Chronic stress associated with hypercaloric diet changes the hippocampal BDNF levels in male Wistar rats

Neuropeptides ◽  
2015 ◽  
Vol 51 ◽  
pp. 75-81 ◽  
Author(s):  
I.C. Macedo ◽  
J.R. Rozisky ◽  
C. Oliveira ◽  
C.M. Oliveira ◽  
G. Laste ◽  
...  
Keyword(s):  
Chronic Stress ◽  
Wistar Rats ◽  
Male Wistar Rats ◽  
Hypercaloric Diet

scholarly journals The Association of Malnutrition and Chronic Stress Models Does Not Present Overlay Effects in Male Wistar Rats

2016 ◽  
Vol 4 ◽  
Author(s):  
Camila Gracyelle de Carvalho Lemes ◽  
Abraão Tiago Batista Guimarães ◽  
Wellington Alves Mizael da Silva ◽  
Bruna de Oliveira Mendes ◽  
Dieferson da Costa Estrela ◽  
...  
Keyword(s):  
Chronic Stress ◽  
Wistar Rats ◽  
Male Wistar Rats ◽  
Stress Models

scholarly journals Effects of chronic stress and high-fat diet on metabolic and nutritional parameters in Wistar rats

2013 ◽  
Vol 57 (8) ◽  
pp. 642-649 ◽  
Author(s):  
Thiago Bruder-Nascimento ◽  
Dijon Henrique Salomé Campos ◽  
Carlos Alves ◽  
Samuel Thomaz ◽  
Antônio Carlos Cicogna ◽  
...  
Keyword(s):  
Chronic Stress ◽  
High Fat Diet ◽  
Wistar Rats ◽  
Normal Diet ◽  
High Fat ◽  
Final Body Weight ◽  
Insulin Resistant ◽  
Male Wistar Rats ◽  
Total Fat ◽  
Level Of Significance

OBJECTIVE: The aim of this study was assess the role of chronic stress on the metabolic and nutritional profile of rats exposed to a high-fat diet. MATERIALS AND METHODS: Thirty-day-old male Wistar rats (70-100 g) were distributed into four groups: normal-diet (NC), chronic stress (St), high-fat diet (HD), and chronic stress/high-fat diet (HD/St). Stress consisted at immobilization during 15 weeks, 5 times per week, 1h per day; and exposure to the high-fat diet lasted 15 weeks. Nutritional and metabolic parameters were assessed. The level of significance was 5%. RESULTS: The HD group had final body weight, total fat, as well as insulin and leptin increased, and they were insulin resistant. The St and HD/St had arterial hypertension and increased levels of corticosterone. Stress blocked the effects of the high-fat diet. CONCLUSION: Chronic stress prevented the appearance of obesity. Our results help to clarify the mechanisms involved in metabolic and nutritional dysfunction, and contribute to clinical cases linked to stress and high-fat diet.

scholarly journals A Hypercaloric pellet-diet cycle induces obesity and co-morbidities in wistar rats

2008 ◽  
Vol 52 (6) ◽  
pp. 968-974 ◽  
Author(s):  
André F. Nascimento ◽  
Mário M. Sugizaki ◽  
André S. Leopoldo ◽  
Ana P. Lima-Leopoldo ◽  
Renata A. M. Luvizotto ◽  
...  
Keyword(s):  
Body Weight ◽  
Glucose Tolerance ◽  
Arterial Pressure ◽  
Wistar Rats ◽  
Systolic Arterial Pressure ◽  
High Serum ◽  
Normal Diet ◽  
Significance Level ◽  
Male Wistar Rats ◽  
Hypercaloric Diet

The present study was carried to develop and analyze the consequences of hypercaloric pellet-diet cycle that promotes obesity in rats. Male Wistar rats were randomly distributed into two groups that received either normal diet (ND; n =32; 3,5 Kcal/g) or a hypercaloric diet (HD; n =32; 4,6 Kcal/g). The ND group received commercial Labina rat feeding while the HD animals received a cycle of five hypercaloric diets over a 14-week period. The effects of the diets were analyzed in terms of body weight, body composition, hormone-metabolite levels, systolic arterial pressure and glucose tolerance at the 5% significance level. The hypercaloric pellet diet cycle promoted an increase in body weight and fat, systolic arterial pressure and a high serum level of glucose, triacylglycerol, insulin and leptin. The HD group also presented an impaired glucose tolerance. In conclusion, the results of this study show that the hypercaloric pellet-diet cycle promoted obesity in Wistar rats and displayed several characteristics that are commonly associated with human obesity, such as high arterial pressure, insulin resistance, hyperglycaemia, hyperinsulinaemia, hyperleptinaemia and dyslipidaemia.

scholarly journals Chronic stress differentially affects antioxidant enzymes and modifies the acute stress response in liver of Wistar rats

2010 ◽  
pp. 729-736
Author(s):  
J Djordjevic ◽  
A Djordjevic ◽  
M Adzic ◽  
A Niciforovic ◽  
MB Radojcic
Keyword(s):  
Antioxidant Enzymes ◽  
Protein Expression ◽  
Chronic Stress ◽  
Wistar Rats ◽  
Acute Stress ◽  
Long Duration ◽  
Male Wistar Rats ◽  
Expression Activity ◽  
Acute Stress Response ◽  
Upstream Regulators

Clinical reports suggest close interactions between stressors, particularly those of long duration, and liver diseases, such as hepatic inflammation, that is proposed to occur via reactive oxygen species. In the present study we have used 21-day social isolation of male Wistar rats as a model of chronic stress to investigate protein expression/activity of liver antioxidant enzymes: superoxide dismutases (SODs), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GLR), and protein expression of their upstream regulators: glucocorticoid receptor (GR) and nuclear factor kappa B (NFkB). We have also characterized these parameters in either naive or chronically stressed animals that were challenged by 30-min acute immobilization. We found that chronic isolation caused decrease in serum corticosterone (CORT) and blood glucose (GLU), increase in NFkB signaling, and disproportion between CuZnSOD, peroxidases (CAT, GPx) and GLR, thus promoting H2O2 accumulation and prooxidative state in liver. The overall results suggested that chronic stress exaggerated responsiveness to subsequent stressor at the level of CORT and GLU, and potentiated GLR response, but compromised the restoration of oxido-reductive balance due to irreversible alterations in MnSOD and GPx.

scholarly journals Morphological Changes in the Testis of Wistar Rats Under the Influence of Non-Specific Chronic Stress

2019 ◽  
pp. 70-74
Author(s):  
E. K. Solodova ◽  
K. A. Kidun ◽  
T. S. Ugolnik
Keyword(s):  
Chronic Stress ◽  
Leydig Cells ◽  
Wistar Rats ◽  
Morphological Changes ◽  
Relative Number ◽  
Interstitial Tissue ◽  
Male Wistar Rats

The experiment on male Wistar rats has demonstrated that the exposure to modelled chronic stress for 10 days causes disturbances of spermatogenesis processes and exerts influence on the decrease of the relative number of Leydig cells in the rats` testis. It has been found that after 10 days of the chronic stress modelling by Ortiz J., the number of active forms of the Leydig cells decreases and the number of non-active forms of steroid-producing cells increases in the interstitial tissue of the testis of the Wistar rats.

Influence of chronic stress on the compositions of hepatic cholesterol and triglyceride in male Wistar rats fed a high fat diet

2012 ◽  
Vol 42 (7) ◽  
pp. 686-695 ◽  
Author(s):  
Siyuan Gao ◽  
Xue Han ◽  
Jihua Fu ◽  
Xiaoling Yuan ◽  
Xing Sun ◽  
...  
Keyword(s):  
Chronic Stress ◽  
High Fat Diet ◽  
Wistar Rats ◽  
Hepatic Cholesterol ◽  
High Fat ◽  
Male Wistar Rats

scholarly journals Morphologic and Morphometric Parameters of the Liver Tissue of Laboratory Animals After Modeling of Chronic Stress

2018 ◽  
pp. 56-60
Author(s):  
A. N. Litvinenko ◽  
D. A. Zinovkin ◽  
T. S. Ugolnik
Keyword(s):  
Chronic Stress ◽  
Liver Tissue ◽  
Blood Circulation ◽  
Wistar Rats ◽  
Morphometric Parameters ◽  
Degenerative Changes ◽  
Laboratory Animals ◽  
Male Wistar Rats ◽  
Experimental Group ◽  
Morphologic Changes

Objective: to study changes in the morphologic and morphometric parameters of the liver tissue in male Wistar rats under chronic Ortiz stress. Material and methods. The study was conducted on 50 male Vistor rats. The experimental group of the animals was subjected to 10-day chronic stress by Ortiz. The morphologic and morphometric parameters of the liver tissue of the animals exposed to chronic stress were studied. Results. The morphologic changes in the liver of the animals which had sustained chronic stress were characterized by impaired blood circulation and degenerative changes of hepatocytes. At the same time, a statistically significant increase in the percentage of binuclear hepatocytes (p = 0.046) and functional cariocellular index (p = 0.03) was found. Conclusion. The effect of chronic stress leads to a change in the morphologic and morphometric parameters of the liver tissue with activation of reparative processes.

Structural and functional renal alterations in five-sixth nephrectomized rats on unrestricted diet

1986 ◽  
Vol 44 ◽  
pp. 342-343
Author(s):  
I. Stachura ◽  
M. Pardo ◽  
J. Costello ◽  
D.M. Landwehr
Keyword(s):  
Wistar Rats ◽  
Renal Damage ◽  
Standard Diet ◽  
Experimental Conditions ◽  
Phosphate Intake ◽  
Dietary Restrictions ◽  
Severe Reduction ◽  
Male Wistar Rats ◽  
Unrestricted Diet ◽  
Progressive Renal Insufficiency

Under experimental conditions severe reduction of renal mass results in the hyperfiltration of the remaining nephrons leading to a progressive renal insufficiency. Similar changes are observed in patients with various renal disorders associated with a loss of the functioning nephrons. The progression of renal damage is accelerated by high protein and phosphate intake, and may be modified by the dietary restrictions.We studied 50 five-sixth nephrectarrized male Wistar rats on a standard diet (Rodent Laboratory Chow 5001 Ralston Purina Co., Richmond, Indiana; containing 23.4% protein) over a 20 week period.

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