Safety of the 2011–12, 2012–13, and 2013–14 seasonal influenza vaccines in pregnancy: Preterm delivery and specific malformations, a study from the case-control arm of VAMPSS

Background: With possible resurgence of the SARS-CoV-2 and low seasonal influenza virus circulation next winter, reviewing evidence on a possible interaction between influenza vaccination and COVID-19 risk is important. Objective: To review studies on the effect of influenza vaccines on non-influenza respiratory disease (NIRD). Methods: Using different search strategies, 18 relevant studies were identified and their strength, limitations and significance were assessed. Results: Analysis of 4 RCT datasets did not suggest increased NIRD risk in recipients of live-attenuated vaccines (LAIV) and results of a cohort study suggested short-term protection consistent with the hypothesis of trained immunity. One RCT, four cohort studies and one test-negative case-control suggested increased NIRD risk in recipients of inactivated influenza vaccines (IIV), whereas five test-negative case-control studies did not show an increased risk associated with a specific viral pathogen. Cross-protection against COVID-19 was suggested in one cross-sectional study on IIV but major biases could not be excluded. Results of four recent ecological studies on COVID-19 were challenging to interpret. Conclusions: Available data on LAIV are reassuring but not all those on IIV. A drastic reorientation of 2020-2021 influenza campaigns is probably not warranted but studies aiming to test COVID-19 risk modification among recipients of seasonal influenza vaccines should be planned and funded.

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Effectiveness of Seasonal Influenza Vaccines against Influenza-Associated Illnesses among US Military Personnel in 2010–11: A Case-Control Approach

PLoS ONE ◽

10.1371/journal.pone.0041435 ◽

2012 ◽

Vol 7 (7) ◽

pp. e41435 ◽

Cited By ~ 19

Author(s):

Angelia A. Eick-Cost ◽

Katie J. Tastad ◽

Alicia C. Guerrero ◽

Matthew C. Johns ◽

Seung-eun Lee ◽

...

Keyword(s):

Military Personnel ◽

Seasonal Influenza ◽

Case Control ◽

Influenza Vaccines ◽

Control Approach ◽

Us Military

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B Cell and Antibody Response to Seasonal Influenza Vaccines in Younger and Older Adults

Case Medical Research ◽

10.31525/ct1-nct04101838 ◽

2019 ◽

Author(s):

Keyword(s):

Older Adults ◽

Antibody Response ◽

B Cell ◽

Seasonal Influenza ◽

Influenza Vaccines

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Evaluating the Effectiveness of Influenza Vaccine in People With At-Risk Medical Conditions: A Test-Negative Design Case-Control Study for the Seasonal Influenza Vaccine Effectiveness II (SIVE II) Project

SSRN Electronic Journal ◽

10.2139/ssrn.3716865 ◽

2020 ◽

Author(s):

Eleftheria Vasileiou ◽

Tanya Englishby ◽

Kimberley Kavanagh ◽

Chris Robertson ◽

Nazir Lone ◽

...

Keyword(s):

At Risk ◽

Influenza Vaccine ◽

Seasonal Influenza ◽

Case Control Study ◽

Case Control ◽

Vaccine Effectiveness ◽

Medical Conditions ◽

Seasonal Influenza Vaccine ◽

Design Case ◽

Control Study

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Urinary total arsenic and arsenic methylation capacity in pregnancy and gestational diabetes mellitus: A case-control study

Chemosphere ◽

10.1016/j.chemosphere.2021.129828 ◽

2021 ◽

Vol 271 ◽

pp. 129828

Author(s):

Wei-Jen Chen ◽

Erin M. Davis ◽

Julie A. Stoner ◽

Candace Robledo ◽

Jean R. Goodman ◽

...

Keyword(s):

Diabetes Mellitus ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Case Control Study ◽

Case Control ◽

Total Arsenic ◽

Arsenic Methylation ◽

Methylation Capacity ◽

Control Study ◽

In Pregnancy

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Willingness to Receive the COVID-19 and Seasonal Influenza Vaccines among the Saudi Population and Vaccine Uptake During the Initial Stage of the National Vaccination Campaign: A Cross-Sectional Survey

Vaccines ◽

10.3390/vaccines9070765 ◽

2021 ◽

Vol 9 (7) ◽

pp. 765

Author(s):

Amel Ahmed Fayed ◽

Abeer Salem Al Shahrani ◽

Leenah Tawfiq Almanea ◽

Nardeen Ibrahim Alsweed ◽

Layla Mohammed Almarzoug ◽

...

Keyword(s):

Saudi Arabia ◽

Perceived Risk ◽

Online Survey ◽

Seasonal Influenza ◽

Vaccination Campaign ◽

Vaccine Uptake ◽

Influenza Vaccines ◽

Vaccine Hesitancy ◽

Cross Sectional ◽

To Receive

This study aimed to assess the willingness to receive the coronavirus disease 2019 (COVID-19) and seasonal influenza vaccines and vaccine uptake during the early stage of the national vaccination campaign in Saudi Arabia. A cross-sectional online survey was conducted among adult Saudis between 20 January and 20 March 2021. The questionnaire addressed vaccine hesitancy, perceived risk, willingness, and vaccine uptake. Approximately 39% of the participants expressed vaccine hesitancy, and 29.8% and 24% felt highly vulnerable to contracting COVID-19 and seasonal influenza, respectively. The majority (59.5%) were willing to receive the COVID-19 vaccine, although only 31.7% were willing to receive the flu vaccine. Adjusted analysis showed that vaccine hesitancy (OR 0.34, 95% CI 0.27–0.43) and the perception of being at high risk (OR 2.78, 95% CI 1.68–4.60) independently affected the intention to be vaccinated. Vaccine hesitancy was similar among those who were willing to be vaccinated (29.8%) and those who had already been vaccinated (33.1%). The perceived risk was significantly higher among those who had been vaccinated (48.1%) than among those who were willing to be vaccinated but had not yet been vaccinated (29.1%). In conclusion, the acceptance of the COVID-19 vaccine in Saudi Arabia is high. Saudis who received the vaccine had a similar level of vaccine hesitancy and a higher level of perceived risk.

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