P.0189 Adaptogenic effect of sideritis scardica, lamiaceae on male wistar rats in a chronic stress model

2021 ◽  
Vol 53 ◽  
pp. S137-S138
Author(s):  
N. Yanchev ◽  
D. Delev ◽  
N. Vilmosh ◽  
I. Kostadinov
Keyword(s):  
Chronic Stress ◽  
Wistar Rats ◽  
Stress Model ◽  
Male Wistar Rats ◽  
Adaptogenic Effect

scholarly journals The Association of Malnutrition and Chronic Stress Models Does Not Present Overlay Effects in Male Wistar Rats

2016 ◽  
Vol 4 ◽  
Author(s):  
Camila Gracyelle de Carvalho Lemes ◽  
Abraão Tiago Batista Guimarães ◽  
Wellington Alves Mizael da Silva ◽  
Bruna de Oliveira Mendes ◽  
Dieferson da Costa Estrela ◽  
...  
Keyword(s):  
Chronic Stress ◽  
Wistar Rats ◽  
Male Wistar Rats ◽  
Stress Models

scholarly journals Effects of chronic stress and high-fat diet on metabolic and nutritional parameters in Wistar rats

2013 ◽  
Vol 57 (8) ◽  
pp. 642-649 ◽  
Author(s):  
Thiago Bruder-Nascimento ◽  
Dijon Henrique Salomé Campos ◽  
Carlos Alves ◽  
Samuel Thomaz ◽  
Antônio Carlos Cicogna ◽  
...  
Keyword(s):  
Chronic Stress ◽  
High Fat Diet ◽  
Wistar Rats ◽  
Normal Diet ◽  
High Fat ◽  
Final Body Weight ◽  
Insulin Resistant ◽  
Male Wistar Rats ◽  
Total Fat ◽  
Level Of Significance

OBJECTIVE: The aim of this study was assess the role of chronic stress on the metabolic and nutritional profile of rats exposed to a high-fat diet. MATERIALS AND METHODS: Thirty-day-old male Wistar rats (70-100 g) were distributed into four groups: normal-diet (NC), chronic stress (St), high-fat diet (HD), and chronic stress/high-fat diet (HD/St). Stress consisted at immobilization during 15 weeks, 5 times per week, 1h per day; and exposure to the high-fat diet lasted 15 weeks. Nutritional and metabolic parameters were assessed. The level of significance was 5%. RESULTS: The HD group had final body weight, total fat, as well as insulin and leptin increased, and they were insulin resistant. The St and HD/St had arterial hypertension and increased levels of corticosterone. Stress blocked the effects of the high-fat diet. CONCLUSION: Chronic stress prevented the appearance of obesity. Our results help to clarify the mechanisms involved in metabolic and nutritional dysfunction, and contribute to clinical cases linked to stress and high-fat diet.

scholarly journals Chronic stress differentially affects antioxidant enzymes and modifies the acute stress response in liver of Wistar rats

2010 ◽  
pp. 729-736
Author(s):  
J Djordjevic ◽  
A Djordjevic ◽  
M Adzic ◽  
A Niciforovic ◽  
MB Radojcic
Keyword(s):  
Antioxidant Enzymes ◽  
Protein Expression ◽  
Chronic Stress ◽  
Wistar Rats ◽  
Acute Stress ◽  
Long Duration ◽  
Male Wistar Rats ◽  
Expression Activity ◽  
Acute Stress Response ◽  
Upstream Regulators

Clinical reports suggest close interactions between stressors, particularly those of long duration, and liver diseases, such as hepatic inflammation, that is proposed to occur via reactive oxygen species. In the present study we have used 21-day social isolation of male Wistar rats as a model of chronic stress to investigate protein expression/activity of liver antioxidant enzymes: superoxide dismutases (SODs), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GLR), and protein expression of their upstream regulators: glucocorticoid receptor (GR) and nuclear factor kappa B (NFkB). We have also characterized these parameters in either naive or chronically stressed animals that were challenged by 30-min acute immobilization. We found that chronic isolation caused decrease in serum corticosterone (CORT) and blood glucose (GLU), increase in NFkB signaling, and disproportion between CuZnSOD, peroxidases (CAT, GPx) and GLR, thus promoting H2O2 accumulation and prooxidative state in liver. The overall results suggested that chronic stress exaggerated responsiveness to subsequent stressor at the level of CORT and GLU, and potentiated GLR response, but compromised the restoration of oxido-reductive balance due to irreversible alterations in MnSOD and GPx.

Chronic stress associated with hypercaloric diet changes the hippocampal BDNF levels in male Wistar rats

Neuropeptides ◽  
2015 ◽  
Vol 51 ◽  
pp. 75-81 ◽  
Author(s):  
I.C. Macedo ◽  
J.R. Rozisky ◽  
C. Oliveira ◽  
C.M. Oliveira ◽  
G. Laste ◽  
...  
Keyword(s):  
Chronic Stress ◽  
Wistar Rats ◽  
Male Wistar Rats ◽  
Hypercaloric Diet

scholarly journals Morphological Changes in the Testis of Wistar Rats Under the Influence of Non-Specific Chronic Stress

2019 ◽  
pp. 70-74
Author(s):  
E. K. Solodova ◽  
K. A. Kidun ◽  
T. S. Ugolnik
Keyword(s):  
Chronic Stress ◽  
Leydig Cells ◽  
Wistar Rats ◽  
Morphological Changes ◽  
Relative Number ◽  
Interstitial Tissue ◽  
Male Wistar Rats

The experiment on male Wistar rats has demonstrated that the exposure to modelled chronic stress for 10 days causes disturbances of spermatogenesis processes and exerts influence on the decrease of the relative number of Leydig cells in the rats` testis. It has been found that after 10 days of the chronic stress modelling by Ortiz J., the number of active forms of the Leydig cells decreases and the number of non-active forms of steroid-producing cells increases in the interstitial tissue of the testis of the Wistar rats.

Influence of chronic stress on the compositions of hepatic cholesterol and triglyceride in male Wistar rats fed a high fat diet

2012 ◽  
Vol 42 (7) ◽  
pp. 686-695 ◽  
Author(s):  
Siyuan Gao ◽  
Xue Han ◽  
Jihua Fu ◽  
Xiaoling Yuan ◽  
Xing Sun ◽  
...  
Keyword(s):  
Chronic Stress ◽  
High Fat Diet ◽  
Wistar Rats ◽  
Hepatic Cholesterol ◽  
High Fat ◽  
Male Wistar Rats

scholarly journals Morphologic and Morphometric Parameters of the Liver Tissue of Laboratory Animals After Modeling of Chronic Stress

2018 ◽  
pp. 56-60
Author(s):  
A. N. Litvinenko ◽  
D. A. Zinovkin ◽  
T. S. Ugolnik
Keyword(s):  
Chronic Stress ◽  
Liver Tissue ◽  
Blood Circulation ◽  
Wistar Rats ◽  
Morphometric Parameters ◽  
Degenerative Changes ◽  
Laboratory Animals ◽  
Male Wistar Rats ◽  
Experimental Group ◽  
Morphologic Changes

Objective: to study changes in the morphologic and morphometric parameters of the liver tissue in male Wistar rats under chronic Ortiz stress. Material and methods. The study was conducted on 50 male Vistor rats. The experimental group of the animals was subjected to 10-day chronic stress by Ortiz. The morphologic and morphometric parameters of the liver tissue of the animals exposed to chronic stress were studied. Results. The morphologic changes in the liver of the animals which had sustained chronic stress were characterized by impaired blood circulation and degenerative changes of hepatocytes. At the same time, a statistically significant increase in the percentage of binuclear hepatocytes (p = 0.046) and functional cariocellular index (p = 0.03) was found. Conclusion. The effect of chronic stress leads to a change in the morphologic and morphometric parameters of the liver tissue with activation of reparative processes.

Structural and functional renal alterations in five-sixth nephrectomized rats on unrestricted diet

1986 ◽  
Vol 44 ◽  
pp. 342-343
Author(s):  
I. Stachura ◽  
M. Pardo ◽  
J. Costello ◽  
D.M. Landwehr
Keyword(s):  
Wistar Rats ◽  
Renal Damage ◽  
Standard Diet ◽  
Experimental Conditions ◽  
Phosphate Intake ◽  
Dietary Restrictions ◽  
Severe Reduction ◽  
Male Wistar Rats ◽  
Unrestricted Diet ◽  
Progressive Renal Insufficiency

Under experimental conditions severe reduction of renal mass results in the hyperfiltration of the remaining nephrons leading to a progressive renal insufficiency. Similar changes are observed in patients with various renal disorders associated with a loss of the functioning nephrons. The progression of renal damage is accelerated by high protein and phosphate intake, and may be modified by the dietary restrictions.We studied 50 five-sixth nephrectarrized male Wistar rats on a standard diet (Rodent Laboratory Chow 5001 Ralston Purina Co., Richmond, Indiana; containing 23.4% protein) over a 20 week period.

Trans-resveratrol supplement lowers lipid peroxidation responses of exercise in male Wistar rats

2020 ◽  
pp. 1-6 ◽  
Author(s):  
Masoud Nasiri ◽  
Saja Ahmadizad ◽  
Mehdi Hedayati ◽  
Tayebe Zarekar ◽  
Mehdi Seydyousefi ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Antioxidant Capacity ◽  
Total Antioxidant Capacity ◽  
Wistar Rats ◽  
Enzymatic Antioxidants ◽  
Acute Response ◽  
Total Antioxidant ◽  
Male Wistar Rats ◽  
Exercise Induced ◽  
And Control

Abstract. Physical exercise increases free radicals production; antioxidant supplementation may improve the muscle fiber’s ability to scavenge ROS and protect muscles against exercise-induced oxidative damage. This study was designed to examine the effects of all-trans resveratrol supplementation as an antioxidant to mediate anti-oxidation and lipid per-oxidation responses to exercise in male Wistar rats. Sixty-four male Wistar rats were randomly divided into four equal number (n = 16) including training + supplement (TS), training (T), supplement (S) and control (C) group. The rats in TS and S groups received a dose of 10 mg/kg resveratrol per day via gavage. The training groups ran on a rodent treadmill 5 times per week at the speed of 10 m/min for 10 min; the speed gradually increased to 30 m/min for 60 minutes at the end of 12th week. The acute phase of exercise protocol included a speed of 25 m/min set to an inclination of 10° to the exhaustion point. Superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) activity, non-enzymatic antioxidants bilirubin, uric acid, lipid peroxidation levels (MDA) and the total antioxidant capacity (TAC) were measured after the exercise termination. The data were analyzed by using one-way ANOVA. The result showed that endurance training caused a significant increase in MDA level [4.5 ± 0.75 (C group) vs. 5.9 ± 0.41 nmol/l (T group)] whereas it decreased the total antioxidant capacity [8.5 ± 1.35 (C group) vs. 7.1 ± 0.55 mmol/l (T group)] (p = 0.001). In addition, GPx and CAT decreased but not significantly (p > 0.05). The training and t-resveratrol supplementation had no significant effect on the acute response of all variables except MDA [4.3 ± 1.4 (C group) vs. 4.0 ± 0.90 nmol/l (TS group)] (p = 0.001) and TAC [8.5 ± 0.90 (C group) vs. 6.6 ± 0.80 mmol/l (TS group)] (p = 0.004). It was concluded that resveratrol supplementation may prevent exercise-induced oxidative stress by preventing lipid peroxidation.

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