Rosiglitazone increases insulin sensitivity and reduces factors associated with insulin resistance in type 2 diabetics

2000 ◽  
Vol 50 ◽  
pp. 64-65 ◽  
Author(s):  
DavidG. Carey ◽  
GaryJ. Cowin ◽  
GrahamJ. Galloway ◽  
DavidM. Doddrell ◽  
JacquelineC. Richards ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Insulin Sensitivity ◽  
Factors Associated ◽  
Type 2 Diabetics

scholarly journals The Effect of Hypoxia and Work Intensity on Insulin Resistance in Type 2 Diabetes

2012 ◽  
Vol 97 (1) ◽  
pp. 155-162 ◽  
Author(s):  
R. Mackenzie ◽  
B. Elliott ◽  
N. Maxwell ◽  
G. Brickley ◽  
P. Watt
Keyword(s):  
Insulin Resistance ◽  
Insulin Sensitivity ◽  
Cell Function ◽  
Resistance Index ◽  
Moderate Intensity ◽  
Fasting Insulin ◽  
Work Intensity ◽  
Insulin Resistance Index ◽  
Type 2 Diabetics

Context: Hypoxia and muscle contraction stimulate glucose transport in vitro. We have previously demonstrated that exercise and hypoxia have an additive effect on insulin sensitivity in type 2 diabetics. Objectives: Our objective was to examine the effects of three different hypoxic/exercise (Hy Ex) trials on glucose metabolism and insulin resistance in the 48 h after acute hypoxia in type 2 diabetics. Design, Participants, and Interventions: Eight male type 2 diabetics completed 60 min of hypoxic [mean (sem) O2 = ∼14.7 (0.2)%] exercise at 90% of lactate threshold [Hy Ex60; 49 (1) W]. Patients completed an additional two hypoxic trials of equal work, lasting 40 min [Hy Ex40; 70 (1) W] and 20 min [Hy Ex20; 140 (12) W]. Main Outcome Measures: Glucose rate of appearance and rate of disappearance were determined using the one-compartment minimal model. Homeostasis models of insulin resistance (HOMAIR), fasting insulin resistance index and β-cell function (HOMAβ-cell) were calculated at 24 and 48 h after trials. Results: Peak glucose rate of appearance was highest during Hy Ex20 [8.89 (0.56) mg/kg · min, P < 0.05]. HOMAIR and fasting insulin resistance index were improved in the 24 and 48 h after Hy Ex60 and Hy Ex40 (P < 0.05). HOMAIR decreased 24 h after Hy Ex20 (P < 0.05) and returned to baseline values at 48 h. Conclusions: Moderate-intensity exercise in hypoxia (Hy Ex60 and Hy Ex40) stimulates acute- and moderate-term improvements in insulin sensitivity that were less apparent in Hy Ex20. Results suggest that exercise duration and not total work completed has a greater influence on acute and moderate-term glucose control in type 2 diabetics.

The effect of exercise, training, and inactivity on insulin sensitivity in diabetics and their relatives: what is new?

2007 ◽  
Vol 32 (3) ◽  
pp. 541-548 ◽  
Author(s):  
Torben Østergård ◽  
Niels Jessen ◽  
Ole Schmitz ◽  
Lawrence J. Mandarino
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Fatty Acids ◽  
Insulin Sensitivity ◽  
Exercise Training ◽  
Large Scale ◽  
High Energy ◽  
First Degree Relatives ◽  
Type 2 Diabetics

Insulin resistance is a hallmark characteristic of type 2 diabetes. However, in healthy first-degree relatives of type 2 diabetics, insulin resistance is often present years before glucose intolerance or diabetes becomes clinically manifest. The mechanisms of insulin resistance involve conditions leading to an increased supply of fatty acids (e.g., high energy intake, obesity) and conditions in which the degradation/oxidation of muscular fatty acids is impaired. Several large-scale studies have documented the fact that increased physical activity can reduce or at least postpone the development of type 2 diabetes, and low physical fitness is a clear independent risk factor for the development of type 2 diabetes. The mechanisms responsible for the improvement in insulin sensitivity after exercise training have been studied extensively, but are not fully understood. This review focuses on insulin resistance in skeletal muscle and, in particular, its relation to changes in aerobic fitness in type 2 diabetics and their first-degree relatives.

Assessment of insulin sensitivity (S I) and glucose effectiveness (S G) from a standardized hyperglucidic breakfast test in type 2 diabetics exhibiting various levels of insulin resistance

2010 ◽  
Vol 50 (2) ◽  
pp. 143-153 ◽  
Author(s):  
Jean-Frédéric Brun ◽  
Edouard Ghanassia ◽  
Christine Fédou ◽  
Sylvain Bordenave ◽  
Eric Raynaud de Mauverger ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Insulin Sensitivity ◽  
Glucose Effectiveness ◽  
Type 2 Diabetics

The effects of very low calorie diet and exercise on insulin sensitivity and secretion in obese type 2 diabetics

2000 ◽  
Vol 50 ◽  
pp. 342
Author(s):  
Munehide Matsuhisa ◽  
Shinichi Gorogawa ◽  
Kentaro Ohtoshi ◽  
Rieko Hayaishi ◽  
Tetsuyuki Yasuda ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Very Low Calorie Diet ◽  
Low Calorie ◽  
Low Calorie Diet ◽  
Type 2 Diabetics ◽  
Diet And Exercise ◽  
Calorie Diet

scholarly journals Factors Associated With Psychological Insulin Resistance in Individuals With Type 2 Diabetes

Diabetes Care ◽  
2010 ◽  
Vol 33 (8) ◽  
pp. 1747-1749 ◽  
Author(s):  
S. Nam ◽  
C. Chesla ◽  
N. A. Stotts ◽  
L. Kroon ◽  
S. L. Janson
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Factors Associated

scholarly journals Amelioration of insulin resistance by rosiglitazone is associated with increased adipose cell size in obese type 2 diabetics

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Jian Yang ◽  
Bjorn Eliasson ◽  
Ulf Smith ◽  
Samuel W. Cushman ◽  
Arthur Sherman
Keyword(s):  
Insulin Resistance ◽  
Cell Size ◽  
Adipose Cell ◽  
Type 2 Diabetics ◽  
Adipose Cell Size

scholarly journals Common Risk Factors in Relatives and Spouses of Patients with Type 2 Diabetes in Developing Prediabetes

Healthcare ◽  
2021 ◽  
Vol 9 (8) ◽  
pp. 1010
Author(s):  
Wei-Hao Hsu ◽  
Chin-Wei Tseng ◽  
Yu-Ting Huang ◽  
Ching-Chao Liang ◽  
Mei-Yueh Lee ◽  
...  
Keyword(s):  
Risk Factors ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Insulin Sensitivity ◽  
Cell Function ◽  
Diabetic Patients ◽  
Β Cell ◽  
Tyg Index ◽  
Β Cell Function

Prediabetes should be viewed as an increased risk for diabetes and cardiovascular disease. In this study, we investigated its prevalence among the relatives and spouses of patients with type 2 diabetes or risk factors for prediabetes, insulin resistance, and β-cell function. A total of 175 individuals were included and stratified into three groups: controls, and relatives and spouses of type 2 diabetic patients. We compared clinical characteristics consisting of a homeostatic model assessment for insulin resistance (HOMA-IR) and beta cell function (HOMA-β), a quantitative insulin sensitivity check index (QUICKI), and triglyceride glucose (TyG) index. After a multivariable linear regression analysis, the relative group was independently correlated with high fasting glucose, a high TyG index, and low β-cell function; the relatives and spouses were independently associated with a low QUICKI. The relatives and spouses equally had a higher prevalence of prediabetes. These study also indicated that the relatives had multiple factors predicting the development of diabetes mellitus, and that the spouses may share a number of common environmental factors associated with low insulin sensitivity.

Sign in / Sign up

Export Citation Format

Share Document