scholarly journals Self-efficacy for managing pain, symptoms, and function in patients with lung cancer and their informal caregivers: Associations with symptoms and distress

Pain ◽  
2008 ◽  
Vol 137 (2) ◽  
pp. 306-315 ◽  
Author(s):  
Laura S. Porter ◽  
Francis J. Keefe ◽  
Jennifer Garst ◽  
Colleen M. McBride ◽  
Donald Baucom
Keyword(s):  
Lung Cancer ◽  
Self Efficacy ◽  
Informal Caregivers ◽  
Pain Symptoms ◽  
And Function

Surgery for Lung Cancer and the Consequences for the Swallow

2016 ◽  
Vol 1 (13) ◽  
pp. 162-168
Author(s):  
Pippa Hales ◽  
Corinne Mossey-Gaston
Keyword(s):  
Lung Cancer ◽  
Treatment Options ◽  
Vocal Cord Palsy ◽  
Subsequent Treatment ◽  
Physiological Reserve ◽  
Palliative Phase ◽  
And Function ◽  
The Impact ◽  
Swallow Function

Lung cancer is one of the most commonly diagnosed cancers across Northern America and Europe. Treatment options offered are dependent on the type of cancer, the location of the tumor, the staging, and the overall health of the person. When surgery for lung cancer is offered, difficulty swallowing is a potential complication that can have several influencing factors. Surgical interaction with the recurrent laryngeal nerve (RLN) can lead to unilateral vocal cord palsy, altering swallow function and safety. Understanding whether the RLN has been preserved, damaged, or sacrificed is integral to understanding the effect on the swallow and the subsequent treatment options available. There is also the risk of post-surgical reduction of physiological reserve, which can reduce the strength and function of the swallow in addition to any surgery specific complications. As lung cancer has a limited prognosis, the clinician must also factor in the palliative phase, as this can further increase the burden of an already compromised swallow. By understanding the surgery and the implications this may have for the swallow, there is the potential to reduce the impact of post-surgical complications and so improve quality of life (QOL) for people with lung cancer.

Self‐Efficacy Scale for Rehabilitation Management for Postoperative Lung Cancer Patients

2017 ◽  
Author(s):  
Fei‐Fei Huang ◽  
Qing Yang ◽  
Xuan Ye Han ◽  
Jing‐Ping Zhang ◽  
Ting Lin
Keyword(s):  
Lung Cancer ◽  
Cancer Patients ◽  
Self Efficacy ◽  
Rehabilitation Management ◽  
Lung Cancer Patients

scholarly journals GPR115 Contributes to Lung Adenocarcinoma Metastasis Associated With LAMC2 and Predicts a Poor Prognosis

2020 ◽  
Vol 10 ◽  
Author(s):  
Yingjing Wang ◽  
Muqi Shi ◽  
Nan Yang ◽  
Xiaoyu Zhou ◽  
Liqin Xu
Keyword(s):  
Lung Cancer ◽  
Lung Adenocarcinoma ◽  
Poor Prognosis ◽  
Human Lung Cancer ◽  
Normal Lung ◽  
Migration And Invasion ◽  
Epithelial Tissue ◽  
Node Metastasis ◽  
Tumor Node Metastasis Stage ◽  
And Function

GPR115, a member of the adhesion G protein-coupled receptor family, is dysregulated in many cancers. However, the expression and function of GRP115 in non-small cell lung cancer (NSCLC) is not clear. Here, we examined the expression pattern, clinical significance, and function of GPR115 in NSCLC by analysis of clinical specimens and human cell lines and bioinformatics analysis. Immunohistochemical analysis of clinical samples showed that GPR115 was significantly upregulated in NSCLC tissues compares with normal lung epithelial tissue (P < 0.05). And GPR115 overexpression is an independent prognostic factor for 5-year overall survival of NSCLC patients [hazard ratio (HR)=1.625, P = 0.008]. Interestingly, higher expression of GPR115 was strongly correlation with differentiation level (P = 0.027), tumor size (P = 0.010), lymph node metastasis (P = 0.022), tumor-node-metastasis stage (P = 0.008), and poor prognosis of lung adenocarcinoma (LUAD, all P = 0.039), but not lung squamous cell carcinoma (LUSC, P > 0.05). Moreover, downregulation of GPR115 by RNA interference in human lung cancer lines inhibited cell proliferation, migration, and invasion. Preliminary bioinformatic analysis confirmed that GPR115 was closely associated with LAMC2 (Spearman correlation coefficient=0.67, P < 0.05), which was accumulated in ECM-receptor interaction and focal adhesion. Consistent with these findings, deceased of GPR115 was associated with E-cadherin, N-cadherin and Vimentin confirmed by western blot. In conclusion, these data suggest that GPR115 may play a role in the tumor growth and metastasis and may have utility as a diagnostic and prognostic marker for LUAD, but not LUSC.

O-GYN-REI-MD-075 Pelvic Pain Symptoms, Psychological Comorbidities, and Function/Quality-of-life in Women with or Without Endometriosis

2016 ◽  
Vol 38 (5) ◽  
pp. 483
Author(s):  
C. Allaire ◽  
Ali Yosef ◽  
Fontayne Wong ◽  
Christina Williams ◽  
Sarka Lisonkova ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Pelvic Pain ◽  
Psychological Comorbidities ◽  
Pain Symptoms ◽  
And Function

scholarly journals 40 YEARS OF IGF1: PAPP-A and cancer

2018 ◽  
Vol 61 (1) ◽  
pp. T1-T10 ◽  
Author(s):  
Cheryl A Conover ◽  
Claus Oxvig
Keyword(s):  
Lung Cancer ◽  
Cell Proliferation ◽  
Growth Factor ◽  
Ewing Sarcoma ◽  
Structure And Function ◽  
Invasion And Metastasis ◽  
Igf Binding Proteins ◽  
Igf Binding ◽  
Igf Receptor ◽  
And Function

The zinc metalloproteinase, PAPP-A, enhances local insulin-like growth factor (IGF) action through cleavage of inhibitory IGF-binding proteins, thereby increasing IGF available for IGF receptor-mediated cell proliferation, migration and survival. In many tumors, enhanced IGF receptor signaling is associated with tumor growth, invasion and metastasis. We will first discuss PAPP-A structure and function, and post-translational inhibitors of PAPP-A expression or proteolytic activity. We will then review the evidence supporting an important role for PAPP-A in many cancers, including breast, ovarian and lung cancer, and Ewing sarcoma.

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