1247 HIGH CHOLESTEROL DIET INDUCES STEATOHEPATITIS IN RAT, AND IS ASSOCIATED WITH OXYSTEROL OVERPRODUCTION AND MITOCHONDRIAL-DEPENDENT UPREGULATED OXIDATIVE STRESS

2013 ◽  
Vol 58 ◽  
pp. S505
Author(s):  
F. Bellanti ◽  
L. Iuliano ◽  
M. Blonda ◽  
G. Iannelli ◽  
R. Tamborra ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol

Resveratrol appears to protect against oxidative stress and steroidogenesis collapse in mice fed high-calorie and high-cholesterol diet

Andrologia ◽  
2014 ◽  
Vol 47 (1) ◽  
pp. 59-65 ◽  
Author(s):  
H.-J. Wang ◽  
Q. Wang ◽  
Z.-M. Lv ◽  
C.-L. Wang ◽  
C.-P. Li ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
High Calorie

scholarly journals Improvement on high-cholesterol diet induced atherosclerosis, lipid profile, oxidative stress and genotoxicity in the liver of mice by Echinops spinosissimus Turra subsp. spinosus

2020 ◽  
Author(s):  
Donyez Frikha Dammak ◽  
Hajer Ben Saad ◽  
Emna Bouattour ◽  
Ons Boudawara ◽  
Raoudha Mezghani Jarraya
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Activities ◽  
Dietary Cholesterol ◽  
Atherogenic Index ◽  
High Cholesterol Diet ◽  
Antioxidant Compounds ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Oxidative Stress Biomarkers

Abstract Background Hypercholesterolemia is a major risk factor for the development of atherosclerosis and endothelial dysfunction. Methods The present study investigates the possible mechanism of Echinops spinosissimus Turra subsp. spinosus ( E. s. spinosus ) flower on the high cholesterol diet. Results Our in vitro results demonstrated the richness of E.s. spinosus flower in antioxidant compounds, and its antioxidant activities. The co-administration of E.s. spinosus (100 or 200 mg/kg/day) with high-fat diet attenuated hepatotoxicity as monitored by the improvement of oxidative stress biomarkers and plasma lipid and liver parameters, when compared to the hypercholesterolemic mice. Atherogenic index and body weight were also reduced markedly, compared to control mice. These results were confirmed by the improvement of histological changes and DNA damage. Conclusion These data indicate that E.s. spinosus flower reduces the hypercholesterolemia risk and atherogenic properties of dietary cholesterol. Its hypocholesterolemic effect may be due to its antioxidant activities and its richness in bioactive molecule.

Artichoke leaf extract supplementation lowers hepatic oxidative stress and inflammation and increases multidrug resistance-associated protein 2 in mice fed a high-fat and high-cholesterol diet

2021 ◽  
Author(s):  
Guo-Chen Liao ◽  
Jia-Hua Jhuang ◽  
Hsien-Tsung Yao
Keyword(s):  
Oxidative Stress ◽  
Multidrug Resistance ◽  
Leaf Extract ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
High Fat ◽  
Cynara Scolymus ◽  
Artichoke Leaf Extract ◽  
Anti Inflammation

Artichoke (Cynara scolymus) leaf extract (ALE) contains many phytonutrients that may have antioxidant and anti-inflammation activities against many diseases including liver damage.

scholarly journals Protective Activities of Dendrobium huoshanense C. Z. Tang et S. J. Cheng Polysaccharide against High-Cholesterol Diet-Induced Atherosclerosis in Zebrafish

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Xiangcheng Fan ◽  
Jichun Han ◽  
Lijun Zhu ◽  
Zhipeng Chen ◽  
Jiajing Li ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Flow Chamber ◽  
Plaque Formation ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Sod Activity ◽  
Natural Medicine ◽  
Low Shear Stress ◽  
Dendrobium Huoshanense

Cardiovascular disease is the highest cause of death, and atherosclerosis (AS) is the primary pathogenesis of many cardiovascular diseases. In this study, we aim to investigate the possible pharmaceutical effects of Dendrobium huoshanense C. Z. Tang et S. J. Cheng polysaccharide (DHP) in AS. We fed zebrafish with high-cholesterol diet (HCD) to establish a zebrafish AS model and treated with DHP and observed plaque formation and neutrophil counts under a fluorescence microscope. Next, a parallel flow chamber was utilized to establish low shear stress- (LSS-) induced endothelial cell (EC) dysfunction model. We observed that DHP significantly improved HCD-induced lipid deposition, oxidative stress, and inflammatory response, mainly showing that DHP significantly increased superoxide dismutase (SOD) activity, decreased plaque formation, and decreased neutrophil recruitment and the levels of total cholesterol (TC), triglyceride (TG), malondialdehyde (MDA), and reactive oxygen species (ROS). Furthermore, DHP significantly improved LSS-induced oxidative stress and EC dysfunction. Our results indicated that DHP can exert treatment effects on AS, which may attribute to its hypolipidemic, antioxidant, anti-inflammatory activities and improving LSS-induced EC dysfunction. DHP has promising potential for further development as a functional natural medicine source targeted at AS prevention.

scholarly journals Attenuated Combined Action of Cyclosporine A and Hyperlipidemia on Atherogenesis in Rabbits by Thymoquinone

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
Ahmed Ragheb ◽  
Ahmed Attia ◽  
Fawzy Elbarbry ◽  
Kailash Prasad ◽  
Ahmed Shoker
Keyword(s):  
Oxidative Stress ◽  
Cyclosporine A ◽  
Rabbit Model ◽  
Group Iv ◽  
Control Group ◽  
High Cholesterol Diet ◽  
Aortic Atherosclerosis ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Group I

This descriptive study investigates in a rabbit model of atherosclerosis (i) the extent of atherogenesis induced by cyclosporine A (CsA) or hyperlipidemia alone or in combination and (ii) whether thymoquinone (TQ), a known herbal antioxidant, offers protection against these effects. New Zealand White female rabbits were assigned to five groups of six animals each: Group I, control; Group II, CsA [25 mg kg−1day−1orally (PO)]; Group III, 1% cholesterol; Group IV, 1% cholesterol + CsA (25 mg kg−1day−1PO); and Group V, 1% cholesterol + CsA (25 mg kg−1day−1PO) + TQ (10 mg kg−1day−1PO). Lipids and oxidative stress parameters [Malondialdehyde (MDA) and protein carbonyl] and aortic atherosclerosis were compared. CsA alone did not show a significant effect on either serum lipids and did not induce atherosclerosis. High-cholesterol diet induced atherosclerosis (45 ± 11% of the intimal surface of aorta was covered with atherosclerotic plaques). CsA and high-cholesterol diet increased atherosclerosis severity as measured from intimal and media lesions, but did not affect the extent of atherosclerosis. TQ decreased aortic MDA by 83%. It was also associated with reduced aortic atherosclerosis extend by 52% compared with Group IV. We concluded that (i) CsA aggravates hyperlipidemia-induced atherosclerosis and (ii) TQ attenuates the oxidative stress and atherogenesis induced by the combined effect of CsA and hyperlipidemia.

Evaluation of hypocholesterolemic effect and antioxidant activity of Boops boops proteins in cholesterol-fed rats

2014 ◽  
Vol 5 (6) ◽  
pp. 1224-1231 ◽  
Author(s):  
Imen Lassoued ◽  
Mariem Trigui ◽  
Zohra Ghlissi ◽  
Rim Nasri ◽  
Kamel Jamoussi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Activity ◽  
High Cholesterol Diet ◽  
Hypocholesterolemic Effect ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Boops Boops ◽  
And Oxidative Stress

The present study attempts to investigate the potential ofBoops boopsproteins and its hydrolysate in the prevention of hypercholesterolemia and oxidative stress in rats fed a high cholesterol diet.

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