“Turn-on” fluorescence probe for Al (III) and Hg (II) ions in aqueous medium: Synthesis, characterization, cytotoxicity, visual results in solution and cancer cells

2022 ◽  
pp. 118448
Author(s):  
Mehmet Oguz ◽  
Alev Oguz ◽  
Asif Ali Bhatti ◽  
Ahmet Kocak ◽  
Mustafa Yilmaz
Keyword(s):  
Cancer Cells ◽  
Aqueous Medium ◽  
Fluorescence Probe ◽  
Turn On ◽  
Visual Results

scholarly journals A Highly Selective Turn-On Fluorescent Probe for the Detection of Zinc

Molecules ◽  
2021 ◽  
Vol 26 (13) ◽  
pp. 3825
Author(s):  
Ling-Yi Shen ◽  
Xiao-Li Chen ◽  
Xian-Jiong Yang ◽  
Hong Xu ◽  
Ya-Li Huang ◽  
...  
Keyword(s):  
High Selectivity ◽  
Fluorescence Probe ◽  
Stoichiometric Ratio ◽  
X Ray Diffraction ◽  
X Ray ◽  
Turn On ◽  
Imine Nitrogen ◽  
System A ◽  
Plot Analysis ◽  
L System

A novel turn-on fluorescence probe L has been designed that exhibits high selectivity and sensitivity with a detection limit of 9.53 × 10−8 mol/L for the quantification of Zn2+. 1H-NMR spectroscopy and single crystal X-ray diffraction analysis revealed the unsymmetrical nature of the structure of the Schiff base probe L. An emission titration experiment in the presence of different molar fractions of Zn2+ was used to perform a Job’s plot analysis. The results showed that the stoichiometric ratio of the complex formed by L and Zn2+ was 1:1. Moreover, the molecular structure of the mononuclear Cu complex reveals one ligand L coordinates with one Cu atom in the asymmetric unit. On adding CuCl2 to the ZnCl2/L system, a Cu-Zn complex was formed and a strong quenching behavior was observed, which inferred that the Cu2+ displaced Zn2+ to coordinate with the imine nitrogen atoms and hydroxyl oxygen atoms of probe L.

A naked-eye visible and turn-on fluorescence probe for Fe3+ and its bioimaging application in living cells

2016 ◽  
Vol 237 ◽  
pp. 501-508 ◽  
Author(s):  
Yaming Liu ◽  
Jinyu Zhang ◽  
Jiaxi Ru ◽  
Xiang Yao ◽  
Yang Yang ◽  
...  
Keyword(s):  
Fluorescence Probe ◽  
Living Cells ◽  
Naked Eye ◽  
Turn On

A Reduction Active Theranostic Nanoparticle for Enhanced Near-Infrared Imaging and Phototherapy by Reducing Glutathione Level in Cancer Cells

2021 ◽  
Vol 21 (12) ◽  
pp. 5965-5971
Author(s):  
Xiaofang Song ◽  
Lifo Ruan ◽  
Tianyu Zheng ◽  
Jun Wei ◽  
Jiayu Zhang ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Disulfide Bonds ◽  
Near Infrared ◽  
Infrared Imaging ◽  
Fluorescent Imaging ◽  
Self Monitoring ◽  
Fluorescent Intensity ◽  
Turn On ◽  
Hyperbranched Poly ◽  
One Step

Facile preparation of a tumoral-stimuli-activated theranostic nanoparticle with simple constituents remains a challenge for tumor theranostic nanosystems. Herein we design a simple reductionresponsive turn-on theranostic nanoparticle for achieving fluorescent imaging and phototherapy combination. The theranostic nanoparticle is prepared by a simple one-step dialysis method of reduction active amphiphilic hyperbranched poly(β-amidoamines) and a near-infrared (NIR) dye indocyanine green (ICG). The fluorescence of ICG is quenched by the aggregation-caused quenching (ACQ) effect. The fluorescent intensity of free ICG at 816 nm was ∼40 times as high as that of particulate ICG. After reductive nanoparticles incubated with dithiothreitol (DTT), the size of the nanoparticles increased from 160 nm to 610 nm by Dynamic light scattering (DLS). As nanoparticles were internalized by cancer cells, the disulfide bonds would be cleaved by intracellular reduction agents like glutathione (GSH), leading to the release of entrapped ICG. The released ICG regained its fluorescence for self-monitoring the release and therapeutic effect of ICG by fluorescence spectra and the quantitative evaluation of NIR fluorescence intensity. Remarkably, nanoparticles can also reinforce antitumor efficacy through photodynamic therapy and GSH depletion property. This study provides new insights into designing turn-on theranostic systems.

scholarly journals “Turn-on” fluorescence probe integrated polymer nanoparticles for sensing biological thiol molecules

2014 ◽  
Vol 4 (1) ◽  
Author(s):  
Chung Yen Ang ◽  
Si Yu Tan ◽  
Yunpeng Lu ◽  
Linyi Bai ◽  
Menghuan Li ◽  
...  
Keyword(s):  
Fluorescence Probe ◽  
Polymer Nanoparticles ◽  
Turn On

scholarly journals A red-emissive antibody–AIEgen conjugate for turn-on and wash-free imaging of specific cancer cells

2017 ◽  
Vol 8 (10) ◽  
pp. 7014-7024 ◽  
Author(s):  
Xiujuan Shi ◽  
Chris Y. Y. Yu ◽  
Huifang Su ◽  
Ryan T. K. Kwok ◽  
Meijuan Jiang ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Cancer Cells ◽  
Turn On ◽  
Specific Cancer ◽  
First Time

For the first time, an AIEgen-conjugated monoclonal antibody is designed for “turn-on” and “wash-free” imaging of EGFR-overexpressed cancer cells.

scholarly journals A New Fluorescence Probe for Rapid Detection of Amyloid

2018 ◽  
Author(s):  
Nidhi Gour ◽  
Vivek Shinh Kshtriya ◽  
Bharti Koshti ◽  
Shradhey Gupta ◽  
khashti Ballabh Joshi ◽  
...  
Keyword(s):  
Rapid Detection ◽  
Control Experiment ◽  
Fluorescence Probe ◽  
Photophysical Properties ◽  
Cost Effective ◽  
The Novel ◽  
High Quantum Yield ◽  
Turn On ◽  
Heat Treated ◽  
Amyloidogenic Peptides

<p>We report efficient synthesis and photophysical properties of a novel fluorescent pyridothiazole based construct by a facile methodology and its application as a sensor for rapid, selective as well as sensitive detection of amyloid fibres. The novel compound has exceptionally high quantum yield and sensitivity. The fluorescence of pyridothiazole construct is completely quenched (Turn-OFF) upon addition of cupric ions and the fluorescence is recovered on addition of amyloidogenic peptides like A<i>β</i><sub>42 </sub>(Turn-ON). The control experiment with native and heat treated BSA suggest that the new probe binds to beeta/<i>β</i> sheets present in amyloid. The new probe offers direct visualization of fluorescence ‘Turn-OFF’ ‘Turn-ON’ under long UV without the use of sophisticated instrumentation. Hence, a very simple, facile and cost-effective methodology for the rapid detection of amyloid is presented and it may in all possibility pave the way for the design of a better probe for sensing amyloids than conventional ThT.</p>

Dissolution-enhanced emission of 1,3,6,8-Tetrakis(p-benzoic acid)pyrene for selectively detecting protamine and “on-to-on” heparin detection in water

2021 ◽  
Author(s):  
Hongtao Li ◽  
Yuting Zhang ◽  
Yan Huang ◽  
Dapeng Cao ◽  
Shitao Wang
Keyword(s):  
Detection Limit ◽  
Benzoic Acid ◽  
Organic Molecule ◽  
Basic Protein ◽  
Fluorescence Probe ◽  
Small Organic Molecule ◽  
Turn On ◽  
Low Detection Limit

We developed a small organic molecule, the 1,3,6,8-Tetrakis(pbenzoic acid)pyrene (TBAPy) as a facile turn-on fluorescence probe for selectively detecting the basic protein protamine in water with a low detection limit...

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