scholarly journals Paradoxical zinc toxicity and oxidative stress in the mammary gland during marginal dietary zinc deficiency

2015 ◽  
Vol 54 ◽  
pp. 84-92 ◽  
Author(s):  
Zeynep Bostanci ◽  
Ronald P. Mack ◽  
Sooyeon Lee ◽  
David I. Soybel ◽  
Shannon L. Kelleher
Keyword(s):  
Oxidative Stress ◽  
Mammary Gland ◽  
Zinc Deficiency ◽  
Zinc Toxicity ◽  
Dietary Zinc ◽  
And Oxidative Stress

scholarly journals The Role Of Dietary Zinc Restriction On Antioxidant Status And Oxidative Stress

2006 ◽  
Vol 20 (4) ◽  
Author(s):  
Richard S Bruno ◽  
Yang Song ◽  
Scott W Leonard ◽  
Alan W Taylor ◽  
Maret G Traber ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Status ◽  
Dietary Zinc ◽  
And Oxidative Stress

Zinc deficiency and oxidative stress in brain: Magnetic resonance investigations in weanling rats

2004 ◽  
Vol 17 (3) ◽  
pp. 161-174 ◽  
Author(s):  
Rheal A. Towner ◽  
Christopher Appleby ◽  
Mark Levy ◽  
Tammy M. Bray
Keyword(s):  
Oxidative Stress ◽  
Magnetic Resonance ◽  
Zinc Deficiency ◽  
Weanling Rats ◽  
And Oxidative Stress

scholarly journals Expression Patterns of Major Genes in Fatty Acid Synthesis, Inflammation and Oxidative Stress Related Pathways and Quality Parameters During the Transition From Colostrum to Milk in Dairy Goats

2020 ◽  
Author(s):  
Akın YAKAN ◽  
Huseyin OZKAN ◽  
Baran ÇAMDEVİREN ◽  
Ufuk KAYA ◽  
İrem KARAASLAN ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Mammary Gland ◽  
Fatty Acid ◽  
Fatty Acid Synthesis ◽  
Transition Period ◽  
Freezing Point ◽  
Expression Patterns ◽  
Acid Synthesis ◽  
Mature Milk ◽  
And Oxidative Stress

Abstract Colostrum is quietly different from mature milk. The molecular regulation of milk secretion and quality in the transition period from colostrum to milk in goats is largely unknown. The present study, mammary gland secretion of goats was collected in 0th, 4th, 7th, 14th and 28th days after parturition. In addition to composition and fatty acid profile of colostrum or milk, FASN, SCD, ACACA, COX-2, NRF2, TLR2, NF-kB, LTF and PTX3 genes expression patterns were determined from milk somatic cells. While somatic cell count (SCC), malondialdehyde (MDA), fat, fat-free dry matter (FFDM), protein and lactose were highest as expression levels of the oxidative and inflammatory genes (P<0.05), freezing point and electrical conductivity were lowest in colostrum. With the continuation of lactation, most of the fatty acids, n3 ratio, and odour index had increased, on the other hand, C14:0 and C16:0 had decreased. In addition, FASN was upregulated almost 3 folds in 14th day (P<0.05). While SCD was similar, ACACA was upregulated more than 5 folds in 7th and 14th days (P<0.05). Furthermore, significant correlations were determined between studied genes. Although colostrum is important for offspring health in terms of inflammation and oxidative stress related pathways, further studies are needed on complex molecular pathways including fatty acid synthesis on goat mammary gland.

Enhanced mitochondrial dysfunction and oxidative stress in the mammary gland of cows with clinical ketosis

2021 ◽  
Author(s):  
Yuxiang Song ◽  
Juan J. Loor ◽  
Congyi Li ◽  
Yusheng Liang ◽  
Na Li ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Mammary Gland ◽  
Mitochondrial Dysfunction ◽  
And Oxidative Stress

Zinc Deficiency and Oxidative Stress Involved in Valproic Acid Induced Hepatotoxicity: Protection by Zinc and Selenium Supplementation

2017 ◽  
Vol 179 (1) ◽  
pp. 102-109 ◽  
Author(s):  
Nematollah Ahangar ◽  
Maloos Naderi ◽  
Abdolali Noroozi ◽  
Maryam Ghasemi ◽  
Ehsan Zamani ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Valproic Acid ◽  
Zinc Deficiency ◽  
Selenium Supplementation ◽  
And Oxidative Stress

scholarly journals Association of Zinc Deficiency with Development of CVD Events in Patients with CKD

Nutrients ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1680
Author(s):  
Shinya Nakatani ◽  
Katsuhito Mori ◽  
Tetsuo Shoji ◽  
Masanori Emoto
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Risk Factors ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Zinc Deficiency ◽  
Serum Zinc ◽  
Arterial Calcification ◽  
And Oxidative Stress

Deficiency of the micronutrient zinc is common in patients with chronic kidney disease (CKD). The aim of this review is to summarize evidence presented in literature for consolidation of current knowledge regarding zinc status in CKD patients, including those undergoing hemodialysis. Zinc deficiency is known to be associated with various risk factors for cardiovascular disease (CVD), such as increased blood pressure, dyslipidemia, type 2 diabetes mellitus, inflammation, and oxidative stress. Zinc may protect against phosphate-induced arterial calcification by suppressing activation of nuclear factor kappa light chain enhancer of activated B. Serum zinc levels have been shown to be positively correlated with T50 (shorter T50 indicates higher calcification propensity) in patients with type 2 diabetes mellitus as well as those with CKD. Additionally, higher intake of dietary zinc was associated with a lower risk of severe abdominal aortic calcification. In hemodialysis patients, the beneficial effects of zinc supplementation in relation to serum zinc and oxidative stress levels was demonstrated in a meta-analysis of 15 randomized controlled trials. Thus, evidence presented supports important roles of zinc regarding antioxidative stress and suppression of calcification and indicates that zinc intake/supplementation may help to ameliorate CVD risk factors in CKD patients.

scholarly journals Dietary zinc source impacts intestinal morphology and oxidative stress in young broilers

2020 ◽  
Vol 99 (1) ◽  
pp. 441-453 ◽  
Author(s):  
Annatachja De Grande ◽  
Saskia Leleu ◽  
Evelyne Delezie ◽  
Christof Rapp ◽  
Stefaan De Smet ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Intestinal Morphology ◽  
Dietary Zinc ◽  
Zinc Source ◽  
And Oxidative Stress

scholarly journals Iron Efflux by PmtA Is Critical for Oxidative Stress Resistance and Contributes Significantly to Group A Streptococcus Virulence

2017 ◽  
Vol 85 (6) ◽  
Author(s):  
Arica R. VanderWal ◽  
Nishanth Makthal ◽  
Azul Pinochet-Barros ◽  
John D. Helmann ◽  
Randall J. Olsen ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Iron Toxicity ◽  
Antioxidant Defenses ◽  
Zinc Toxicity ◽  
Invasive Infection ◽  
Sequencing Analysis ◽  
Bacterial Survival ◽  
Content Type ◽  
Group A ◽  
And Oxidative Stress

ABSTRACT Group A Streptococcus (GAS) is a human-only pathogen that causes a spectrum of disease conditions. Given its survival in inflamed lesions, the ability to sense and overcome oxidative stress is critical for GAS pathogenesis. PerR senses oxidative stress and coordinates the regulation of genes involved in GAS antioxidant defenses. In this study, we investigated the role of PerR-controlled metal transporter A (PmtA) in GAS pathogenesis. Previously, PmtA was implicated in GAS antioxidant defenses and suggested to protect against zinc toxicity. Here, we report that PmtA is a P1B4-type ATPase that functions as an Fe(II) exporter and aids GAS defenses against iron intoxication and oxidative stress. The expression of pmtA is specifically induced by excess iron, and this induction requires PerR. Furthermore, a pmtA mutant exhibited increased sensitivity to iron toxicity and oxidative stress due to an elevated intracellular accumulation of iron. RNA-sequencing analysis revealed that GAS undergoes significant alterations in gene expression to adapt to iron toxicity. Finally, using two mouse models of invasive infection, we demonstrated that iron efflux by PmtA is critical for bacterial survival during infection and GAS virulence. Together, these data demonstrate that PmtA is a key component of GAS antioxidant defenses and contributes significantly to GAS virulence.

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