Microwave (MW) promoted high yield expedient synthesis of steryl ferulates – A class of novel biologically active compounds: A comparative study of their antioxidant activity with that of naturally occurring γ-oryzanol

Steroids ◽  
2016 ◽  
Vol 107 ◽  
pp. 37-44 ◽  
Author(s):  
Ashma Begum ◽  
Preetismita Borah ◽  
Pritish Chowdhury
Keyword(s):  
Antioxidant Activity ◽  
Comparative Study ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
High Yield ◽  
Active Compounds ◽  
Naturally Occurring ◽  
Steryl Ferulates

scholarly journals The bio-flavanoid concentrate of Vitis vinifera L. ‘Red Aladasturi’

2019 ◽  
pp. 91-102
Author(s):  
Roland Kopaliani ◽  
Temur Gvinianidze ◽  
Rezo Jabnidze
Keyword(s):  
Antioxidant Activity ◽  
Moisture Content ◽  
Vitis Vinifera ◽  
Raw Materials ◽  
Initial Moisture Content ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Vitis Vinifera L ◽  
Hammer Mill ◽  
Active Compounds

This paper dwells on the uvological characteristics of cultivar Vitis vinifera L. ‘Red Aladasturi’ grape raw materials growing in the viticulture and winemaking zone of Imereti (Georgia), as well as biologically active compounds and antioxidant activity of hydrophilic extracts and liquid concentrates of its solid matters (stone and skin). Research also covered hydrophilic extracts of grape skin and stone thickened by the vacuum of ‘Red Aladasturi’ grapes raw materials, as well as the concentrates produced from their composition. For research, there were used gravimetric, extractive, spectral and chromatographic methods. We processed samples of grapes raw materials according to the following pattern: identifying qualitative indicators of grapes raw materials; passing grapes raw materials through the DMCSI-type grape clustercomb divider; pressing-out the combless must in a basket press and separation of juice; vacuum sublimation drying of juiceless sweet pomace with an initial moisture content of 45–65% to a final moisture content of 9–10%; separation of the ‘Red Aladasturi’ cultivar’s skin and stone dried to the moisture content of 9–10%, using tea sorting machine designed by G. Lominadze; crushing separately the skin and stone in a micro-mill (TP2 Hammer Mill) until the fraction of 50–100 µm. we have blended the obtained grape-stone ethanol and fluid extracts containing 74–75% of solid maters at an equal ratio (1:1:1) and assessed biologically active compounds and antioxidant activity in this composition. It has been established that the bio-flavanoid liquid concentrate ‘Red Aladasturi’ is strong antioxidant  (55.31–57.45%), and one tablespoon or 8–9 ml of it contains 110–127 mg of flavanoids, which is 105–110% of a full day of rations per person per day.

scholarly journals Biologically Active Compounds and Antioxidant Activity of the Plants from CSBG SB RAS Collection of the Asteraceae Family

2021 ◽  
Vol 38 ◽  
pp. 00055
Author(s):  
Elena Khramova ◽  
Tatyana Kukushkina ◽  
Tatyana Shaldaeva ◽  
Yuliya Pshenichkina
Keyword(s):  
Antioxidant Activity ◽  
Phenolic Compounds ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Achillea Millefolium ◽  
Artemisia Absinthium ◽  
Tanacetum Vulgare ◽  
Active Compounds ◽  
Artemisia Dracunculus ◽  
Pectin Substances

The article presents Data on the content of biologically active compounds (BAC) and the total phenolic antioxidants activity (TPA) evaluated for leaves and inflorescences of Achillea millefolium, Anthemis tinctoria, Artemisia absinthium, A. dracunculus, Leucanthemum vulgare, Pyrethrum balsamita, P. macrophyllum, Tanacetum vulgare. The leaves and inflorescences of the plants contain flavonols, catechins, tannins, carotenoids, pectin substances. High content of phenolic compounds was found in Artemisia dracunculus and Achillea millefolium (352.34 – 398.99 mg/g of DW). The highest level of catechins was registered in inflorescences (8.01 mg/g) and leaves (4.58 mg/g) of Artemisia absinthium. The content of pectin substances in the studied plants was quite high, with the biggest share of protopectins (50.6 – 95.9 mg/g). The maximum quantity of pectins was found in the leaves and inflorescences of Leucanthemum vulgare (11.2-12.7 mg/g), protopectins – in the leaves of Tanacetum vulgare (95.9 mg/g). The highest content of carotenoids was found in the leaves of plants, except for Leucanthemum vulgare. The highest antioxidant activity was recorded for water-ethanol extracts from leaves of Achillea millefolium (up to 1.09 mg/g) and inflorescences of Artemisia dracunculus (0.94 mg/g) plants due to the increased content of phenolic compounds, in particular flavonols and tannins, compared to the other species.

scholarly journals Biologically Active Compounds and Antioxidant Activity of the Plants from CSBG SB RAS Collection of the Rosaceae Family (I)

2020 ◽  
Vol 24 ◽  
pp. 00035
Author(s):  
Elena Khramova ◽  
Tatyana Kukushkina ◽  
Tatyana Shaldaeva ◽  
Yuliya Pshenichkina ◽  
Galina Vysochina
Keyword(s):  
Antioxidant Activity ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Total Phenolic ◽  
Phenolic Antioxidants ◽  
Active Compounds ◽  
Antioxidants Activity ◽  
Rosaceae Family ◽  
Sanguisorba Officinalis ◽  
Pectin Substances

The article presents Dara on the content of biologically active compounds (BAC) and the total phenolic antioxidants activity (TPA) evaluated for leaves and inflorescences of eight species from the Rosaceae family: Padus avium, Malus baccata, Alhemilla vulgaris, Potentilla inquinans, Filipendula vulgaris, F. palmata, Sanguisorba officinalis, S. alpina. It was determined that leaves and inflorescences contain flavonols, catechins, tannins, carotenoids, saponins, pectin substances. Usually, woody plants tend to accumulate less BAC and TPA than herbs. The highest level of flavonols and tannins was registered in inflorescences of F. vulgaris (12.25% and 45.02 %). The content of pectin substances was quite high, with the biggest share of protopectins (4.4-10.65%). The maximum quantity of catechins (4.76%) was found in the leaves of F. palmata, saponins – in the inflorescences of M. baccata (20.77%). The highest content of carotenoids was found in the leaves of plants, most notably in P. inquinans (1.00 mg/g). The highest antioxidant activity was recorded for water-ethanol extracts from inflorescences (up to 7.77 mg/g) and leaves (2.11 mg/g) of F. vulgaris and A. vulgaris plants due to increased content of phenolic compounds, in particular flavonols and tannins, compared to the other species.

scholarly journals Chirospecific synthesis: Catalysis and chiral pool hand in hand

2011 ◽  
Vol 83 (3) ◽  
pp. 435-443 ◽  
Author(s):  
Ari M. P. Koskinen
Keyword(s):  
Amino Acids ◽  
Natural Products ◽  
Chemical Synthesis ◽  
New Technologies ◽  
Amino Alcohols ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
New Techniques ◽  
Active Compounds ◽  
Naturally Occurring

Nature provides us with a wonderful pool of enantiopure starting materials for synthesis: amino acids, sugars, and many (but not all!) terpenes can be isolated even in large quantities in an uncompromised 100 % ee. Vicinal amino alcohols constitute a versatile group of organic structures; they are, in principle, available in enantiopure form from the chiral pool compounds or through chiral catalysis; they are potent intermediates for the synthesis of natural products and medicinally/biologically active compounds, and they provide a highly desirable scaffold for the construction of ligands for metals as well as organocatalysts. These new techniques will open up valuable new possibilities for the invention of new technologies for chemical synthesis, the desired course of chemical discoveries for the future. A robust entry to enantiopure vicinal amino alcohols from inexpensive naturally occurring amino acids has therefore become a key challenge for our endeavors in the development of methodology.

scholarly journals Palladium- and copper-mediated N-aryl bond formation reactions for the synthesis of biological active compounds

2011 ◽  
Vol 7 ◽  
pp. 59-74 ◽  
Author(s):  
Carolin Fischer ◽  
Burkhard Koenig
Keyword(s):  
Large Scale ◽  
Standard Procedure ◽  
Bond Formation ◽  
Reaction Times ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
High Yield ◽  
Active Compounds ◽  
Advantages And Disadvantages ◽  
Ring Structures

N-Arylated aliphatic and aromatic amines are important substituents in many biologically active compounds. In the last few years, transition-metal-mediated N-aryl bond formation has become a standard procedure for the introduction of amines into aromatic systems. While N-arylation of simple aromatic halides by simple amines works with many of the described methods in high yield, the reactions may require detailed optimization if applied to the synthesis of complex molecules with additional functional groups, such as natural products or drugs. We discuss and compare in this review the three main N-arylation methods in their application to the synthesis of biologically active compounds: Palladium-catalysed Buchwald–Hartwig-type reactions, copper-mediated Ullmann-type and Chan–Lam-type N-arylation reactions. The discussed examples show that palladium-catalysed reactions are favoured for large-scale applications and tolerate sterically demanding substituents on the coupling partners better than Chan–Lam reactions. Chan–Lam N-arylations are particularly mild and do not require additional ligands, which facilitates the work-up. However, reaction times can be very long. Ullmann- and Buchwald–Hartwig-type methods have been used in intramolecular reactions, giving access to complex ring structures. All three N-arylation methods have specific advantages and disadvantages that should be considered when selecting the reaction conditions for a desired C–N bond formation in the course of a total synthesis or drug synthesis.

scholarly journals Effect of Hormonization Treatment on Yield Quantity and Quality, Contents of Biologically Active Compounds, and Antioxidant Activity in ‘Einset Seedless’ Grapevine Fruits and Raisins

Molecules ◽  
2021 ◽  
Vol 26 (20) ◽  
pp. 6206
Author(s):  
Magdalena Kapłan ◽  
Kamila Klimek ◽  
Ewa Jabłońska-Ryś ◽  
Aneta Sławińska ◽  
Anna Stój
Keyword(s):  
Antioxidant Activity ◽  
Life Sciences ◽  
Field Studies ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Active Compounds ◽  
Analysis Technique ◽  
Effect On Yield ◽  
The University ◽  
Food Dryer

In this study, we determined the effect of hormonization treatment on yield quantity and quality, content of biologically active compounds, and antioxidant activity in fruits and raisins of ‘Einset Seedless’ grapevine. Field studies were conducted in 2017 at Nobilis Vineyard (50°39′ N; 21°34′ E) in the Sandomierz Upland. Analytical studies were carried out in the Laboratory of the University of Life Sciences in Lublin. Hormonized fruits and raisins, which were dried at 40 °C in a food dryer for 7 days, were the experimental material. It was shown that the application of the hormonization treatment had a significant effect on yield size and quality. The hormonization treatment and the form of plant material analyzed had a significant effect on the content of biologically active compounds and the antioxidant activity in ‘Einset Seedless’ grapevine fruits and raisins. The concentration of applied gibberellic acid had a significant effect on the levels of acidity, content of anthocyanins, and antioxidant activity determined with the FRAP and DPPH methods. The application of the multivariate analysis technique showed that, in the fresh fruits and raisins, the level of biologically active compounds and antioxidant activity in the case of the 200 mg∙GA3∙L−1 concentration and in the control combination was similar but differed significantly in the case of the 300 mg∙GA3∙L−1 application.

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