Risk factors of early menopause in two generations of gainfully employed French women

Maturitas ◽  
1997 ◽  
Vol 26 (3) ◽  
pp. 165-174 ◽  
Author(s):  
B. Cassou ◽  
F. Derriennic ◽  
C. Monfort ◽  
P. Dell'Accio ◽  
A. Touranchet
2021 ◽  
Author(s):  
Darina Peycheva ◽  
Alice Sullivan ◽  
Rebecca Hardy ◽  
Alex Bryson ◽  
Gabriella Conti ◽  
...  

Using data from two generations of British women followed from birth through childhood and into adulthood, we investigate risk factors for the onset of natural menopause before the age of 45 (known as early menopause). We focus on key stages during the life course to understand when risk factors are particularly harmful. We find that earlier cessation of menstruation is influenced by circumstances at birth. Women born in lower social class families, whose mother smoked during the pregnancy or who were short-term breastfed (one month or less) were more likely to undergo menopause before 45. Early menopause is also associated with poorer cognitive ability and smoking in childhood. Adult health behaviour also matters. Smoking is positively correlated with early menopause, while regular exercise (one to several times a week) and moderate frequency of alcohol drinking (one to three times a month) in women's early thirties are associated with a reduced risk of early menopause. The occurrence of gynaecological problems by women's early thirties is also linked to early menopause. We note that some of these factors (e.g. health behaviours) are modifiable and thus the risks may be preventable.


2017 ◽  
Vol 108 (3) ◽  
pp. e120-e121
Author(s):  
S. Choe ◽  
Y. Kim ◽  
I. Kang ◽  
C. Sim ◽  
J. Heo ◽  
...  

Heart ◽  
2019 ◽  
Vol 105 (21) ◽  
pp. 1656-1660 ◽  
Author(s):  
Laura Young ◽  
Leslie Cho

Despite an overall reduction in cardiovascular disease (CVD) mortality in the USA, the rate of coronary heart disease and CVD mortality is on the rise in younger women aged 35 to 54 years. This has been attributed to an increasing prevalence of CVD risk factors, which can portend disparate outcomes in women versus men. Women with diabetes and those who smoke have an excess relative risk of CVD when compared with their male counterparts. In addition to these discrepancies in traditional risk factors, a number of clinical conditions unique to women have been shown to increase CVD risks such as pre-eclampsia, gestational diabetes, polycystic ovary syndrome, early menopause and autoimmune diseases. The majority of these sex-specific risk factors can be identified at an early age, allowing for aggressive risk factor modification through lifestyle changes and, in certain patients, medications. The recently published 2018 American College of Cardiology and American Heart Association (ACC/AHA) hypercholesterolaemia and 2019 ACC/AHA primary prevention guidelines reflect this, citing pre-eclampsia, early menopause and autoimmune diseases as ‘risk enhancers’ that if present may favour initiation of statin therapy in borderline or intermediate risk patients. This comprehensive review addresses both traditional and unique risk factors of CVD in women, as well as sex-specific risk stratification and management options.


2021 ◽  
Vol 11 (2) ◽  
pp. 63-67
Author(s):  
Blessy Maria Thomas ◽  
Alan Kuriakose ◽  
Joshua John Joseph ◽  
Nimisha George ◽  
Purnima Ashok

Osteoporosis is a highly prevalent health issue among postmenopausal women, which can be prevented if identified in the early stages. The use of Osteoporosis Self - assessment Tool (OST) will help in identifying the risk of osteoporosis and hence will allow the patients to seek the best treatment if required. In this study we assessed the prevalence of risk factors for osteoporosis in 400 Postmenopausal women and have measured the osteoporotic risk using OST. The risk factors and risk scores were correlated using spearman’s rho correlation analysis. As per the postmenopausal classification, 52% of the population belonged to the late stage. Average BMI of the population was found to be 19.5 that is borderline of the normal which indicates the risk for Osteoporosis. Attaining early menopause 243(60.75%) and history of fall 223(55.75%) was the most common risk factors found in the population. Using OST, 78 patients were identified with high risk. The correlation between OST and risk factors revealed that OST is positively significant with the progression of menopausal stage. Patient education regarding the use and interpretation of OST will help to identify risk of osteoporosis; this should be implemented within the primary gynecological care units for the better outcome. Keywords: Osteoporosis, postmenopausal women, risk factors, Osteoporosis Self - assessment Tool.


2010 ◽  
Vol 20 (1) ◽  
pp. 186-192 ◽  
Author(s):  
Anna Murray ◽  
Claire E. Bennett ◽  
John R.B. Perry ◽  
Michael N. Weedon ◽  
ReproGen Consortium ◽  
...  

ScienceRise ◽  
2021 ◽  
pp. 34-39
Author(s):  
Yevheniia Lukianets

Object of research: Women in whom the risk of osteoporotic fractures was assessed using the FRAX, Q-Fracture algorithms, and the risk factors for osteoporosis and their role in the development of osteoporotic fractures were studied. Investigated problem: the use of various algorithms in the practice of a family doctor to assess the 10-year risk of osteoporotic fractures. Main scientific results: A decrease in bone mineral density was found in 51.4 % of the surveyed women, of whom osteopenia was in 48.7 %, osteoporosis in 2.9 % of women. The risk of fractures according to all algorithms was higher in women of the age group 70–79 years: FRAX Total – 8.87±3.2, FRAX Hip – 4.03±3.1, Q fracture total – 12.87±1.5, Q fracture Hip – 7.97±2.7, FRAX Total without BMD – 11.9±5.5, FRAX Hip without BMD – 6.3±4.8. Age correlates negatively with the T score (r=–0.47, p=0.007) and positively with the FRAX Total algorithms without BMD (r=–0.47, p=0.003), FRAX Hip without BMD (r=0.78, p=0.006), Q fracture total (r=0.86, p=0.007), Q fracture Hip (r=0.92, p=0.008), FRAX Hip with BMD (r=0.55, p=0.009). No statistically significant difference was found with FRAX Total with BMD (r=0.21, p=0.345). Risk factors: 14.3 % of women had fractures of various localization; fractures in parents were noted by 37.1 % of respondents; a decrease in height by 3 cm during life occurred in 13.3 %. Early menopause (up to 45 years old) occurred in 11.4 % of women. Physical activity less than 30 minutes a day was noted by 68.6 %. The area of practical use of the research results: the primary level of medical care. Innovative technological product: early identification of risk factors for osteoporosis and calculation of the risk of fractures will reduce the medical and social consequences of complications in osteoporosis. Scope of application of the innovative technological product: in the clinical practice of general practitioners.


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