New insights into the relationship of neurogenesis and affect: tickling induces hippocampal cell proliferation in rats emitting appetitive 50-kHz ultrasonic vocalizations

Neuroscience ◽  
2009 ◽  
Vol 163 (4) ◽  
pp. 1024-1030 ◽  
Author(s):  
M. Wöhr ◽  
M. Kehl ◽  
A. Borta ◽  
A. Schänzer ◽  
R.K.W. Schwarting ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Ultrasonic Vocalizations ◽  
Hippocampal Cell ◽  
Relationship Of ◽  
The Relationship

scholarly journals Cell Proliferation and Cortical Cell Production in Relation to Wool Growth

1979 ◽  
Vol 32 (3) ◽  
pp. 317 ◽  
Author(s):  
Patricia A Wilson ◽  
BF Short
Keyword(s):  
Cell Proliferation ◽  
Nutrient Intake ◽  
Cortical Cell ◽  
Cortical Cells ◽  
Wool Growth ◽  
Wide Range ◽  
High Level ◽  
Relationship Of ◽  
The Relationship ◽  
Germinal Cells

The relationship of wool growth to cell proliferation in the follicle bulb and to the subsequent migration and growth of the fibre cortical cells was investigated in 10 Peppin Merino sheep. These sheep had been maintained on a low, medium or high level of nutrient intake to ensure a wide range in wool growth. The number and mitotic activity of the germinal cells in the follicle bulb were determined after administration of colchicine. Cortical cell size was measured following isolation of the fibre cells by acid-treatment of wool.

Effect of MiR-21 on Regulating the Proliferation of Synovial Fibroblasts in Rheumatoid Arthritis

2020 ◽  
Vol 10 (7) ◽  
pp. 1052-1058
Author(s):  
Zhichao Li ◽  
Jin Wang ◽  
Jing Yang
Keyword(s):  
Rheumatoid Arthritis ◽  
Cell Proliferation ◽  
Cell Apoptosis ◽  
Mrna Level ◽  
Synovial Fibroblasts ◽  
Control Group ◽  
Spearman Correlation ◽  
Qrt Pcr ◽  
Relationship Of ◽  
The Relationship

Background: This study investigated whether miR-21 regulates the expression of STAT3 and affects FLS cells. Methods: MiR-21 and STAT3 mRNA level was assessed by qRT-PCR and STAT3 and p-STAT3 level was evaluated by Western blot. Spearman correlation was used to analyze the relationship between miR-21 and STAT3 mRNA expression in synovial tissue of RA patients. FLS cells were treated with IL-17A, and the cells without treatment was included as the control group. Under IL-17A treatment, FLS cells were divided into 2 groups: miR-NC group and miR-21 mimic group. MiR-21, STAT3, p-STAT3 expression were detected and compared. EdU staining was used to detect cell proliferation and flow cytometry was used to measure cell apoptosis. Results: There was a target relationship of miR-21 with STAT3 mRNA. IL-17A treatment significantly downregulated miR-21 in FLS cells, upregulated STAT3 and p-STAT3 and enhanced cell proliferation. Transfection of miR21 mimic significantly downregulated STAT3 and p-STAT3 in FLS cells, reduced cell proliferation and increased cell apoptosis. Conclusion: MiR-21 overexpression down-regulates STAT3, inhibits FLS cell proliferation and promotes apoptosis, indicating that it might be a therapeutic target for treating RA.

scholarly journals Prognostic Significance ofNOTCH1andFBXW7Mutations in Pediatric T-ALL

2010 ◽  
Vol 28 (6) ◽  
pp. 353-360 ◽  
Author(s):  
Yucel Erbilgin ◽  
Muge Sayitoglu ◽  
Ozden Hatirnaz ◽  
Omer Dogru ◽  
Arzu Akcay ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
T Cell ◽  
Notch Signaling ◽  
B Lymphocyte ◽  
Prognostic Significance ◽  
Notch Signaling Pathway ◽  
Biological Data ◽  
Multicellular Organisms ◽  
Relationship Of ◽  
The Relationship

The NOTCH signaling pathway plays important role in the development of multicellular organisms, as it regulates cell proliferation, survival, and differentiation. In adults, it is essential for the T- or B-lymphocyte lineage commitment.NOTCH1and FBXW7 mutations both lead the activation of theNOTCH1pathway and are found in the majority of T-ALL patients. In this study, the mutation analysis ofNOTCH1andFBXW7genes was performed in 87 pediatric T-ALLs who were treated on the ALL-BFM protocols. In 19 patients (22%), activatingNOTCH1mutations were observed either in the heterodimerization domain or in the PEST domain and 7 cases (10%) demonstrated FBXW7 mutations (2 cases had bothNOTCH1andFBXW7mutations). We also analyzed the relationship of the mutation data between the clinical and biological data of the patients.NOTCH1andFBXW7,NOTCH1alone were found correlated with lower initial leucocyte counts which was independent from the sex and T- cell immunophenotype. However,NOTCH1andFBXW7mutations were not predictive of outcome in the overall cohort of pediatric T-ALLs.

Feline Panleukopenia: II. The Relationship of Intestinal Mucosal Cell Proliferation Rates to Viral Infection and Development of Lesions

1977 ◽  
Vol 14 (2) ◽  
pp. 173-181 ◽  
Author(s):  
J. H. Carlson ◽  
F. W. Scott
Keyword(s):  
Cell Proliferation ◽  
Unit Length ◽  
Mucosal Cell ◽  
Proximal Jejunum ◽  
Specific Pathogen Free ◽  
Mucosal Cells ◽  
Specific Pathogen ◽  
Infected Cells ◽  
Relationship Of ◽  
The Relationship

Proliferation rates of small intestinal mucosal cells of noninfected germfree and specific pathogen-free kittens were compared to the incidence of infected cells and microscopic lesions in kittens experimentally infected with panleukopenia virus. Mucosal crypt length, cells per crypt, mitotic index and villous length were greater in specific pathogen-free kittens than in germfree kittens. Crypt cells per unit length and villous length per crypt length ratio were greater in germfree kittens. The cryptal cell proliferation rate of specific pathogen-free kittens was 2.24 times that of germfree kittens. Mucosal crypt length, cell per crypt and villous length were greater in the proximal jejunum than in the midjejunum of kittens within groups. Cell proliferation rates per crypt did not differ between areas of the intestine in kittens within groups. There were more virus-infected cells and lesions in specific pathogen-free kittens than in germfree kittens. The incidence of virus-infected cells and lesions was greater in the proximal jejunum and decreased along the small intestine.

scholarly journals SCHWANN CELL PROLIFERATION IN DEVELOPING MOUSE SCIATIC NERVE

1967 ◽  
Vol 34 (3) ◽  
pp. 735-743 ◽  
Author(s):  
A. K. Asbury
Keyword(s):  
Cell Cycle ◽  
Cell Proliferation ◽  
Sciatic Nerve ◽  
Schwann Cell ◽  
Schwann Cells ◽  
Generation Time ◽  
Dividing Cells ◽  
Mitotic Figures ◽  
Relationship Of ◽  
The Relationship

Proliferation of Schwann cells in neonatal mouse sciatic nerve was studied radioautographically in 1-µ glycol methacrylate sections. 28 mice were injected with thymidine-3H, 4 µc/g, 48 hr after birth, and were killed serially over the next 4 days. For the cell cycle following injection, the generation time was approximately 24 hr as determined by grain-count halving data; the duration of synthesis phase was 8 hr as determined from a curve constructed from the per cent of mitotic figures containing label; and the labeling index was 9% at 2 hr after injection. With these estimates, the per cent of Schwann cells proliferating was calculated to be 27%. In addition, roughly 25% of dividing cells appeared to cease division during the cell cycle under study. The relationship of these findings to other events during maturation of nerve is discussed.

scholarly journals MicroRNA-3666 Regulates Thyroid Carcinoma Cell Proliferation via MET

2016 ◽  
Vol 38 (3) ◽  
pp. 1030-1039 ◽  
Author(s):  
Gang Wang ◽  
Chengzhong Cai ◽  
Lei Chen
Keyword(s):  
Cell Proliferation ◽  
Cell Growth ◽  
Thyroid Carcinoma ◽  
Cell Apoptosis ◽  
Luciferase Reporter ◽  
Bioinformatics Analyses ◽  
Survival And Growth ◽  
Relationship Of ◽  
The Relationship

Background/Aims: Thyroid carcinoma (TC) is a highly lethal malignant cancer and its carcinogenesis remains undetermined. Dysregulation of microRNAs (miRNAs) is well known to be involved in the development of various cancers, including TC, whereas a role of miR-3666 in the pathogenesis of TC has not been appreciated. Methods: We analyzed the levels of MET and miR-3666 in TC tissue and the relationship of miR-3666 levels with patients' prognosis. We then overexpressed miR-3666 by miRNA mimics transfection and inhibited miR-3666 by miRNA antisense transfection in TC cells. Cell survival and growth were analyzed by CCK-8 assay and MTT assay, respectively. Cell apoptosis and proliferation were analyzed by flow cytometry. Bioinformatics analyses were applied to predict miR-3666 targets, which was then confirmed using luciferase reporter assay. Results: We detected significantly higher levels of MET, and significantly lower levels of miR-3666 in TC tissue, compared to the adjacent non-tumor tissue. Moreover, the low miR-3666 levels were associated with poor survival of the patients. Overexpression of miR-3666 significantly inhibited cell growth, while depletion of miR-3666 increased cell growth in TC cells. Moreover, the effects of miR-3666 on cell growth appeared to result from alteration in cell proliferation, rather than changes in cell apoptosis. MiR-3666 was found to bind to the 3'-UTR of MET mRNA to inhibit its translation in TC cells. Conclusion: Reduced miR-3666 levels in TC tissue may promotes TC growth, possibly through MET-mediated cell proliferation.

scholarly journals A nuclear antigen associated with cell proliferation and blast transformation.

1981 ◽  
Vol 154 (6) ◽  
pp. 1899-1909 ◽  
Author(s):  
Y Takasaki ◽  
J S Deng ◽  
E M Tan
Keyword(s):  
Cell Proliferation ◽  
Dna Synthesis ◽  
Lupus Erythematosus ◽  
Nuclear Antigen ◽  
Blast Transformation ◽  
B Lymphoid ◽  
Relationship Of ◽  
The Relationship ◽  
Proliferating Cell ◽  
Nucleolar Staining

A nuclear antigen associated with cell proliferation (proliferating cell nuclear antigen-PCNA) and blast transformation is recognized by autoantibodies in the sera of some patients with systemic lupus erythematosus. This autoantibody is a precipitating antibody and also reacts in immunofluorescence, staining the nucleoplasm of proliferating and blast-transformed cells. The autoantibody was used as a reagent to determine the distribution of PCNA in a synchronized continuous B lymphoid cell line (WiL-2) and in mitogen-induced blast-transformed lymphocytes. In WiL-2 cells, PCNA was detected as speckled nucleoplasmic staining in G1, S, and G2 phases of the cell cycle. In addition, during late G1 and early S phases, PCNA was also detected in the nucleolus. During mitogen-induced blast transformation of lymphocytes, PCNA was noticed in the nucleolus before the initiation of DNA synthesis and later became nucleoplasmic with disappearance of nucleolar staining. These studies demonstrate that the relationship of PCNA to proliferation and blast transformation may be associated with events related to DNA synthesis in these cells.

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