scholarly journals Vitamin D supplementation after the menopause

2020 ◽  
Vol 11 ◽  
pp. 204201882093129
Author(s):  
Faustino R. Pérez-López ◽  
Peter Chedraui ◽  
Stefan Pilz
Keyword(s):  
Metabolic Syndrome ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Postmenopausal Women ◽  
Vitamin D Supplementation ◽  
Lifestyle Changes ◽  
The Body ◽  
Mineral Density ◽  
The Metabolic Syndrome ◽  
Vitamin D Levels

The purpose of this review was to assess recent evidence regarding the effects of low vitamin D levels on some highly prevalent clinical conditions of postmenopausal women. We reviewed and selected recent literature regarding menopause-related conditions associated with vitamin D deficiency and interventions to manage them. Low circulating 25-hydroxyvitamin D (25(OH)D) levels related to menopause are linked to diet, lifestyle, changes in body composition, insulin sensitivity, and reduced physical activity. Vitamin D supplementation increases serum 25(OH)D levels while normalizing parathyroid hormone and bone markers, and in women with serum 25(OH)D levels below 10 ng/ml supplementation may improve bone mineral density. Low vitamin D status has been associated with the metabolic syndrome, high triglyceride levels, and low high-density lipoprotein cholesterol levels. When compared with placebo, vitamin D supplementation may lower the risk of the metabolic syndrome, hypertriglyceridemia, and hyperglycemia. There is an inverse relationship between fat mass and serum 25(OH)D levels and, therefore, the dosage of supplementation should be adjusted according to the body mass index. Although vitamin D supplementation may improve glucose metabolism in prediabetic subjects, data regarding muscle strength are conflictive. There is evidence that vitamin D over-treatment, to reach extremely high circulating 25(OH)D levels, does not result in better clinical outcomes. The identification and treatment of vitamin D deficiency in postmenopausal women may improve their general health and health outcomes. Vitamin D supplementation should preferably be based on the use of either cholecalciferol or calcifediol.

scholarly journals Relationship between Serum Vitamin D Levels and HDL Cholesterol in Postmenopausal Women from Colombian Caribbean

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Luz Adriana Sarmiento-Rubiano ◽  
José Armando Angarita Ruidiaz ◽  
Héctor Fernando Suarez Dávila ◽  
Alfonso Suarez Rodríguez ◽  
Roberto C. Rebolledo-Cobos ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Postmenopausal Women ◽  
Serum Vitamin ◽  
Hdl Cholesterol ◽  
Serum Vitamin D ◽  
The Metabolic Syndrome ◽  
Increased Risk ◽  
Vitamin D Levels

Background. Previous evidence suggests that metabolic disorders in postmenopausal women could be related with low serum vitamin D levels. For example, vitamin D deficiency has been associated with increased risk factors for cardiovascular disease (CVD), mainly those related with metabolic syndrome.Objective. To assess the relationship between the serum vitamin D (25-OH-D) levels and the metabolic syndrome markers in postmenopausal women.Methods. This descriptive and cross-sectional study was conducted in 183 postmenopausal women of four municipalities from Colombian Caribbean. The serum 25-OH-D levels and the anthropometric and biochemical markers were assessed and correlated with metabolic syndrome.Results. The average value of serum vitamin D (25-OH-D) was 26.34 ± 9.08 ng/mL, and 69.95% of the women had vitamin D levels <30 ng/mL, of which 43.72% were with insufficiency (<30 to >20 ng/mL) and 26.23% with deficiency (<20 ng/mL). Of the evaluated women, the 81.42% seemed to have metabolic syndrome. Through the linear regression, one significant positive association was observed between the HDL cholesterol and the 25-OH-D levels (P=0.014).Conclusion. In the evaluated population in this study, vitamin D deficiency is related with low HDL cholesterol levels.

scholarly journals Role of Vitamin D in Cardiometabolic Diseases

2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
Chaoxun Wang
Keyword(s):  
Metabolic Syndrome ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Vascular Inflammation ◽  
Left Ventricular ◽  
Bone Diseases ◽  
The Body ◽  
Cvd Risk ◽  
Increased Risk ◽  
Vitamin D Levels

Vitamin D deficiency is a highly prevalent condition. Low vitamin D levels have long been associated with bone diseases, such as rickets in children and osteomalacia and osteoporosis in adults. However, it has become apparent in recent years that adequate vitamin D levels are also important for optimal functioning of many organs and tissues throughout the body, including the cardiovascular system. Evolving data indicate that vitamin D deficiency is associated with an increased risk of cardiovascular disease (CVD). Studies have shown that low vitamin D levels are associated with hypertension, diabetes, metabolic syndrome, left ventricular hypertrophy, and chronic vascular inflammation, all of which are risk factors for CVD. This paper reviews the definition and pathophysiology of vitamin D deficiency, clinical evidence linking vitamin D and CVD risk, diabetes and its complications, and metabolic syndrome.

scholarly journals High Prevalence of Vitamin D Deficiency Despite Supplementation in Premenopausal Women With Breast Cancer Undergoing Adjuvant Chemotherapy

2009 ◽  
Vol 27 (13) ◽  
pp. 2151-2156 ◽  
Author(s):  
Katherine D. Crew ◽  
Elizabeth Shane ◽  
Serge Cremers ◽  
Donald J. McMahon ◽  
Dinaz Irani ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Black Women ◽  
Adjuvant Chemotherapy ◽  
Vitamin D Deficiency ◽  
White Women ◽  
Premenopausal Women ◽  
Vitamin D Supplementation ◽  
Mineral Density ◽  
Vitamin D Levels

Purpose Vitamin D deficiency is associated with increased breast cancer risk and decreased breast cancer survival. The purpose of this study was to determine the prevalence of vitamin D deficiency, as measured by serum 25-hydroxyvitamin D (25-OHD), in premenopausal women at initiation of adjuvant chemotherapy for breast cancer and after 1 year of vitamin D supplementation. Patients and Methods The study included 103 premenopausal women from the northeastern United States with stages I to III breast cancer who received adjuvant chemotherapy and participated in a 1-year zoledronate intervention trial. All patients were prescribed vitamin D3 (cholecalciferol) 400 IU and calcium carbonate 1,000 mg daily. At baseline and at 6 and 12 months, bone mineral density (BMD) measurements were obtained and blood was collected and analyzed in batches for serum 25-OHD. Vitamin D deficiency was defined as serum 25-OHD less than 20 ng/mL, insufficiency as 20 to 29 ng/mL, and sufficiency as 30 ng/mL or greater. Results At baseline, 74% of women were vitamin D deficient (median, 17 ng/mL). Vitamin D deficiency was slightly less common in white women (66%) compared with black (80%) and Hispanic (84%) women. After vitamin D supplementation for 1 year, less than 15% of white and Hispanic women, and no black women, achieved sufficient 25-OHD levels. Vitamin D levels did not correlate with baseline BMD and were not altered by chemotherapy or bisphosphonate use. Conclusion Vitamin D deficiency is highly prevalent in women with breast cancer. The current recommended dietary allowance of vitamin D is too low to increase serum 25-OHD greater than 30 ng/mL. Optimal dosing for bone health and, possibly, improved survival has yet to be determined.

scholarly journals Prevalence of vitamin D deficiency in urban south Indians with different grades of glucose tolerance

2020 ◽  
Vol 124 (2) ◽  
pp. 209-216 ◽  
Author(s):  
Ramamoorthy Jayashri ◽  
Ulagamathesan Venkatesan ◽  
Coimbatore S. Shanthirani ◽  
Mohan Deepa ◽  
Ranjit Mohan Anjana ◽  
...  
Keyword(s):  
Vitamin D ◽  
Glucose Tolerance ◽  
Vitamin D Deficiency ◽  
Indian Population ◽  
Vitamin D Supplementation ◽  
South Indian Population ◽  
The Metabolic Syndrome ◽  
South Indian ◽  
Urban South ◽  
Vitamin D Levels

AbstractThe present study assessed the prevalence of vitamin D deficiency in an urban south Indian population in individuals with different grades of glucose tolerance. A total of 1500 individuals (900 normal glucose tolerance (NGT), 300 prediabetes and 300 with type 2 diabetes mellitus (T2DM)) who were not on vitamin D supplementation were randomly selected from the Chennai Urban Rural Epidemiological Study follow-up study. Anthropometric, clinical examination and biochemical investigations (25-hydroxyvitamin D (25(OH)D), insulin, glycated Hb (HbA1c) and serum lipids) were measured. Vitamin D deficiency was defined as serum 25(OH)D < 20·0 ng/ml, insufficiency as 20–29·9 ng/ml and sufficiency as ≥30 ng/ml. Of the 1500 individuals studied, 45 % were males and the mean age was 46 (sd 12) years. Vitamin D levels lowered with increasing degrees of glucose tolerance (NGT: 21 (sd 11); prediabetes: 19 (sd 10); T2DM: 18 (sd 11) ng/ml, P < 0·001). The overall prevalence of vitamin D deficiency was 55 % and was significantly higher among individuals with T2DM (63 %) followed by prediabetes (58 %) and NGT (51 %) (Pfor trend < 0·001). Women had 1·6 times the risk of vitamin D deficiency compared with men (unadjusted OR 1·6 (95 % CI 1·3, 2·0) and adjusted OR 1·6 (95 % CI 1·2, 1·9)). However, there was no increasing trend observed with increasing age. The prevalence of abdominal obesity (66 v. 49 %), generalised obesity (80 v. 64 %), the metabolic syndrome (45 v. 37 %) and insulin resistance (38 v. 27 %) was significantly higher in those with vitamin D deficiency compared with those without. This study shows that vitamin D deficiency is highly prevalent in this urban south Indian population and was higher among individuals with T2DM and prediabetes compared with those with NGT.

scholarly journals Role of Vitamin D in the Metabolic Syndrome

Nutrients ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 830
Author(s):  
Lucía Melguizo-Rodríguez ◽  
Víctor J. Costela-Ruiz ◽  
Enrique García-Recio ◽  
Elvira De Luna-Bertos ◽  
Concepción Ruiz ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Glycosylated Hemoglobin ◽  
Elevated Serum ◽  
High Body Mass Index ◽  
Lifestyle Changes ◽  
Plasma Vitamin ◽  
Preventive Strategy ◽  
The Metabolic Syndrome

The prevalence of hypovitaminosis D has risen in developed countries over the past few years in association with lifestyle changes and an increase in unhealthy habits. Vitamin D deficiency has been implicated in various diseases, including metabolic syndrome (MetS), which is clinically defined by a set of metabolic and vascular disorders. The objective of this study was to review scientific evidence on the relationship between MetS and vitamin D deficiency to support the development of prevention strategies and health education programs. An inverse relationship has been reported between plasma vitamin D concentrations and the features that define MetS, i.e., elevated serum concentrations of glucose, total cholesterol, low-density lipoproteins, triglycerides, glycosylated hemoglobin, and a high body mass index. Numerous studies have described the benefits of vitamin D supplementation to improve outcomes in individuals with MetS. Interventions to maintain optimal vitamin D concentrations are proposed as a preventive strategy against MetS.

Vitamin D supplementation improves the metabolic syndrome risk profile in postmenopausal women

Climacteric ◽  
2019 ◽  
Vol 23 (1) ◽  
pp. 24-31 ◽  
Author(s):  
P. P. Ferreira ◽  
L. Cangussu ◽  
F. N. Bueloni-Dias ◽  
C. L. Orsatti ◽  
E. B. Schmitt ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Vitamin D ◽  
Postmenopausal Women ◽  
Risk Profile ◽  
Vitamin D Supplementation ◽  
The Metabolic Syndrome

Vitamin D supplementation, the metabolic syndrome and oxidative stress in obese children

2017 ◽  
Vol 30 (4) ◽  
Author(s):  
Tal Grunwald ◽  
Shruti Fadia ◽  
Bruce Bernstein ◽  
Matthew Naliborski ◽  
Shufang Wu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Vitamin D Supplementation ◽  
Urban Setting ◽  
Obese Children ◽  
The Metabolic Syndrome ◽  
Vitamin D Levels ◽  
Before And After ◽  
And Oxidative Stress

AbstractBackground:Previous studies suggest that vitamin D may play a role in cardiovascular and metabolic health. Oxidative stress has also been implicated in the development of cardiovascular disease. Evidence suggests that vitamin D deficiency may contribute to the occurrence of oxidative stress. This study aimed to determine whether treatment and correction of vitamin D deficiency in obese children led to changes in their metabolic profile, independent of changes in adiposity. In addition, we aimed to determine whether vitamin D deficiency and oxidative stress are causally related in obese children.Methods:In the retrospective arm, chart review identified 32 obese children who experienced normalization of vitamin D deficiency or insufficiency with vitamin D supplementation. We then correlated laboratory and anthropometric data with vitamin D levels. In the prospective arm of the study, urinary 8-isoprostane and hydrogen peroxide were measured before and after correction of vitamin D deficiency/insufficiency and correlated to vitamin D levels in seven patients.Results:In our predominantly Hispanic population of obese children in an urban setting, we demonstrated a cause-effect relationship between vitamin D deficiency and oxidative stress. In contrast, we found no association between vitamin D status, adiposity, and markers of insulin sensitivity, nor any effect of vitamin D treatment on the same parameters.Conclusions:These discordant findings suggest a differential effect of vitamin D on cardiovascular risk factors such as oxidative stress and insulin resistance. To confirm these findings, further prospective studies with larger sample size and longer follow-up are warranted.

scholarly journals Vitamin D Deficiency is Associated with Anemia, Cardiovascular Risk, and Lifestyle

2021 ◽  
Vol 11 (1) ◽  
pp. 134-138
Author(s):  
Hawro D. Ismael ◽  
Goran Q. Othman ◽  
Azad H. Amin ◽  
Jabbar H. Odey ◽  
Badraddin U. Abdullah ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Iron Status ◽  
Lipid Level ◽  
Serum Lipid Level ◽  
The Body ◽  
Index Number ◽  
Public And Private ◽  
Vitamin D Levels

Traditionally, Vitamin D has been associated primarily with bone health, while further investigations revealed that a sufficient amount is important for many organ functions. Data of 314 individuals were obtained from Erbil governorate public and private hospitals from patients admitted to there for testing their level of Vitamin D and other tests according to their doctor’s prescription. The variable related to their lifestyle, metabolic syndrome, and hematology evaluations were obtained. The body mass index , number of sleeping hours, number of hours spent with electronic devices, serum lipid level anemia-related tests were measured. The results showed that serum 25(OH) Vitamin D levels in studied individuals were related to hyperlipidemia serum cholesterol measures. The level of Vitamin B12 and Iron status were lower in the Vitamin D deficiency (VDD) individuals. Mean platelet volume was higher in vitamin-deficient patients which induces the risk of cardiovascular (CV) diseases. This finding suggests the relation between VDD and metabolic syndrome, CV, and anemia-related measurement.

scholarly journals Interim Assessment of Vitamin D Sufficiency in a Prospective Cohort of Late Postmenopausal Women

2020 ◽  
Vol 16 (19) ◽  
pp. 24-29
Author(s):  
N.V. Izmozherova ◽  
◽  
A.A. Popov ◽  
А.A. Vikhareva ◽  
Ye.A. Safyanik ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Postmenopausal Women ◽  
Physical Functioning ◽  
Prospective Cohort ◽  
Vitamin D Supplementation ◽  
Middle Urals ◽  
Dominant Hand ◽  
Cross Sectional ◽  
Vitamin D Levels

Objective: to assess vitamin D repletion in prospective cohort of late postmenopausal women and to establish the contribution of vitamin D deficiency and measures for its prevention to physical functioning of women. Material and methods. 107 postmenopausal Middle Urals region residents were recruited to a prospective cohort nested cross-sectional study. The data were obtained from 2016 to 2019. Results. According to the concentration level of 25(OH)D, an adequate level was detected in 24 patients (22.4%), insufficiency in 35 (32.7%), deficiency in 48 cases (44.8%). No significant seasonal differences in vitamin D levels were found. Patients significantly differed in age, according to the wrist dynamometry of dominant hand and according to results of tandem test. By the inclusion visit, 89 patients (83.1%) were not receiving vitamin D supplementation, 18 persons (16.8%) were compliant to cholecalciferol prophylactic doses consumption, had significantly higher values of 25(OH)D in the blood. Vitamin D deficiency and insufficiency in the group not receiving cholecalciferol were significantly more common than in the group who followed the recommendations. Conclusion. Deficiency and insufficiency of vitamin D are detected with high frequency in the residents of the Middle Urals in late postmenopause. Prophylactic administration of cholecalciferol did not achieve optimal concentration of vitamin D, but contributed to its higher values. Women who were optimally provided with vitamin D had significantly better physical functioning.

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