A comprehensive review: Biological activity, modification and synthetic methodologies of prenylated flavonoids

2021 ◽  
Vol 191 ◽  
pp. 112895
Author(s):  
Shaochun Shi ◽  
Jichong Li ◽  
Xuemei Zhao ◽  
Qingbo Liu ◽  
Shao-Jiang Song
Keyword(s):  
Biological Activity ◽  
Comprehensive Review ◽  
Prenylated Flavonoids ◽  
Synthetic Methodologies

scholarly journals A Comprehensive Review of the Structure Elucidation and Biological Activity of Triterpenoids from Ganoderma spp.

Molecules ◽  
2014 ◽  
Vol 19 (11) ◽  
pp. 17478-17535 ◽  
Author(s):  
Qing Xia ◽  
Huazheng Zhang ◽  
Xuefei Sun ◽  
Haijuan Zhao ◽  
Lingfang Wu ◽  
...  
Keyword(s):  
Biological Activity ◽  
Structure Elucidation ◽  
Comprehensive Review

Saussurea lappa: A Comprehensive Review on its Pharmacological Activity and Phytochemistry

2020 ◽  
Vol 6 (1) ◽  
pp. 13-23
Author(s):  
Reyaz Hassan ◽  
Mubashir Hussain Masoodi
Keyword(s):  
Biological Activity ◽  
Adverse Effects ◽  
Chemical Constituents ◽  
Literature Survey ◽  
Perennial Herb ◽  
Comprehensive Review ◽  
Saussurea Lappa ◽  
Therapeutic Uses ◽  
Wide Range ◽  
Anti Inflammatory

Around 3000 species of Saussurea are known, however Saussurea lappa Clarke which is perennial herb and has been traditionally used as anticancer, anti-inflammatory, antiviral, medicine without many adverse effects. Phytochemistry of Saussurea lappa after thorough literature survey revealed various varied and copious metabolites such as sesquiterpenes, flavonoids, phytosterols, lignans, terpenes. Many of these compounds have been found to possess a wide range of biological activity such as anticancer, anti-inflammatory, anti-hepatotoxic, anti-viral, etc. Among sesquiterpenes particularly Dehydrocostuslactone, dihydrocostunolide, costunolide Lappadilactone, have been isolated as the main chemical constituents. This review aims to cover published work from public databases (e.g. PubMed, Google Scholar, ResearchGate) and Non-English, Ph.D./MS thesis databases (e.g. CKNIChina, Jairo-Japan, Myto-Malaysia, Shodhganga-India) with a particular focus on phytochemistry and therapeutic uses of different fractions as well as isolated compounds from Saussurea lappa.

Cannabis Phenolics and their Bioactivities

2018 ◽  
Vol 25 (10) ◽  
pp. 1160-1185 ◽  
Author(s):  
Federica Pollastro ◽  
Alberto Minassi ◽  
Luigia Grazia Fresu
Keyword(s):  
Biological Activity ◽  
Phenolic Compounds ◽  
Cannabis Sativa ◽  
Biological Activities ◽  
Bibliographic Databases ◽  
Systematic Research ◽  
Prenylated Flavonoids ◽  
Beneficial Effects ◽  
Almost All

Background: Although Cannabis sativa L. is one of the most versatile plant species with multipurpose use both as medical, alimentary source and as psychoactive abuse, its biomedical relevance focused the attention on major cannabinoids. Phytochemical characterization of cannabis highlights the presence of various non-cannabinoids constituents including flavonoids, spiroindans, dihyrostilbenes, dihydrophenanthrenes, lignanamides, steroids and alkaloids. This review aims to identify polyphenols present in this plant, their biosynthesis, their bioactivities and their synthesis, when this occurred. Methods: We undertook a systematic research focused on bibliographic databases including all noncannabinoids phenolics in various C. sativa strains from their isolation, structural elucidation, their biological activity to their synthesis. Result: Nevertheless, attention has so far been focused only on cannabinoids (more than one hundred isolated), cannabis is a complex plant able to produce more than 480 chemical entities that represent almost all of the different biogenetic classes. Regarding phenolic compounds, the plant biosynthesises a plethora of unique non-cannabinoids second metabolites, such as prenylated flavonoids, stilbenoids derivatives and lignanammides. Conclusion: Cannabis is a plant with high pharmacological and nutrition values, its potentialities and applications are not only circumscribed to cannabinoids biological activities, but also defined by noncannabinoid compounds. The combination of other cannabinoids together with noncannabinoid components could enhance the beneficial effects of THC and could reduce undesirable side effects.

scholarly journals A COMPREHENSIVE REVIEW ON SYNTHESIS AND BIOLOGICAL ACTIVITY OF SCHIFF BASES

2019 ◽  
Vol 10 (5) ◽  
pp. 1-8
Author(s):  
Divya Gupta ◽  
Dharam Pal Pathak ◽  
Garima Kapoor ◽  
Rubina Bhutani
Keyword(s):  
Biological Activity ◽  
Schiff Bases ◽  
Comprehensive Review

Seco-tetracyclic and Seco-pentacyclic Triterpenoids from Nature: Phytochemistry, Biological Activity: A Review

2021 ◽  
Vol 18 ◽  
Author(s):  
Yingkai Liu ◽  
Yuqing Jian ◽  
Mengru Cao ◽  
Bin Wang ◽  
Yixing Qiu ◽  
...  
Keyword(s):  
Natural Products ◽  
Biological Activity ◽  
Special Class ◽  
Biological Activities ◽  
Pentacyclic Triterpenoids ◽  
Comprehensive Review ◽  
Chemical Structures

: Seco-tetracyclic and seco-pentacyclic triterpenoids are a special class of triterpenoids with ring/rings cleaved on the original skeleton structures. A class of important triterpene derivatives, seco-tetracyclic and seco-pentacyclic triterpenoids, have long stimulated the interest and attention of botanists and natural products chemists. There is no systematic and comprehensive review for them. This review is focused on the phytochemical investigations and biological activities of seco-tetracyclic and seco-pentacyclic triterpenoids from nature, covering the literature from 2000-2019. This review describes 310 seco-tetracyclic and 139 seco-pentacyclic triterpenoids discovered from 154 species belong to 97 genera, which cover the chemical structures, types, sources, and bioactivities of compounds. The literature from 2000-2019 is reviewed and 208 references are cited.

scholarly journals Synthetic Chiral Derivatives of Xanthones: Biological Activities and Enantioselectivity Studies

Molecules ◽  
2019 ◽  
Vol 24 (4) ◽  
pp. 791 ◽  
Author(s):  
Carla Fernandes ◽  
Maria Carraro ◽  
João Ribeiro ◽  
Joana Araújo ◽  
Maria Tiritan ◽  
...  
Keyword(s):  
Biological Activity ◽  
Biological Activities ◽  
Pharmacological Activities ◽  
Sar Studies ◽  
Naturally Occurring ◽  
Structure Activity ◽  
Wide Range ◽  
Synthetic Methodologies ◽  
Derivatives Of ◽  
Biological And Pharmacological Activities

Many naturally occurring xanthones are chiral and present a wide range of biological and pharmacological activities. Some of them have been exhaustively studied and subsequently, obtained by synthesis. In order to obtain libraries of compounds for structure activity relationship (SAR) studies as well as to improve the biological activity, new bioactive analogues and derivatives inspired in natural prototypes were synthetized. Bioactive natural xanthones compromise a large structural multiplicity of compounds, including a diversity of chiral derivatives. Thus, recently an exponential interest in synthetic chiral derivatives of xanthones (CDXs) has been witnessed. The synthetic methodologies can afford structures that otherwise could not be reached within the natural products for biological activity and SAR studies. Another reason that justifies this trend is that both enantiomers can be obtained by using appropriate synthetic pathways, allowing the possibility to perform enantioselectivity studies. In this work, a literature review of synthetic CDXs is presented. The structures, the approaches used for their synthesis and the biological activities are described, emphasizing the enantioselectivity studies.

scholarly journals Comprehensive review on sea buckthorn: Biological activity and its potential uses

2021 ◽  
Vol 10 (5) ◽  
pp. 942-953
Author(s):  
Roshan Kumar Shah ◽  
Aniket Idate ◽  
Vishal Ugale ◽  
Poorva .
Keyword(s):  
Biological Activity ◽  
Sea Buckthorn ◽  
Comprehensive Review

Synthetic Phosphonic Acids as Potent Tools to Study Phosphonate Enzymology

Synlett ◽  
2019 ◽  
Vol 30 (07) ◽  
pp. 770-776 ◽  
Author(s):  
K. Pallitsch ◽  
T. Kalina ◽  
T. Stanković
Keyword(s):  
Biological Activity ◽  
Enzyme Inhibitor ◽  
Phosphorus Cycle ◽  
Phosphonic Acids ◽  
Enantiomerically Pure ◽  
Phosphorus Containing ◽  
Fast Pace ◽  
Phosphorus Source ◽  
Synthetic Methodologies ◽  
High Yields

Phosphonic acids are highly stable phosphorus-containing compounds, which have been proposed as important intermediates in the global phosphorus cycle. Biogenic phosphonates as well as their synthetic analogues play an important role as potential enzyme inhibitor drugs and as alternative phosphorus source for microbes. Despite these properties, their metabolism is still poorly understood. New degradative pathways and unknown compounds are identified at fast pace. However, most of these pathways include a variety of unique enzymatic transformations, which are difficult to characterize – especially without sufficient amounts of the potential substrates and intermediates of the postulated transformations in hands. Thus, there is a great need for the development of synthetic methodologies to access phosphonic acids in high yields and in enantiomerically pure form for the use in enzymatic studies and in studies on the biological activity of newly isolated natural products, which are often only obtained in low yields. In this Synpacts article we aim at highlighting our recent contributions to this field.1 Introduction2 Phosphonates as Alternative Phosphorus Source3 The Application of Phosphonates in Enzymatic Studies4 Conclusion

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