Saussurea lappa: A Comprehensive Review on its Pharmacological Activity and Phytochemistry

2020 ◽  
Vol 6 (1) ◽  
pp. 13-23
Author(s):  
Reyaz Hassan ◽  
Mubashir Hussain Masoodi
Keyword(s):  
Biological Activity ◽  
Adverse Effects ◽  
Chemical Constituents ◽  
Literature Survey ◽  
Perennial Herb ◽  
Comprehensive Review ◽  
Saussurea Lappa ◽  
Therapeutic Uses ◽  
Wide Range ◽  
Anti Inflammatory

Around 3000 species of Saussurea are known, however Saussurea lappa Clarke which is perennial herb and has been traditionally used as anticancer, anti-inflammatory, antiviral, medicine without many adverse effects. Phytochemistry of Saussurea lappa after thorough literature survey revealed various varied and copious metabolites such as sesquiterpenes, flavonoids, phytosterols, lignans, terpenes. Many of these compounds have been found to possess a wide range of biological activity such as anticancer, anti-inflammatory, anti-hepatotoxic, anti-viral, etc. Among sesquiterpenes particularly Dehydrocostuslactone, dihydrocostunolide, costunolide Lappadilactone, have been isolated as the main chemical constituents. This review aims to cover published work from public databases (e.g. PubMed, Google Scholar, ResearchGate) and Non-English, Ph.D./MS thesis databases (e.g. CKNIChina, Jairo-Japan, Myto-Malaysia, Shodhganga-India) with a particular focus on phytochemistry and therapeutic uses of different fractions as well as isolated compounds from Saussurea lappa.

Ethnomedicinal uses, Phytochemistry and Pharmacological Aspects of the Genus Berberis Linn: A Comprehensive Review

2020 ◽  
Vol 23 ◽  
Author(s):  
Roohi Mohi-ud-din ◽  
Reyaz Hassan Mir ◽  
Prince Ahad Mir ◽  
Saeema Farooq ◽  
Syed Naiem Raza ◽  
...  
Keyword(s):  
Chemical Constituents ◽  
Pharmacological Activities ◽  
Traditional Use ◽  
Comprehensive Review ◽  
Wide Range ◽  
Anti Cancer ◽  
Comprehensive Survey ◽  
Ethnomedicinal Uses

Background: Genus Berberis (family Berberidaceae), which contains about 650 species and 17 genera worldwide, has been used in folklore and various traditional medicine systems. Berberis Linn. is the most established group among genera with around 450-500 species across the world. This comprehensive review will not only help researchers for further evaluation but also provide substantial information for future exploitation of species to develop novel herbal formulations. Objective: The present review is focussed to summarize and collect the updated review of information of Genus Berberis species reported to date regarding their ethnomedicinal information, chemical constituents, traditional/folklore use, and reported pharmacological activities on more than 40 species of Berberis. Conclusion: A comprehensive survey of the literature reveals that various species of the genus possess various phytoconstituents mainly alkaloids, flavonoid based compounds isolated from different parts of a plant with a wide range of pharmacological activities. So far, many pharmacological activities like anti-cancer, anti-hyperlipidemic, hepatoprotective, immunomodulatory, anti-inflammatory both in vitro & in vivo and clinical study of different extracts/isolated compounds of different species of Berberis have been reported, proving their importance as a medicinal plant and claiming their traditional use.

Dihydroquercetin as potential immunonutrient in treatment of COVID-19

2021 ◽  
pp. 28-32
Author(s):  
V. V. Tatarinov ◽  
S. V. Orlova ◽  
E. A. Nikitina ◽  
E. V. Prokopenko ◽  
A. N. Vodolazkaya ◽  
...  
Keyword(s):  
Biological Activity ◽  
Recovery Period ◽  
Enzymatic Reactions ◽  
Target Organs ◽  
Wide Range ◽  
Complex Therapy ◽  
Main Target ◽  
Low Toxicity ◽  
Anti Inflammatory

The main aspects of the antiviral, anti-inflammatory, antioxidant and hepatoprotective properties of dihydroquercetin (DHQ), which may affect the course of COVID-19, are considered. Given the low toxicity and a wide range of biological activity, aimed not only at suppressing enzymatic reactions with the participation of coronavirus, but also at eliminating the lesions caused by it in all the main target organs, dihydroquercetin can be recommended for inclusion in the complex therapy of the disease and during the recovery period of COVID-19.

scholarly journals TERMINALIA CHEBULA: SUCCESS FROM BOTANY TO ALLOPATHIC AND AYURVEDIC PHARMACY

2016 ◽  
Vol 9 (5) ◽  
pp. 21
Author(s):  
Varun Garg ◽  
Barinder Kaur ◽  
Sachin Kumar Singh ◽  
Bimlesh Kumar
Keyword(s):  
Chemical Constituents ◽  
Present Review ◽  
Terminalia Chebula ◽  
Pharmacological Activities ◽  
Therapeutic Uses ◽  
Anti Cancer ◽  
Anti Oxidant ◽  
Anti Inflammatory

ABSTRACTTerminalia chebula (TC) is a unique herb having various therapeutic potentials as anti-inflammatory, antioxidant, anticancer, and digestant. It belongsto family Combretaceae. In the present review, an attempt has been made to decipher classification, chemical constituents, therapeutic uses, andpatents that have been reported for TC. Various pharmacological activities of TC that make it as potential medicine and its Ayurvedic formulationsare highlighted.Keywords: Terminalia chebula, Anti-oxidant, Anti-cancer, Ayurvedic formulations, Anti-oxidant.

scholarly journals MIRACLE AYURVEDIC HERB - ASHWAGANDHA (WITHANIA SOMNIFERA DUNAL)

2021 ◽  
Vol 9 (8) ◽  
pp. 1778-1788
Author(s):  
Bargale Sushant Sukumar
Keyword(s):  
Withania Somnifera ◽  
Chemical Constituents ◽  
Immunomodulatory Activity ◽  
Indian Ginseng ◽  
Aerial Parts ◽  
Wide Range ◽  
The World ◽  
Anti Inflammatory ◽  
Ayurvedic Herb ◽  
Present World

Ayurveda is successfully implemented as a primary healthcare system in India, and it is flourishing in the promotion of health around the world. Ayurveda aims to create a society happily, healthy, and peaceful. In general, the simple regimes mentioned in Ayurveda texts are of immense use faced by the present world today regarding health pro- motion. Ashwagandha (Withania Somnifera) is usually referred to as 'Indian winter cherry' or 'Indian Ginseng'. It is a shrub grown in India and North America whose roots have been used by Ayurvedic practitioners for thousands of years. Ashwagandha is one of Ayurveda's most essential herbs, used as Rasayana for its wide range of health benefits for centuries. Chemicals constitute of Ashwagandha (Withania Somnifera)- The chemistry of Ashwagan- dha (Withania Somnifera) has been widely studied and numerous categories of chemical constituents have been described, extracted, and isolated, such as steroidal lactones, alkaloids, flavonoids, tannin, etc. More than 12 alka- loids, 40 withanolides and several sitoindosides have currently been isolated from the aerial parts, roots, and berries of the Withania species and have been recorded. The principal biochemical element of Ashwagandha (WS) root is withanolides, which are steroidal alkaloids and steroidal lactones. The pharmacological activity of Ashwagan- dha- It has been shown to have pharmacological importance as an Adaptogen, Antibiotic, abortifacient, aphrodisiac, Astringent, Anti-inflammatory, deobstructive, diuretic, narcotic, sedative, and tonic through centuries of Ayurvedic medicinal practice using Ashwagandha (Withania Somnifera). Along with these Ashwagandha acts as Anti-stress,Anticarcinogenic activity, Anti-inflammatory activity, Anti-aging activity, Cardioprotective activity, hypothyroid activity and Immunomodulatory activity. Keywords: Ashwagandha, Withania Somnifera, Alkaloids, Withanoids, sitoindosides

Prunella vulgaris L: Critical Pharmacological, Expository Traditional uses and Extensive Phytochemistry: A Review

2021 ◽  
Vol 18 ◽  
Author(s):  
Reyaz Hassan Mir ◽  
Mohammad Faizan Bhat ◽  
Gifty Sawhney ◽  
Parveen Kumar ◽  
Nusrit Iqbal Andrabi ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Phenolic Acid ◽  
Research Literature ◽  
Biologically Active ◽  
Bibliographic Databases ◽  
Prunella Vulgaris ◽  
Volatile Oils ◽  
Therapeutic Uses ◽  
Wide Range ◽  
Anti Inflammatory

Background: Prunella vulgaris, family Lamiaceae also known as self-heal, has been traditionally used as an expectorant, anti-inflammatory, anti-pyretic, and anti-rheumatic. Due to widespread distribution of the plant, Vulgaris is also called ‘vulgar’ in Latin adjective meaning common. Objective: The objective of this review was to describe the relevant aspects of phytochemistry and therapeutic uses of different fractions as well as isolated compounds from Prunella vulgaris. An attempt was also made to enumerate the possible leads e.g. betulinic acid, oleanolic acid, ursolic acid, umbelliferone, scopoletin, esculetin, luteolin, homoorientin, Rosmarinic acid and cinaroside for further development. Method: For peer-reviewed research literature, we undertook a structured search of bibliographic databases using a focused review question. Scientific databases such as PubMed, Scopus, Science Direct, and Google Scholar were used Results: Phytochemistry of Prunella vulgaris (PV) after a thorough literature survey revealed varied and copious metabolites, such as triterpenoids, phenolic acid, sterols, carbohydrates, coumarins, fatty acids, and volatile oils. Many of these compounds have been found to possess wide range of biological activity per se, including anti-microbial, immunosuppressive, anti-cancer, cardio-protective, anti-allergic and anti-inflammatory. Conclusion: Prunella vulgaris is a medicinal plant of immense medicinal importance having a variety of compounds such as such as triterpenoids, phenolic acid, sterols, carbohydrates, coumarins, fatty acids, and volatile oils and diversity in pharmacological spectrum. The plant could be further exploited, to isolate the various biologically active constituents responsible for its activity.

KASNI (CICHORIUM INTYBUS L.): A REVIEW ON MEDICINAL UTILITY IN PERSPECTIVE OF UNANI MEDICINE

2020 ◽  
Vol 13 (2) ◽  
Author(s):  
Mohd Afsahul Kalam ◽  
Bazila Majeed ◽  
Aieman Yaqoob ◽  
Riehana Ghani ◽  
Shafiqur Rahman
Keyword(s):  
Chemical Constituents ◽  
Sesquiterpene Lactones ◽  
Hepatoprotective Activity ◽  
Cichorium Intybus ◽  
Perennial Herb ◽  
Internal Organs ◽  
Unani Medicine ◽  
Tartaric Acids ◽  
Therapeutic Uses ◽  
Bright Blue

Kasni (Cichorium intybus L.) or Chicory is a perennial herb of the dandelion family, (Asteraceae), usually with bright blue flowers, rarely white or pink which is used widely in Unani System of Medicine. It is an erect and procumbent herb that attains about 40-80cm hight. There are two main varieties of Kasni one issweet and second is wild. The most popular variety of Kasni used for medicinal purposes is Cichorium intybus L. Different parts of the herb are used for medicinal purposes like leaves, seeds and root. It is well known for the resolvent action of internal organs and especially for its hepatoprotective and nephroprotective properties, regarding the hepatoprotective activity, chicory extract reduces the levels of hepatic enzymes such as alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase. It contains dietary fiber Inulin which is useful in treating diabetes and constipation. Besides inulin it contains other chemical constituents like sesquiterpene lactones, coumarins, citric and tartaric acids, lactic, acetic, palmitic, pyruvic acid etc. Its leaves contain vitamin B2 and C, root contains series of glucofructosans. The main actions which are attributed to chicory are deobstruent, diuretic, blood purifier, antipyretic and antiinflammatory as mentioned in Unani medicine. It is recommended in the treatment of jaundice, gastritis, ascites, arthritis, asthma and many other disorders, either alone or in compound form. This review gives knowledge on distribution, morphology, phytochemistry and pharmacological aspects along with its therapeutic uses in perspective of Unani System of Medicine.

Comparison of Virgin Coconut Oil with 5% Amlexanox in Management of Minor Recurrent Aphthous Ulcers - A Randomized Control Trial

2021 ◽  
Vol 13 (2) ◽  
pp. 16-22
Author(s):  
Dr. Kavitha Ravindran Nambiar ◽  
Dr. Krupashankar R ◽  
Dr. Veena S N ◽  
Dr. Neha Vijay ◽  
Dr. Kavitha A P
Keyword(s):  
Adverse Effects ◽  
Coconut Oil ◽  
Signs And Symptoms ◽  
Virgin Coconut Oil ◽  
Ulcer Size ◽  
Aphthous Ulcers ◽  
Wide Range ◽  
Recurrent Aphthous Ulcers ◽  
Group A ◽  
Anti Inflammatory

Objective: Recurrent Aphthous Ulcer (RAU) is a common (75-80%) painful inflammatory ulcerative disorder of the non-keratinized oral mucosa. Wide range of antiseptics, anti-inflammatory, antibiotics and corticosteroids are available for treatment. Amlexanox is a topical anti-inflammatory and anti-allergic drug used to treat RAS. Recently, there has been increase in interest in use of essential oil and herbal medicine in managing RAU, one such natural product is virgin coconut oil. This study is aimed to determine the efficacy of VCO in management of signs and symptoms of minor recurrent aphthous ulcers. Methodology: 40 patients were included for the study who were randomly divided into two groups. 20 patients in Group A (VCO) and 20 patients in Group B (5%Amlexanox). Primary outcome measured were reduction in ulcer size (in mm) and pain (VAS 1-10). Results: There is high statistical significant difference within the groups in ulcer healing and pain reduction (p=0.00) on 3rd and 5th day. In group A significant reduction in pain was present on the 5th day (p=0.02) and no significant reduction in ulcer size (p=0.083). No adverse effects were reported in either group. Conclusion: VCO could be used as an effective and safe drug in managing the signs and symptoms of RAS. It is edible oil with no known adverse effects and could be a safe therapeutic alternative in children and pregnant women.

scholarly journals Chemical Constituents and Pharmacological Activities of Steroid Saponins Isolated from Rhizoma Paridis

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Fen Liu ◽  
Luning Li ◽  
Xinchen Tian ◽  
Dengtian Zhang ◽  
Wenxue Sun ◽  
...  
Keyword(s):  
Biological Activity ◽  
Animal Models ◽  
Chemical Constituents ◽  
Herbal Drugs ◽  
Pharmacological Activities ◽  
Chemical Structures ◽  
Comprehensive Exploitation ◽  
Paris Polyphylla ◽  
Pharmacological Studies ◽  
Anti Inflammatory

Rhizoma Paridis, the rhizome of liliaceous plants Paris polyphylla, is one of the most commonly used herbal drugs in China. Phytochemical and pharmacological studies have shown that steroid saponins were the major effective ingredients of Rhizoma Paridis to exert antitumor, anti-inflammatory, hemostasis, and antifibrosis functions. In this review, we discussed the chemical structures of steroid saponins and their related biological activity and mechanisms in cellular and animal models, aiming to provide a reference for future comprehensive exploitation and development of saponins.

scholarly journals A review on Indole and Benzothiazole derivatives its importance

2019 ◽  
Vol 9 (1-s) ◽  
pp. 505-509 ◽  
Author(s):  
Shaheen Sulthana ◽  
P. Pandian
Keyword(s):  
Heterocyclic Compounds ◽  
Structural Modification ◽  
Biological Activities ◽  
New Product ◽  
Review Article ◽  
Literature Survey ◽  
Pharmacological Activities ◽  
Benzothiazole Derivatives ◽  
Wide Range ◽  
Anti Inflammatory

In recent years heterocyclic compounds analogues and derivatives have attracted wide attention due to their useful biological and pharmacological properties. Indole, Benzothiazole and its analogs are versatile substrates, which can be used for the synthesis of numerous heterocyclic compounds. Indole, Benzothiazole and its derivatives are used in organic synthesis and they are used in evaluating new product that possesses different biological activities. Hence, their extensive structural modification has result in different analogues of Indole and Benzothiazole derivatives depicting wide range of biological and pharmacological activities such as antiviral, anticonvulsant, anti-inflammatory, analgesic, antimicrobial and anticancer. This review article literature survey summarizes the synthesis and pharmacological activities of Indole, Benzothiazole and its derivatives. Keywords: Indole, Benzothiazole, antiviral, anticonvulsant, anti-inflammatory, analgesic, antimicrobial and anticancer

A COMPREHENSIVE REVIEW OF PHYTOCHEMICAL AND PHARMACOLOGICAL OVERVIEW ON CELOSIA CRISTATA FOR FUTURE PROSPECTIVE RESEARCH

2020 ◽  
pp. 21-24
Author(s):  
MAHAVEER SING ◽  
SRAVAN KUMAR P ◽  
BIRENDRA SHRIVASTAVA ◽  
PAMULA REDDY B
Keyword(s):  
Traditional Medicine ◽  
Chemical Constituents ◽  
Pharmacological Activities ◽  
Comprehensive Review ◽  
Wide Range ◽  
Celosia Cristata ◽  
Prospective Research ◽  
Different Parts

Celosia cristata (CC) is used in traditional medicine to cure several disorders. It is a member of the genus Celosia and is commonly known as cockscomb, since the flower looks like the head on a rooster. Many sensitive ingredients were isolated from different parts of the plant. The recent studies showed that the plant exerted a wide range of pharmacological activities. The chemical constituents and pharmacological activities of CC were presented in this review.

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