scholarly journals Morphological Changes in the Testis of Wistar Rats Under the Influence of Non-Specific Chronic Stress

2019 ◽  
pp. 70-74
Author(s):  
E. K. Solodova ◽  
K. A. Kidun ◽  
T. S. Ugolnik
Keyword(s):  
Chronic Stress ◽  
Leydig Cells ◽  
Wistar Rats ◽  
Morphological Changes ◽  
Relative Number ◽  
Interstitial Tissue ◽  
Male Wistar Rats

The experiment on male Wistar rats has demonstrated that the exposure to modelled chronic stress for 10 days causes disturbances of spermatogenesis processes and exerts influence on the decrease of the relative number of Leydig cells in the rats` testis. It has been found that after 10 days of the chronic stress modelling by Ortiz J., the number of active forms of the Leydig cells decreases and the number of non-active forms of steroid-producing cells increases in the interstitial tissue of the testis of the Wistar rats.

scholarly journals Morphological alterations in the heart and aorta of rats treated with glucocorticoids

2015 ◽  
Vol 32 (04) ◽  
pp. 231-235
Author(s):  
R. Dantas ◽  
K. Souza ◽  
D. Santos ◽  
V. Feitosa ◽  
E. Fioretto ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Histological Analysis ◽  
Saline Solution ◽  
Morphological Changes ◽  
Morphological Structure ◽  
Control Group ◽  
Morphological Alterations ◽  
Heart Chamber ◽  
Male Wistar Rats ◽  
Synthetic Glucocorticoid

Abstract Introduction: The objective of this study was to analyze the morphological structure of the heart and aorta of rats treated with the synthetic glucocorticoid dexamethasone. Material and Methods: Male Wistar rats were divided into two groups: 08 control rats undergoing treatment with a 0.9% saline solution for 10 days and 08 rats treated for 10 days with dexamethasone (2mg/kg animal weight). Results: Histological analysis detected a mild cardiac hypertrophy and 15% reduction of collagen located in the aorta of animals treated with glucocorticoid when compared to the control group. Conclusion: We conclude that treatment with dexamethasone for a period of 10 consecutive days is able to promote morphological changes in the structure of the heart chamber and, impair morphological structure of aorta.

scholarly journals The Association of Malnutrition and Chronic Stress Models Does Not Present Overlay Effects in Male Wistar Rats

2016 ◽  
Vol 4 ◽  
Author(s):  
Camila Gracyelle de Carvalho Lemes ◽  
Abraão Tiago Batista Guimarães ◽  
Wellington Alves Mizael da Silva ◽  
Bruna de Oliveira Mendes ◽  
Dieferson da Costa Estrela ◽  
...  
Keyword(s):  
Chronic Stress ◽  
Wistar Rats ◽  
Male Wistar Rats ◽  
Stress Models

scholarly journals THE EFFECT OF SEMBUNG LEAF EXTRACT (BLUMEA BALSAMIFERA) ON THE NUMBER AND DIAMETER OF RATS LEYDIG CELLS INDUCED BY HIGH-FAT DIET

2021 ◽  
Vol 21 (no 1) ◽  
Author(s):  
Gede Widhiantara ◽  
Anak Agung Ayu Putri Permatasari ◽  
Putu Angga Wiradana
Keyword(s):  
Treatment Group ◽  
Leydig Cells ◽  
Wistar Rats ◽  
Leaf Extract ◽  
Control Group ◽  
Control Group Design ◽  
Core Diameter ◽  
Post Test ◽  
Male Wistar Rats ◽  
The Mean

This study aims to determine the morphology of Leydig cells in hyperlipidemic wistar rats after having administered with sembung (Blumea balsamifera) extract orally. This study utilised a randomized post-test only control group design. The sample in this study were 16 adult male wistar rats (Rattus novergicus) aged 3-4 months with a body weight of 150-200 grams, which were equally and randomly divided into two groups, namely control group (hyperlipidaemia and sterile aquadest) and treatment group (hyperlipidaemia and sembung leaf extract). Hyperlipidaemia was induced with lard administration for 50 days. Data were analysed statistically using the Independent t-test. The results showed that the number of Leydig cells in the treatment group was higher than the control group with 68.13 ± 1.89 and 55.63 ± 1.92 cells respectively (P <0.05). In addition, the mean Leydig cell core diameter of the control group, 5.00 ± 0.34 µm, was smaller compared to the treatment group which was 5.80 ± 0.20 µm (P <0.05). It can be inferred that sembung leaf extract provides a protective effect against damage to Leydig cells due to hyperlipidaemia.

scholarly journals Effects of chronic stress and high-fat diet on metabolic and nutritional parameters in Wistar rats

2013 ◽  
Vol 57 (8) ◽  
pp. 642-649 ◽  
Author(s):  
Thiago Bruder-Nascimento ◽  
Dijon Henrique Salomé Campos ◽  
Carlos Alves ◽  
Samuel Thomaz ◽  
Antônio Carlos Cicogna ◽  
...  
Keyword(s):  
Chronic Stress ◽  
High Fat Diet ◽  
Wistar Rats ◽  
Normal Diet ◽  
High Fat ◽  
Final Body Weight ◽  
Insulin Resistant ◽  
Male Wistar Rats ◽  
Total Fat ◽  
Level Of Significance

OBJECTIVE: The aim of this study was assess the role of chronic stress on the metabolic and nutritional profile of rats exposed to a high-fat diet. MATERIALS AND METHODS: Thirty-day-old male Wistar rats (70-100 g) were distributed into four groups: normal-diet (NC), chronic stress (St), high-fat diet (HD), and chronic stress/high-fat diet (HD/St). Stress consisted at immobilization during 15 weeks, 5 times per week, 1h per day; and exposure to the high-fat diet lasted 15 weeks. Nutritional and metabolic parameters were assessed. The level of significance was 5%. RESULTS: The HD group had final body weight, total fat, as well as insulin and leptin increased, and they were insulin resistant. The St and HD/St had arterial hypertension and increased levels of corticosterone. Stress blocked the effects of the high-fat diet. CONCLUSION: Chronic stress prevented the appearance of obesity. Our results help to clarify the mechanisms involved in metabolic and nutritional dysfunction, and contribute to clinical cases linked to stress and high-fat diet.

scholarly journals The effect of SRIH-14 or octreotide on the morphological characteristics of adrenal medulla using newcast

2010 ◽  
Vol 62 (1) ◽  
pp. 93-96
Author(s):  
Svetlana Trifunovic ◽  
B. Filipovic ◽  
V. Ajdzanovic ◽  
Milica Manojlovic-Stojanoski ◽  
Natasa Nestorovic ◽  
...  
Keyword(s):  
Body Weight ◽  
Adrenal Medulla ◽  
Wistar Rats ◽  
Adrenal Glands ◽  
Morphological Characteristics ◽  
Interstitial Tissue ◽  
Adult Males ◽  
Vascular Tissues ◽  
Male Wistar Rats ◽  
The Absolute

The effects of chronic treatments with either SRIH-14 or octreotide on the adrenal medulla of male Wistar rats were examined. Adult males received subcutaneous (s.c.) injections of 20 ?g/100 g body weight of either SRIH-14 or octreotide twice a day for 28 consecutive days. The absolute weights and the absolute volumes of the adrenal glands significantly (p<0.05) decreased after either treatment. The adrenal medulla was analyzed by histological and stereological methods using newCAST. Compared to the control, the relative volumes of the vascular tissues significantly (p < 0.05) decreased - by 40% and 25% in the SRIH-14- and octreotide-treated groups, respectively. In the SRIH-14- and octreotide-treated groups the relative volumes of chromaffin and interstitial tissue increased by 6% and 5% (p < 0.05), respectively. These findings show that both SRIH-14 and octreotide affect the morphological characteristics of the adrenal zona medullaris in a similar manner.

ASTAXANTHIN MENGHAMBAT PENURUNAN JUMLAH SEL LEYDIG DAN KADAR TESTOSTERON PADA TIKUS WISTAR JANTAN YANG DIPAPAR DENGAN ASAP ROKOK

2020 ◽  
Vol 3 (1) ◽  
pp. 56-64
Author(s):  
Andrew Lie ◽  
Wimpie Pangkahila ◽  
L.P. Iin Indrayani Maker
Keyword(s):  
Cell Count ◽  
Cigarette Smoke ◽  
Leydig Cell ◽  
Testosterone Level ◽  
Leydig Cells ◽  
Wistar Rats ◽  
Control Group ◽  
Study Group ◽  
Significant Difference ◽  
Male Wistar Rats

Background. The exposure of cigarette smoke impacts negatively on Leydig cell count and testosterone level. Astaxanthin is known for its ability to neutralize free radicals far more potent than any other kind of antioxidant. Research objectives. This research aims to prove the effect of Astaxanthin in inhibiting decrease of Leydig cell count and testosterone level in male Wistar rats exposed with cigarette smoke. Methodology. The posttest only control group study design was conducted on 36 male Wistar rats, 12-16 weeks in age, with 200-210 grams body weight. Samples were randomly divided into two groups, consisting of a control group exposed with cigarette smoke and 0.5 ml of aquadest and a study group exposed with cigarette smoke and 0.1 mg of astaxanthin/200 gr BW daily for 30 days. On day 31, blood samples were taken to measure the testosterone level. Both testes were taken for Leydig cells count assessment. Comparative analysis was done to see any significant difference between the study and control group. Research results. The results show that the mean number of Leydig cells and testosterone levels in the study group was significantly higher than the control group (p<0.01). Conclusion. Oral astaxanthin administration inhibited the decrease of Leydig cell count and testosterone level in male Wistar rats exposed with cigarette smoke. Key words: Astaxanthin, Testosterone, Leydig Cell, Andropause

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