692: The Age-Related Decline in Testosterone is Significantly Exacerbated in Obese Men with the Metabolic Syndrome: What Are the Implications of This for the Relatively High Incidence of Erectile Dysfunction Observed in These Men?

A great amount of scientific evidence supports that Oxidative Stress (OxS) can contribute to telomeric attrition and also plays an important role in the development of certain age-related diseases, among them the metabolic syndrome (MetS), which is characterised by clinical and biochemical alterations such as obesity, dyslipidaemia, arterial hypertension, hyperglycaemia, and insulin resistance, all of which are considered as risk factors for type 2 diabetes mellitus (T2DM) and cardiovascular diseases, which are associated in turn with an increase of OxS. In this sense, we review scientific evidence that supports the association between OxS with telomere length (TL) dynamics and the relationship with MetS components in aging. It was analysed whether each MetS component affects the telomere length separately or if they all affect it together. Likewise, this review provides a summary of the structure and function of telomeres and telomerase, the mechanisms of telomeric DNA repair, how telomere length may influence the fate of cells or be linked to inflammation and the development of age-related diseases, and finally, how the lifestyles can affect telomere length.

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Associations of n-3 Fatty Acids and Fish Consumption with the Metabolic Syndrome in College Students (P18-022-19)

Current Developments in Nutrition ◽

10.1093/cdn/nzz039.p18-022-19 ◽

2019 ◽

Vol 3 (Supplement_1) ◽

Author(s):

Nicole Karazurna ◽

Caitlin Porter ◽

Jesse Stabile Morrell ◽

Sherman Bigornia

Keyword(s):

Risk Factors ◽

College Students ◽

Metabolic Syndrome ◽

Young Adults ◽

Fish Consumption ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

The Metabolic Syndrome ◽

Age Related

Abstract Objectives Evidence suggests that omega-3 fatty acid (n-3 FA) and fish consumption may reduce the risk of the metabolic syndrome (MetS) in older adults. We previously reported that MetS components are prevalent among college students. Identifying modifiable risk factors of developing MetS and its components in young adults will inform potential targets to reduce the risk of age-related health conditions. Our objectives were to measure the cross-sectional impacts of n-3 FA and fish consumption on ≥2 or ≥3 MetS criteria and individual criteria among college students. Methods The College Health and Nutrition Assessment Survey is an on-going cross-sectional study at a public New England college. We examined data from Jan 2008 – May 2017. After excluding those with missing data our final sample size was n = 4271 for n-3 FA & n = 2072 for fish intake analyses. Diet was assessed by a 3 day food record; MetS criteria were collected in fasted state. We expressed n-3 FAs as g/1000 kcals/d. Servings of fish/week was obtained via an online survey. Individuals were categorized as consuming ≥ 2 servings/week or not. MetS was defined as meeting ≥ 3 criteria: elevated glucose, triglycerides, blood pressure, waist circumference, and low HDL. Analyses were conducted by logistic regression. Results The average n-3 FA intake was 0.4 g/1000 kcal/d ± 0.25 & 40% consumed ≥ 2 servings of fish/week. Prevalence estimates for meeting ≥ 2 criteria was 18.8% and 4.8% for MetS. In sex- and energy- adjusted models, n-3 FA consumption was inversely associated with MetS (OR = 0.38; 95%CI: 0.20, 0.71) and ≥2 MetS criteria (OR = 0.67; 95%CI: 0.49, 0.91). Associations were no longer significant after considering additional confounders. Fish consumption was not significantly associated with MetS or ≥2 criteria in any model. Further n-3 FAs and fish consumption was not associated with any individual MetS criteria. Conclusions In this cross-sectional study among college students, n-3 FA and fish consumption were not significantly associated with MetS outcomes. Further research is needed in this population using longitudinal study designs to understand long-term impact of n-3 consumption on the development of MetS and associated cardio metabolic risk factors in young adults. Funding Sources New Hampshire Agriculture Experiment Station and USDA National Institute of Food and Agriculture Hatch Project 1010738.

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Parameters of Glucose Homeostasis in the Recognition of the Metabolic Syndrome in Young Adults with Prader–Willi Syndrome

Journal of Clinical Medicine ◽

10.3390/jcm10235635 ◽

2021 ◽

Vol 10 (23) ◽

pp. 5635

Author(s):

Graziano Grugni ◽

Antonio Fanolla ◽

Fiorenzo Lupi ◽

Silvia Longhi ◽

Antonella Saezza ◽

...

Keyword(s):

Metabolic Syndrome ◽

Glucose Homeostasis ◽

Tolerance Test ◽

Oral Glucose ◽

Prader Willi Syndrome ◽

Insulinogenic Index ◽

Glucose Levels ◽

The Metabolic Syndrome ◽

Diagnostic Threshold ◽

Age Related

To verify the accuracy of different indices of glucose homeostasis in recognizing the metabolic syndrome in a group of adult patients with Prader–Willi syndrome (PWS), 102 PWS patients (53 females/49 males), age ±SD 26.9 ± 7.6 yrs, Body Mass Index (BMI) 35.7 ± 10.7, were studied. The following indices were assessed in each subject during an oral glucose tolerance test (OGTT): 1 h (>155 mg/dL) and 2 h (140–199 mg/dL) glucose levels, the oral disposition index (ODI), the insulinogenic index (IGI), the insulin resistance (HOMA-IR) were evaluated at baseline, 1 h and 2 h. Although minor differences among indices were found, according to the ROC analysis, no index performed better in recognizing MetS. Furthermore, the diagnostic threshold levels changed over the years and therefore the age-related thresholds were calculated. The easily calculated HOMA-IR at baseline may be used to accurately diagnose MetS, thus avoiding more complicated procedures.

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Testosterone Deficiency and Risk Factors in the Metabolic Syndrome: Implications for Erectile Dysfunction

Urologic Clinics of North America ◽

10.1016/j.ucl.2011.02.004 ◽

2011 ◽

Vol 38 (2) ◽

pp. 175-183 ◽

Cited By ~ 23

Author(s):

Andre T. Guay ◽

Abdulmaged Traish

Keyword(s):

Risk Factors ◽

Metabolic Syndrome ◽

Erectile Dysfunction ◽

Testosterone Deficiency ◽

The Metabolic Syndrome

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Testosterone Associations with Erectile Dysfunction, Diabetes, and the Metabolic Syndrome

European Urology Supplements ◽

10.1016/j.eursup.2007.07.002 ◽

2007 ◽

Vol 6 (16) ◽

pp. 847-857 ◽

Cited By ~ 46

Author(s):

T. Hugh Jones

Keyword(s):

Metabolic Syndrome ◽

Erectile Dysfunction ◽

The Metabolic Syndrome

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Acupuncture and Neurostimulation Therapy for Erectile Dysfunction in the Patients with the Metabolic Syndrome

Journal of New Medical Technologies ◽

10.12737/9074 ◽

2015 ◽

Vol 22 (1) ◽

pp. 38-46

Author(s):

Долаев ◽

R. Dolaev

Keyword(s):

Metabolic Syndrome ◽

Electrical Stimulation ◽

Erectile Dysfunction ◽

Endothelial Dysfunction ◽

Therapeutic Effect ◽

Biochemical Markers ◽

The Metabolic Syndrome ◽

Treat Ment ◽

Integrated Indicators ◽

Stimulation Of

There were 40 patients with a metabolic syndrome with erectile dysfunction under observation. All patients received physiotherapy exercises, psychotherapeutic correction of a sex disadaptation, epicutaneous electrical stimulation of cavernous bodies of a penis and muscles of a pelvic bottom, and acupuncture according to specially developed scheme. It is proved that the combination of medical methods provides duration of therapeutic effect after course of treat-ment. Normalization of integrated indicators of the International index of erectile function came at 72,5% of patients. Vegetative indicators reached values of norm at 72,5% of patients, normalization of volume of a prostate came at 72,5% of patients, a prostate hemodynamic – at 70% of patients. The penil hemodynamic was normalized at 72,5% of patients. Normalization of functional activity hypothalamic – adrenal and testicular system came at 70% of patients. Components of a copulative cycle reached values of norm at 70% of patients. Carbohydrate metabolism was normalized at 75%, lipide – at 72,5%, biochemical markers of endothelial dysfunction – at 72,5% of patients, the index of exacerbations of a metabolic syndrome decreased by 1,9 times. The remote results of therapeutic effect in 1 year after treatment showed that appreciable improvement was observed at 55%, improvement – at 25%, without improvement – at 20% of patients.

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Age-Related Changes in Gustatory, Homeostatic, Reward, and Memory Processing of Sweet Taste in the Metabolic Syndrome: An fMRI Study

Perception ◽

10.1177/0301006616686097 ◽

2017 ◽

Vol 46 (3-4) ◽

pp. 283-306 ◽

Cited By ~ 10

Author(s):

Aaron Jacobson ◽

Erin Green ◽

Lori Haase ◽

Jacquelyn Szajer ◽

Claire Murphy

Keyword(s):

Risk Factors ◽

Metabolic Syndrome ◽

Sweet Taste ◽

Interactive Effects ◽

Energy Regulation ◽

Imaging Data ◽

Orbital Frontal Cortex ◽

Taste System ◽

The Metabolic Syndrome ◽

Age Related

Age affects the human taste system at peripheral and central levels. Metabolic syndrome is a constellation of risk factors (e.g., abdominal obesity and hypertension) that co-occur, increase with age, and heighten risk for cardiovascular disease, diabetes, and cognitive decline. Little is known about how age, metabolic syndrome, and hunger state interact to influence how the brain processes information about taste. We investigated brain activation during the hedonic evaluation of a pleasant, nutritive stimulus (sucrose) within regions critical for taste, homeostatic energy regulation, and reward, as a function of the interactions among age, metabolic syndrome, and hunger condition. We scanned young and elderly adults, half with risk factors associated with metabolic syndrome twice: Once fasted overnight and once after a preload. Functional magnetic resonance imaging data indicated significant effects of age as well as interactive effects with metabolic syndrome and hunger condition. Age-related differences in activation were dependent on the hunger state in regions critical for homoeostatic energy regulation and basic as well as higher order sensory processing and integration. The effects of age and metabolic syndrome on activation in the insula, orbital frontal cortex, caudate, and the hypothalamus may have particularly important implications for taste processing, energy regulation, and dietary choices.

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