Antimicrobial tanzawaic acid derivatives from the endophytic Penicillium citrinum BCC71086

Tetrahedron ◽  
2022 ◽  
pp. 132645
Author(s):  
Aibrohim Dramae ◽  
Chakapong Intaraudom ◽  
Nantiya Bunbamrung ◽  
Nattawut Boonyuen ◽  
Patchanee Auncharoen ◽  
...  
Keyword(s):  
Penicillium Citrinum

scholarly journals Rare Chromone Derivatives from the Marine-Derived Penicillium citrinum with Anti-Cancer and Anti-Inflammatory Activities

Marine Drugs ◽  
2021 ◽  
Vol 19 (1) ◽  
pp. 25
Author(s):  
Yi-Cheng Chu ◽  
Chun-Hao Chang ◽  
Hsiang-Ruei Liao ◽  
Ming-Jen Cheng ◽  
Ming-Der Wu ◽  
...  
Keyword(s):  
A549 Cells ◽  
Penicillium Citrinum ◽  
Signaling Cascades ◽  
Human Neutrophils ◽  
Cytotoxic Activities ◽  
Western Blot Assay ◽  
Chromone Derivatives ◽  
Anti Cancer ◽  
Ic50 Values ◽  
Induced Apoptosis

Three new and rare chromone derivatives, epiremisporine C (1), epiremisporine D (2), and epiremisporine E (3), were isolated from marine-derived Penicillium citrinum, together with four known compounds, epiremisporine B (4), penicitrinone A (5), 8-hydroxy-1-methoxycarbonyl-6-methylxanthone (6), and isoconiochaetone C (7). Among the isolated compounds, compounds 2–5 significantly decreased fMLP-induced superoxide anion generation by human neutrophils, with IC50 values of 6.39 ± 0.40, 8.28 ± 0.29, 3.62 ± 0.61, and 2.67 ± 0.10 μM, respectively. Compounds 3 and 4 exhibited cytotoxic activities with IC50 values of 43.82 ± 6.33 and 32.29 ± 4.83 μM, respectively, against non-small lung cancer cell (A549), and Western blot assay confirmed that compounds 3 and 4 markedly induced apoptosis of A549 cells, through Bcl-2, Bax, and caspase 3 signaling cascades.

scholarly journals Gut mycobiota alterations in patients with COVID-19 and H1N1 infections and their associations with clinical features

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Longxian Lv ◽  
Silan Gu ◽  
Huiyong Jiang ◽  
Ren Yan ◽  
Yanfei Chen ◽  
...  
Keyword(s):  
Clinical Features ◽  
Internal Transcribed Spacer ◽  
Candida Glabrata ◽  
Penicillium Citrinum ◽  
Medical Attention ◽  
C Reactive Protein ◽  
Fungal Burden ◽  
Reactive Protein ◽  
Bacterial Microbiota ◽  
The Relationship

AbstractThe relationship between gut microbes and COVID-19 or H1N1 infections is not fully understood. Here, we compared the gut mycobiota of 67 COVID-19 patients, 35 H1N1-infected patients and 48 healthy controls (HCs) using internal transcribed spacer (ITS) 3-ITS4 sequencing and analysed their associations with clinical features and the bacterial microbiota. Compared to HCs, the fungal burden was higher. Fungal mycobiota dysbiosis in both COVID-19 and H1N1-infected patients was mainly characterized by the depletion of fungi such as Aspergillus and Penicillium, but several fungi, including Candida glabrata, were enriched in H1N1-infected patients. The gut mycobiota profiles in COVID-19 patients with mild and severe symptoms were similar. Hospitalization had no apparent additional effects. In COVID-19 patients, Mucoromycota was positively correlated with Fusicatenibacter, Aspergillus niger was positively correlated with diarrhoea, and Penicillium citrinum was negatively correlated with C-reactive protein (CRP). In H1N1-infected patients, Aspergillus penicilloides was positively correlated with Lachnospiraceae members, Aspergillus was positively correlated with CRP, and Mucoromycota was negatively correlated with procalcitonin. Therefore, gut mycobiota dysbiosis occurs in both COVID-19 patients and H1N1-infected patients and does not improve until the patients are discharged and no longer require medical attention.

scholarly journals Specificity of a New Metalloproteinase from Penicillium citrinum.

1991 ◽  
Vol 55 (8) ◽  
pp. 2191-2193 ◽  
Author(s):  
Eiji ICHISHIMA ◽  
Megumi YAMAGUCHI ◽  
Hiroshi YANO ◽  
Youhei YAMAGATA ◽  
Ken-ichi HIRANO
Keyword(s):  
Penicillium Citrinum

Mutation breeding of nuclease p1 production in Penicillium citrinum by low-energy ion beam implantation

2011 ◽  
Vol 28 (2) ◽  
pp. 544-549 ◽  
Author(s):  
Qinting He ◽  
Nan Li ◽  
Xiaochun Chen ◽  
Qi Ye ◽  
Jianxin Bai ◽  
...  
Keyword(s):  
Ion Beam ◽  
Mutation Breeding ◽  
Penicillium Citrinum ◽  
Low Energy ◽  
Nuclease P1 ◽  
Ion Beam Implantation

Enhancement of nuclease P1 production by Penicillium citrinum YL104 immobilized on activated carbon filter sponge

2014 ◽  
Vol 99 (3) ◽  
pp. 1145-1153 ◽  
Author(s):  
Nan Zhao ◽  
Hengfei Ren ◽  
Zhenjian Li ◽  
Ting Zhao ◽  
Xinchi Shi ◽  
...  
Keyword(s):  
Activated Carbon ◽  
Penicillium Citrinum ◽  
Nuclease P1 ◽  
Activated Carbon Filter ◽  
Carbon Filter
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