Leptin, TNF-receptor (R)-2 and TNF-α contribute to insulin resistance in normal pregnancy and gestational diabetes

2000 ◽  
Vol 50 ◽  
pp. 426
Author(s):  
G Winkler ◽  
E Baranyi ◽  
Zs Melczer ◽  
E Braun ◽  
O Szekeres ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Gestational Diabetes ◽  
Normal Pregnancy ◽  
Tnf Receptor ◽  
Tnf Α

scholarly journals Molecular mechanisms of insulin resistance in normal pregnancy and gestational diabetes

2021 ◽  
Vol 2021 (1) ◽  
pp. 22-30
Author(s):  
L.V. Zhuravlyova ◽  
◽  
N.V. Sokolnikova ◽  
T.A. Rogachova ◽  
◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Gestational Diabetes ◽  
Molecular Mechanisms ◽  
Normal Pregnancy ◽  
Inflammatory Factors ◽  
Ppar Γ ◽  
Tnf Α ◽  
Therapeutic Measures ◽  
Glut 4 Translocation ◽  
Further Development

The purpose of this review article is to analyze current information on the molecular mechanisms of gestational diabetes and the prospects for their use in the further development of new effective treatments for this common pathology. Decreased ability of insulin to bind to its receptor, decreased IRS-1 expression and GLUT-4 translocation, and increased levels of p85α-PI-3 kinase subunits are involved in the development of insulin resistance during pregnancy. In gestational diabetes, there are not only more significant changes of the above mentioned indicators, but also increased levels of pro-inflammatory factors: TNF-α, IL-6, leptin and decreased insulin-sensitizing factors: adiponectin and PPAR-γ. Therapeutic measures aimed at normalizing the secretion of cytokines and adipokines reduce the risk of gestational diabetes mellitus and its complications and require further development

Cellular Mechanisms for Insulin Resistance in Normal Pregnancy and Gestational Diabetes

Diabetes Care ◽  
2007 ◽  
Vol 30 (Supplement 2) ◽  
pp. S112-S119 ◽  
Author(s):  
L. A. Barbour ◽  
C. E. McCurdy ◽  
T. L. Hernandez ◽  
J. P. Kirwan ◽  
P. M. Catalano ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Gestational Diabetes ◽  
Normal Pregnancy ◽  
Cellular Mechanisms

scholarly journals Anti-inflammatory activities of puerarin in high-fat diet-fed rats with streptozotocin-induced gestational diabetes mellitus

2020 ◽  
Vol 47 (10) ◽  
pp. 7537-7546 ◽  
Author(s):  
Wenting Xu ◽  
Mengyu Tang ◽  
Jiahui Wang ◽  
Lihong Wang
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Density Lipoprotein ◽  
Reproductive Organs ◽  
Control Group ◽  
High Fat ◽  
Adipose Tissues ◽  
Tnf Α

Abstract To investigate the effect of puerarin on insulin resistance and inflammation in rats with gestational diabetes mellitus (GDM). Gestational diabetic model rats were established by intraperitoneal injection of streptozotocin (25 mg/kg) combined with high-fat feeding and were randomly assigned to three groups: the control group, the GDM group, and the puerarin-treated group. Puerarin was intragastrically administered to rats daily until the offspring were born. The rats in both the GDM group and control group were administered the same volume of normal saline. Serum total cholesterol, triglycerides, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol in all groups of rats were measured. Haematoxylin and eosin staining was used to evaluate morphological changes in the liver, pancreas, and adipose tissues around the reproductive organs. Western blotting was carried out to measure the protein expression of IRS-1 and inflammatory factors, including TNF-α, TLR4, MyD88 and phosphorylated NF-κB, in the adipose tissues around the reproductive organs. Puerarin had preventive effects on GDM-induced pathological changes and ameliorated glucose and lipid metabolism disorders in GDM rats. Puerarin upregulated IRS-1 expression and decreased the protein expression of TNF-α, TLR4, and MyD88 as well as the levels of phosphorylated NF-κB in adipose tissues around the reproductive organs in GDM rats. This study indicated that puerarin exerts anti-inflammatory effects by downregulating the important TLR4/MyD88/NF-κB inflammatory signalling pathway. Therefore, puerarin can decrease the expression of TNF-α and ameliorate insulin resistance in GDM rats, suggesting the potential efficacy of puerarin in GDM treatment.

scholarly journals Correlation of maternal serum fetuin/alpha2-HS-glycoprotein concentration with maternal insulin resistance and anthropometric parameters of neonates in normal pregnancy and gestational diabetes

2002 ◽  
pp. 243-248 ◽  
Author(s):  
L Kalabay ◽  
K Cseh ◽  
A Pajor ◽  
E Baranyi ◽  
GM Csakany ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Gestational Diabetes ◽  
Pregnant Women ◽  
Normal Pregnancy ◽  
Tnf Alpha ◽  
Control Group ◽  
Anthropometric Parameters ◽  
Necrosis Factor Alpha ◽  
C Peptide ◽  
Glucose Ratio

OBJECTIVE: Human fetuin/alpha(2)-HS-glycoprotein (AHSG) is a 49 kDa serum and tissue protein which is a natural inhibitor of insulin receptor signaling. We investigated serum AHSG levels during pregnancy and whether the protein is involved in insulin resistance observed in healthy pregnant women and patients with gestational diabetes. DESIGN: One hundred and four healthy pregnant women and 23 of their neonates, 30 patients with gestational diabetes and their neonates and 30 healthy age-matched non-pregnant females as a control group were investigated in a case-control cross-sectional study. METHODS: Serum AHSG was determined by radial immunodiffusion. RESULTS: We observed an increase of serum AHSG concentration in the second and third trimesters. Gestational diabetes patients had significantly higher AHSG levels than healthy pregnant women and non-pregnant controls. There was a highly significant positive correlation between serum AHSG concentration and indirect parameters of insulin resistance, i.e. tumor necrosis factor-alpha (TNF-alpha), leptin, C-peptide and C-peptide/blood glucose ratio. There was also a negative correlation between maternal AHSG, TNF-alpha, leptin levels and head circumference, body length and body weight of newborns. CONCLUSION: AHSG, TNF-alpha and leptin may contribute to insulin resistance during normal pregnancy and gestational diabetes. AHSG along with these cytokines may also negatively regulate neonatal skeletal development.

Blockade of Tumor Necrosis Factor (TNF) Receptor Type 1-Mediated TNF-α Signaling Protected Wistar Rats from Diet-Induced Obesity and Insulin Resistance

Endocrinology ◽  
2008 ◽  
Vol 149 (6) ◽  
pp. 2943-2951 ◽  
Author(s):  
Huifang Liang ◽  
Bingjiao Yin ◽  
Hailong Zhang ◽  
Shu Zhang ◽  
Qingling Zeng ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Wistar Rats ◽  
Receptor Type ◽  
Tnf Receptor ◽  
Diet Induced Obesity ◽  
Tnf Α ◽  
Necrosis Factor

Absence of pregnancy-induced alterations in tissue insulin sensitivity in the offspring of diabetic rats

1991 ◽  
Vol 131 (3) ◽  
pp. 387-393 ◽  
Author(s):  
K. Holemans ◽  
L. Aerts ◽  
F. A. Van Assche
Keyword(s):  
Insulin Resistance ◽  
Gestational Diabetes ◽  
Normal Pregnancy ◽  
Diabetic Rats ◽  
Metabolic Clearance ◽  
Response Curves ◽  
Pregnant Rats ◽  
Peripheral Tissues ◽  
Glucose Levels ◽  
Peripheral Insulin Resistance

ABSTRACT We have previously demonstrated insulin resistance in the liver and peripheral tissues of the adult offspring of rats made diabetic with streptozotocin (SDF rats). In this study, a euglycaemic hyperinsulinaemic clamp was used to test the hypothesis that insulin resistance is further aggravated during pregnancy in SDF rats. Normal pregnancy was accompanied by a decrease in the sensitivity of the liver and peripheral tissues to insulin, with a normal responsiveness to insulin. In SDF rats no further decrease in the sensitivity of peripheral tissues to insulin occurred during pregnancy when compared with non-pregnant rats, and the dose–response curves of the glucose metabolic clearance rate during hyperinsulinaemia were similar in pregnant control and pregnant SDF rats. There was, however, a modest decrease in the sensitivity of the liver to insulin during pregnancy in SDF rats. The normal increase in plasma insulin levels during pregnancy was blunted in SDF rats: this resulted in increased glucose levels in maternal and fetal rats and increased fetal insulin concentrations, features compatible with mild 'gestational diabetes'. In conclusion, gestational diabetes develops in pregnant SDF rats, although there is no further deterioration in peripheral insulin resistance. Journal of Endocrinology (1991) 131, 387–393

Insulin resistance, serum interleukin-6 and TNF-α levels during normal pregnancy

2011 ◽  
Vol 44 (13) ◽  
pp. S254
Author(s):  
Abdolreza Sotoodeh Jahromi ◽  
Parvin Zareian
Keyword(s):  
Insulin Resistance ◽  
Interleukin 6 ◽  
Normal Pregnancy ◽  
Tnf Α

scholarly journals The Association Between Pregnancy Serum TNF-α Level and Postpartum Insulin Resistance in Pregnant Women With Gestational Diabetes Mellitus

2020 ◽  
Author(s):  
Hossein Chiti ◽  
Mohammad Hossein Izadi ◽  
Saeideh Mazloomzadeh
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Serum Level ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Healthy Subjects ◽  
Tnf Α ◽  
Significant Difference ◽  
Α Level

Insulin resistance in gestational diabetes increases maternal and fetal complications. Tumor necrosis factor-alpha (TNF-α) is an inflammatory factor associated with insulin resistance. The aim of this study was to determine the association between pregnancy serum TNF-α level and postpartum insulin resistance in patients with gestational diabetes mellitus. 50 pregnant women, including 25 cases of gestational diabetes and 25 healthy pregnant women, were evaluated. First, during the third trimester of pregnancy, serum TNF-α level of all cases were measured. Two months after delivery, based on the obtained results from insulin levels and a 2-hour glucose tolerance test, HOMA-IR and HOMA-B were calculated, and the association between serum TNF-α level and insulin resistance was determined. Data were analyzed using independent t-test, Mann-Whitney, and chi-square test in SPSS software. The mean serum level of TNF-α in women with gestational diabetes mellitus was higher than healthy subjects, but there was no significant difference between the two groups. The serum level of insulin, HOMA-IR and HOMA-B indices in women with gestational diabetes mellitus were higher than healthy subjects, with a significant difference in all of the measures between two groups (P=0.0001). There was no significant correlation between TNF-α and HOMAIR levels in insulin-resistant mothers two months after delivery (r=−0.33). Also, no significant correlation was detected between pregnancy TNF-α levels and HOMA-B index. Despite the higher serum levels of insulin, HOMA-IR, and HOMA-B in the diabetic group, the serum TNF-α level did not show any correlation with insulin resistance after delivery.

scholarly journals Association of Insulin Resistance with Serum Interleukin-6 and TNF-α Levels during Normal Pregnancy

2011 ◽  
Vol 6 ◽  
pp. BMI.S6150 ◽  
Author(s):  
Abdolreza Sotoodeh Jahromi ◽  
Parvin Zareian ◽  
Abdolhossein Madani
Keyword(s):  
Insulin Resistance ◽  
Pregnant Women ◽  
Gestational Age ◽  
Normal Pregnancy ◽  
Cross Sectional Study ◽  
Enzyme Linked Immunosorbent Assay ◽  
Cross Sectional ◽  
Tnf Α ◽  
Factor Α

Overview The purpose of this study was to evaluate the role of Tumor Necrosis Factor-α (TNF-α) in insulin resistance (IR) during normal pregnancy. Approach This cross sectional study was carried out on 86 healthy pregnant women including 26, 23 and 37 individuals in the 1st, 2nd and 3rd trimesters, respectively, and in 21 healthy non pregnant women. Serum TNF-α concentration was measured by Enzyme Linked Immunosorbent Assay (ELISA) method. Results There were significant differences between serum TNF-α and IL-6 levels in pregnant women as compared with maternal healthy controls. There was significant correlation between gestational age and Body Mass Index (BMI) (r = 0.28, P = 0.01). There was no significant correlation between gestational age and insulin resistance (IR). We also did not find correlations between IR and TNF-α and IR and IL-6 in pregnant women. Conclusion In conclusion, our findings suggest that TNF-α and IL-6 are not greatly contributed to pregnancy induced insulin resistance in normal pregnancy.

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