THE FAMILY INCIDENCE OF ACUTE RHEUMATISM

The Lancet ◽  
1935 ◽  
Vol 225 (5819) ◽  
pp. 560-561
Keyword(s):  
PEDIATRICS ◽  
1955 ◽  
Vol 15 (5) ◽  
pp. 610-619
Author(s):  
Morris Fishbein

THE POET John Donne wrote that no man is an island. Never was this more apt than when applied to the person who is suffering with a crippling disease. For him isolation is disastrous. If intelligent and left too much alone, he becomes embittered, sullen and perhaps an enemy of society. If unintelligent, he deteriorates slowly and steadily into a parasitic, vegetable-like existence, which may eventually sap the lives of all about him. The modern approach to the problem emphasizes adjustment of the handicapped person to the family, the community, and even the nation. All these forces are brought to bear from the social, economic and psychologic points of view, so that such a person is able to live an existence as nearly normal as possible. He contributes to rather than lives upon the society that encompasses him. This consideration of the social aspects of rheumatic heart disease is concerned with these problems and with the extent to which the individual, the family, the community and the nation are able to solve them. On July 29, 1789, Edward Jenner, who first introduced vaccination against smallpox, reported to the medical society in Gloucestershire, England, on "Disease of the Heart Following Acute Rheumatism." The case was illustrated by dissection. This was probably the first reference to rheumatic fever in scientific medical reports. Unfortunately neither the paper nor any record other than its title has ever been found. Perhaps the first physician who pointedly called attention to the association of acute rheumatism and heart disease was David Pitcairn, born in 1749.


PEDIATRICS ◽  
1969 ◽  
Vol 43 (4) ◽  
pp. 590-590
Author(s):  
T. E. C.

A widely held popular belief in this country and in England until recently was that children with red hair were especially prone to develop rheumatic fever. Physicians as distinguished as Sir George Frederic Still (1868-1941) also shared this view as is shown in the following quotation which is taken from his famous textbook, Common Dlsorders and Diseases of Children. There is one further phenomenon which is noteworthy in rheumatic children and which is perhaps worth mentioning here, although it is necessarily noticeable also in adults-the association of red hair with rheumatism and rheumatic heredity. The following observation may serve to illustrate it. In four days there were amongst my out-patients eleven children with red hair. Of these, two were attending with articular rheumatism; one had occasional pain and swelling in the knees, his mother had red hair and frequent pain in the limbs, and her brother and sister had "rheumatic fever;" one had "pains in the knees" and his mother had "rheumatism;" three others showed a history of "rheumatic fever" in the mother or father; one was attending with chorea; one had a brother attending with articular rheumatism; only two out of the eleven showed no rheumatism or chorea in themselves or their families. Amongst 80 children with red hair (including the 11 already mentioned) 24 were attending with definite manifestations of acute rheumatism, articulan or cardiac or chorea; 6 had pains in the limb which were almost certainly rheumatic, and of the remaining 50 cases 17 showed a family history of acute rheumatism (including chorea) in parents or brothers or sisters; so that there was rheumatism either in the child or the family in 47 out of 80; i.e. in 58 percent.


1934 ◽  
Vol 6 (1) ◽  
pp. 3-12 ◽  
Author(s):  
J. A. FRASER ROBERTS ◽  
W. A. R. THOMSON
Keyword(s):  

1988 ◽  
Vol 62 (03) ◽  
pp. 419-423 ◽  
Author(s):  
Baba Senowbari-Daryan ◽  
George D. Stanley

Two Upper Triassic sphinctozoan sponges of the family Sebargasiidae were recovered from silicified residues collected in Hells Canyon, Oregon. These sponges areAmblysiphonellacf.A. steinmanni(Haas), known from the Tethys region, andColospongia whalenin. sp., an endemic species. The latter sponge was placed in the superfamily Porata by Seilacher (1962). The presence of well-preserved cribrate plates in this sponge, in addition to pores of the chamber walls, is a unique condition never before reported in any porate sphinctozoans. Aporate counterparts known primarily from the Triassic Alps have similar cribrate plates but lack the pores in the chamber walls. The sponges from Hells Canyon are associated with abundant bivalves and corals of marked Tethyan affinities and come from a displaced terrane known as the Wallowa Terrane. It was a tropical island arc, suspected to have paleogeographic relationships with Wrangellia; however, these sponges have not yet been found in any other Cordilleran terrane.


Author(s):  
E. S. Boatman ◽  
G. E. Kenny

Information concerning the morphology and replication of organism of the family Mycoplasmataceae remains, despite over 70 years of study, highly controversial. Due to their small size observations by light microscopy have not been rewarding. Furthermore, not only are these organisms extremely pleomorphic but their morphology also changes according to growth phase. This study deals with the morphological aspects of M. pneumoniae strain 3546 in relation to growth, interaction with HeLa cells and possible mechanisms of replication.The organisms were grown aerobically at 37°C in a soy peptone yeast dialysate medium supplemented with 12% gamma-globulin free horse serum. The medium was buffered at pH 7.3 with TES [N-tris (hyroxymethyl) methyl-2-aminoethane sulfonic acid] at 10mM concentration. The inoculum, an actively growing culture, was filtered through a 0.5 μm polycarbonate “nuclepore” filter to prevent transfer of all but the smallest aggregates. Growth was assessed at specific periods by colony counts and 800 ml samples of organisms were fixed in situ with 2.5% glutaraldehyde for 3 hrs. at 4°C. Washed cells for sectioning were post-fixed in 0.8% OSO4 in veronal-acetate buffer pH 6.1 for 1 hr. at 21°C. HeLa cells were infected with a filtered inoculum of M. pneumoniae and incubated for 9 days in Leighton tubes with coverslips. The cells were then removed and processed for electron microscopy.


Author(s):  
A.D. Hyatt

Bluetongue virus (BTV) is the type species os the genus orbivirus in the family Reoviridae. The virus has a fibrillar outer coat containing two major structural proteins VP2 and VP5 which surround an icosahedral core. The core contains two major proteins VP3 and VP7 and three minor proteins VP1, VP4 and VP6. Recent evidence has indicated that the core comprises a neucleoprotein center which is surrounded by two protein layers; VP7, a major constituent of capsomeres comprises the outer and VP3 the inner layer of the core . Antibodies to VP7 are currently used in enzyme-linked immunosorbant assays and immuno-electron microscopical (JEM) tests for the detection of BTV. The tests involve the antibody recognition of VP7 on virus particles. In an attempt to understand how complete viruses can interact with antibodies to VP7 various antibody types and methodologies were utilized to determine the physical accessibility of the core to the external environment.


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