126: Metabolic Syndrome and Risk of Prostate Cancer: Nhanes 2001-2002

2006 ◽  
Vol 175 (4S) ◽  
pp. 40-40
Author(s):  
Aruna V. Sarma ◽  
Lauren P. Wallner ◽  
Stephanie Daignault ◽  
John T. Wei
Keyword(s):  
Prostate Cancer ◽  
Metabolic Syndrome

scholarly journals Metabolic syndrome in patients with prostate cancer

2008 ◽  
Vol 126 (5) ◽  
pp. 274-278 ◽  
Author(s):  
Iúri Amorim de Santana ◽  
Gustavo Souza Moura ◽  
Nivaldo Farias Vieira ◽  
Rosana Cipolotti
Keyword(s):  
Prostate Cancer ◽  
Metabolic Syndrome ◽  
Body Mass ◽  
Specific Antigen ◽  
Density Lipoprotein ◽  
Positive Association ◽  
Serum Glucose ◽  
Anthropometric Parameters ◽  
Cross Sectional ◽  
Waist To Hip Ratio

CONTEXT AND OBJECTIVE: Prostate cancer (PCa) is the second most common cancer among men in Brazil. Recently, several studies have hypothesized a relationship between PCa and metabolic syndrome (MS). The aim here was to identify an association between MS and PCa. DESIGN AND SETTING: Cross-sectional study, Fundação de Beneficência Hospital de Cirurgia (FBHC) and Universidade Federal de Sergipe. METHODS: Laboratory and anthropometric parameters were compared between PCa patients (n = 16) and controls (n = 16). RESULTS: The PCa patients showed significantly greater frequency of MS than did the controls (p = 0.034). Serum glucose was higher and high-density lipoprotein-cholesterol was lower than in the controls, although without significant differences. There were significant differences in blood pressure (p = 0.029) and waist-to-hip ratio (p = 0.004). Pearson linear correlation showed a positive association between waist-to-hip ratio and prostate specific antigen (r = 0.584 and p = 0.028). Comparing subgroups with and without MS among the PCa patients, significant differences (p < 0.05) in weight, height, body mass index, hip circumference and lean body mass were observed, thus showing higher central obesity in those with MS. The serum glucose values were also higher in MS patients (p = 0.006), thus demonstrating that insulin resistance has a role in MS physiopathology. CONCLUSIONS: Our study suggests that MS may exert an influence on the development of PCa. However, it would be necessary to expand the investigation field with larger sample sizes and cohorts studied, to test the hypothesis generated in this study.

Rural and Urban Differences in Stage at Diagnosis of Prostate Cancer in Hunan Province, China

2016 ◽  
Vol 26 (3) ◽  
pp. 171-186
Author(s):  
Liuxun Li ◽  
Elaina Y. Chen ◽  
Mingjiang Zha ◽  
Xiaoping Zheng ◽  
Zhi Long ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Metabolic Syndrome ◽  
Urban Areas ◽  
Pearson Correlation ◽  
Hunan Province ◽  
Stage At Diagnosis ◽  
Delay In Diagnosis ◽  
Psa Screening ◽  
Rural And Urban ◽  
Rural Patients

This study set out to investigate whether patients in rural areas tend to have more advanced prostate cancer (PCa) than urban areas in Hunan province, define possible factors related to the stage at diagnosis of PCa between rural and urban areas, and to determine the potential correlations between these factors and PCa stage at time of diagnosis. Data were used from a retrospective database of 490 PCa patients from the Third XiangYa hospital. Rural and urban differences in PCa stage, age, delay in diagnosis, prostate specific antigen (PSA) values, PSA screening, and metabolic syndrome were described and analyzed. Pearson correlation, Spearman correlation, and multiple linear regression were performed to examine the correlations between factors which may attribute to regional differences and stage. The percentage of advanced stage in rural cases was higher than in urban cases. Moreover, younger age, longer delay in diagnosis, less metabolic syndrome, and fewer PSA screening prior to diagnosis were observed in rural patients compared with the urban patients. Current study revealed that rural patients were more likely to have advanced PCa stage and PSA values at time of diagnosis. Perhaps, most importantly, these data demonstrated that both rural and urban patients in Hunan province suffered from an unacceptable frequency of advanced PCa, presumably from lack of routine PSA screening.

scholarly journals Serum Omentin Levels in Patients with Prostate Cancer and Associations with Sex Steroids and Metabolic Syndrome

2020 ◽  
Vol 9 (4) ◽  
pp. 1179
Author(s):  
Artur Borowski ◽  
Lucyna Siemińska
Keyword(s):  
Prostate Cancer ◽  
Metabolic Syndrome ◽  
Sex Steroids ◽  
Specific Antigen ◽  
Sex Hormone Binding Globulin ◽  
Total Testosterone ◽  
Serum Concentrations ◽  
Prostate Hyperplasia ◽  
Metabolic Characteristics ◽  
Persistent Inflammation

Mechanisms linking obesity and prostate cancer (PC) include increased insulin signaling, persistent inflammation, and altered adipocytokines secretion. Previous studies indicated that omentin may play a potential role in cancerogenesis of different sites, including the prostate. In this study, we focused on the hormonal and metabolic characteristics of men recruited for prostate biopsy. We evaluated serum concentrations of adipocytokines and sex steroids where concentrations are related to the adiposity: omentin, leptin, testosterone, estradiol, and sex hormone-binding globulin (SHBG). Aim: The aim of the study was to assess the concentration of serum omentin in men with PC. We also investigated relationships between omentin, leptin, sex steroids, SHBG, age, and metabolic syndrome (MS). Methods: Our study was conducted on 72 patients with PC and 65 men with benign prostate hyperplasia (BPH). Both groups were compared for body mass index. Results: Comparing men with PC to subjects with BPH there were significantly higher serum concentrations of omentin, estradiol, and prostate specific antigen (PSA) in the former. Estradiol/testosterone ratio, which is a marker of testosterone to estradiol conversion, was also significantly higher in the PC group. MS was diagnosed in 47 men with PC and in 30 men with BPH, the prevalence was significantly higher in the PC group. When the subjects with PC were subdivided into two subgroups, the serum omentin did not differ between those with MS and without MS. In the overall sample serum, omentin was positively associated with age, SHBG, and leptin. A positive correlation was also found between omentin and estradiol/testosterone ratio, and negatively with testosterone/SHBG ratio. Positive correlations were noted between age and SHBG, PSA and estradiol/testosterone ratio. In our study, a drop of total testosterone and testosterone/SHBG ratio, due to age, was also demonstrated. Conclusions: In patients with prostate cancer, serum omentin may be a diagnostic indicator. Omentin levels do not correlate with estradiol or testosterone concentrations but they are related to the testosterone/SHBG ratio. Omentin is not associated with an increased likelihood of having metabolic syndrome in men with prostate cancer.

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