Aluminium-induced changes in hemato-biochemical parameters, lipid peroxidation and enzyme activities of male rabbits: protective role of ascorbic acid

Toxicology ◽  
2004 ◽  
Vol 199 (1) ◽  
pp. 47-57 ◽  
Author(s):  
Mokhtar I Yousef
2014 ◽  
Vol 66 (3) ◽  
pp. 1271-1279 ◽  
Author(s):  
Jelena Mladenovic ◽  
Milica Paunovic ◽  
Milos Matic ◽  
Veroljub Knezevic ◽  
Branka Ognjanovic ◽  
...  

The effects of subchronic exposure to copper (Cu) on lipid peroxidation, hemato-biochemical parameters, and the possible protective role of flavonoids Quercetin and (-)-Epicatechin were studied. Male Wistar albino rats were treated with Cu (560 mg/L, p.o. as CuCl2?2H2O for 5 weeks) and Quercetin and (-)-Epicatechin (40 mg/kg BW each, i.p., every third day during the last 3 weeks) alone or in combination. Cu increased the concentration of lipid peroxides, decreased the number of erythrocytes, hemoglobin and hematocrit values and increased the activities of aspartate aminotransferase, alanine aminotransferase and lactate dehydrogenase. Coadministration of Quercetin and (-)-Epicatechin with Cu lowered the process of lipid peroxidation and restored examined hemato-biochemical parameters to control values. Our results indicate that Cu induced oxidative damage in erythrocytes, which led to anemia, while Quercetin and (-)-Epicatechin showed a protective effect on the hemato-biochemical processes in the blood of rats.


1992 ◽  
Vol 111 (1-2) ◽  
Author(s):  
Sunil Chakrabarty ◽  
Anuradha Nandi ◽  
ChinmayK. Mukhopadhyay ◽  
InduB. Chatterjee

2010 ◽  
Vol 48 (7) ◽  
pp. 1806-1810 ◽  
Author(s):  
Ebru Çetin ◽  
Murat Kanbur ◽  
Sibel Silici ◽  
Gökhan Eraslan

2010 ◽  
Vol 92 (5) ◽  
pp. 947-953 ◽  
Author(s):  
Rajinder Raina ◽  
Pawan K. Verma ◽  
Nrip K. Pankaj ◽  
Vinay Kant ◽  
Shahid Prawez

2009 ◽  
Vol 30 (11) ◽  
pp. 1205-1214 ◽  
Author(s):  
Zafer Türkmen ◽  
Kültiğin Çavuşoğlu ◽  
Kürşat Çavuşoğlu ◽  
Kürşad Yapar ◽  
Emine Yalçin

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