N-6 and n-3 fatty acid cholesteryl esters in relation to incident stroke in a Dutch adult population: A nested case–control study

Aim: Dietary polyunsaturated fatty acids (PUFA) are inversely related to coronary heart disease (CHD) in epidemiological studies. We examined the associations of plasma n-6 and n-3 PUFA in cholesteryl esters with fatal CHD in a nested case-control study. Methods We used data from two population-based cohort studies in Dutch adults aged 20-65 years. Blood sampling and data collection took place from 1987–1997 and subjects were followed for 8–19 years. We identified 279 incident cases of fatal CHD (235 fatal myocardial infarctions and 44 cardiac arrests) and randomly selected 279 controls, matched on age, gender, and enrollment date. Odds ratios (OR) with 95% confidence intervals (95%CI) were calculated per standard deviation (SD) increase of fatty acids in cholesteryl esters using multivariable conditional logistic regression models. Results After adjustment for confounders, the OR (95% CI) for fatal CHD per SD increase in plasma linoleic acid was 0.89 (0.74-1.06). Additional adjustment for plasma total cholesterol and systolic blood pressure attenuated this association (OR: 0.95; 95% CI: 0.78–1.15). Plasma arachidonic acid was not associated with fatal CHD (OR per SD: 1.11; 95% CI: 0.92-1.35). The ORs (95% CI) for fatal CHD for an SD increase in n-3 PUFA were 0.92 (0.74-1.15) for plasma alpha-linolenic acid and 1.06 (0.88-1.27) for plasma EPA-DHA. Conclusion In this Dutch adult population, arachidonic acid and n-3 PUFA in cholesteryl esters were not related to fatal CHD. Our data support findings from previous prospective studies showing a lower proportion of linoleic acid in plasma cholesteryl esters in CHD cases.

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Red blood cell membrane trans fatty acid levels and risk of non-Hodgkin lymphoma: a prospective nested case–control study

American Journal of Clinical Nutrition ◽

10.1093/ajcn/nqaa251 ◽

2020 ◽

Vol 112 (6) ◽

pp. 1576-1583

Author(s):

Andres V Ardisson Korat ◽

Yu-Han Chiu ◽

Kimberly A Bertrand ◽

Shumin Zhang ◽

Mara M Epstein ◽

...

Keyword(s):

Logistic Regression ◽

Fatty Acid ◽

Case Control Study ◽

Positive Association ◽

Case Control ◽

Blood Draw ◽

Non Hodgkin Lymphoma ◽

Rbc Membrane ◽

Nested Case Control ◽

Control Study

ABSTRACT Background Trans fatty acid (TFA) intake persists in much of the world, posing ongoing threats to public health that warrant further elucidation. Published evidence suggests a positive association of self-reported TFA intake with non-Hodgkin lymphoma (NHL) risk. Objectives To confirm those reports, we conducted a prospective study of prediagnosis RBC membrane TFA levels and risk of NHL and common NHL histologic subtypes. Methods We conducted a nested case–control study in Nurses’ Health Study and Health Professionals Follow-Up Study participants with archived RBC specimens and no history of cancer at blood draw (1989–1090 and 1994–1995, respectively). We confirmed 583 incident NHL cases (332 women and 251 men) and individually matched 583 controls on cohort (sex), age, race, and blood draw date/time. We analyzed RBC membrane TFA using GLC (in 2013–2014) and expressed individual TFA levels as a percentage of total fatty acids. We used unconditional logistic regression adjusted for the matching factors to estimate ORs and 95% CIs for overall NHL risk per 1 SD increase in TFA level and assessed histologic subtype-specific associations with multivariable polytomous logistic regression. Results Total and individual TFA levels were not associated with risk of all NHL or most subtypes. We observed a positive association of total TFA levels with diffuse large B cell lymphoma (DLBCL) risk [n = 98 cases; OR (95% CI) per 1 SD increase: 1.30 (1.05, 1.61); P = 0.015], driven by trans 18:1n–9(ω-9)/elaidic acid [OR (95% CI): 1.34 (1.08, 1.66); P = 0.007], trans 18:1n–7/vaccenic acid [OR (95% CI): 1.28 (1.04, 1.58); P = 0.023], and trans 18:2n–6t,t [OR (95% CI): 1.26 (1.01, 1.57); P = 0.037]. Conclusions Our findings extended evidence for TFA intake and DLBCL risk but not for other NHL subtypes. Reduced TFA consumption through dietary choices or health policy measures may support prevention of DLBCL, an aggressive NHL subtype.

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Blood fatty acid patterns are associated with prostate cancer risk in a prospective nested case–control study

Cancer Causes & Control ◽

10.1007/s10552-016-0794-6 ◽

2016 ◽

Vol 27 (9) ◽

pp. 1153-1161 ◽

Cited By ~ 4

Author(s):

Meng Yang ◽

Azalea Ayuningtyas ◽

Stacey A. Kenfield ◽

Howard D. Sesso ◽

Hannia Campos ◽

...

Keyword(s):

Prostate Cancer ◽

Fatty Acid ◽

Cancer Risk ◽

Case Control Study ◽

Prostate Cancer Risk ◽

Case Control ◽

Fatty Acid Patterns ◽

Nested Case Control ◽

Control Study

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Linoleic acid, a dietary n-6 polyunsaturated fatty acid, and the aetiology of ulcerative colitis: a nested case–control study within a European prospective cohort study

Yearbook of Gastroenterology ◽

10.1016/s0739-5930(10)79514-3 ◽

2010 ◽

Vol 2010 ◽

pp. 141-142

Author(s):

M.F. Picco

Keyword(s):

Ulcerative Colitis ◽

Cohort Study ◽

Fatty Acid ◽

Linoleic Acid ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Case Control Study ◽

Case Control ◽

Nested Case Control ◽

Control Study

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Long-chain n-3 fatty acid levels in baseline serum phospholipids do not predict later occurrence of depressive episodes: A nested case-control study within a cohort of middle-aged French men and women

Prostaglandins Leukotrienes and Essential Fatty Acids ◽

10.1016/j.plefa.2009.06.002 ◽

2009 ◽

Vol 81 (4) ◽

pp. 265-271 ◽

Cited By ~ 18

Author(s):

Pierre Astorg ◽

Sandrine Bertrais ◽

Jean-Marc Alessandri ◽

Philippe Guesnet ◽

Emmanuelle Kesse-Guyot ◽

...

Keyword(s):

Fatty Acid ◽

Case Control Study ◽

Case Control ◽

Baseline Serum ◽

Men And Women ◽

Nested Case Control ◽

Depressive Episodes ◽

Control Study ◽

Long Chain ◽

Serum Phospholipids

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Risk of Gestational Diabetes Mellitus in relation to Plasma Concentrations of Fatty Acid-Binding Protein 4: A Nested Case-Control Study in China

Journal of Diabetes Research ◽

10.1155/2021/6681432 ◽

2021 ◽

Vol 2021 ◽

pp. 1-6

Author(s):

Chuyao Jin ◽

Lizi Lin ◽

Na Han ◽

Zhiling Zhao ◽

Xiangrong Xu ◽

...

Keyword(s):

Diabetes Mellitus ◽

Insulin Resistance ◽

Fatty Acid ◽

Fatty Acid Binding Protein ◽

Case Control Study ◽

Case Control ◽

Fatty Acid Binding ◽

Acid Binding Protein ◽

Nested Case Control ◽

Control Study

Objective. The study is aimed at examining the effects of fatty acid-binding protein 4 (FABP4) on insulin resistance and gestational diabetes mellitus (GDM). Methods. Based on a prospective birth cohort in Beijing, China, we conducted a nested case-control study and analyzed 135 GDM case-control pairs matched by age and the gestational week when they took the oral glucose tolerance test. We performed linear regression to analyze the association of plasma FABP4 concentrations with insulin resistance. We used logistic regression to estimate odds ratios (ORs) of FABP4 for GDM, controlling for potential confounders, including dietary intake and physical activity. Results. Plasma FABP4 levels in the first and second trimesters were positively associated with fasting insulin and homeostasis model assessment for insulin resistance (HOMA-IR) in the second trimester (both P < 0.001 ). Compared with those in the lowest FABP4 tertile, women in the highest tertile of FABP4 levels in the first and second trimesters had 1.053 times ( OR = 2.053 , 95% CI 1.091 to 3.863) and 1.447 times ( OR = 2.447 , 95% CI 1.305 to 4.588) higher risk of developing GDM. Conclusions. Elevated FABP4 levels in the first and second trimesters were associated with a higher level of insulin resistance and greater GDM risk, indicating FABP4 might predict women with high risk of developing GDM.

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