Eu3+-Induced Polysaccharide Nano-Dumbbell Aggregates (PNDA) as Drug Carriers to Smartly Report Drug Concentration through Variable Fluorescence

2021 ◽  
pp. 129724
Author(s):  
Zhengxing Song ◽  
Jing Wang ◽  
Jing Wang ◽  
Jin Liu ◽  
Xinzhi Wang ◽  
...  
Keyword(s):  
Drug Concentration ◽  
Drug Carriers ◽  
Variable Fluorescence

scholarly journals Understanding Surface Interaction and Inclusion Complexes between Piroxicam and Native or Crosslinked β-Cyclodextrins: The Role of Drug Concentration

Molecules ◽  
2020 ◽  
Vol 25 (12) ◽  
pp. 2848 ◽  
Author(s):  
Giuseppina Raffaini ◽  
Fabio Ganazzoli
Keyword(s):  
Inclusion Complexes ◽  
Drug Concentration ◽  
A Priori ◽  
Drug Carriers ◽  
Release Process ◽  
Drug Molecules ◽  
Molecular Dynamics Methods ◽  
Kinetics Of ◽  
Good Agreement

Drug concentration plays an important role in the interaction with drug carriers affecting the kinetics of release process and toxicology effects. Cyclodextrins (CDs) can solubilize hydrophobic drugs in water enhancing their bioavailability. In this theoretical study based on molecular mechanics and molecular dynamics methods, the interactions between β-cyclodextrin and piroxicam, an important nonsteroidal anti-inflammatory drug, were investigated. At first, both host–guest complexes with native β-CD in the 1:1 and in 2:1 stoichiometry were considered without assuming any initial a priori inclusion: the resulting inclusion complexes were in good agreement with literature NMR data. The interaction between piroxicam and a β-CD nanosponge (NS) was then modeled at different concentrations. Two inclusion mechanisms were found. Moreover, piroxicam can interact with the external NS surface or with its crosslinkers, also forming one nanopore. At larger concentration, a nucleation process of drug aggregation induced by the first layer of adsorbed piroxicam molecules is observed. The flexibility of crosslinked β-CDs, which may be swollen or quite compact, changing the surface area accessible to drug molecules, and the dimension of the aggregate nucleated on the NS surface are important factors possibly affecting the kinetics of release, which shall be theoretically studied in more detail at specific concentrations.

Stimuli-Responsive Capsule Membranes for Controlled Release in Pharmaceutical Applications

2017 ◽  
Vol 23 (2) ◽  
pp. 295-301 ◽  
Author(s):  
Zhuang Liu ◽  
Xiao-Jie Ju ◽  
Wei Wang ◽  
Rui Xie ◽  
Lu Jiang ◽  
...  
Keyword(s):  
Controlled Release ◽  
Drug Concentration ◽  
Drug Carriers ◽  
Burst Release ◽  
Stimuli Responsive ◽  
Pharmaceutical Applications ◽  
Conventional Drug ◽  
Controllable Release ◽  
Capsule Size

Background: In conventional drug delivery, the drug concentration in the blood raises once the drug taken, and then peaks and declines. Since each drug has a level above which it is toxic and another level below which it is ineffective, the drug concentration in a patient at a particular time depends on compliance with the prescribed routine. Methods: To achieve more effective efficacy and fewer side effects of drugs, the drug carriers with desirable dosing and controllable release property of drugs are highly desired. Stimuli-responsive capsules with smart gating membranes or hydrogel-based membranes as capsule shells are ideal candidates. The smart capsule membranes enable efficient encapsulation of drugs within the large inner volume, and the responsive gating membranes or hydrogel-based membranes could control the release rate of encapsulated drugs in responding to environmental stimuli. The trigger stimuli could be either artificial or natural ones corresponding to specific diseases, such as temperature, pH, glucose concentration, specific ion, light, and magnetic field. Results: This review highlights the recent development in stimuli-responsive capsule membranes for controlled release in pharmaceutical applications, including two types of stimuli-responsive capsule membranes with different architectures for on/off release and burst release, which can achieve potential uses of case-dependent on/off release and burst release. Conclusion: The preponderances of the smart capsule membranes are that the capsules are with controllable inner space for drug vehicles with desired dose and stimuli-responsive membrane as shell to release drugs at a desired site and/or moment. However, the actual difficulties for the stimuli-responsive capsule membrane systems to go before they can be applied widely in the biomedical fields are discussed. The future works should focus on the improvements of biocompatibility, biodegradability and stimuli-responsiveness of the capsule membranes, easy and scalable fabrication techniques with further decrease of the capsule size for more efficient in vivo applications, and the diversification of the multi-compartmental capsule architectures with multi-stimuli-responsive characteristics for controlled release.

Physicochemical Characterization of Solid Dispersions of Cefdinir with PVP K-30 and PEG 4000

2010 ◽  
Vol 3 (2) ◽  
pp. 948-956
Author(s):  
Kumar P ◽  
S Kumar ◽  
A Kumar ◽  
M Chander
Keyword(s):  
Solid Dispersions ◽  
Physicochemical Characterization ◽  
Drug Carriers ◽  
Dissolution Properties ◽  
Rate Of Dissolution ◽  
Peg 4000 ◽  
Release Studies ◽  
Crystalline Nature ◽  
Physical Mixtures

The purpose of this study was to prepare and characterize solid dispersions of the antibacterial agent Cefdinir with PEG 4000 and PVP K-30 with a view to improve its dissolution properties. Investigations of the properties of the dispersions were performed using release studies, X-ray powder diffraction (XRD) and Fourier transform infrared (FTIR). The results obtained showed that the rate of dissolution of Cefdinir was considerably improved when formulated in solid dispersions with PVP K-30 and PEG 4000 as compared with pure drug and physical mixtures. The results from XRD studies showed the transition of crystalline nature of drug to amorphous form, while FTIR studies demonstrated the absence of drug-carriers interaction.

Optimization of Gold Nanoparticles Synthesis using Design of Experiments Technique

2017 ◽  
Vol 68 (7) ◽  
pp. 1518-1423
Author(s):  
Adina Turcu Stiolica ◽  
Mariana Popescu ◽  
Maria Viorica Bubulica ◽  
Carmen Nicoleta Oancea ◽  
Claudiu Nicolicescu ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Zeta Potential ◽  
Design Of Experiments ◽  
Process Model ◽  
Sodium Citrate ◽  
Drug Carriers ◽  
Chloroauric Acid ◽  
Gold Colloids ◽  
Citrate Concentration ◽  
Vis Spectroscopy

Gold nanoparticles are considered the newest drug carriers for different diseases. Therefore it is appropriate continuous optimization of their preparation. In this study, gold colloids with an average size of 1 - 26 nm were obtained by the reduction of tetrachloroauric acid with trisodium citrate. The nanomaterials were characterized by UV-Vis spectroscopy and dynamic light scattering technique. In addition, zeta potential was measured for samples synthesized in order to determine the stability of the colloids. A Two-level Full Factorial design was chosen to determine the optimum set of process parameters (chloroauric acid concentration and sodium citrate concentration) and their effect on various gold nanoparticles characteristics (size and zeta potential). These effects were quantified using Design of Experiments (DoE) with 5 runs and 1 centerpoint. The selected objective and process model in this investigation are screening and interaction. Findings from this research show that to obtain particles larger than 35 nm, it is recommended to increase sodium citrate concentration, at low chloroauric acid values. These conditions will help to achieve smaller zeta potential, too.

Multimodality CT/SPECT Evaluation of Micelle Drug Carriers for Treatment of Breast Tumors

2008 ◽  
Author(s):  
Elvin Blanco ◽  
Brent D. Weinberg ◽  
Jinming Gao
Keyword(s):  
Breast Tumors ◽  
Drug Carriers

Recent Advances on Glioblastoma Multiforme and Nano-drug Carriers: A Review

2019 ◽  
Vol 26 (31) ◽  
pp. 5862-5874 ◽  
Author(s):  
Wang Liao ◽  
Shengnuo Fan ◽  
Yuqiu Zheng ◽  
Shaowei Liao ◽  
Ying Xiong ◽  
...  
Keyword(s):  
Stem Cells ◽  
Glioblastoma Multiforme ◽  
Self Assembly ◽  
Poor Prognosis ◽  
Drug Delivery Systems ◽  
Drug Carriers ◽  
Therapeutic Resistance ◽  
Average Survival ◽  
Nano Drug Delivery ◽  
New Development

Glioblastoma Multiforme (GBM) is the most frequent glioma with a poor prognosis. The mainstay treatment for GBM is chemotherapy, but the average survival of GBM remains unsatisfactory due to therapeutic resistance. Poor permeability restricted by the Blood Brain Barrier (BBB) and the presence of Glioblastoma Stem Cells (GSCs) remain as two problems for chemotherapy. Recently, nanocarriers have attracted much attention in the research of GBM, owing to their advantages in self-assembly, biosafety, release controllability, and BBB penetrability, making them promising candidates for GBM treatment. This article aims to review the biologic signatures of BBB and GSCs, as well as the new development of nano-drug delivery systems to facilitate our understanding of targeted treatment for GBM.

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