (r = 0.68), high triglycerides (r = 0.74) and low HDL (r = 0.71). The average concentration of 25 (OH) D decreased with an increase in the number of MS components (p = 0.016). Conclusions: VD deficiency in postmenopausal women was associated with a higher prevalence of MS. Women with HDL deficiency had a higher risk of MS, hypertriglyceridemia, and low HDL levels compared to those with adequate levels.

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Relationship between Serum Vitamin D Levels and HDL Cholesterol in Postmenopausal Women from Colombian Caribbean

Journal of Nutrition and Metabolism ◽

10.1155/2018/9638317 ◽

2018 ◽

Vol 2018 ◽

pp. 1-6 ◽

Cited By ~ 3

Author(s):

Luz Adriana Sarmiento-Rubiano ◽

José Armando Angarita Ruidiaz ◽

Héctor Fernando Suarez Dávila ◽

Alfonso Suarez Rodríguez ◽

Roberto C. Rebolledo-Cobos ◽

...

Keyword(s):

Metabolic Syndrome ◽

Vitamin D ◽

Vitamin D Deficiency ◽

Postmenopausal Women ◽

Serum Vitamin ◽

Hdl Cholesterol ◽

Serum Vitamin D ◽

The Metabolic Syndrome ◽

Increased Risk ◽

Vitamin D Levels

Background. Previous evidence suggests that metabolic disorders in postmenopausal women could be related with low serum vitamin D levels. For example, vitamin D deficiency has been associated with increased risk factors for cardiovascular disease (CVD), mainly those related with metabolic syndrome.Objective. To assess the relationship between the serum vitamin D (25-OH-D) levels and the metabolic syndrome markers in postmenopausal women.Methods. This descriptive and cross-sectional study was conducted in 183 postmenopausal women of four municipalities from Colombian Caribbean. The serum 25-OH-D levels and the anthropometric and biochemical markers were assessed and correlated with metabolic syndrome.Results. The average value of serum vitamin D (25-OH-D) was 26.34 ± 9.08 ng/mL, and 69.95% of the women had vitamin D levels <30 ng/mL, of which 43.72% were with insufficiency (<30 to >20 ng/mL) and 26.23% with deficiency (<20 ng/mL). Of the evaluated women, the 81.42% seemed to have metabolic syndrome. Through the linear regression, one significant positive association was observed between the HDL cholesterol and the 25-OH-D levels (P=0.014).Conclusion. In the evaluated population in this study, vitamin D deficiency is related with low HDL cholesterol levels.

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Prevalence and association of metabolic syndrome and vitamin D deficiency among postmenopausal women in a rural block of West Bengal, India

PLoS ONE ◽

10.1371/journal.pone.0188331 ◽

2017 ◽

Vol 12 (11) ◽

pp. e0188331 ◽

Cited By ~ 9

Author(s):

Soumi Srimani ◽

Indranil Saha ◽

Debnath Chaudhuri

Keyword(s):

Metabolic Syndrome ◽

Vitamin D ◽

Vitamin D Deficiency ◽

Postmenopausal Women ◽

West Bengal

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Insulin resistance in Saudi postmenopausal women with and without metabolic syndrome and its association with vitamin D deficiency

Journal of Clinical & Translational Endocrinology ◽

10.1016/j.jcte.2014.09.001 ◽

2015 ◽

Vol 2 (1) ◽

pp. 42-47 ◽

Cited By ~ 2

Author(s):

Eman M. Alissa ◽

Wafa A. Alnahdi ◽

Nabil Alama ◽

Gordon A. Ferns

Keyword(s):

Insulin Resistance ◽

Metabolic Syndrome ◽

Vitamin D ◽

Vitamin D Deficiency ◽

Postmenopausal Women

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Vitamin D supplementation after the menopause

Therapeutic Advances in Endocrinology and Metabolism ◽

10.1177/2042018820931291 ◽

2020 ◽

Vol 11 ◽

pp. 204201882093129

Author(s):

Faustino R. Pérez-López ◽

Peter Chedraui ◽

Stefan Pilz

Keyword(s):

Metabolic Syndrome ◽

Vitamin D ◽

Vitamin D Deficiency ◽

Postmenopausal Women ◽

Vitamin D Supplementation ◽

Lifestyle Changes ◽

The Body ◽

Mineral Density ◽

The Metabolic Syndrome ◽

Vitamin D Levels

The purpose of this review was to assess recent evidence regarding the effects of low vitamin D levels on some highly prevalent clinical conditions of postmenopausal women. We reviewed and selected recent literature regarding menopause-related conditions associated with vitamin D deficiency and interventions to manage them. Low circulating 25-hydroxyvitamin D (25(OH)D) levels related to menopause are linked to diet, lifestyle, changes in body composition, insulin sensitivity, and reduced physical activity. Vitamin D supplementation increases serum 25(OH)D levels while normalizing parathyroid hormone and bone markers, and in women with serum 25(OH)D levels below 10 ng/ml supplementation may improve bone mineral density. Low vitamin D status has been associated with the metabolic syndrome, high triglyceride levels, and low high-density lipoprotein cholesterol levels. When compared with placebo, vitamin D supplementation may lower the risk of the metabolic syndrome, hypertriglyceridemia, and hyperglycemia. There is an inverse relationship between fat mass and serum 25(OH)D levels and, therefore, the dosage of supplementation should be adjusted according to the body mass index. Although vitamin D supplementation may improve glucose metabolism in prediabetic subjects, data regarding muscle strength are conflictive. There is evidence that vitamin D over-treatment, to reach extremely high circulating 25(OH)D levels, does not result in better clinical outcomes. The identification and treatment of vitamin D deficiency in postmenopausal women may improve their general health and health outcomes. Vitamin D supplementation should preferably be based on the use of either cholecalciferol or calcifediol.

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Vitamin D deficiency and risk of metabolic syndrome

Endocrine Abstracts ◽

10.1530/endoabs.56.p291 ◽

2018 ◽

Author(s):

Alena Andreeva ◽

Olga Belyaeva ◽

Anna Bystrova ◽

Elena Bajenova ◽

Tatiana Karonova

Keyword(s):

Metabolic Syndrome ◽

Vitamin D ◽

Vitamin D Deficiency

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Vitamin D Levels Correlate with Metabolic Syndrome Criteria in Algerian Patients: The Ex-vivo Immunomodulatory Effect of α, 25 Dihydroxyvitamin D3

Endocrine Metabolic & Immune Disorders - Drug Targets ◽

10.2174/1871530320666200402121917 ◽

2020 ◽

Vol 20 (8) ◽

pp. 1282-1294

Author(s):

Meroua Bouchemal ◽

Djennat Hakem ◽

Malha Azzouz ◽

Chafia Touil-Boukoffa ◽

Dalila Mezioug

Keyword(s):

Metabolic Syndrome ◽

Vitamin D ◽

Vitamin D Deficiency ◽

Active Metabolite ◽

Mononuclear Cells ◽

Ex Vivo ◽

No Production ◽

Immunomodulatory Effects ◽

Immune Balance ◽

Vitamin D Levels

Background: Metabolic syndrome (MetS) is a combination of metabolic disorders with increased risks for several diseases, such as cardiovascular diseases and diabetes. It is associated with the presence of various inflammatory molecules. Vitamin D plays an important role in the regulation of metabolism homeostasis. Objective: The main goal of this work is to investigate vitamin D levels among Algerian MetS patients and its possible outcomes on key molecules of the immune response, as well, the immunomodulatory effects of its active metabolite. Methods: We evaluated vitamin D status by the electrochemiluminescence method, Nitric Oxide (NO) levels by the Griess method and Matrix Metalloproteinases (MMPs) activities such as MMP-2 and MMP-9 by zymography in plasma of patients and healthy controls (HC). The immunomodulatory effects of the active metabolite of vitamin D (α-25 (OH)2D3) on the production of NO, IL-6, IL-10, TGF- β and s-CTLA-4 were assessed by Griess method and ELISA, in peripheral blood mononuclear cells (PBMCs) of Algerian MetS patients and HC. MMPs activities were also determined ex-vivo, while iNOS expression was assessed by immunofluorescence staining. Results: Severe vitamin D deficiency was registered in Algerian MetS patients. The deficiency was found to be associated with an elevated in vivo NO production and high MMPs activity. Interestingly, α-25 (OH)2D3 declined the NO/iNOS system and IL-6 production, as well as MMPs activities. However, the ex-vivo production of IL-10, TGF-β increased in response to the treatment. We observed in the same way, the implication of s-CTLA-4 in MetS, which was markedly up-regulated with α-25 (OH)2D3. Conclusion: Our report indicated the relationship between MetS factors and Vitamin D deficiency. The ex-vivo findings emphasize its impact on maintaining regulated immune balance.

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Association of serum 25-hydroxyvitamin D with metabolic syndrome and type 2 diabetes: a one sample Mendelian randomization study

BMC Geriatrics ◽

10.1186/s12877-021-02307-6 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Jing Xiao ◽

Jingyi Lv ◽

Shiyu Wang ◽

Yang Zhou ◽

Lunwen Chen ◽

...

Keyword(s):

Type 2 Diabetes ◽

Metabolic Syndrome ◽

Vitamin D ◽

Vitamin D Deficiency ◽

Mendelian Randomization ◽

Middle Aged ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D ◽

Randomization Analysis

Abstract Background Vitamin D deficiency has been associated with type 2 diabetes (T2D) and metabolic syndrome (MS) and its components. However, it is unclear whether a low concentration of vitamin D is the cause or consequence of these health conditions. Thus, this study aimed to evaluate the association of vitamin D concentrations and its genetic risk scores (GRSs) with MS and its component diseases, such as T2D, in middle-aged and elderly participants from rural eastern China. Methods A subset of 2393 middle-aged and elderly individuals were selected from 70,458 participants of the Nantong Chronic Diseases Study of 2017–2018 in China. We used two 25-hydroxyvitamin D (25[OH]D) synthesis single-nucleotide polymorphisms (SNPs) (DHCR7-rs12785878 and CYP2R1-rs10741657) and two 25(OH) D metabolism SNPs (GC-rs2282679 and CYP24A1-rs6013897) for creating GRSs, which were used as instrumental variables to assess the effect of genetically lowered 25(OH) D concentrations on MS and T2D based on the Wald ratio. F statistics were used to validate that the four SNPs genetically determined 25(OH) D concentrations. Results Compared to vitamin D sufficient individuals, individuals with vitamin D insufficiency had an odds ratio (OR [95% confidence interval {CI}]) of MS of 1.30 (1.06–1.61) and of T2D of 1.32 (1.08–1.64), individuals with vitamin D deficiency had an ORs (95% CI) of MS of 1.50 (1.24–1.79) and of T2D of 1.47 (1.12–1.80), and those with vitamin D severe deficiency had an ORs (95% CI) of MS of 1.52 (1.29–1.85) and of T2D of 1.54 (1.27–1.85). Mendelian randomization analysis showed a 25-nmol/L decrease in genetically instrumented serum 25(OH) D concentrations using the two synthesis SNPs (DHCR7 and CYP2R1 genes) associated with the risk of T2D and abnormal diastolic blood pressure (DBP) with ORs of 1.10 (95%CI: 1.02–1.45) for T2D and 1.14 (95%CI: 1.03–1.43) for DBP. Conclusions This one sample Mendelian randomization analysis shows genetic evidence for a causal role of lower 25(OH) D concentrations in promoting of T2D and abnormal DBP in middle-aged and elderly participants from rural China.

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