scholarly journals Analysis of genes regulated by DUX4 via oxidative stress reveals potential therapeutic targets for treatment of facioscapulohumeral dystrophy

Redox Biology ◽  
2021 ◽  
pp. 102008
Author(s):  
Anna Karpukhina ◽  
Ivan Galkin ◽  
Yinxing Ma ◽  
Carla Dib ◽  
Roman Zinovkin ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Therapeutic Targets ◽  
Facioscapulohumeral Dystrophy

scholarly journals Oxidative stress and DNA damage after cerebral ischemia: Potential therapeutic targets to repair the genome and improve stroke recovery

2018 ◽  
Vol 134 ◽  
pp. 208-217 ◽  
Author(s):  
Peiying Li ◽  
R. Anne Stetler ◽  
Rehana K. Leak ◽  
Yejie Shi ◽  
Yan Li ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Cerebral Ischemia ◽  
Therapeutic Targets ◽  
Stroke Recovery

Oxidative Stress Induced Cell Cycle Arrest: Potential Role of PRX-2 and GSTP-1 as Therapeutic Targets in Hepatocellular Carcinoma

2021 ◽  
Vol 28 ◽  
Author(s):  
Abeer Mohsin ◽  
Kanwal Haneef ◽  
Amber Ilyas ◽  
Shamshad Zarina ◽  
Zehra Hashim
Keyword(s):  
Oxidative Stress ◽  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Therapeutic Approach ◽  
Therapeutic Targets ◽  
Dependent Manner ◽  
Cycle Arrest ◽  
Incidence And Mortality ◽  
The World

Background: The increasing incidence and mortality rate of HCC is a major concern, especially for developing countries of the world. Hence, extensive research is being carried out in order to explore new approaches for developing successful therapeutic strategies for HCC. The controversial role of oxidative stress in the prognosis and treatment of various diseases such as cancer has become the area of great interest and intrigue for many scientists throughout the world. Objective: We aim to investigate the role of induced oxidative stress on the suppression of HCC Huh-7 cancerous cells as therapeutic approach. Methods: Induction of oxidative stress via H2O2 treatment produced cell cytotoxicity in a dose dependent manner and also led to the over expression of GSTP-1 and PRX-2. The expression of GSTP-1 and PRX-2 was compared in HCC Huh-7 treated, untreated cells and normal hepatocytes using immunocytochemistry. Furthermore, the effects of oxidative stress on cell cycle arrest were also studied through flow cytometry. Results: Our study demonstrated the inhibition of cancer cell proliferation as a result of H2O2 induction by arresting the cell cycle at G2 phase. Conclusion: The induction of oxidative stress could be a potential therapeutic approach for treating HCC in the future. GSTP-1 and PRX-2 can serve as substantial therapeutic targets for the treatment of HCC.

scholarly journals Nitric oxide synthase inhibition and oxidative stress in cardiovascular diseases: Possible therapeutic targets?

2013 ◽  
Vol 140 (3) ◽  
pp. 239-257 ◽  
Author(s):  
Luc Rochette ◽  
Julie Lorin ◽  
Marianne Zeller ◽  
Jean-Claude Guilland ◽  
Luc Lorgis ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Cardiovascular Diseases ◽  
Nitric Oxide Synthase ◽  
Therapeutic Targets ◽  
Oxide Synthase ◽  
And Oxidative Stress

Oxidative stress, autophagy, epigenetic changes and regulation by miRNAs as potential therapeutic targets in osteoarthritis

2016 ◽  
Vol 108 ◽  
pp. 1-10 ◽  
Author(s):  
Sergio Portal-Núñez ◽  
Pedro Esbrit ◽  
María José Alcaraz ◽  
Raquel Largo
Keyword(s):  
Oxidative Stress ◽  
Therapeutic Targets ◽  
Epigenetic Changes

scholarly journals The Mitochondria: A Target of Polyphenols in the Treatment of Diabetic Cardiomyopathy

2020 ◽  
Vol 21 (14) ◽  
pp. 4962 ◽  
Author(s):  
Humna Bhagani ◽  
Suzanne A. Nasser ◽  
Ali Dakroub ◽  
Ahmed F. El-Yazbi ◽  
Assaad A. Eid ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Glucose Metabolism ◽  
Protective Effect ◽  
Diabetic Cardiomyopathy ◽  
Mitochondrial Biogenesis ◽  
Ventricular Dysfunction ◽  
Therapeutic Targets ◽  
Ros Production ◽  
Oxygen Species

Diabetic cardiomyopathy (DCM) is a constellation of symptoms consisting of ventricular dysfunction and cardiomyocyte disarray in the presence of diabetes. The exact cause of this type of cardiomyopathy is still unknown; however, several processes involving the mitochondria, such as lipid and glucose metabolism, reactive oxygen species (ROS) production, apoptosis, autophagy and mitochondrial biogenesis have been implicated. In addition, polyphenols have been shown to improve the progression of diabetes. In this review, we discuss some of the mechanisms by which polyphenols, particularly resveratrol, play a role in slowing the progression of DCM. The most important intermediates by which polyphenols exert their protective effect include Bcl-2, UCP2, SIRT-1, AMPK and JNK1. Bcl-2 acts to attenuate apoptosis, UCP2 decreases oxidative stress, SIRT-1 increases mitochondrial biogenesis and decreases oxidative stress, AMPK increases autophagy, and JNK1 decreases apoptosis and increases autophagy. Our dissection of these molecular players aims to provide potential therapeutic targets for the treatment of DCM.

scholarly journals Oxidative stress, DNA damage, and the telomeric complex as therapeutic targets in acute neurodegeneration

2013 ◽  
Vol 62 (5) ◽  
pp. 764-775 ◽  
Author(s):  
Joshua A. Smith ◽  
Sookyoung Park ◽  
James S. Krause ◽  
Naren L. Banik
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Therapeutic Targets

scholarly journals Oxidative Stress and Liver Cancer: Etiology and Therapeutic Targets

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Zhanpeng Wang ◽  
Zhuonan Li ◽  
Yanshuo Ye ◽  
Lijuan Xie ◽  
Wei Li
Keyword(s):  
Oxidative Stress ◽  
Liver Cancer ◽  
Molecular Mechanisms ◽  
Therapeutic Targets ◽  
The Body ◽  
Liver Carcinogenesis ◽  
Cancer Etiology ◽  
Nonalcoholic Fatty Liver ◽  
The Impact ◽  
The Relationship

Accumulating evidence has indicated that oxidative stress (OS) is associated with the development of hepatocellular carcinoma (HCC). However, the mechanisms remain largely unknown. Normally, OS occurs when the body receives any danger signal—from either an internal or external source—and further induces DNA oxidative damage and abnormal protein expression, placing the body into a state of vulnerability to the development of various diseases such as cancer. There are many factors involved in liver carcinogenesis, including hepatitis B virus (HBV) and hepatitis C virus (HCV) infection, alcohol abuse, and nonalcoholic fatty liver disease (NAFLD). The relationship between OS and HCC has recently been attracting increasing attention. Therefore, elucidation of the impact of OS on the development of liver carcinogenesis is very important for the prevention and treatment of liver cancer. This review focuses mainly on the relationship between OS and the development of HCC from the perspective of cellular and molecular mechanisms and the etiology and therapeutic targets of HCC.

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