Novel neuroprotective effects of the aqueous extracts from Verbena officinalis Linn

Ethyl acetate (EA), methanol (MeOH), and aqueous extracts of aerial parts of Anthemis tinctoria var. pallida (ATP) and A. cretica subsp. tenuiloba (ACT) were investigated for their phenol and flavonoid content, antioxidant, and key enzyme inhibitory potentials. All extracts displayed antiradical effects, with MeOH and aqueous extracts being a superior source of antioxidants. On the other hand, EA and MeOH extracts were potent against AChE and BChE. Enzyme inhibitory effects against tyrosinase and α-glucosidase were observed, as well. We also studied Anthemis extracts in an ex vivo experimental neurotoxicity paradigm. We assayed extract influence on oxidative stress and neurotransmission biomarkers, including lactate dehydrogenase (LDH) and serotonin (5-HT), in isolated rat cortex challenged with K+ 60 mM Krebs-Ringer buffer (excitotoxicity stimulus). An untargeted proteomic analysis was finally performed in order to explore the putative mechanism in the brain. The pharmacological study highlighted the capability of ACT water extract to blunt K+ 60 mM increase in LDH level and 5-HT turnover, and restore physiological activity of specific proteins involved in neuron morphology and neurotransmission, including NEFMs, VAMP-2, and PKCγ, thus further supporting the neuroprotective role of ACT water extract.

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Potential Properties of Plant Sprout Extracts on Amyloidβ

Biochemistry Research International ◽

10.1155/2016/9347468 ◽

2016 ◽

Vol 2016 ◽

pp. 1-11 ◽

Cited By ~ 2

Author(s):

Mizue Okada ◽

Yoshinori Okada

Keyword(s):

Absorption Spectrum ◽

Gel Electrophoresis ◽

Inhibition Mechanism ◽

Elisa Assay ◽

Aqueous Extracts ◽

Structure Modification ◽

Neuroprotective Effects ◽

Red Cabbage ◽

Binding Experiment ◽

Monomer Band

The aim of this study is to examine the amyloidβ(Aβ) inhibition mechanism of plant sprouts’ aqueous extracts (PSAE). In this study, we screened the effects of five plant sprouts’ extracts on Aβ(1–42) structure modification using gel electrophoresis. In PSAE, no band of Aβmonomer was recognized in Japanese butterbur. Similarly, the Aβmonomer band became light in buckwheat, red cabbage, broccoli, and brussels. The neuroprotective effects of PSAE were evaluated by measuring levels of Aβin mixtures (Aβ and PSAE) with AβELISA assay. The treatment with PSAE decreased Aβlevels. The results indicated that the levels of red cabbage, Japanese butterbur, and broccoli were 9.6, 28.0, and 44.0%, respectively. The lowest value was observed with buckwheat. Furthermore, we carried out a Congo Red (CR) and Aβbinding experiment of PSAE to confirm the modification mechanism of PSAE. The correlation coefficient for the absorption spectrum peak of CR was found to be bigger than 0.8 (r=0.882) which proved that the Aβlevels could be attributed to the peak of CR. In conclusion, we demonstrated that treatment with PSAE effectively decreases Aβconcentration. Thus, the mechanism that decreased the Aβlevels may be modification by PSAE.

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Neuroprotective effects of aqueous extracts of Uncaria tomentosa: Insights from 6-OHDA induced cell damage and transgenic Caenorhabditis elegans model

Neurochemistry International ◽

10.1016/j.neuint.2013.03.001 ◽

2013 ◽

Vol 62 (7) ◽

pp. 940-947 ◽

Cited By ~ 15

Author(s):

Zhenhua Shi ◽

Zhongbing Lu ◽

Yashuo Zhao ◽

Yueqi Wang ◽

Xi Zhao-Wilson ◽

...

Keyword(s):

Caenorhabditis Elegans ◽

Cell Damage ◽

Aqueous Extracts ◽

Neuroprotective Effects ◽

Uncaria Tomentosa

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Activity Engagement in Cognitive Aging: A Review of the Evidence

Perspectives on Neurophysiology and Neurogenic Speech and Language Disorders ◽

10.1044/nnsld23.1.35 ◽

2013 ◽

Vol 23 (1) ◽

pp. 1-12 ◽

Cited By ~ 2

Author(s):

Yvonne Rogalski ◽

Muriel Quintana

Keyword(s):

Older Adults ◽

Cognitive Decline ◽

Cognitive Aging ◽

Social Activity ◽

Current Evidence ◽

Omega 3 ◽

Neuroprotective Effects ◽

Activity Engagement ◽

Age Related ◽

Age Related Cognitive Decline

The population of older adults is rapidly increasing, as is the number and type of products and interventions proposed to prevent or reduce the risk of age-related cognitive decline. Advocacy and prevention are part of the American Speech-Language-Hearing Association’s (ASHA’s) scope of practice documents, and speech-language pathologists must have basic awareness of the evidence contributing to healthy cognitive aging. In this article, we provide a brief overview outlining the evidence on activity engagement and its effects on cognition in older adults. We explore the current evidence around the activities of eating and drinking with a discussion on the potential benefits of omega-3 fatty acids, polyphenols, alcohol, and coffee. We investigate the evidence on the hypothesized neuroprotective effects of social activity, the evidence on computerized cognitive training, and the emerging behavioral and neuroimaging evidence on physical activity. We conclude that actively aging using a combination of several strategies may be our best line of defense against cognitive decline.

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