scholarly journals Correlation between preoperative serum alpha-fetoprotein levels and survival with respect to the surgical treatment of hepatocellular carcinoma at a tertiary care hospital in Veracruz, Mexico

2017 ◽  
Vol 82 (4) ◽  
pp. 357-360
Author(s):  
G. Martínez-Mier ◽  
S. Esquivel-Torres ◽  
A. Nava-Lacorte ◽  
F.A. Lajud-Barquín ◽  
S. Zilli-Hernández ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Surgical Treatment ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Alpha Fetoprotein ◽  
Care Hospital ◽  
Preoperative Serum ◽  
Serum Alpha Fetoprotein

SCCA-IgM in hepatocellular carcinoma patients treated with transarterial chemoembolization: gender-related differences

2020 ◽  
Vol 14 (10) ◽  
pp. 855-867
Author(s):  
Filippo Pelizzaro ◽  
Federica Soldà ◽  
Romilda Cardin ◽  
Angela Imondi ◽  
Anna Sartori ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Transarterial Chemoembolization ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Immunoglobulin M ◽  
Care Hospital ◽  
Squamous Cell Carcinoma Antigen ◽  
Preclinical Models ◽  
Relevant Variable ◽  
Gender Specific

Aim: Squamous cell carcinoma antigen immune complexed with immunoglobulin M (SCCA-IgM) is a useful but not completely satisfactory biomarker of hepatocellular carcinoma (HCC). Considering its gender-specific behavior in preclinical models, we investigated gender-related differences of SCCA-IgM as a prognostic marker in HCC. Patients & methods: Two hundred and eight prospectively recruited patients treated with transarterial chemoembolization in a single tertiary care hospital were retrospectively evaluated. Correlations between SCCA-IgM levels, clinical characteristics and survival were assessed according to gender. Results: When the disease was advanced, SCCA-IgM was higher in males and lower in females. Levels below 130 AU/ml predicted a significantly longer survival in males (p = 0.007) and a shorter survival in females (p = 0.01). Conclusion: In predicting the prognosis of HCC patients, the interpretation of SCCA-IgM should consider gender as a relevant variable.

Results of a surgical resection of pulmonary metastasis from hepatocellular carcinoma: prognostic impact of the preoperative serum alpha-fetoprotein level

Surgery Today ◽  
2011 ◽  
Vol 42 (6) ◽  
pp. 526-531 ◽  
Author(s):  
Taro Ohba ◽  
Tokujiro Yano ◽  
Tsukihisa Yoshida ◽  
Daigo Kawano ◽  
Shuichi Tsukamoto ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Surgical Resection ◽  
Pulmonary Metastasis ◽  
Alpha Fetoprotein ◽  
Prognostic Impact ◽  
Preoperative Serum ◽  
Serum Alpha Fetoprotein

scholarly journals HEPATOCELLULAR CARCINOMA

2016 ◽  
Vol 23 (02) ◽  
pp. 209-212
Author(s):  
Khalil ur Rehman ◽  
Dr. Muhammad Samiullah ◽  
Sidra Sharif ◽  
Saira Farhat
Keyword(s):  
Hepatocellular Carcinoma ◽  
Tumor Size ◽  
Tertiary Care ◽  
Alpha Fetoprotein ◽  
Enzyme Linked Immunosorbent Assay ◽  
Care Hospital ◽  
Cross Sectional ◽  
Liver Cancers ◽  
Size Groups ◽  
Group B

Background: Hepatocellular carcinoma (HCC) also known as malignanthepatoma, accounts for most of the liver cancers. Alpha fetoprotein (AFP) has been undoubtedlywidely used as a marker for the detection and monitoring of HCC. This study aimed to find thecorrelation of serum alpha fetoprotein and tumor size in HCC in the tertiary care hospital. StudyDesign: This cross sectional descriptive study. Setting: Pathology Department of Allama IqbalMedical College, Lahore (AIMC). Materials and Methods: The study was carried out on 45HCC patients (13 females and 32 males) came to Jinnah Hospital Lahore. Five ml of venousblood was drawn aseptically from anterior cubital vein of patients and added into plain vial toclot. The samples were centrifuged, to get the plasma separated from blood cells. Serum AFPwas measured by using Enzyme linked Immunosorbent Assay technique (ELISA). Results:There were 10 (22.2%), 19 (42.2%), 16 (35.6) cases in AFP group 1,2,3 respectively. While10 (22.2%), 13 (28.8%), 22 (48.8%) cases in tumor size groups A,B,C. Group C with largetumor size got 48.8% raised AFP levels as compared to group B (28.8%) and group A (10%).Conclusion: This study shows there is significant correlation between serum AFP and tumorsize in HCC (r=0.668). Serum AFP progressively increases with tumor size especially in largersize. Although AFP have suboptimal sensitivity but it is still proves a beneficial in early diagnosisand screening of HCC, when used in combination of USG/Imaging technique.

Profile of hepatocellular carcinoma in a tertiary care hospital in Punjab in northern India

2013 ◽  
Vol 33 (1) ◽  
pp. 35-40 ◽  
Author(s):  
Ajit Sood ◽  
Vandana Midha ◽  
Omesh Goyal ◽  
Prerna Goyal ◽  
Neena Sood ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Care Hospital ◽  
Northern India

scholarly journals Sero-Occurrence of HBV/HCV Co-infection and Levels of Liver Enzymes among Patients at a Tertiary Care Hospital in Central India: a Pilot Study

2019 ◽  
Vol 8 (1) ◽  
Author(s):  
Prabha Desikan ◽  
Aseem Rangnekar ◽  
Zeba Khan ◽  
Nikita Panwalkar ◽  
Protiti Bose ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Disease ◽  
Hepatitis B ◽  
Liver Function ◽  
Liver Enzymes ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Central India ◽  
Liver Function Tests ◽  
Care Hospital

Introduction: Hepatitis B and C viral infections share common modes of transmission and account for a large proportion of liver disease burden across the globe. Patients with Hepatitis B (HBV) and Hepatitis C virus (HCV) co-infection may have more severe liver disease and are potentially at higher risk for developing hepatocellular carcinoma. The aim of this study was to assess the sero-occurrence of HBV/HCV co-infection by examining the medical records of tertiary care hospital patients in Central India and determine the extent of liver damage based on liver function tests (LFTs).Methods: Patients with a positive test for HBV surface antigen (HBsAg) over a period of 10 years were identified from laboratory records in a tertiary care facility in central India. Records of 51,075 consecutive non-duplicate blood samples were then screened for a positive HBV and HCV tests. LFT, liver enzymes, and bilirubin data were also extracted. Means and standard deviations were determined for continuous variables, and the difference in means was compared using a independent samples t-test. Associations between HBV/HCV co-infection status and demographic variables were calculated using Pearson’s Chi-squared test. A p-value less than 0.05 was considered statistically significant.Results: In this study, 1674 (3.27%) screened patients were positive for HBsAg and the sero-occurrence of co-infection with HCV in HBsAg positive patients was reported in 28 individuals (1.67%). There was no significant gender difference for HBV/HCV co-infection (p>0.05). HBV/HCV co-infection was observed more frequently in the 31-60 year old age group (p=0.001). HBV/HCV co-infected patients had significantly higher levels of liver enzymes and bilirubin than those with HBsAg mono-infection (p=0.001).Conclusion: Liver function tests are potentially important predictors for HBV/HCV coinfection. Screening for HCV co-infection in HBsAg-positive patients is recommended in India. Detection of co-infection may enable timely preventive/therapeutic interventions aimed at preventing progression to hepatocellular carcinoma.

scholarly journals COVID-19 pandemic: Impact on the management of patients with hepatocellular carcinoma at a tertiary care hospital

PLoS ONE ◽  
2021 ◽  
Vol 16 (8) ◽  
pp. e0256544
Author(s):  
Katharina Pomej ◽  
Bernhard Scheiner ◽  
Lukas Hartl ◽  
Lorenz Balcar ◽  
Tobias Meischl ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Patient Care ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Median Number ◽  
Care Hospital ◽  
Period 2 ◽  
Number Of Patients ◽  
Tumor Boards ◽  
The Impact

Background Patients with hepatocellular carcinoma (HCC) represent a vulnerable population potentially negatively affected by COVID-19-associated reallocation of healthcare resources. Here, we report the impact of COVID-19 on the management of HCC patients in a large tertiary care hospital. Methods We retrospectively analyzed clinical data of HCC patients who presented at the Vienna General Hospital, between 01/DEC/2019 and 30/JUN/2020. We compared patient care before (period 1) and after (period 2) implementation of COVID-19-associated healthcare restrictions on 16/MAR/2020. Results Of 126 patients, majority was male (n = 104, 83%) with a mean age of 66±11 years. Half of patients (n = 57, 45%) had impaired liver function (Child-Pugh stage B/C) and 91 (72%) had intermediate-advanced stage HCC (BCLC B-D). New treatment, was initiated in 68 (54%) patients. Number of new HCC diagnoses did not differ between the two periods (n = 14 vs. 14). While personal visits were reduced, an increase in teleconsultation was observed (period 2). Number of patients with visit delays (n = 31 (30%) vs. n = 10 (10%); p = 0.001) and imaging delays (n = 25 (25%) vs. n = 7 (7%); p = 0.001) was higher in period 2. Accordingly, a reduced number of patients was discussed in interdisciplinary tumor boards (lowest number in April (n = 24), compared to a median number of 57 patients during period 1). Median number of elective/non-elective admissions was not different between the periods. One patient contracted COVID-19 with lethal outcome. Conclusions Changes in patient care included reduced personal contacts but increased telephone visits, and delays in diagnostic procedures. The effects on long-term outcome need to be determined.

scholarly journals Pattern of Tumour among Hepatocelluar Carcinoma Patients attended at a Tertiary Care Hospital in Dhaka City

2019 ◽  
Vol 6 (1) ◽  
pp. 6-9
Author(s):  
Md Akter Hossain ◽  
Md Saiful Haque ◽  
Md Ashikur Rahman ◽  
Zinat Nasreen ◽  
Mostaque Ahmed Bhuiya ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Ct Scan ◽  
Tertiary Care Hospital ◽  
Histopathological Examination ◽  
Tertiary Care ◽  
Care Hospital ◽  
Dhaka City ◽  
Hepatocelluar Carcinoma ◽  
Solitary Lesion ◽  
Study Population

Background: The pattern of hepatocelluar carcinoma may vary in different patients. Objective: The purpose of the present study was to see the pattern of hepatocelluar carcinoma among the patients attended at a tertiary care hospital in Dhaka city. Methodology: This cross-sectional study was carried out in the Department of Radiology and Imaging at Dhaka Medical College, Dhaka and Banghabandhu Sheikh Mujib Medical University, Dhaka from January 2007 to May 2008 for a period of around one and half year. All the patients presented with hepatocellular carcinoma at the age group of more than 20 years with both sexes were selected as study population. The patients were undergone CT-scan examination and the confirmation was performed by histopathological examination. The details of the pattern of tumor among the hepatocellular carcinoma patients were examined and were recorded. Result: A total number of 50 patients were recruited in this study after fulfilling the inclusion and exclusion criteria. Mean age with SD of study population was 48.78 ±12.07. Within 25 cases of HCC as diagnosed by CT scan 13(52%) had solitary lesion 7(28%) had multiple lesions and remaining 5(20%) had diffuse lesions. The tumour size of 8 cm or more was the highest which was 10 in numbers. However, 4 to 8 cm was found in 7(28.0%) cases and 3 to 4 cm was detected in 3(12.0%) cases. Conclusion: In conclusion most of the HCC is solitary lesion with more than 8 cm in size. Journal of Current and Advance Medical Research 2019;6(1):6-9

A Retrospective Study on Clinical Characteristics of Hepatocellular Carcinoma in a Tertiary Care Hospital

2011 ◽  
Vol 4 (6) ◽  
pp. 404-405
Author(s):  
Dr.K.Narayanasamy Dr.K.Narayanasamy ◽  
◽  
R.Parvathavarthini R.Parvathavarthini ◽  
Dr.A.Chezhian Dr.A.Chezhian ◽  
Dr.R.Senthil Kumar
Keyword(s):  
Hepatocellular Carcinoma ◽  
Retrospective Study ◽  
Clinical Characteristics ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Care Hospital
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