Metabolic risk factors and cervical cancer in the metabolic syndrome and cancer project (Me–Can)

The metabolic syndrome is a constellation of metabolic risk factors including atherogenic dyslipidemia (elevated serum triglycerides, reduced high-density lipoprotein (HDL) cholesterol), elevated blood pressure, dysglycemia (insulin resistance and elevated serum glucose), a pro-inflammatory state, and a prothrombotic state. Most persons with metabolic syndrome are obese, and usually have abdominal obesity. Generally, obesity is a reflection of overnutrition. A current view is that when adipose tissue fails to store all excess nutrients as triglyceride, lipid begins to accumulate in various tissues (eg, muscle, liver, pancreas, and heart). This accumulation is called ectopic lipid. Various mechanisms have been proposed whereby ectopic lipid is detrimental in different tissues; these derangements induce metabolic risk factors. The foundation of the metabolic syndrome thus appears to be overnutrition, that is, more nutrient intake than can be safely disposed by lipid oxidation. Excess dietary carbohydrate also induces ectopic lipid. Of interest, less than half of obese individuals develop metabolic syndrome. Through various mechanisms they adapt to overnutrition so as to minimize lipid overload in tissues, and consequently, prevent the syndrome.

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Restorative yoga and metabolic risk factors: The Practicing Restorative Yoga vs. Stretching for the Metabolic Syndrome (PRYSMS) randomized trial

Journal of Diabetes and its Complications ◽

10.1016/j.jdiacomp.2013.12.001 ◽

2014 ◽

Vol 28 (3) ◽

pp. 406-412 ◽

Cited By ~ 31

Author(s):

Alka M. Kanaya ◽

Maria Rosario G. Araneta ◽

Sarah B. Pawlowsky ◽

Elizabeth Barrett-Connor ◽

Deborah Grady ◽

...

Keyword(s):

Risk Factors ◽

Metabolic Syndrome ◽

Randomized Trial ◽

Metabolic Risk Factors ◽

Metabolic Risk ◽

The Metabolic Syndrome

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Trends in known and undiagnosed diabetes, HbA1c levels, cardio-metabolic risk factors and diabetes treatment target achievement in repeated cross-sectional surveys – The Tromsø Study 1994-2016

10.1101/2020.10.30.20222117 ◽

2020 ◽

Author(s):

Petja Lyn Langholz ◽

Tom Wilsgaard ◽

Inger Njølstad ◽

Rolf Jorde ◽

Laila Arnesdatter Hopstock

Keyword(s):

Risk Factors ◽

Metabolic Syndrome ◽

Metabolic Risk Factors ◽

Undiagnosed Diabetes ◽

Metabolic Risk ◽

Diabetes Treatment ◽

Cross Sectional ◽

Treatment Target ◽

The Metabolic Syndrome ◽

Hba1c Levels

AbstractObjectivesThe aim of this study was to investigate time trends in known and undiagnosed diabetes, HbA1c levels, and other cardio-metabolic risk factors in the general population as well as treatment target achievement among those with diabetes.Design and settingRepeated cross-sectional surveys in the population-based Tromsø Study.MethodsWe used age-adjusted generalized estimating equation models to study trends in self-reported and undiagnosed (HbA1c ≥6.5%) diabetes, cardio-metabolic risk factors and the metabolic syndrome in 27281 women and men aged 40-84 years examined in up to four surveys of the Tromsø Study between 1994 and 2016. Further, we analyzed trends in diabetes treatment target achievement.ResultsDuring 1994-2016 diabetes prevalence increased in women (2.3% to 3.9%) and men (2.4% to 5.3%) and in all age-groups, while the proportion of undiagnosed diabetes in women (33% to 20%) and men (37% to 27%) decreased. Blood pressure and total cholesterol decreased, while waist circumference increased in participants with and without diabetes, leading to a relatively stable prevalence of the metabolic syndrome throughout the study period. There was a marginal increase in HbA1c levels among participants without diabetes. Only half of those with diabetes achieved the treatment target of HbA1c ≤7.0%.ConclusionIn the last two decades diabetes prevalence increased, while the proportion of undiagnosed diabetes declined. The prevalence of the metabolic syndrome remained stable throughout, driven by opposing trends with an increase in obesity and a decrease in other cardio-metabolic risk factors. HbA1c treatment target achievement did not improve.

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Microvascular dysfunction: causative role in the association between hypertension, insulin resistance and the metabolic syndrome?

Essays in Biochemistry ◽

10.1042/bse0420163 ◽

2006 ◽

Vol 42 ◽

pp. 163-176 ◽

Cited By ~ 16

Author(s):

Erik H. Serné ◽

Renate T. de Jongh ◽

Etto C. Eringa ◽

Richard G. Ijzerman ◽

Michiel P. de Boer ◽

...

Keyword(s):

Risk Factors ◽

Insulin Resistance ◽

Metabolic Syndrome ◽

Microvascular Dysfunction ◽

Metabolic Risk Factors ◽

Causative Role ◽

Metabolic Risk ◽

The Metabolic Syndrome ◽

Increased Risk ◽

Potential Factor

The metabolic syndrome defines a clustering of metabolic risk factors that confers an increased risk for type 2 diabetes and cardiovascular disease. The metabolic syndrome seems to have multiple etiological factors and microvascular dysfunction may be one potential factor explaining the clustering of multiple metabolic risk factors including hypertension, obesity, insulin resistance and glucose intolerance. Microvascular dysfunction may increase not only peripheral vascular resistance and blood pressure, but may also decrease insulin-mediated glucose uptake in muscle. The present article summarizes some of the data concerning the role of microvascular dysfunction in the metabolic syndrome.

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