Long noncoding RNA DANCR mediates cisplatin resistance in glioma cells via activating AXL/PI3K/Akt/NF-κB signaling pathway

2018 ◽  
Vol 118 ◽  
pp. 233-241 ◽  
Author(s):  
Yangang Ma ◽  
Guanghua Zhou ◽  
Mengyou Li ◽  
Dianfeng Hu ◽  
Lianqun Zhang ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Cisplatin Resistance ◽  
Glioma Cells

Long noncoding RNA H19 contributes to the proliferation and autophagy of glioma cells through mTOR/ULK1 pathway

Neuroreport ◽  
2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Wei Zhao ◽  
Xiaoyan Lin ◽  
Han Han ◽  
Hongxu Zhang ◽  
Xiaoli Li ◽  
...  
Keyword(s):  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Glioma Cells

Long Noncoding RNA HOXA Cluster Anti-Sense RNA 2 Inhibits Mycoplasma pneumoniae-Induced Inflammation by Regulating the Nuclear Factor-KappaB Signaling Pathway

2021 ◽  
Vol 11 (11) ◽  
pp. 2262-2273
Author(s):  
Mei Feng ◽  
Chengjie Zhuo ◽  
Xuefen Zhu
Keyword(s):  
Cell Viability ◽  
Signaling Pathway ◽  
Mycoplasma Pneumoniae ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Flow Cytometric Analysis ◽  
Inflammatory Factors ◽  
Epithelial Cell Line ◽  
Inflammatory Factor ◽  
Hoxa Cluster

Mycoplasma pneumoniae (MP) is the primary cause of community-acquired lung inflammation. The MP-induced manifestations of pneumonia are associated with the release of pro-inflammatory cytokines; however, the mechanisms of MP-induced inflammation have not been fully clarified. The purpose of the present study was to determine whether long noncoding RNA HOXA cluster anti-sense RNA 2 (lncRNA HOXA-AS2) is involved in MP-induced inflammation. A model of MP-induced cellular inflammation was established using the human BEAS-2B lung epithelial cell line and lncRNA HOXA-AS2 levels were detected using reverse transcription-quantitative (RT-q) PCR. MTT and flow cytometric analysis were used to assess cell viability and apoptosis, respectively. The secretion of pro-inflammatory factors including tumor necrosis factor (TNF)-α, interleukin (IL)-1β and IL-6 were measured by ELISA, and protein levels of phosho- (p-)p65 and p-NF-κB inhibitor α (p-IκBα) were detected by western blotting. The results suggest that MP infection significantly decreases the level of lncRNA HOXA-AS2 in BEAS-2B cells. lncRNA HOXA-AS2 overexpression significantly enhanced cell viability, inhibited apoptosis, decreased pro-inflammatory factor expression (TNF-α, IL-β and IL-6) and inhibited NF-κB pathway activation in MP-stimulated BEAS-2B cells. Conversely, lncRNA HOXA-AS2-knockdown resulted in the opposite effects. In conclusion, lncRNA HOXA-AS2 is involved in MP infection-induced inflammation and regulates the NF-κB signaling pathway.

A novel long noncoding RNA FAF inhibits apoptosis via upregulating FGF9 through PI3K/AKT signaling pathway in ischemia–hypoxia cardiomyocytes

2019 ◽  
Vol 234 (12) ◽  
pp. 21973-21987 ◽  
Author(s):  
Hao‐Jie Shi ◽  
Ming‐Wei Wang ◽  
Jia‐Teng Sun ◽  
Hao Wang ◽  
Ya‐Fei Li ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Akt Signaling ◽  
Akt Signaling Pathway
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