Study of the relationship between how ethanol affects learning and memory and the expression of p21 WAF1/CIP1 in the female mouse hippocampus

: Neurological diseases bring great mental and physical torture to the patients, and have long-term and sustained negative effects on families and society. The attention to neurological diseases is increasing, and the improvement of the material level is accompanied by an increase in the demand for mental level. The p75 neurotrophin receptor (p75NTR) is a low-affinity neurotrophin receptor and involved in diverse and pleiotropic effects in the developmental and adult central nervous system (CNS). Since neurological diseases are usually accompanied by the regression of memory, the pathogenesis of p75NTR also activates and inhibits other signaling pathways, which has a serious impact on the learning and memory of patients. The results of studies shown that p75NTR is associated with LTP/LTD-induced synaptic enhancement and inhibition, suggest that p75NTR may be involved in the progression of synaptic plasticity. And its pro-apoptotic effect is associated with activation of proBDNF and inhibition of proNGF, and TrkA/p75NTR imbalance leads to pro-survival or pro-apoptotic phenomena. It can be inferred that p75NTR mediates apoptosis in the hippocampus and amygdale, which may affect learning and memory behavior. This article mainly discusses the relationship between p75NTR and learning memory and associated mechanisms, which may provide some new ideas for the treatment of neurological diseases.

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Resveratrol attenuates arsenic-induced cognitive deficits via modulation of Estrogen-NMDAR-BDNF signalling pathway in female mouse hippocampus

Psychopharmacology ◽

10.1007/s00213-021-05871-2 ◽

2021 ◽

Author(s):

Kamakshi Mehta ◽

Kamlesh Kumar Pandey ◽

Balpreet Kaur ◽

Pushpa Dhar ◽

Saroj Kaler

Keyword(s):

Cognitive Deficits ◽

Female Mouse ◽

Signalling Pathway ◽

Mouse Hippocampus

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Ferroptosis contributes to isoflurane-induced neurotoxicity and learning and memory impairment

Cell Death Discovery ◽

10.1038/s41420-021-00454-8 ◽

2021 ◽

Vol 7 (1) ◽

Author(s):

Pengfei Liu ◽

Jing Yuan ◽

Yetong Feng ◽

Xin Chen ◽

Guangsuo Wang ◽

...

Keyword(s):

Cell Death ◽

Learning And Memory ◽

Memory Impairment ◽

Close Association ◽

Dimethyl Fumarate ◽

Dependent Manner ◽

Transport Chain ◽

The Relationship

AbstractFerroptosis is a novel type of programmed cell death, which is different from apoptosis and autophagic cell death. Recently, ferroptosis has been indicated to contribute to the in vitro neurotoxicity induced by isoflurane, which is one of the most common anesthetics in clinic. However, the in vivo position of ferroptosis in isoflurane-induced neurotoxicity as well as learning and memory impairment remains unclear. In this study, we mainly explored the relationship between ferroptosis and isoflurane-induced learning and memory, as well as the therapeutic methods in mouse model. Our results indicated that isoflurane induced the ferroptosis in a dose-dependent and time-dependent manner in hippocampus, the organ related with learning and memory ability. In addition, the activity of cytochrome c oxidase/Complex IV in mitochondrial electron transport chain (ETC) was increased by isoflurane, which might further contributed to cysteine deprivation-induced ferroptosis caused by isoflurane exposure. More importantly, isoflurane-induced ferroptosis could be rescued by both ferroptosis inhibitor (ferrostatin-1) and mitochondria activator (dimethyl fumarate), which also showed effective therapeutic action against isoflurane-induced learning and memory impairment. Taken together, our data indicate the close association among ferroptosis, mitochondria and isoflurane, and provide a novel insight into the therapy mode against isoflurane-induced learning and memory impairment.

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Resveratrol protects against inorganic arsenic-induced oxidative damage and cytoarchitectural alterations in female mouse hippocampus

Acta Histochemica ◽

10.1016/j.acthis.2021.151792 ◽

2021 ◽

Vol 123 (7) ◽

pp. 151792

Author(s):

K. Mehta ◽

B. Kaur ◽

KK Pandey ◽

P. Dhar ◽

S. Kaler

Keyword(s):

Oxidative Damage ◽

Female Mouse ◽

Inorganic Arsenic ◽

Mouse Hippocampus

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Relationship of Depression and function of Attention, Planning and Verbal Learning and Memory

Thematics Journal of Geography ◽

10.26643/tjg.v8i9.8420 ◽

2019 ◽

Vol 8 (9) ◽

pp. 214-225

Author(s):

Nongmeikapam Premika Devi

Keyword(s):

Learning And Memory ◽

Verbal Learning ◽

Education Level ◽

Auditory Verbal Learning ◽

And Function ◽

Age Range ◽

Relationship Of ◽

The Relationship ◽

Minimum Education ◽

Hiv Aids

The present study examines the relationship of depression and the neuropsychologicalfunction of attention, planning and auditory verbal learning and memory among individualswith HIV/AIDS. 200 subjects who were HIV/AIDS positive (100 males and 100 females) andwere within age range of 20 to 50 years and minimum education level of 8th standard weretaken. The result indicates that Depression slows down the performance of attention; alsodepression most likely decreases the function of auditory verbal learning and memory

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Short-Term Memory Deficits in the SLEEP Inbred Panel

Clocks & Sleep ◽

10.3390/clockssleep1040036 ◽

2019 ◽

Vol 1 (4) ◽

pp. 471-488 ◽

Cited By ~ 1

Author(s):

Shailesh Kumar ◽

Kirklin R. Smith ◽

Yazmin L. Serrano Negron ◽

Susan T. Harbison

Keyword(s):

Learning And Memory ◽

Sleep Duration ◽

Genetic Architecture ◽

Short Term Memory ◽

Morphological Changes ◽

Brain Structures ◽

Social Conditions ◽

Short Term ◽

The Relationship ◽

The Brain

Although sleep is heritable and conserved across species, sleep duration varies from individual to individual. A shared genetic architecture between sleep duration and other evolutionarily important traits could explain this variability. Learning and memory are critical traits sharing a genetic architecture with sleep. We wanted to know whether learning and memory would be altered in extreme long or short sleepers. We therefore assessed the short-term learning and memory ability of flies from the Sleep Inbred Panel (SIP), a collection of 39 extreme long- and short-sleeping inbred lines of Drosophila. Neither long nor short sleepers had appreciable learning, in contrast to a moderate-sleeping control. We also examined the response of long and short sleepers to enriched social conditions, a paradigm previously shown to induce morphological changes in the brain. While moderate-sleeping control flies had increased daytime sleep and quantifiable increases in brain structures under enriched social conditions, flies of the Sleep Inbred Panel did not display these changes. The SIP thus emerges as an important model for the relationship between sleep and learning and memory.

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A-016 The Relationship between Visual Memory and Performance in Virtual Reality Among Older Adults

Archives of Clinical Neuropsychology ◽

10.1093/arclin/acaa068.016 ◽

2020 ◽

Vol 35 (6) ◽

pp. 806-806

Author(s):

Flores E ◽

Gutierrez R ◽

Shorter S ◽

Mollenkopf K ◽

Childers L ◽

...

Keyword(s):

Older Adults ◽

Virtual Reality ◽

Learning And Memory ◽

Visual Memory ◽

Procedural Learning ◽

Virtual Reality Environment ◽

Meal Preparation ◽

Immediate Recall ◽

And Performance ◽

The Relationship

Abstract Objective Over the past fifty years, many traditional paper-and-pencil neuropsychological tests have been translated to new computerized devices (Canini et al., 2014). Virtual reality offers neuropsychologists an opportunity to observe patients’ neurocognitive functioning in an immersive, lifelike environment, rich in visual stimuli (Morganti, 2004), yet relatively little is known about the relationship between visual memory and performance on learning and memory tasks in virtual reality environments. The purpose of this study was to investigate, among older adults, the relationship between visual memory, as measured by a traditional paper-and-pencil test, and procedural learning and memory performance in a virtual reality environment simulating meal preparation tasks. Methods Older adults (N = 73) ages 55-90 (M = 72.77, SD = 7.87) were administered the Weschler Adult Intelligence Scale-Fourth Edition (WMS-IV) Visual Reproduction Immediate Recall and the Virtual Kitchen Protocol (VPK), a virtual reality-based measure of learning and memory for meal preparation tasks. Results Participants performance on the immediate portion of WMS-IV, visual reproduction, correlated with their performance on the VPK teaching trial (r = .65, p = 0.01), immediate recall (r = .51, p = 0.01), delayed recall (r = .58, p = 0.01), and forced choice recognition ( r = ..54, p = 0.01) of Job Sim. Conclusion Results suggest that visual memory aids healthy older adults in procedural learning and memory tasks in the Virtual Kitchen Protocol, a virtual reality environment simulating meal preparation tasks. These results suggest that visual memory ability is germane to performance in virtual reality environments that are rich in visual stimuli.

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