PT08.5: Elevated C-Reactive Protein, Low Skeletal Muscle Mass, and Low Visceral Adipose Tissue are Associated with Reduced Overall Survival in Patients with Resectable Colorectal Liver Metastases

2017 ◽  
Vol 36 ◽  
pp. S47-S48
Author(s):  
D.P.J. Van Dijk ◽  
M. Krill ◽  
F. Farshidfar ◽  
T. Li ◽  
S.S. Rensen ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Overall Survival ◽  
Adipose Tissue ◽  
Liver Metastases ◽  
Visceral Adipose Tissue ◽  
Colorectal Liver Metastases ◽  
Skeletal Muscle Mass ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Visceral Adipose

Whole-body skeletal muscle mass is not related to glucose tolerance or insulin sensitivity in overweight and obese men and women

2008 ◽  
Vol 33 (4) ◽  
pp. 769-774 ◽  
Author(s):  
Jennifer L. Kuk ◽  
Katherine Kilpatrick ◽  
Lance E. Davidson ◽  
Robert Hudson ◽  
Robert Ross
Keyword(s):  
Skeletal Muscle ◽  
Adipose Tissue ◽  
Insulin Sensitivity ◽  
Glucose Tolerance ◽  
Muscle Mass ◽  
Visceral Adipose Tissue ◽  
Skeletal Muscle Mass ◽  
Whole Body ◽  
Men And Women ◽  
Visceral Adipose

The relationship between skeletal muscle mass, visceral adipose tissue, insulin sensitivity, and glucose tolerance was examined in 214 overweight or obese, but otherwise healthy, men (n = 98) and women (n = 116) who participated in various exercise and (or) weight-loss intervention studies. Subjects had a 75 g oral glucose tolerance test and (or) insulin sensitivity measures by a 3 h hyperinsulinemic–euglycemic clamp technique. Whole-body skeletal muscle mass and visceral adipose tissue were measured using a multi-slice magnetic resonance imaging protocol. Total body skeletal muscle mass was not associated with any measure of glucose metabolism in men or women (p > 0.10). These observations remained independent of age and total adiposity. Conversely, visceral adipose tissue was a significant predictor of various measures of glucose metabolism in both men and women with or without control for age and (or) total body fat (p < 0.05). Although skeletal muscle is a primary site for glucose uptake and deposition, these findings suggest that unlike visceral adipose tissue, whole-body skeletal muscle mass per se is not associated with either glucose tolerance or insulin sensitivity in overweight and obese men and women.

Relationship between C-reactive protein and visceral adipose tissue in healthy Japanese subjects

2004 ◽  
Vol 6 (4) ◽  
pp. 249-258 ◽  
Author(s):  
Y. Saijo ◽  
N. Kiyota ◽  
Y. Kawasaki ◽  
Y. Miyazaki ◽  
J. Kashimura ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Visceral Adipose Tissue ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Visceral Adipose ◽  
Japanese Subjects

C-reactive protein is highly expressed in visceral adipose tissue of obese but not lean subjects: A post mortem study

2017 ◽  
Vol 263 ◽  
pp. e122 ◽  
Author(s):  
Nurul Ain Noorjamal ◽  
Effat Omar ◽  
Mansharan Kaur ◽  
Mohd Shah Mahmood ◽  
Ahmad Hafizam Hasmi ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Visceral Adipose Tissue ◽  
Post Mortem ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Visceral Adipose

scholarly journals Growth Hormone Decreases Visceral Fat and Improves Cardiovascular Risk Markers in Women with Hypopituitarism: A Randomized, Placebo-Controlled Study

2008 ◽  
Vol 93 (6) ◽  
pp. 2063-2071 ◽  
Author(s):  
Catherine Beauregard ◽  
Andrea L. Utz ◽  
Amber E. Schaub ◽  
Lisa Nachtigall ◽  
Beverly M. K. Biller ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Cardiovascular Risk ◽  
Visceral Adipose Tissue ◽  
High Sensitivity ◽  
Risk Markers ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Tissue Plasminogen ◽  
Study Participants ◽  
Visceral Adipose

Abstract Context: Data regarding gender-specific efficacy of GH on critical endpoints are lacking. There are no randomized, placebo-controlled studies of physiological GH therapy solely in women. Objective: Our objective was to determine the effects of physiological GH replacement on cardiovascular risk markers and body composition in women with GH deficiency (GHD). Design: This was a 6-month, randomized, placebo-controlled, double-blind study. Setting: The study was conducted at the General Clinical Research Center. Study Participants: 43 women with GHD due to hypopituitarism were included in the study. Intervention: Study participants were randomized to receive GH (goal mid-normal serum IGF-1) or placebo. Main Outcome Measures: Cardiovascular risk markers, including high-sensitivity C-reactive protein, tissue plasminogen activator, and body composition, including visceral adipose tissue by cross-sectional computed tomography, were measured. Results: Mean daily GH dose was 0.67 mg. The mean IGF-1 sd score increased from −2.5 ± 0.3 to −1.4 ± 0.9 (GH) (P &lt; 0.0001 vs. placebo). High-sensitivity C-reactive protein decreased by 38.2 ± 9.6% (GH) vs.18.2 ± 6.0% (placebo) (P = 0.03). Tissue plasminogen activator and total cholesterol decreased, and high-density lipoprotein increased. Homeostasis model assessment-insulin resistance and other markers were unchanged. Body fat decreased [−5.1 ± 2.0 (GH) vs. 1.9 ± 1.0% (placebo); P = 0.002] as did visceral adipose tissue [−9.0 ± 5.9 (GH) vs. 4.3 ± 2.7% (placebo); P = 0.03]. Change in IGF-1 level was inversely associated with percent change in visceral adipose tissue (r = −0.61; P = 0.002), total body fat (r = −0.69; P &lt; 0.0001), and high-sensitivity C-reactive protein (r = −0.51; P = 0.003). Conclusions: Low-dose GH replacement in women with GHD decreased total and visceral adipose tissue and improved cardiovascular markers, with a relatively modest increase in IGF-1 levels and without worsening insulin resistance.

scholarly journals C-reactive protein as a predictor of prognosis following curative resection for colorectal liver metastases

2007 ◽  
Vol 96 (2) ◽  
pp. 222-225 ◽  
Author(s):  
V K H Wong ◽  
H Z Malik ◽  
Z Z R Hamady ◽  
A Al-Mukhtar ◽  
D Gomez ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Colorectal Liver Metastases ◽  
Curative Resection ◽  
C Reactive Protein ◽  
Reactive Protein

Influence of diet and exercise on skeletal muscle and visceral adipose tissue in men

1996 ◽  
Vol 81 (6) ◽  
pp. 2445-2455 ◽  
Author(s):  
Robert Ross ◽  
John Rissanen ◽  
Heather Pedwell ◽  
Jennifer Clifford ◽  
Peter Shragge
Keyword(s):  
Skeletal Muscle ◽  
Body Weight ◽  
Adipose Tissue ◽  
Visceral Adipose Tissue ◽  
Whole Body ◽  
Relative Reduction ◽  
Body Regions ◽  
Diet And Exercise ◽  
Magnetic Resonance Imaging Mri ◽  
Visceral Adipose

Ross, Robert, John Rissanen, Heather Pedwell, Jennifer Clifford, and Peter Shragge. Influence of diet and exercise on skeletal muscle and visceral adipose tissue in men. J. Appl. Physiol. 81(6): 2445–2455, 1996.—The effects of diet only (DO) and diet combined with either aerobic (DA) or resistance (DR) exercise on subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT), lean tissue (LT), and skeletal muscle (SM) tissue were evaluated in 33 obese men (DO, n= 11; DA, n = 11; DR, n = 11). All tissues were measured by using a whole body multislice magnetic resonance imaging (MRI) model. Within each group, significant reductions were observed for body weight, SAT, and VAT ( P < 0.05). The reductions in body weight (∼10%) and SAT (∼25%) and VAT volume (∼35%) were not different between groups ( P > 0.05). For all treatments, the relative reduction in VAT was greater than in SAT ( P < 0.05). For the DA and DR groups only, the reduction in abdominal SAT (∼27%) was greater ( P < 0.05) than that observed for the gluteal-femoral region (∼20%). Conversely, the reduction in VAT was uniform throughout the abdomen regardless of treatment ( P > 0.05). MRI-LT and MRI-SM decreased both in the upper and lower body regions for the DO group alone ( P < 0.05). Peak O2 uptake (liters) was significantly improved (∼14%) in the DA group as was muscular strength (∼20%) in the DR group ( P< 0.01). These findings indicate that DA and DR result in a greater preservation of MRI-SM, mobilization of SAT from the abdominal region, by comparison with the gluteal-femoral region, and improved functional capacity when compared with DO in obese men.

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