Type 2 diabetes and cardiovascular disease in South Asians

2011 ◽  
Vol 5 (1) ◽  
pp. 45-56 ◽  
Author(s):  
Nitin Gholap ◽  
Melanie Davies ◽  
Kiran Patel ◽  
Naveed Sattar ◽  
Kamlesh Khunti
Author(s):  
Raj S. Bhopal

Coronary heart disease (CHD) and stroke, collectively cardiovascular disease (CVD), are caused by narrowing and blockage of the arteries supplying the heart and brain, respectively. In type 2 diabetes (DM2) insulin is insufficient to maintain normal blood glucose. Until the 1980s, CHD, stroke, and DM2 were seen as problems of the modern lifestyles of rich countries. South Asians should have been protected, e.g. by less smoking, more vegetarianism, and lower levels of obesity. However, the contrary was true and South Asians have high susceptibility to these diseases. The established causes cannot account for the susceptibility. For example, obesity tends to be lower in South Asians than in European origin people but DM2, though caused by obesity, is about three times commoner. About ten major groups of explanations have been published. The aim of this book is to produce a synthesis of the causal explanations to guide prevention, clinical care, and research.


2019 ◽  
Vol 7 (1) ◽  
pp. e000765 ◽  
Author(s):  
Mirthe Muilwijk ◽  
Frederick Ho ◽  
Heather Waddell ◽  
Anne Sillars ◽  
Paul Welsh ◽  
...  

ObjectiveTo investigate whether the health implications of having type 2 diabetes (T2D) were different in South Asian compared with white European participants.Research design and methodsProspective data from UK Biobank were used, and 457 935 participants of white European and 7102 of South Asian background were included. Cox proportional regression was performed to investigate the association between T2D and health outcome by ethnicity.ResultsOver a mean of 7.0 years (IQR 6.3–7.6) of follow-up, 12 974 participants had died, and 30 347 and 27 159 developed cardiovascular disease (CVD) and cancer, respectively. South Asians had a higher risk for CVD mortality (HR: 1.42, 95% CI 1.07 to 1.89) and incidence (HR: 1.78, 95% CI 1.63 to 1.94), but a decreased risk for cancer mortality (HR: 0.59, 95% CI 0.41 to 0.85) and incidence (HR: 0.80, 95% CI 0.70 to 0.92) compared with white Europeans. Compared with individuals without T2D, both white Europeans and South Asians with T2D had a higher risk for all-cause mortality (1.59 (1.48 to 1.71) vs 2.83 (1.76 to 4.53)), CVD mortality (2.04 (1.82 to 2.28) vs 4.40 (2.37 to 8.16)) and CVD incidence (1.37 (1.31 to 1.44) vs 1.60 (1.31 to 1.95)), respectively. However, the magnitude of the risk was higher for South Asians than white Europeans.ConclusionsAlthough T2D was associated with a higher risk for all-cause mortality and CVD incidence and mortality, in both white Europeans and South Asians, the risk experienced by South Asians with T2D was higher than their white European counterparts.


Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1655-P
Author(s):  
SOO HEON KWAK ◽  
JOSEP M. MERCADER ◽  
AARON LEONG ◽  
BIANCA PORNEALA ◽  
PEITAO WU ◽  
...  

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