scholarly journals Juvenile myopia progression, risk factors and interventions

2012 ◽  
Vol 26 (3) ◽  
pp. 293-297 ◽  
Author(s):  
Elliott H. Myrowitz
Keyword(s):  
Risk Factors ◽  
Myopia Progression ◽  
Progression Risk

scholarly journals A multicenter Spanish study of atropine 0.01% in childhood myopia progression

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Inés Pérez-Flores ◽  
Beatríz Macías-Murelaga ◽  
Jesús Barrio-Barrio ◽  
Inés Pérez Flores ◽  
Marta Valcárcel Vizcaíno ◽  
...  
Keyword(s):  
Risk Factors ◽  
Adverse Effects ◽  
Pupil Diameter ◽  
Pediatric Population ◽  
Anterior Chamber Depth ◽  
Eye Drops ◽  
Myopia Progression ◽  
Telephone Consultation ◽  
Progression Risk

AbstractTo evaluate the efficacy and safety of atropine 0.01% eye drops for myopia control in a multicentric pediatric Spanish cohort. An interventional, prospective, multicenter study was designed. Children aged between 6 and 14 years, with myopia between − 2.00 D to − 6.00 D, astigmatism < 1.50 D and documented previous annual progression greater than − 0.5 D (cycloplegic spherical equivalent, SE) were included. Once nightly atropine 0.01% eye drops in each eye were prescribed to all participants for 12 months. Age, gender, ethnicity and iris color were registered. All patients underwent the same follow-up protocol in every center: baseline visit, telephone consultation 2 weeks later and office controls at 4, 8 and 12 months. At each visit, best-corrected visual acuity, and cycloplegic autorefraction were assessed. Axial length (AL), anterior chamber depth and pupil diameter were measured on an IOL Master (Carl Zeiss Meditec, Inc, Dublin, CA). Adverse effects were registered in a specific questionnaire. Mean changes in cycloplegic SE and AL in the 12 months follow-up were analyzed. SE progression during treatment was compared with the SE progression in the year before enrollment for each patient. Correlation between SE and AL, and annual progression distribution were evaluated. Progression risk factors were analyzed by multivariate logistic regression analyses. Of the 105 recruited children, 92 completed the treatment. Mean SE and AL changes were − 0.44 ± 0.41 D and 0.27 ± 0.20 mm respectively. Mean SE progression was lower than the year before treatment (− 0.44 ± 0.41 D versus − 1.01 ± 0.38 D; p < 0.0001). An inverse correlation between SE progression and AL progression (r: − 0.42; p < 0.0001) was found. Fifty-seven patients (62%) had a SE progression less than − 0.50 D. No risk factors associated with progression could be identified in multivariate analyses. Mean pupil diameter increment at 12-months visit was 0.74 ± 1.76 mm. The adverse effects were mild and infrequent, and decreased over the time. Atropine 0.01% is effective and safe for myopia progression control in a multicentric Spanish children cohort. We believe this efficacy might be extensible to the myopic pediatric population from Western countries with similar social and demographic features. More studies about myopia progression risk factors among atropine treated patients are needed.

scholarly journals Validation of the adjusted multi-biomarker disease activity score as a prognostic test for radiographic progression in rheumatoid arthritis: a combined analysis of multiple studies

2021 ◽  
Vol 23 (1) ◽  
Author(s):  
Jeffrey R. Curtis ◽  
Michael E. Weinblatt ◽  
Nancy A. Shadick ◽  
Cecilie H. Brahe ◽  
Mikkel Østergaard ◽  
...  
Keyword(s):  
Risk Factors ◽  
Disease Activity ◽  
Radiographic Progression ◽  
Protein Biomarkers ◽  
Significant Information ◽  
Disease Activity Measure ◽  
Conventional Dmards ◽  
Risk Curve ◽  
Progression Risk ◽  
Clinical Measures

Abstract Background The multi-biomarker disease activity (MBDA) test measures 12 serum protein biomarkers to quantify disease activity in RA patients. A newer version of the MBDA score, adjusted for age, sex, and adiposity, has been validated in two cohorts (OPERA and BRASS) for predicting risk for radiographic progression. We now extend these findings with additional cohorts to further validate the adjusted MBDA score as a predictor of radiographic progression risk and compare its performance with that of other risk factors. Methods Four cohorts were analyzed: the BRASS and Leiden registries and the OPERA and SWEFOT studies (total N = 953). Treatments included conventional DMARDs and anti-TNFs. Associations of radiographic progression (ΔTSS) per year with the adjusted MBDA score, seropositivity, and clinical measures were evaluated using linear and logistic regression. The adjusted MBDA score was (1) validated in Leiden and SWEFOT, (2) compared with other measures in all four cohorts, and (3) used to generate curves for predicting risk of radiographic progression. Results Univariable and bivariable analyses validated the adjusted MBDA score and found it to be the strongest, independent predicator of radiographic progression (ΔTSS > 5) compared with seropositivity (rheumatoid factor and/or anti-CCP), baseline TSS, DAS28-CRP, CRP SJC, or CDAI. Neither DAS28-CRP, CDAI, SJC, nor CRP added significant information to the adjusted MBDA score as a predictor, and the frequency of radiographic progression agreed with the adjusted MBDA score when it was discordant with these measures. The rate of progression (ΔTSS > 5) increased from < 2% in the low (1–29) adjusted MBDA category to 16% in the high (45–100) category. A modeled risk curve indicated that risk increased continuously, exceeding 40% for the highest adjusted MBDA scores. Conclusion The adjusted MBDA score was validated as an RA disease activity measure that is prognostic for radiographic progression. The adjusted MBDA score was a stronger predictor of radiographic progression than conventional risk factors, including seropositivity, and its prognostic ability was not significantly improved by the addition of DAS28-CRP, CRP, SJC, or CDAI.

Prevalence and risk factors of pseudomyopia in a Chinese children population: the Anyang Childhood Eye Study

2020 ◽  
pp. bjophthalmol-2020-316341
Author(s):  
Meng-Tian Kang ◽  
Catherine Jan ◽  
ShiMing Li ◽  
Mayinuer Yusufu ◽  
Xintong Liang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cohort Study ◽  
Independent Risk Factor ◽  
Chinese Children ◽  
Spherical Equivalent ◽  
Market Survey ◽  
Myopia Progression ◽  
School Based ◽  
Near Work ◽  
Myopic Progression

AimsTo investigate the prevalence and predictors of pseudomyopia in Chinese children and its association with myopia progression.MethodsA prospective, school-based, cohort study of 6- and 13-year-old children was conducted in Anyang, China. Pre-cycloplegic and post-cycloplegic autorefraction were performed at baseline and 1 year later. Pseudomyopia was defined as spherical equivalent refractive (SER) error in the better–seeing eye ≤−0.50 D before cycloplegia and >−0.50 D after cycloplegia. Among pseudomyopic children, pseudomyopic power was defined as non-cycloplegic SER subtracted from cycloplegic SER. Market survey was collected in all optometry stores in Anyang city to investigate how cycloplegia is used for refracting children.ResultsA total of 2612 children aged 6 years and 1984 children aged 13 years were included. Of the two cohorts, median cycloplegic SER (IQR) was 1.00 D (0.50, 1.38) and −1.13 D (−2.63, 0.13) respectively, myopia prevalence was 5.2% and 61.0%, pseudomyopia prevalence was 24.1% and 18.9%, and median pseudomyopic power was 1.13 D (0.63, 1.63) and 0.38 D (0.13, 0.88). In both cohorts, greater baseline hyperopia was the strongest predictor of pseudomyopia (p<0.001), whereas time spent on near work was not associated with pseudomyopic power (p>0.05). After 1 year, 15.6% (98/629) of 6-year-olds and 10.7% (40/374) of 13-year-olds with pseudomyopia developed myopia. Compared with myopes, pseudomyopic children with the same pre-cycloplegic SER had slower myopic progression (p<0.001). Among all 127 optometry stores in Anyang, only 4 (3.15%) used cycloplegia for refracting children.ConclusionPseudomyopia is more prevalent in younger, more hyperopic children. Pseudomyopia is not an independent risk factor for myopic progression in this setting.

Risk factors for myopia progression in second-grade primary school children in Taipei: a population-based cohort study

2017 ◽  
Vol 101 (12) ◽  
pp. 1611-1617 ◽  
Author(s):  
Chih-Chien Hsu ◽  
Nicole Huang ◽  
Pei-Yu Lin ◽  
Shao-You Fang ◽  
Der-Chong Tsai ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cohort Study ◽  
Primary School ◽  
School Children ◽  
Population Based ◽  
Primary School Children ◽  
Second Grade ◽  
Myopia Progression

The progression risk factors of children with transfusion-independent non-severe aplastic anemia

2013 ◽  
Vol 97 (2) ◽  
pp. 210-215 ◽  
Author(s):  
Shuchun Wang ◽  
Yumei Chen ◽  
Yao Zou ◽  
Yizhou Zheng ◽  
Xiaofan Zhu
Keyword(s):  
Risk Factors ◽  
Aplastic Anemia ◽  
Severe Aplastic Anemia ◽  
Progression Risk

scholarly journals Natural variability in the disease course of SSc-ILD: implications for treatment

2021 ◽  
Vol 30 (159) ◽  
pp. 200340
Author(s):  
Madelon C. Vonk ◽  
Ulrich A. Walker ◽  
Elizabeth R. Volkmann ◽  
Michael Kreuter ◽  
Sindhu R. Johnson ◽  
...  
Keyword(s):  
Risk Factors ◽  
Topoisomerase I ◽  
Vital Capacity ◽  
Predictive Power ◽  
Risk Scores ◽  
Disease Course ◽  
Progression Risk ◽  
Composite Risk ◽  
Using Data ◽  
Insight Into

Interstitial lung disease (ILD) affects approximately 50% of patients with systemic sclerosis (SSc) and is the leading cause of death in SSc. Our objective was to gain insight into the progression of SSc-associated ILD (SSc-ILD). Using data from longitudinal clinical trials and observational studies, we assessed definitions and patterns of progression, risk factors for progression, and implications for treatment. SSc-ILD progression was commonly defined as exceeding specific thresholds of lung function worsening and/or increasing radiographic involvement. One definition used in several studies is decline in forced vital capacity (FVC) of ≥10%, or ≥5–10% plus a decline in diffusing capacity of the lung for carbon monoxide ≥15%. Based on these criteria, 20–30% of patients in observational cohorts develop progressive ILD, starting early in the disease course and progressing at a highly variable rate.Risk factors such as age, FVC, extent of fibrosis and presence of anti-topoisomerase I antibodies can help predict progression of SSc-ILD, though composite risk scores may offer greater predictive power. Whilst the variability of the disease course in SSc-ILD makes risk stratification of patients challenging, the decision to initiate, change or stop treatment should be based on a combination of the current disease state and the speed of progression.

scholarly journals Progression & risk factors CKD 1-5 (2)

2011 ◽  
Vol 4 (suppl 2) ◽  
pp. 4.s2.47-4.s2.47
Author(s):  
I. Bouba ◽  
C. Bountouri ◽  
E. Dounousi ◽  
V. Kiatou ◽  
I. Georgiou ◽  
...  
Keyword(s):  
Risk Factors ◽  
Progression Risk

scholarly journals Generational Difference of Axial Length and Its Risk Factors in Urban and Rural China

2019 ◽  
Vol 2019 ◽  
pp. 1-7 ◽  
Author(s):  
Zhong Lin ◽  
Balamurali Vasudevan ◽  
Kenneth J Ciuffreda ◽  
Tie Ying Gao ◽  
Hong Jia Zhou ◽  
...  
Keyword(s):  
Risk Factors ◽  
Axial Length ◽  
Rural Areas ◽  
Rural China ◽  
Chinese Children ◽  
Older Children ◽  
Myopia Progression ◽  
Multivariable Regression ◽  
The Difference ◽  
Urban And Rural Areas

Purpose. To compare the axial length difference (ALD) and the estimated generational axial length shift (ALS) from parents to their children and its risk factors in urban and rural China. Methods. Participants were enrolled from two longitudinal cohort studies, the Beijing Myopia Progression Study (BMPS) and the Handan Offspring Myopia Study (HOMS). Ocular biometry was performed in both parents and their children. ALD was defined as the difference between the children’s axial length and the corresponding parental axial length. Generational ALS was estimated according to a binominal prediction model at 18 years of age. Results. 237 and 380 urban and rural Chinese children (6–17 years) and their parents from the BMPS and HOMS, respectively, were enrolled. Children’s axial length was estimated to be closest to the parental axial length at 11 and 9 years of age in the urban and rural areas, respectively; the estimated generational ALS would be 1.53 and 0.57 mm, respectively. Multivariable regression analysis revealed that older children (urban β = 0.26, p<0.001; rural β = 0.11, p<0.001) and males had larger ALD (urban β = 0.55, p<0.001; rural β = 0.52, p<0.001) in both areas. Furthermore, urban children with more educated parents (fathers: β = −0.30, p=0.002; mothers: β = −0.29, p=0.004) and more outdoor activity (β = −0.23, p=0.006) had a less ALD. Conclusions. The urban generational axial length shift was estimated to be approximately 1 mm longer than that of the rural area. These results suggest different environmental effects on the ocular development in these two populations of Chinese children.

Computer Usage and Myopia Progression: An Evidence Based Case Report

2018 ◽  
Vol 24 (8) ◽  
pp. 6073-6076
Author(s):  
Rebecca Octavia Fransisca ◽  
Dhanasari Vidiawati
Keyword(s):  
Computer Usage ◽  
Evidence Based ◽  
Video Display ◽  
Myopia Progression ◽  
Video Display Terminals ◽  
Technology Advancement ◽  
Computer Vision Syndrome ◽  
Progression Risk ◽  
Abstract Screening ◽  
Near Work

As the technology advancement, we tend to work more using computer or another video display terminals (VDT). VDT usage often causes eyes problems (computer vision syndrome) or even refractive errors. This study aims to evaluate computer or VDT exposure as prognostic factor in myopia regression among young adults. Literature review method using medical journal is conducted through three databases (PubMed, Cochrane, and Ebsco). Keywords used are myopia, myopia progression, computer, and job (including their synonyms). Thirty-two articles were collected. Through title and abstract screening, filtering doubles, and exclusion, only three articles that can be critically appraised. Based on these articles, myopia progression proportion among the population is around 10,5% with myopia progression risk around −0,16 D annually. Myopia progression predictor factor is near work (along with computer and VDT usage). Myopia progression is related with near work notably computer usage. Thus, near work exposure should be decreased to prevent myopia progression.

Sign in / Sign up

Export Citation Format

Share Document