Designed cyclopentenone prostaglandin derivatives as neurite outgrowth-promoting compounds for CAD cells, a rat catecholaminergic neuronal cell line of the central nervous system

2000 ◽  
Vol 291 (3) ◽  
pp. 167-170 ◽  
Author(s):  
Takumi Satoh ◽  
Kyoji Furuta ◽  
Keiichiro Tomokiyo ◽  
Masaaki Suzuki ◽  
Yasuyoshi Watanabe
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Neurite Outgrowth ◽  
Cell Line ◽  
Neuronal Cell ◽  
Neuronal Cell Line ◽  
The Central Nervous System ◽  
Cad Cells ◽  
Cyclopentenone Prostaglandin

Apoptosis Induced by Differentiation or Serum Deprivation in an Immortalized Central Nervous System Neuronal Cell Line

2002 ◽  
Vol 67 (5) ◽  
pp. 1908-1920 ◽  
Author(s):  
Eva M. Eves ◽  
Lawrence H. Boise ◽  
Craig B. Thompson ◽  
Andrew J. Wagner ◽  
Nissim Hay ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cell Line ◽  
Neuronal Cell ◽  
Serum Deprivation ◽  
Neuronal Cell Line

scholarly journals Expression of the transcription factor NFATp in a neuronal cell line and in the murine nervous system.

1994 ◽  
Vol 269 (45) ◽  
pp. 28181-28186
Author(s):  
A M Ho ◽  
J Jain ◽  
A Rao ◽  
P G Hogan
Keyword(s):  
Nervous System ◽  
Transcription Factor ◽  
Cell Line ◽  
Neuronal Cell ◽  
Neuronal Cell Line

scholarly journals Detection and Characterization of Autoantibodies to Neuronal Cell-Surface Antigens in the Central Nervous System

2016 ◽  
Vol 9 ◽  
Author(s):  
Marleen H. van Coevorden-Hameete ◽  
Maarten J. Titulaer ◽  
Marco W. J. Schreurs ◽  
Esther de Graaff ◽  
Peter A. E. Sillevis Smitt ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cell Surface ◽  
Neuronal Cell ◽  
Surface Antigens ◽  
Cell Surface Antigens ◽  
The Central Nervous System

engrailed controls glial/neuronal cell fate decisions at the midline of the central nervous system

Neuron ◽  
1994 ◽  
Vol 13 (3) ◽  
pp. 541-554 ◽  
Author(s):  
Barry G. Condron ◽  
Nipam H. Patel ◽  
Kai Zinn
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cell Fate ◽  
Neuronal Cell ◽  
Cell Fate Decisions ◽  
The Central Nervous System

Protective peptides derived from novel glial proteins

2000 ◽  
Vol 28 (4) ◽  
pp. 452-455 ◽  
Author(s):  
D. E. Brenneman ◽  
C. Y. Spong ◽  
I. Gozes
Keyword(s):  
Oxidative Stress ◽  
Central Nervous System ◽  
Nervous System ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Short Peptides ◽  
Significant Efficacy ◽  
The Central Nervous System ◽  
Human Neurodegenerative Disease

In studying the mediators of VIP neurotrophism in the central nervous system, two glial proteins have been discovered. Both of these proteins contain short peptides that exhibit femtomolar potency in preventing neuronal cell death from a wide variety of neurotoxic substances. Extension of these peptides to models of oxidative stress or neurodegeneration in vivo have indicated significant efficacy in protection. These peptides, both as individual agents and in combination, have promise as possible protective agents in the treatment of human neurodegenerative disease and in pathologies involving oxidative stress.

scholarly journals Upregulation of lncRNA147410.3 in the Brain of Mice With Chronic Toxoplasma Infection Promoted Microglia Apoptosis by Regulating Hoxb3

2021 ◽  
Vol 15 ◽  
Author(s):  
Yongliang Wang ◽  
Ruxia Han ◽  
Zhejun Xu ◽  
Xiahui Sun ◽  
Chunxue Zhou ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Target Gene ◽  
Neuronal Cell ◽  
Scientific Basis ◽  
Cns Development ◽  
Toxoplasma Infection ◽  
Key Factor ◽  
The Central Nervous System ◽  
The Brain

Toxoplasma gondii is neurotropic and affects the function of nerve cells, while the mechanism is unclear. LncRNAs are abundantly enriched in the brain and participated in the delicate regulation of the central nervous system (CNS) development. However, whether these lncRNAs are involved in the regulation of microglia activation during the process of T. gondii infection is largely unknown. In this study, the upregulation of a novel lncRNA147410.3 (ENSMUST00000147410.3) was identified as a key factor to influence this process. The target gene of lncRNA147410.3 was predicted and identified as Hoxb3. The localization of lncRNA147410.3 in the brain and cells was proved in the nucleus of neuroglia through FISH assay. Furthermore, the function of lncRNA147410.3 on neuronal cell was confirmed that lncRNA147410.3 could affect proliferation, differentiation, and apoptosis of mouse microglia by positively regulating Hoxb3. Thus, our study explored the modulatory action of lncRNA147410.3 in T. gondii infected mouse brain, providing a scientific basis for using lncRNA147410.3 as a therapeutic target to treat neurological disorder induced by T. gondii.

scholarly journals The Role of Microglia during West Nile Virus Infection of the Central Nervous System

Vaccines ◽  
2020 ◽  
Vol 8 (3) ◽  
pp. 485 ◽  
Author(s):  
Sarah Stonedahl ◽  
Penny Clarke ◽  
Kenneth L. Tyler
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
West Nile Virus ◽  
Immune Cells ◽  
Neuronal Cell ◽  
The United States ◽  
Health Concern ◽  
West Nile ◽  
The Central Nervous System

Encephalitis resulting from viral infections is a major cause of hospitalization and death worldwide. West Nile Virus (WNV) is a substantial health concern as it is one of the leading causes of viral encephalitis in the United States today. WNV infiltrates the central nervous system (CNS), where it directly infects neurons and induces neuronal cell death, in part, via activation of caspase 3-mediated apoptosis. WNV infection also induces neuroinflammation characterized by activation of innate immune cells, including microglia and astrocytes, production of inflammatory cytokines, breakdown of the blood-brain barrier, and infiltration of peripheral leukocytes. Microglia are the resident immune cells of the brain and monitor the CNS for signs of injury or pathogens. Following infection with WNV, microglia exhibit a change in morphology consistent with activation and are associated with increased expression of proinflammatory cytokines. Recent research has focused on deciphering the role of microglia during WNV encephalitis. Microglia play a protective role during infections by limiting viral growth and reducing mortality in mice. However, it also appears that activated microglia are triggered by T cells to mediate synaptic elimination at late times during infection, which may contribute to long-term neurological deficits following a neuroinvasive WNV infection. This review will discuss the important role of microglia in the pathogenesis of a neuroinvasive WNV infection. Knowledge of the precise role of microglia during a WNV infection may lead to a greater ability to treat and manage WNV encephalitis.

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